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sonoma

Id Subject Object Predicate Lexical cue
T-0 0-15 GENE denotes microRNA-218-5p
T-1 24-34 POSREG denotes protective
T-2 35-39 REG denotes role
T-3 43-75 CPA denotes eosinophilic airway inflammation
T-4 80-89 REG denotes targeting
T-5 90-99 GENE denotes δ-catenin
T-6 120-126 DISEASE denotes asthma
T-7 140-161 GENE denotes microRNA (miR)-218-5p
T-8 165-173 REG denotes involved
T-9 237-243 DISEASE denotes asthma
T-10 277-287 GENE denotes miR-218-5p
T-11 302-316 NEGREG denotes down-regulated
T-12 344-354 GENE denotes miR-218-5p
T-13 363-367 REG denotes role
T-14 371-377 DISEASE denotes asthma
T-15 432-442 GENE denotes miR-218-5p
T-16 466-472 DISEASE denotes asthma
T-17 515-525 GENE denotes miR-218-5p
T-18 526-536 MPA denotes expression
T-19 563-569 DISEASE denotes asthma
T-20 657-667 GENE denotes miR-218-5p
T-21 668-678 MPA denotes expression
T-22 683-702 CPA denotes airway eosinophilia
T-23 724-730 GENE denotes CTNND2
T-24 737-743 REG denotes target
T-25 747-757 GENE denotes miR-218-5p
T-26 767-777 MPA denotes expression
T-27 917-921 REG denotes role
T-28 925-942 PATHWAY denotes miR-218-5p-CTNND2
T-29 975-1003 CPA denotes allergic airway inflammation
T-30 1025-1035 GENE denotes miR-218-5p
T-31 1036-1046 MPA denotes expression
T-32 1065-1074 NEGREG denotes decreased
T-33 1079-1089 NEGREG denotes negatively
T-34 1090-1100 REG denotes correlated
T-35 1106-1117 CPA denotes eosinophils
T-36 1191-1197 DISEASE denotes asthma
T-37 1225-1231 GENE denotes CTNND2
T-38 1242-1251 GENE denotes δ-catenin
T-39 1259-1265 REG denotes target
T-40 1269-1279 GENE denotes miR-218-5p
T-41 1293-1299 GENE denotes CTNND2
T-42 1327-1339 POSREG denotes up-regulated
T-43 1424-1430 DISEASE denotes asthma
T-44 1441-1457 GENE denotes IL-13-stimulated
T-45 1502-1508 GENE denotes CTNND2
T-46 1509-1519 MPA denotes expression
T-47 1520-1530 POSREG denotes positively
T-48 1531-1541 REG denotes correlated
T-49 1547-1566 CPA denotes airway eosinophilia
T-50 1570-1576 DISEASE denotes asthma
T-51 1585-1599 GENE denotes mmu-miR-218-5p
T-52 1600-1610 MPA denotes expression
T-53 1620-1629 NEGREG denotes decreased
T-54 1635-1641 GENE denotes Ctnnd2
T-55 1642-1652 MPA denotes expression
T-56 1657-1666 POSREG denotes increased
T-57 1688-1716 CPA denotes allergic airway inflammation
T-58 1732-1746 GENE denotes mmu-miR-218-5p
T-59 1747-1761 POSREG denotes overexpression
T-60 1762-1772 NEGREG denotes suppressed
T-61 1773-1799 CPA denotes airway hyperresponsiveness
T-62 1801-1833 CPA denotes eosinophilic airway inflammation
T-63 1838-1844 GENE denotes Ctnnd2
T-64 1845-1858 POSREG denotes up-regulation
T-65 1888-1900 VAR denotes perturbation
T-66 1904-1914 GENE denotes miR-218-5p
T-67 1918-1924 GENE denotes CTNND2
T-68 1925-1935 MPA denotes expression
T-69 1950-1957 REG denotes altered
T-70 1968-1973 GENE denotes CCL26
T-71 1974-1984 MPA denotes expression
T-72 2074-2084 GENE denotes miR-218-5p
T-73 2093-2103 POSREG denotes protective
T-74 2112-2144 CPA denotes eosinophilic airway inflammation
T-75 2149-2158 REG denotes targeting
T-76 2159-2165 GENE denotes CTNND2
T-77 2186-2192 DISEASE denotes asthma
T-78 2198-2209 NEGREG denotes suppressing
T-79 2220-2225 GENE denotes CCL26
