> top > docs > PubMed:31545278 > annotations

PubMed:31545278 JSONTXT

Annnotations TAB JSON ListView MergeView

silkworm_phenotype

Id Subject Object Predicate Lexical cue
T77496 939-946 BMO_00137 denotes kidneys
T77495 692-704 BMO_00555 denotes green cocoon
T77494 537-549 BMO_00555 denotes green cocoon
T9 269-279 Chemical:MESH:D005419 denotes flavonoids
T8 247-255 Disease:MESH:D003920 denotes diabetes
T77492 692-704 BMO_00555 denotes green cocoon
T7 206-208 Disease:MESH:D003928 denotes DN
T6438 1759-1771 BMO_00555 denotes green cocoon
T63280 537-549 BMO_00555 denotes green cocoon
T6 184-204 Disease:MESH:D003928 denotes Diabetic nephropathy
T56452 71-83 BMO_00555 denotes green cocoon
T5 166-170 Species:10090 denotes mice
T48004 939-946 BMO_00137 denotes kidneys
T44 1817-1819 Disease:MESH:D003928 denotes DN
T43 1797-1812 Species:1407750 denotes herbal medicine
T42 1750-1758 Species:7091 denotes silkworm
T40 1507-1515 Disease:MESH:D005355 denotes fibrosis
T4 157-165 Disease:MESH:D003920 denotes diabetic
T39 1449-1453 Species:10090 denotes mice
T38 1406-1409 Chemical:MESH:D005978 denotes GSH
T37 1382-1393 Chemical:MESH:D005978 denotes glutathione
T36 1351-1361 Chemical:MESH:D013481 denotes superoxide
T35 1321-1325 Species:10090 denotes mice
T27 1165-1186 Disease:MESH:D007680 denotes renal tumour necrosis
T26 1118-1122 Species:10090 denotes mice
T25 1109-1117 Disease:MESH:D003920 denotes diabetic
T24 1053-1060 Chemical:MESH:D005947 denotes glucose
T23 766-770 Species:10090 denotes mice
T22 757-765 Disease:MESH:D003920 denotes Diabetic
T21 723-734 Species:7091 denotes Bombyx mori
T20 714-722 Species:7091 denotes silkworm
T2 62-70 Species:7091 denotes silkworm
T19 650-653 Chemical:MESH:D013311 denotes STZ
T18 634-648 Chemical:MESH:D013311 denotes streptozotocin
T17 605-609 Species:10090 denotes mice
T16 590-598 Disease:MESH:D003920 denotes diabetic
T15 577-579 Disease:MESH:D003928 denotes DN
T14 562-573 Species:7091 denotes Bombyx mori
T13 553-561 Species:7091 denotes silkworm
T12 496-506 Chemical:MESH:D044949 denotes kaempferol
T11 482-491 Chemical:MESH:D011794 denotes quercetin
T10 375-395 Disease:MESH:D003928 denotes diabetic nephropathy
T1 24-33 Chemical:MESH:D005419 denotes flavonoid

