PubMed:31734525 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/31734525","sourcedb":"PubMed","sourceid":"31734525","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/31734525","text":"Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls.\nINTRODUCTION: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural \"fear network\". We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli.\nMETHOD: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific \"Westphal-Paradigm\". It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety.\nRESULTS: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC).\nDISCUSSION: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. 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