T-80 2226-2236 REG denotes expression
R-23 T-57 T-56 ThemeOf allergic airway inflammation,increased
R-24 T-57 T-53 ThemeOf allergic airway inflammation,decreased
R-25 T-5 T-4 ThemeOf δ-catenin,targeting
R-27 T-61 T-60 ThemeOf airway hyperresponsiveness,suppressed
R-0 T-22 T-21 ThemeOf airway eosinophilia,expression
R-1 T-23 T-24 ThemeOf CTNND2,target
R-2 T-23 T-26 ThemeOf CTNND2,expression
R-3 T-31 T-32 ThemeOf expression,decreased
R-4 T-34 T-33 ThemeOf correlated,negatively
R-5 T-35 T-33 ThemeOf eosinophils,negatively
R-6 T-35 T-34 ThemeOf eosinophils,correlated
R-7 T-35 T-32 ThemeOf eosinophils,decreased
R-8 T-36 T-34 ThemeOf asthma,correlated
R-9 T-36 T-32 ThemeOf asthma,decreased
R-10 T-37 T-39 ThemeOf CTNND2,target
R-11 T-38 T-39 ThemeOf δ-catenin,target
R-12 T-41 T-42 ThemeOf CTNND2,up-regulated
R-13 T-43 T-42 ThemeOf asthma,up-regulated
R-14 T-45 T-46 ThemeOf CTNND2,expression
R-15 T-46 T-48 ThemeOf expression,correlated
R-16 T-46 T-47 ThemeOf expression,positively
R-17 T-49 T-48 ThemeOf airway eosinophilia,correlated
R-18 T-50 T-48 ThemeOf asthma,correlated
R-19 T-50 T-49 ThemeOf asthma,airway eosinophilia
R-20 T-52 T-53 ThemeOf expression,decreased
R-21 T-54 T-55 ThemeOf Ctnnd2,expression
R-22 T-55 T-56 ThemeOf expression,increased
R-26 T-59 T-60 CauseOf overexpression,suppressed
R-28 T-63 T-64 ThemeOf Ctnnd2,up-regulation
R-29 T-64 T-60 ThemeOf up-regulation,suppressed
R-30 T-6 T-4 ThemeOf asthma,targeting
R-31 T-65 T-69 CauseOf perturbation,altered
R-32 T-67 T-65 ThemeOf CTNND2,perturbation
R-33 T-67 T-68 ThemeOf CTNND2,expression
R-34 T-71 T-69 ThemeOf expression,altered
R-35 T-75 T-73 CauseOf targeting,protective
R-36 T-75 T-78 CauseOf targeting,suppressing
R-37 T-78 T-73 CauseOf suppressing,protective
R-38 T-74 T-73 ThemeOf eosinophilic airway inflammation,protective
R-39 T-76 T-75 ThemeOf CTNND2,targeting
R-40 T-77 T-75 ThemeOf asthma,targeting
R-41 T-20 T-21 ThemeOf miR-218-5p,expression
R-42 T-17 T-18 ThemeOf miR-218-5p,expression
R-43 T-14 T-13 ThemeOf asthma,role
R-44 T-12 T-13 ThemeOf miR-218-5p,role
R-45 T-10 T-11 ThemeOf miR-218-5p,down-regulated
R-46 T-7 T-8 ThemeOf microRNA (miR)-218-5p,involved
R-47 T-2 T-1 ThemeOf role,protective
R-48 T-0 T-1 CauseOf microRNA-218-5p,protective
R-49 T-4 T-2 ThemeOf targeting,role
R-50 T-9 T-10 ThemeOf asthma,miR-218-5p
R-51 T-25 T-24 ThemeOf miR-218-5p,target
R-52 T-19 T-18 ThemeOf asthma,expression
R-53 T-28 T-27 ThemeOf miR-218-5p-CTNND2,role
R-54 T-29 T-27 ThemeOf allergic airway inflammation,role
R-55 T-30 T-31 ThemeOf miR-218-5p,expression
R-56 T-40 T-39 ThemeOf miR-218-5p,target
R-57 T-47 T-48 ThemeOf positively,correlated
R-58 T-58 T-59 ThemeOf mmu-miR-218-5p,overexpression
R-59 T-51 T-52 ThemeOf mmu-miR-218-5p,expression
R-60 T-62 T-60 ThemeOf eosinophilic airway inflammation,suppressed
R-61 T-66 T-65 ThemeOf miR-218-5p,perturbation
R-62 T-66 T-68 ThemeOf miR-218-5p,expression
R-63 T-70 T-71 ThemeOf CCL26,expression
R-64 T-79 T-80 ThemeOf CCL26,expression
R-65 T-80 T-78 ThemeOf expression,suppressing
R-66 T-72 T-73 CauseOf miR-218-5p,protective

sonoma2

Id Subject Object Predicate Lexical cue
T0 0-15 GENE denotes microRNA-218-5p
T1 16-21 REG denotes plays
T2 24-34 POSREG denotes protective
T3 35-39 REG denotes role
