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PubMed:31658266 JSONTXT

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Id Subject Object Predicate Lexical cue
T1317 1222-1225 B0U4M4 denotes pdf
T1318 1222-1225 PR:Q99988 denotes pdf
T1319 1222-1225 A1JRZ1 denotes pdf
T1320 1222-1225 B2RMJ1 denotes pdf
T1321 1222-1225 A5EWL8 denotes pdf
T1322 1222-1225 Q03QL3 denotes pdf
T1323 1222-1225 A4ST57 denotes pdf
T1324 1222-1225 Q051Q7 denotes pdf
T1325 1222-1225 Q9K9I9 denotes pdf
T1326 1222-1225 Q9Z6J2 denotes pdf
T1327 1222-1225 A5CF65 denotes pdf
T1328 1222-1225 A5TZF5 denotes pdf
T1329 1222-1225 Q8Z1W9 denotes pdf
T1330 1222-1225 Q83GH8 denotes pdf
T1331 1222-1225 P57948 denotes pdf
T1 19-25 PR:000007103 denotes DOMINO
T2 19-25 CVCL_D935 denotes DOMINO
T3 34-44 2294143 denotes Drosophila
T4 34-44 504603 denotes Drosophila
T5 34-44 2294139 denotes Drosophila
T6 34-44 2294145 denotes Drosophila
T7 34-44 2294141 denotes Drosophila
T8 34-44 2294142 denotes Drosophila
T9 34-44 2294144 denotes Drosophila
T10 34-44 2294140 denotes Drosophila
T11 34-44 D004330 denotes Drosophila
T12 34-44 2080301 denotes Drosophila
T13 45-63 GO:0048512 denotes circadian behavior
T14 78-84 CL:0000540 denotes neuron
T15 78-96 GO:0070050 denotes neuron maintenance
T1218 456-459 B9DTD6 denotes PDF
T16 168-178 2294143 denotes Drosophila
T17 168-178 504603 denotes Drosophila
T18 168-178 2294139 denotes Drosophila
T19 168-178 2294145 denotes Drosophila
T20 168-178 2294141 denotes Drosophila
T21 168-178 2294142 denotes Drosophila
T22 168-178 2294144 denotes Drosophila
T23 168-178 2294140 denotes Drosophila
T24 168-178 D004330 denotes Drosophila
T25 168-178 2080301 denotes Drosophila
T26 260-263 B0U4M4 denotes PDF
T27 260-263 PR:Q99988 denotes PDF
T28 260-263 A1JRZ1 denotes PDF
T29 260-263 B2RMJ1 denotes PDF
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T186 260-263 A2BZN6 denotes PDF
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T190 260-263 Q1JEV7 denotes PDF
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T206 260-263 B1XJP0 denotes PDF
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T185 260-263 CVCL_1G97 denotes PDF
T434 364-367 B0U4M4 denotes PDF
T435 364-367 PR:Q99988 denotes PDF
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T526 364-367 A0QQP8 denotes PDF
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T543 364-367 Q493I1 denotes PDF
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T550 364-367 B8ZL02 denotes PDF
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T552 364-367 B4SKH7 denotes PDF
T553 364-367 B3EPG5 denotes PDF
T554 364-367 A0LEJ7 denotes PDF
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T559 364-367 Q5QXI5 denotes PDF
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T561 364-367 Q8NZB7 denotes PDF
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T563 364-367 Q03MP6 denotes PDF
T564 364-367 Q2GE16 denotes PDF
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T566 364-367 Q5M1R9 denotes PDF
T567 364-367 Q9F2F0 denotes PDF
T568 364-367 P63918 denotes PDF
T569 364-367 B2IQS1 denotes PDF
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T1002 456-459 CVCL_1G97 denotes PDF
T1251 496-506 2294143 denotes Drosophila
T1252 496-506 504603 denotes Drosophila
T1253 496-506 2294139 denotes Drosophila
T1254 496-506 2294145 denotes Drosophila
T1255 496-506 2294141 denotes Drosophila
T1256 496-506 2294142 denotes Drosophila
T1257 496-506 2294144 denotes Drosophila
T1258 496-506 2294140 denotes Drosophila
T1259 496-506 D004330 denotes Drosophila
T1260 496-506 2080301 denotes Drosophila
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T1263 507-511 PR:Q10668 denotes SWI2
T1264 507-511 PR:Q8SXT3 denotes SWI2
T1265 507-511 PR:P22082 denotes SWI2
T1267 512-516 PR:P22082 denotes SNF2
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T1269 517-524 CHEBI:36080 denotes protein
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T1271 517-524 PR:000000001 denotes protein
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T1274 525-531 CVCL_D935 denotes DOMINO
