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PubMed:3180550 JSONTXT

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sonoma

Id Subject Object Predicate Lexical cue
T-0 0-12 DISEASE denotes Alkaptonuria
T-1 17-27 CPA denotes ochronosis
T-2 272-290 MPA denotes oxidation products
T-3 292-298 REG denotes giving
T-4 331-341 CPA denotes ochronosis
T-5 444-447 MPA denotes HGA
T-6 482-490 GENE denotes collagen
T-7 544-556 DISEASE denotes alkaptonuria
T-8 741-755 MPA denotes urinary levels
T-9 759-762 GENE denotes HGA
T-10 865-875 CPA denotes ochronosis
T-11 121-133 DISEASE denotes alkaptonuria
T-12 134-138 NEGREG denotes lack
T-13 180-189 MPA denotes retention
T-14 213-216 MPA denotes HGA
T-15 193-211 MPA denotes homogentistic acid
T-16 398-407 REG denotes catalyses
T-17 425-442 MPA denotes homogentisic acid
T-18 139-168 ENZYME denotes homogentisate 1,2-dioxygenase
T-19 92-105 MPA denotes HGA excretion
T-20 412-421 MPA denotes oxidation
R-0 T-11 T-12 ThemeOf alkaptonuria,lack
R-1 T-12 T-13 CauseOf lack,retention
R-2 T-12 T-3 CauseOf lack,giving
R-3 T-14 T-13 ThemeOf HGA,retention
R-4 T-4 T-3 ThemeOf ochronosis,giving
R-5 T-9 T-8 ThemeOf HGA,urinary levels
R-6 T-18 T-12 ThemeOf "homogentisate 1,2-dioxygenase",lack
R-7 T-15 T-13 ThemeOf homogentistic acid,retention
R-8 T-20 T-16 ThemeOf oxidation,catalyses
R-9 T-17 T-20 ThemeOf homogentisic acid,oxidation
R-10 T-5 T-20 ThemeOf HGA,oxidation

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-46 Sentence denotes Alkaptonuria and ochronosis in three siblings.
TextSentencer_T2 47-106 Sentence denotes Ascorbic acid treatment monitored by urinary HGA excretion.
TextSentencer_T3 107-342 Sentence denotes Patients with alkaptonuria lack homogentisate 1,2-dioxygenase leading to retention of homogentistic acid (HGA) in body fluids and eventually to tissue deposition of oxidation products, giving rise to the clinical picture of ochronosis.
TextSentencer_T4 343-557 Sentence denotes Ascorbic acid is a known inhibitor of the enzyme which catalyses the oxidation of homogentisic acid (HGA) to the polymer with affinity for collagen and was used in the treatment of three siblings with alkaptonuria.
TextSentencer_T5 558-614 Sentence denotes Ascorbic acid 500 mg bid was administered for 12 months.
TextSentencer_T6 615-729 Sentence denotes Two of the siblings tolerated the treatment, and in one the symptoms improved, whereas in the other they worsened.
TextSentencer_T7 730-801 Sentence denotes Plasma and urinary levels of HGA were monitored with a new HPLC method.
TextSentencer_T8 802-876 Sentence denotes Ascorbic acid is not effective in the treatment of symptomatic ochronosis.
T1 0-46 Sentence denotes Alkaptonuria and ochronosis in three siblings.
T2 47-106 Sentence denotes Ascorbic acid treatment monitored by urinary HGA excretion.
T3 107-342 Sentence denotes Patients with alkaptonuria lack homogentisate 1,2-dioxygenase leading to retention of homogentistic acid (HGA) in body fluids and eventually to tissue deposition of oxidation products, giving rise to the clinical picture of ochronosis.
T4 343-557 Sentence denotes Ascorbic acid is a known inhibitor of the enzyme which catalyses the oxidation of homogentisic acid (HGA) to the polymer with affinity for collagen and was used in the treatment of three siblings with alkaptonuria.
T5 558-614 Sentence denotes Ascorbic acid 500 mg bid was administered for 12 months.
T6 615-729 Sentence denotes Two of the siblings tolerated the treatment, and in one the symptoms improved, whereas in the other they worsened.
T7 730-801 Sentence denotes Plasma and urinary levels of HGA were monitored with a new HPLC method.
T8 802-876 Sentence denotes Ascorbic acid is not effective in the treatment of symptomatic ochronosis.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 139-168 gene:3081 denotes homogentisate 1,2-dioxygenase
T1 121-133 disease:C0002066 denotes alkaptonuria
T2 139-168 gene:3081 denotes homogentisate 1,2-dioxygenase
T3 331-341 disease:C0028817 denotes ochronosis
R1 T0 T1 associated_with "homogentisate 1,2-dioxygenase",alkaptonuria
R2 T2 T3 associated_with "homogentisate 1,2-dioxygenase",ochronosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
3180550-1#32#61#gene3081 139-168 gene3081 denotes homogentisate 1,2-dioxygenase
3180550-1#14#26#diseaseC0002066 121-133 diseaseC0002066 denotes alkaptonuria
32#61#gene308114#26#diseaseC0002066 3180550-1#32#61#gene3081 3180550-1#14#26#diseaseC0002066 associated_with "homogentisate 1,2-dioxygenase",alkaptonuria

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 251-257 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 17-27 HP:0030764 denotes ochronosis
AB1 331-341 HP:0030764 denotes ochronosis
AB2 865-875 HP:0030764 denotes ochronosis

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 0-12 ORDO:56 denotes Alkaptonuria
AB1 121-133 ORDO:56 denotes alkaptonuria
AB2 544-556 ORDO:56 denotes alkaptonuria

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 251-257 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue