PubMed:31852285 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"T2","span":{"begin":91,"end":349},"obj":"Sentence"},{"id":"T3","span":{"begin":350,"end":522},"obj":"Sentence"},{"id":"T4","span":{"begin":523,"end":664},"obj":"Sentence"},{"id":"T5","span":{"begin":665,"end":746},"obj":"Sentence"},{"id":"T6","span":{"begin":747,"end":892},"obj":"Sentence"},{"id":"T7","span":{"begin":893,"end":1079},"obj":"Sentence"},{"id":"T8","span":{"begin":1080,"end":1317},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"T2","span":{"begin":91,"end":349},"obj":"Sentence"},{"id":"T3","span":{"begin":350,"end":522},"obj":"Sentence"},{"id":"T4","span":{"begin":523,"end":664},"obj":"Sentence"},{"id":"T5","span":{"begin":665,"end":746},"obj":"Sentence"},{"id":"T6","span":{"begin":747,"end":892},"obj":"Sentence"},{"id":"T7","span":{"begin":893,"end":1079},"obj":"Sentence"},{"id":"T8","span":{"begin":1080,"end":1317},"obj":"Sentence"}],"text":"Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties.\nMulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases for hundreds of years; however, after years of research efforts, little information is available on its anti-inflammatory components and underlying mechanism. We developed novel carbon dots (CDs) derived from MSC carbonisata (MSC-CDs), for the first time, with an average diameter of 2.26-9.35 nm and a quantum yield (QY) of 6.32%. The MSC-CDs were prepared using a modified pyrolysis method, and no further modification and external surface passivation agent was required. With abundant surface groups, MSC-CDs showed distinct solubility and bioactivity. In this study, we innovatively used three classical experimental models of inflammation to evaluate the anti-inflammatory bioactivity of MSC-CDs. The results indicated that MSC-CDs exhibited marked anti-inflammatory bioactivity which was likely mediated by inhibition of the expression of interleukin-6 and tumour necrosis factor-α. These results suggest that MSC-CDs possess a remarkable anti-inflammatory property, which provides evidence to support further investigation of the considerable potential and effective material basis of this traditional Chinese medicine."}

{"project":"silkwormbase","denotations":[{"id":"T13","span":{"begin":1111,"end":1114},"obj":"Chemical:-"},{"id":"T2","span":{"begin":39,"end":45},"obj":"Chemical:MESH:D002244"},{"id":"T3","span":{"begin":91,"end":115},"obj":"Disease:OMIM:613630"},{"id":"T4","span":{"begin":369,"end":380},"obj":"Chemical:-"},{"id":"T5","span":{"begin":382,"end":385},"obj":"Chemical:-"},{"id":"T6","span":{"begin":421,"end":424},"obj":"Chemical:-"},{"id":"T7","span":{"begin":531,"end":534},"obj":"Chemical:-"},{"id":"T8","span":{"begin":699,"end":702},"obj":"Chemical:-"},{"id":"T9","span":{"begin":822,"end":834},"obj":"Disease:MESH:D007249"},{"id":"T1","span":{"begin":15,"end":23},"obj":"Species:7091"},{"id":"T10","span":{"begin":888,"end":891},"obj":"Chemical:-"},{"id":"T11","span":{"begin":924,"end":927},"obj":"Chemical:-"},{"id":"T12","span":{"begin":1054,"end":1069},"obj":"Disease:MESH:D009336"}],"text":"Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties.\nMulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases for hundreds of years; however, after years of research efforts, little information is available on its anti-inflammatory components and underlying mechanism. We developed novel carbon dots (CDs) derived from MSC carbonisata (MSC-CDs), for the first time, with an average diameter of 2.26-9.35 nm and a quantum yield (QY) of 6.32%. The MSC-CDs were prepared using a modified pyrolysis method, and no further modification and external surface passivation agent was required. With abundant surface groups, MSC-CDs showed distinct solubility and bioactivity. In this study, we innovatively used three classical experimental models of inflammation to evaluate the anti-inflammatory bioactivity of MSC-CDs. The results indicated that MSC-CDs exhibited marked anti-inflammatory bioactivity which was likely mediated by inhibition of the expression of interleukin-6 and tumour necrosis factor-α. These results suggest that MSC-CDs possess a remarkable anti-inflammatory property, which provides evidence to support further investigation of the considerable potential and effective material basis of this traditional Chinese medicine."}

{"project":"silkworm","denotations":[{"id":"T1","span":{"begin":15,"end":23},"obj":"Species:7091"},{"id":"T2","span":{"begin":39,"end":45},"obj":"Chemical:MESH:D002244"},{"id":"T3","span":{"begin":91,"end":115},"obj":"Disease:OMIM:613630"},{"id":"T4","span":{"begin":369,"end":380},"obj":"Chemical:-"},{"id":"T5","span":{"begin":382,"end":385},"obj":"Chemical:-"},{"id":"T6","span":{"begin":421,"end":424},"obj":"Chemical:-"},{"id":"T7","span":{"begin":531,"end":534},"obj":"Chemical:-"},{"id":"T8","span":{"begin":699,"end":702},"obj":"Chemical:-"},{"id":"T9","span":{"begin":822,"end":834},"obj":"Disease:MESH:D007249"},{"id":"T10","span":{"begin":888,"end":891},"obj":"Chemical:-"},{"id":"T11","span":{"begin":924,"end":927},"obj":"Chemical:-"},{"id":"T12","span":{"begin":1054,"end":1069},"obj":"Disease:MESH:D009336"},{"id":"T13","span":{"begin":1111,"end":1114},"obj":"Chemical:-"}],"text":"Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties.\nMulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases for hundreds of years; however, after years of research efforts, little information is available on its anti-inflammatory components and underlying mechanism. We developed novel carbon dots (CDs) derived from MSC carbonisata (MSC-CDs), for the first time, with an average diameter of 2.26-9.35 nm and a quantum yield (QY) of 6.32%. The MSC-CDs were prepared using a modified pyrolysis method, and no further modification and external surface passivation agent was required. With abundant surface groups, MSC-CDs showed distinct solubility and bioactivity. In this study, we innovatively used three classical experimental models of inflammation to evaluate the anti-inflammatory bioactivity of MSC-CDs. The results indicated that MSC-CDs exhibited marked anti-inflammatory bioactivity which was likely mediated by inhibition of the expression of interleukin-6 and tumour necrosis factor-α. These results suggest that MSC-CDs possess a remarkable anti-inflammatory property, which provides evidence to support further investigation of the considerable potential and effective material basis of this traditional Chinese medicine."}