T1275 533-536 D004290 denotes DOM
T1276 533-536 D004290 denotes DOM
T1277 533-536 PR:Q9NDJ2 denotes DOM
T1278 560-578 GO:0048512 denotes circadian behavior
T1281 593-596 PR:Q9NDJ2 denotes DOM
T1279 593-596 D004290 denotes DOM
T1280 593-596 D004290 denotes DOM
T1284 787-790 PR:Q9NDJ2 denotes DOM
T1282 787-790 D004290 denotes DOM
T1283 787-790 D004290 denotes DOM
T1287 792-795 PR:Q9NDJ2 denotes DOM
T1285 792-795 D004290 denotes DOM
T1286 792-795 D004290 denotes DOM
T1290 802-805 PR:Q9NDJ2 denotes DOM
T1288 802-805 D004290 denotes DOM
T1289 802-805 D004290 denotes DOM
T1293 843-846 PR:Q9NDJ2 denotes DOM
T1291 843-846 D004290 denotes DOM
T1292 843-846 D004290 denotes DOM
T1296 902-905 PR:Q9NDJ2 denotes DOM
T1294 902-905 D004290 denotes DOM
T1295 902-905 D004290 denotes DOM
T1299 995-998 PR:Q9NDJ2 denotes DOM
T1297 995-998 D004290 denotes DOM
T1298 995-998 D004290 denotes DOM
T1302 1005-1008 PR:Q9NDJ2 denotes DOM
T1300 1005-1008 D004290 denotes DOM
T1301 1005-1008 D004290 denotes DOM
T1303 1023-1031 SO:0000167 denotes promoter
T1304 1074-1082 PR:000016340 denotes timeless
T1305 1074-1082 PR:Q9R1X4 denotes timeless
T1306 1074-1082 PR:Q9Z2Y1 denotes timeless
T1307 1074-1082 PR:Q9UNS1 denotes timeless
T1311 1103-1110 PR:000000001 denotes protein
T1312 1103-1110 SO:0000104 denotes protein
T1308 1103-1110 GO:0003675 denotes protein
T1309 1103-1110 CHEBI:36080 denotes protein
T1310 1103-1110 CHEBI:11122 denotes protein
T1315 1154-1157 PR:Q9NDJ2 denotes DOM
T1313 1154-1157 D004290 denotes DOM
T1314 1154-1157 D004290 denotes DOM
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T1666 1222-1225 B5F7R3 denotes pdf
T1667 1222-1225 Q3AC18 denotes pdf
T1668 1222-1225 Q89BN9 denotes pdf
T1669 1222-1225 O84357 denotes pdf
T1670 1222-1225 Q8ER96 denotes pdf
T1671 1222-1225 B2FIR4 denotes pdf
T1672 1222-1225 Q04RW4 denotes pdf
T1673 1222-1225 B4SBG6 denotes pdf
T1674 1222-1225 B5YIL7 denotes pdf
T1675 1222-1225 Q057D2 denotes pdf
T1676 1222-1225 C4L7Y4 denotes pdf
T1677 1222-1225 B8FHH0 denotes pdf
T1678 1222-1225 A3PTZ4 denotes pdf
T1679 1222-1225 A4W418 denotes pdf
T1680 1222-1225 B2G6P1 denotes pdf
T1681 1222-1225 A1KRE5 denotes pdf
T1682 1222-1225 B0UWZ5 denotes pdf
T1683 1222-1225 B1GZ10 denotes pdf
T1684 1222-1225 B2I8S4 denotes pdf
T1685 1222-1225 Q68XG1 denotes pdf
T1686 1222-1225 B6JJP8 denotes pdf
T1687 1222-1225 P59493 denotes pdf
T1688 1222-1225 B5YT06 denotes pdf
T1689 1222-1225 P63913 denotes pdf
T1690 1222-1225 Q98PN3 denotes pdf
T1691 1222-1225 A8ZUK5 denotes pdf
T1692 1222-1225 B9DTD6 denotes pdf
T1693 1222-1225 P0DC96 denotes pdf
T1694 1222-1225 B5XNC4 denotes pdf
T1695 1222-1225 Q72H33 denotes pdf
T1696 1222-1225 Q64VP5 denotes pdf
T1697 1222-1225 B1AJA6 denotes pdf
T1698 1222-1225 Q039N7 denotes pdf
T1699 1222-1225 B8CWS6 denotes pdf
T1700 1222-1225 A5ESQ7 denotes pdf
T1701 1222-1225 B1JJH8 denotes pdf
T1702 1222-1225 Q8DWC2 denotes pdf
T1703 1222-1225 A1A2Z1 denotes pdf
T1704 1222-1225 A5FGV5 denotes pdf
T1705 1222-1225 B1MIN9 denotes pdf
T1706 1222-1225 B4RDT8 denotes pdf
T1707 1222-1225 Q1QTJ5 denotes pdf
T1708 1222-1225 Q8D258 denotes pdf
T1709 1222-1225 C1CF38 denotes pdf
T1710 1222-1225 Q8DP79 denotes pdf
T1711 1222-1225 B9L0C1 denotes pdf
T1712 1222-1225 Q4FNG1 denotes pdf
T1713 1222-1225 C0R5A2 denotes pdf
T1714 1222-1225 A8EXV2 denotes pdf
T1715 1222-1225 A5FRA7 denotes pdf
T1716 1222-1225 B2U2Q4 denotes pdf
T1717 1222-1225 Q7V3K7 denotes pdf
T1718 1222-1225 Q7VQC0 denotes pdf
T1719 1222-1225 P56419 denotes pdf
T1720 1222-1225 C0QI55 denotes pdf
T1721 1222-1225 B1XSN2 denotes pdf
T1722 1222-1225 C1CQR2 denotes pdf
T1723 1222-1225 P63917 denotes pdf
T1724 1222-1225 Q3IDI2 denotes pdf
T1476 1222-1225 CVCL_1G97 denotes pdf
T1884 1262-1265 CVCL_1G97 denotes PDF
T2133 1262-1274 Q9W4Y2 denotes PDF-receptor
T2134 1275-1284 GO:0023052 denotes signaling
T2135 1297-1307 D001145 denotes arrhythmia
T2136 1297-1307 D001145 denotes arrhythmia
T2139 1334-1337 PR:Q9NDJ2 denotes DOM
T2137 1334-1337 D004290 denotes DOM
T2138 1334-1337 D004290 denotes DOM
T2142 1418-1421 PR:Q9NDJ2 denotes DOM