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-171 Sentence denotes The renal protection of flavonoid-rich ethanolic extract from silkworm green cocoon involves in inhibiting TNF-α-p38 MAP kinase signalling pathway in type 2 diabetic mice.
T2 172-183 Sentence denotes BACKGROUND:
T3 184-256 Sentence denotes Diabetic nephropathy (DN) is one of the major complications of diabetes.
T4 257-396 Sentence denotes Sericin and flavonoids are two bioactive substances which have been demonstrated to have some therapeutical effect on diabetic nephropathy.
T5 397-655 Sentence denotes The aim of this paper is to investigate the effect of ethanolic extract (EE) rich in quercetin and kaempferol and their glucosides from the green cocoon of silkworm Bombyx mori on DN in type 2 diabetic (T2D) mice induced by high-fat and streptozotocin (STZ).
T6 656-664 Sentence denotes METHODS:
T7 665-756 Sentence denotes Ethanolic extract from the green cocoon shell of silkworm Bombyx mori was used as material.
T8 757-947 Sentence denotes Diabetic mice were orally treated with three doses (150, 250 and 350 mg/kg) of the extract for 7 weeks, then the levels of oxidases and related inflammatory factors were measured in kidneys.
T9 948-956 Sentence denotes RESULTS:
T10 957-1123 Sentence denotes Compared with the negative control, EE administration resulted in an evident reduction in blood glucose levels and an improvement of the body weight in diabetic mice.
T11 1124-1326 Sentence denotes Oral EE could inhibit the expressions of renal tumour necrosis factor TNF-α, monocyte chemoattractant protein-1 (MCP-1), fibronectin (FN) and P38 mitogen-activated protein kinase (p38 MAPK) in T2D mice.
T12 1327-1470 Sentence denotes Moreover, the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) were significantly elevated in T2D mice treated with EE.
T13 1471-1483 Sentence denotes CONCLUSIONS:
T14 1484-1701 Sentence denotes The activities of anti-fibrosis and anti-inflammation contributed to the renal protective effects by reducing oxidative stress, which might be mediated by the inhibition of the TNF-α-p38 MAP kinase signalling pathway.
T15 1702-1820 Sentence denotes It is suggested that the ethanolic extract from silkworm green cocoon might be potential as an herbal medicine for DN.
T1 0-171 Sentence denotes The renal protection of flavonoid-rich ethanolic extract from silkworm green cocoon involves in inhibiting TNF-α-p38 MAP kinase signalling pathway in type 2 diabetic mice.
T2 172-183 Sentence denotes BACKGROUND:
T3 184-256 Sentence denotes Diabetic nephropathy (DN) is one of the major complications of diabetes.
T4 257-396 Sentence denotes Sericin and flavonoids are two bioactive substances which have been demonstrated to have some therapeutical effect on diabetic nephropathy.
T5 397-655 Sentence denotes The aim of this paper is to investigate the effect of ethanolic extract (EE) rich in quercetin and kaempferol and their glucosides from the green cocoon of silkworm Bombyx mori on DN in type 2 diabetic (T2D) mice induced by high-fat and streptozotocin (STZ).
T6 656-664 Sentence denotes METHODS:
T7 665-756 Sentence denotes Ethanolic extract from the green cocoon shell of silkworm Bombyx mori was used as material.
T8 757-947 Sentence denotes Diabetic mice were orally treated with three doses (150, 250 and 350 mg/kg) of the extract for 7 weeks, then the levels of oxidases and related inflammatory factors were measured in kidneys.
T9 948-956 Sentence denotes RESULTS:
T10 957-1123 Sentence denotes Compared with the negative control, EE administration resulted in an evident reduction in blood glucose levels and an improvement of the body weight in diabetic mice.
T11 1124-1326 Sentence denotes Oral EE could inhibit the expressions of renal tumour necrosis factor TNF-α, monocyte chemoattractant protein-1 (MCP-1), fibronectin (FN) and P38 mitogen-activated protein kinase (p38 MAPK) in T2D mice.
T12 1327-1470 Sentence denotes Moreover, the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) were significantly elevated in T2D mice treated with EE.
T13 1471-1483 Sentence denotes CONCLUSIONS:
T14 1484-1701 Sentence denotes The activities of anti-fibrosis and anti-inflammation contributed to the renal protective effects by reducing oxidative stress, which might be mediated by the inhibition of the TNF-α-p38 MAP kinase signalling pathway.
T15 1702-1820 Sentence denotes It is suggested that the ethanolic extract from silkworm green cocoon might be potential as an herbal medicine for DN.

