> top > docs > PubMed:31774226 > annotations

PubMed:31774226 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Characterization of a chloroquine-induced canine model of pruritus and skin inflammation.
T2 90-101 Sentence denotes BACKGROUND:
T3 102-242 Sentence denotes Chloroquine (CQ) is a prototypical systemic and intradermal pruritogen for histamine-independent (nonhistaminergic) itch in mice and humans.
T4 243-310 Sentence denotes The predictive validity of this model is poorly documented in dogs.
T5 311-332 Sentence denotes HYPOTHESIS/OBJECTIVE:
T6 333-404 Sentence denotes To determine pruritogenic and inflammatory effects of systemic and i.d.
T7 405-435 Sentence denotes CQ injections in healthy dogs.
T8 436-444 Sentence denotes ANIMALS:
T9 445-489 Sentence denotes Ten healthy purpose-bred laboratory beagles.
T10 490-512 Sentence denotes METHODS AND MATERIALS:
T11 513-640 Sentence denotes All dogs were randomized to receive i.d. (200 and 400 µg/site), intravenous (2 mg/kg) and subcutaneous (3 mg/kg) CQ injections.
T12 641-746 Sentence denotes Dogs were video-recorded for 30 min after i.d. injections and for 300 min after i.v. and s.c. injections.
T13 747-808 Sentence denotes Buffered saline injections served as controls for each route.
T14 809-900 Sentence denotes Global wheal scores were evaluated at 30 min post-i.d. injection by a blinded investigator.
T15 901-909 Sentence denotes RESULTS:
T16 910-1082 Sentence denotes All dogs showed wheal and erythema at the CQ i.d. injection sites; global wheal scores of each CQ concentration were significantly increased compared to placebo (P ≤ 0.05).
T17 1083-1228 Sentence denotes Blinded evaluation revealed no significant increase in generalized pruritic behaviour (pruritic seconds) after i.v. or s.c. administration of CQ.
T18 1229-1381 Sentence denotes Intradermal injections induced mild localized acute pruritic behaviours at the site of injections at 200 µg (P = 0.06) and 400 µg (P = 0.27) CQ in dogs.
T19 1382-1419 Sentence denotes CONCLUSION AND CLINICAL SIGNIFICANCE:
T20 1420-1505 Sentence denotes To the best of the authors' knowledge, this is the first report which shows that i.d.
T21 1506-1566 Sentence denotes CQ injections may induce acute inflammation in healthy dogs.
T22 1567-1772 Sentence denotes By contrast to the systemic CQ-induced pruritus reported previously in healthy mice and dogs, no significant pruritic behaviours were observed after CQ injection, regardless of the route of administration.
T1 0-89 Sentence denotes Characterization of a chloroquine-induced canine model of pruritus and skin inflammation.
T2 90-101 Sentence denotes BACKGROUND:
T3 102-242 Sentence denotes Chloroquine (CQ) is a prototypical systemic and intradermal pruritogen for histamine-independent (nonhistaminergic) itch in mice and humans.
T4 243-310 Sentence denotes The predictive validity of this model is poorly documented in dogs.
T5 311-332 Sentence denotes HYPOTHESIS/OBJECTIVE:
T6 333-404 Sentence denotes To determine pruritogenic and inflammatory effects of systemic and i.d.
T7 405-435 Sentence denotes CQ injections in healthy dogs.
T8 436-444 Sentence denotes ANIMALS:
T9 445-489 Sentence denotes Ten healthy purpose-bred laboratory beagles.
T10 490-512 Sentence denotes METHODS AND MATERIALS:
T11 513-640 Sentence denotes All dogs were randomized to receive i.d. (200 and 400 µg/site), intravenous (2 mg/kg) and subcutaneous (3 mg/kg) CQ injections.
T12 641-746 Sentence denotes Dogs were video-recorded for 30 min after i.d. injections and for 300 min after i.v. and s.c. injections.
T13 747-808 Sentence denotes Buffered saline injections served as controls for each route.
T14 809-900 Sentence denotes Global wheal scores were evaluated at 30 min post-i.d. injection by a blinded investigator.
T15 901-909 Sentence denotes RESULTS:
T16 910-1082 Sentence denotes All dogs showed wheal and erythema at the CQ i.d. injection sites; global wheal scores of each CQ concentration were significantly increased compared to placebo (P ≤ 0.05).
T17 1083-1228 Sentence denotes Blinded evaluation revealed no significant increase in generalized pruritic behaviour (pruritic seconds) after i.v. or s.c. administration of CQ.
T18 1229-1381 Sentence denotes Intradermal injections induced mild localized acute pruritic behaviours at the site of injections at 200 µg (P = 0.06) and 400 µg (P = 0.27) CQ in dogs.
T19 1382-1419 Sentence denotes CONCLUSION AND CLINICAL SIGNIFICANCE:
T20 1420-1505 Sentence denotes To the best of the authors' knowledge, this is the first report which shows that i.d.
T21 1506-1566 Sentence denotes CQ injections may induce acute inflammation in healthy dogs.
T22 1567-1772 Sentence denotes By contrast to the systemic CQ-induced pruritus reported previously in healthy mice and dogs, no significant pruritic behaviours were observed after CQ injection, regardless of the route of administration.