T2140 1418-1421 D004290 denotes DOM
T2141 1418-1421 D004290 denotes DOM
T2143 1505-1513 CHEBI:36080 denotes proteins

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 98-164 DRI_Background denotes Circadian clocks control daily rhythms in behavior and physiology.
T2 165-327 DRI_Background denotes In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
T3 328-473 DRI_Challenge denotes Despite the importance of sLNvs and PDF in circadian behavior, little is known about factors that control sLNvs maintenance and PDF accumulation.
T4 474-579 DRI_Approach denotes Here, we identify the Drosophila SWI2/SNF2 protein DOMINO (DOM) as a key regulator of circadian behavior.
T5 580-738 DRI_Background denotes Depletion of DOM in circadian neurons eliminates morning anticipatory activity under light dark cycle and impairs behavioral rhythmicity in constant darkness.
T6 739-842 DRI_Background denotes Interestingly, the two major splice variants of DOM, DOM-A and DOM-B have distinct circadian functions.
T7 843-989 DRI_Background denotes DOM-A depletion mainly leads to arrhythmic behavior, while DOM-B knockdown lengthens circadian period without affecting the circadian rhythmicity.
T8 990-1122 DRI_Approach denotes Both DOM-A and DOM-B bind to the promoter regions of key pacemaker genes period and timeless, and regulate their protein expression.
T9 1123-1226 DRI_Approach denotes However, we identify that only DOM-A is required for the maintenance of sLNvs and transcription of pdf.
T10 1227-1353 DRI_Outcome denotes Lastly, constitutive activation of PDF-receptor signaling rescued the arrhythmia and period lengthening of DOM downregulation.
T11 1354-1536 DRI_Outcome denotes Taken together, our findings reveal that two splice variants of DOM play distinct roles in circadian rhythms through regulating abundance of pacemaker proteins and sLNvs maintenance.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 19-25 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOMINO
T2 260-263 CVCL_1G97|Spontaneously_immortalized_cell_line|Sahyadria denisonii denotes PDF
T3 364-367 CVCL_1G97|Spontaneously_immortalized_cell_line|Sahyadria denisonii denotes PDF
T4 456-459 CVCL_1G97|Spontaneously_immortalized_cell_line|Sahyadria denisonii denotes PDF
T5 480-482 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T6 525-531 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOMINO
T7 533-536 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T8 541-542 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 593-596 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T10 650-658 CVCL_C410|Hybridoma|Mus musculus denotes activity
T11 787-790 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T12 792-795 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T13 796-797 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T14 802-805 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T15 806-807 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T16 843-846 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T17 847-848 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T18 902-905 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T19 906-907 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T20 995-998 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T21 999-1000 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T22 1005-1008 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T23 1009-1010 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T24 1132-1134 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T25 1154-1157 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T26 1158-1159 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T27 1222-1225 CVCL_1G97|Spontaneously_immortalized_cell_line|Sahyadria denisonii denotes pdf
T28 1248-1258 CVCL_C410|Hybridoma|Mus musculus denotes activation
T29 1262-1265 CVCL_1G97|Spontaneously_immortalized_cell_line|Sahyadria denisonii denotes PDF
T30 1334-1337 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM
T31 1418-1421 CVCL_D935|Induced_pluripotent_stem_cell|Homo sapiens denotes DOM