PubMed:31704059
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 120-353 | DRI_Challenge | denotes | The eye imaginal disc-specific knockdown of dFIG4, a Drosophila homolog of FIG4 that is one of the Charcot-Marie-Tooth disease (CMT)-causing genes, induces an aberrant adult compound eye morphology, the so-called rough eye phenotype. |
| T2 | 354-403 | DRI_Approach | denotes | We previously performed modifier screening on the |
| T3 | 428-572 | DRI_Approach | denotes | rough eye phenotype and identified several genes, including CR18854, encoding a long non-coding RNA (lncRNA) as genetic interactants with dFIG4. |
| T4 | 573-719 | DRI_Outcome | denotes | In the present study, in more extensive genetic screening, we found that the deletion of a gene locus encoding both Odorant rector 46a (Or46a) and |
| T5 | 735-816 | DRI_Outcome | denotes | effectively suppressed the rough eye phenotype induced by the knockdown of dFIG4. |
| T6 | 817-896 | DRI_Approach | denotes | Both genes were located on the same locus, but oriented in opposite directions. |
| T7 | 897-1081 | DRI_Approach | denotes | In order to identify which of these genes is responsible for the suppression of the rough eye phenotype, we established a CR43467-specific knockdown line using the CRISPR-dCas9 system. |
| T8 | 1082-1210 | DRI_Approach | denotes | By using this system, we demonstrated that the CR43467 gene, but not the Or46a gene, genetically interacted with the dFIG4 gene. |
| T9 | 1211-1377 | DRI_Outcome | denotes | The knockdown of CR43467 rescued the reductions in the length of synaptic branches and number of boutons at neuromuscular junctions induced by the knockdown of dFIG4. |
| T10 | 1378-1430 | DRI_Outcome | denotes | The vacuole enlargement phenotype induced by the fat |
| T11 | 1451-1521 | DRI_Outcome | denotes | knockdown was also effectively suppressed by the knockdown of CR43467. |
| T12 | 1522-1674 | DRI_Background | denotes | The knockdown of CR43467 also suppressed the rough eye phenotype induced by other peripheral neuropathy-related genes, such as dCOA7, dHADHB, and dPDHB. |
| T13 | 1675-1785 | DRI_Approach | denotes | We herein identified another gene encoding lncRNA, CR43467 as a genetic interactant with the CMT-causing gene. |
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 37-56 | SO:0001877 | denotes | long non-coding RNA |
| T1 | 37-56 | D062085 | denotes | long non-coding RNA |
| T6 | 53-56 | GO:0005562 | denotes | RNA |
| T9 | 102-105 | CVCL_YL11 | denotes | CMT |
| T8 | 102-105 | I6WHP7 | denotes | CMT |
| T10 | 114-118 | SO:0000704 | denotes | gene |
| T11 | 124-127 | UBERON:0000019 | denotes | eye |
| T12 | 124-127 | UBERON:0000970 | denotes | eye |
| T13 | 124-127 | UBERON:0010230 | denotes | eye |
| T14 | 128-141 | UBERON:0000939 | denotes | imaginal disc |
| T15 | 173-183 | 2294143 | denotes | Drosophila |
| T16 | 173-183 | 504603 | denotes | Drosophila |
| T17 | 173-183 | 2294139 | denotes | Drosophila |
| T18 | 173-183 | 2294145 | denotes | Drosophila |
| T19 | 173-183 | 2294141 | denotes | Drosophila |
| T20 | 173-183 | 2294142 | denotes | Drosophila |
| T21 | 173-183 | 2294144 | denotes | Drosophila |
| T22 | 173-183 | 2294140 | denotes | Drosophila |
| T23 | 173-183 | D004330 | denotes | Drosophila |
| T24 | 173-183 | 2080301 | denotes | Drosophila |
| T25 | 184-191 | SO:0000853 | denotes | homolog |
| T31 | 195-199 | PR:Q91WF7 | denotes | FIG4 |
| T32 | 195-199 | PR:Q92562 | denotes | FIG4 |
| T33 | 195-199 | PR:Q7XZU3 | denotes | FIG4 |
| T34 | 195-199 | PR:000031137 | denotes | FIG4 |
| T35 | 195-199 | PR:P42837 | denotes | FIG4 |
| T42 | 219-246 | D002607 | denotes | Charcot-Marie-Tooth disease |