silkworm

Id Subject Object Predicate Lexical cue
T1 24-33 Chemical:MESH:D005419 denotes flavonoid
T2 62-70 Species:7091 denotes silkworm
T3 107-112 Gene:21926 denotes TNF-α
T4 157-165 Disease:MESH:D003920 denotes diabetic
T5 166-170 Species:10090 denotes mice
T6 184-204 Disease:MESH:D003928 denotes Diabetic nephropathy
T7 206-208 Disease:MESH:D003928 denotes DN
T8 247-255 Disease:MESH:D003920 denotes diabetes
T9 269-279 Chemical:MESH:D005419 denotes flavonoids
T10 375-395 Disease:MESH:D003928 denotes diabetic nephropathy
T11 482-491 Chemical:MESH:D011794 denotes quercetin
T12 496-506 Chemical:MESH:D044949 denotes kaempferol
T13 553-561 Species:7091 denotes silkworm
T14 562-573 Species:7091 denotes Bombyx mori
T15 577-579 Disease:MESH:D003928 denotes DN
T16 590-598 Disease:MESH:D003920 denotes diabetic
T17 605-609 Species:10090 denotes mice
T18 634-648 Chemical:MESH:D013311 denotes streptozotocin
T19 650-653 Chemical:MESH:D013311 denotes STZ
T20 714-722 Species:7091 denotes silkworm
T21 723-734 Species:7091 denotes Bombyx mori
T22 757-765 Disease:MESH:D003920 denotes Diabetic
T23 766-770 Species:10090 denotes mice
T24 1053-1060 Chemical:MESH:D005947 denotes glucose
T25 1109-1117 Disease:MESH:D003920 denotes diabetic
T26 1118-1122 Species:10090 denotes mice
T27 1165-1186 Disease:MESH:D007680 denotes renal tumour necrosis
T28 1194-1199 Gene:21926 denotes TNF-α
T29 1201-1235 Gene:20296 denotes monocyte chemoattractant protein-1
T30 1237-1242 Gene:20296 denotes MCP-1
T31 1245-1256 Gene:14268 denotes fibronectin
T32 1258-1260 Gene:14268 denotes FN
T33 1266-1302 Gene:26416 denotes P38 mitogen-activated protein kinase
T34 1304-1312 Gene:26416 denotes p38 MAPK
T35 1321-1325 Species:10090 denotes mice
T36 1351-1361 Chemical:MESH:D013481 denotes superoxide
T37 1382-1393 Chemical:MESH:D005978 denotes glutathione
T38 1406-1409 Chemical:MESH:D005978 denotes GSH
T39 1449-1453 Species:10090 denotes mice
T40 1507-1515 Disease:MESH:D005355 denotes fibrosis
T41 1661-1666 Gene:21926 denotes TNF-α
T42 1750-1758 Species:7091 denotes silkworm
T43 1797-1812 Species:1407750 denotes herbal medicine
T44 1817-1819 Disease:MESH:D003928 denotes DN

silkwormbase

Id Subject Object Predicate Lexical cue
T1 24-33 Chemical:MESH:D005419 denotes flavonoid
T10 375-395 Disease:MESH:D003928 denotes diabetic nephropathy
T11 482-491 Chemical:MESH:D011794 denotes quercetin
T12 496-506 Chemical:MESH:D044949 denotes kaempferol
T13 553-561 Species:7091 denotes silkworm
T14 562-573 Species:7091 denotes Bombyx mori
T15 577-579 Disease:MESH:D003928 denotes DN
T16 590-598 Disease:MESH:D003920 denotes diabetic
T17 605-609 Species:10090 denotes mice
T18 634-648 Chemical:MESH:D013311 denotes streptozotocin
T19 650-653 Chemical:MESH:D013311 denotes STZ
T2 62-70 Species:7091 denotes silkworm
T20 714-722 Species:7091 denotes silkworm
T21 723-734 Species:7091 denotes Bombyx mori
T22 757-765 Disease:MESH:D003920 denotes Diabetic
T23 766-770 Species:10090 denotes mice
T24 1053-1060 Chemical:MESH:D005947 denotes glucose
T25 1109-1117 Disease:MESH:D003920 denotes diabetic
T26 1118-1122 Species:10090 denotes mice
T27 1165-1186 Disease:MESH:D007680 denotes renal tumour necrosis
T35 1321-1325 Species:10090 denotes mice
T36 1351-1361 Chemical:MESH:D013481 denotes superoxide
T37 1382-1393 Chemical:MESH:D005978 denotes glutathione
T38 1406-1409 Chemical:MESH:D005978 denotes GSH
T39 1449-1453 Species:10090 denotes mice
T4 157-165 Disease:MESH:D003920 denotes diabetic
T40 1507-1515 Disease:MESH:D005355 denotes fibrosis
T42 1750-1758 Species:7091 denotes silkworm
T43 1797-1812 Species:1407750 denotes herbal medicine
T44 1817-1819 Disease:MESH:D003928 denotes DN
T48004 939-946 BMO_00137 denotes kidneys
T5 166-170 Species:10090 denotes mice
T56452 71-83 BMO_00555 denotes green cocoon
T6 184-204 Disease:MESH:D003928 denotes Diabetic nephropathy
T63280 537-549 BMO_00555 denotes green cocoon
T6438 1759-1771 BMO_00555 denotes green cocoon
T7 206-208 Disease:MESH:D003928 denotes DN
T77492 692-704 BMO_00555 denotes green cocoon
T8 247-255 Disease:MESH:D003920 denotes diabetes
T9 269-279 Chemical:MESH:D005419 denotes flavonoids
T77494 537-549 BMO_00555 denotes green cocoon
T77495 692-704 BMO_00555 denotes green cocoon
T77496 939-946 BMO_00137 denotes kidneys