| T43 | 219-246 | D002607 | denotes | Charcot-Marie-Tooth disease |
| T44 | 233-238 | UBERON:0001091 | denotes | Tooth |
| T50 | 248-251 | CVCL_YL11 | denotes | CMT |
| T49 | 248-251 | I6WHP7 | denotes | CMT |
| T52 | 288-306 | UBERON:0000018 | denotes | adult compound eye |
| T57 | 339-342 | UBERON:0000019 | denotes | eye |
| T58 | 339-342 | UBERON:0000970 | denotes | eye |
| T59 | 339-342 | UBERON:0010230 | denotes | eye |
| T60 | 434-437 | UBERON:0000019 | denotes | eye |
| T61 | 434-437 | UBERON:0000970 | denotes | eye |
| T62 | 434-437 | UBERON:0010230 | denotes | eye |
| T64 | 508-527 | SO:0001877 | denotes | long non-coding RNA |
| T63 | 508-527 | D062085 | denotes | long non-coding RNA |
| T68 | 524-527 | GO:0005562 | denotes | RNA |
| T70 | 529-535 | D062085 | denotes | lncRNA |
| T71 | 650-658 | SO:0000159 | denotes | deletion |
| T72 | 664-668 | SO:0000704 | denotes | gene |
| T73 | 720-726 | D062085 | denotes | lncRNA |
| T74 | 768-771 | UBERON:0000019 | denotes | eye |
| T75 | 768-771 | UBERON:0000970 | denotes | eye |
| T76 | 768-771 | UBERON:0010230 | denotes | eye |
| T77 | 987-990 | UBERON:0000019 | denotes | eye |
| T78 | 987-990 | UBERON:0000970 | denotes | eye |
| T79 | 987-990 | UBERON:0010230 | denotes | eye |
| T80 | 1061-1067 | SO:0001459 | denotes | CRISPR |
| T81 | 1137-1141 | SO:0000704 | denotes | gene |
| T82 | 1161-1165 | SO:0000704 | denotes | gene |
| T83 | 1205-1209 | SO:0000704 | denotes | gene |
| T84 | 1319-1332 | D009468 | denotes | neuromuscular |
| T85 | 1319-1332 | D009468 | denotes | neuromuscular |
| T86 | 1382-1389 | GO:0005773 | denotes | vacuole |
| T88 | 1427-1430 | CHEBI:24021 | denotes | fat |
| T89 | 1427-1435 | UBERON:0003916 | denotes | fat body |
| T90 | 1427-1435 | UBERON:0003917 | denotes | fat body |
| T91 | 1573-1576 | UBERON:0000019 | denotes | eye |
| T92 | 1573-1576 | UBERON:0000970 | denotes | eye |
| T93 | 1573-1576 | UBERON:0010230 | denotes | eye |
| T94 | 1604-1625 | D010523 | denotes | peripheral neuropathy |
| T95 | 1604-1625 | D010523 | denotes | peripheral neuropathy |
| T96 | 1704-1708 | SO:0000704 | denotes | gene |
| T97 | 1718-1724 | D062085 | denotes | lncRNA |
| T98 | 1768-1771 | I6WHP7 | denotes | CMT |
| T99 | 1768-1771 | CVCL_YL11 | denotes | CMT |
| T100 | 1780-1784 | SO:0000704 | denotes | gene |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 35-36 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T2 | 60-61 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T3 | 100-101 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T4 | 102-105 | CVCL_YL11|Embryonic_stem_cell|Homo sapiens | denotes | CMT |
| T5 | 171-172 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T6 | 208-211 | CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis | denotes | one |
| T7 | 248-251 | CVCL_YL11|Embryonic_stem_cell|Homo sapiens | denotes | CMT |
| T8 | 276-278 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
| T9 | 276-278 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
| T10 | 354-356 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
| T11 | 506-507 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T12 | 632-634 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
| T13 | 662-663 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T14 | 1002-1004 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
| T15 | 1017-1018 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T16 | 1104-1106 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
| T17 | 1675-1677 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
| T18 | 1737-1738 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T19 | 1768-1771 | CVCL_YL11|Embryonic_stem_cell|Homo sapiens | denotes | CMT |