T4 43-75 CPA denotes eosinophilic airway inflammation
T5 43-75 DISEASE denotes eosinophilic airway inflammation
T6 80-89 REG denotes targeting
T7 90-99 GENE denotes δ-catenin
T8 109-116 GENE denotes catenin
T9 120-126 DISEASE denotes asthma
T10 124-130 DISEASE denotes ma. BA
T11 149-161 GENE denotes (miR)-218-5p
T12 152-161 GENE denotes R)-218-5p
T13 165-173 REG denotes involved
T14 201-220 CPA denotes airway inflammation
T15 204-223 DISEASE denotes way inflammation. I
T16 237-243 DISEASE denotes asthma
T17 240-246 DISEASE denotes hma ep
T18 277-287 GENE denotes miR-218-5p
T19 280-287 GENE denotes -218-5p
T20 302-316 NEGREG denotes down-regulated
T21 344-354 GENE denotes miR-218-5p
T22 346-353 GENE denotes R-218-5
T23 355-360 REG denotes plays
T24 363-367 REG denotes role
T25 371-377 DISEASE denotes asthma
T26 373-399 DISEASE denotes thma airway inflammation.
T27 378-397 CPA denotes airway inflammation
T28 424-428 REG denotes role
T29 432-442 GENE denotes miR-218-5p
T30 433-440 GENE denotes iR-218-
T31 466-472 DISEASE denotes asthma
T32 467-493 DISEASE denotes sthma airway inflammation.
T33 473-492 CPA denotes airway inflammation
T34 506-514 REG denotes measured
T35 515-525 GENE denotes miR-218-5p
T36 515-522 GENE denotes miR-218
T37 526-536 MPA denotes expression
T38 563-569 DISEASE denotes asthma
T39 636-648 REG denotes correlations
T40 657-667 GENE denotes miR-218-5p
T41 657-664 GENE denotes miR-218
T42 668-678 MPA denotes expression
T43 683-702 CPA denotes airway eosinophilia
T44 690-702 DISEASE denotes eosinophilia
T45 724-730 GENE denotes CTNND2
T46 737-743 REG denotes target
T47 747-757 GENE denotes miR-218-5p
T48 747-754 GENE denotes miR-218
T49 767-777 MPA denotes expression
T50 784-791 GENE denotes catenin
T51 917-921 REG denotes role
T52 925-932 GENE denotes miR-218
T53 933-950 PATHWAY denotes 5p-CTNND2 pathway
T54 933-942 GENE denotes 5p-CTNND2
T55 975-1003 CPA denotes allergic airway inflammation
T56 975-1003 DISEASE denotes allergic airway inflammation
T57 1024-1031 GENE denotes miR-21
T58 1025-1035 GENE denotes miR-218-5p
T59 1036-1046 MPA denotes expression
T60 1065-1074 NEGREG denotes decreased
T61 1079-1089 NEGREG denotes negatively
T62 1090-1100 REG denotes correlated
T63 1106-1117 CPA denotes eosinophils
T64 1121-1135 CPA denotes induced sputum
T65 1170-1187 CPA denotes type 2 biomarkers
T66 1190-1196 DISEASE denotes asthm
T67 1191-1197 DISEASE denotes asthma
T68 1224-1230 GENE denotes CTNND
T69 1225-1231 GENE denotes CTNND2
T70 1242-1251 GENE denotes δ-catenin
T71 1259-1265 REG denotes target
T72 1269-1279 GENE denotes miR-218-5p
T73 1272-1279 GENE denotes -218-5p
T74 1293-1299 GENE denotes CTNND2
T75 1296-1302 GENE denotes ND2 wa
T76 1327-1339 POSREG denotes up-regulated
T77 1340-1347 GENE denotes catenin
T78 1375-1382 GENE denotes catenin
T79 1424-1430 DISEASE denotes asthma
T80 1441-1457 GENE denotes IL-13-stimulated
T81 1441-1457 GENE denotes IL-13-stimulated
T82 1502-1508 GENE denotes CTNND2
T83 1509-1519 MPA denotes expression
T84 1520-1530 POSREG denotes positively
T85 1531-1541 REG denotes correlated
T86 1547-1566 CPA denotes airway eosinophilia
T87 1547-1576 DISEASE denotes airway eosinophilia in asthma
T88 1570-1576 DISEASE denotes asthma
T89 1585-1596 GENE denotes mmu-miR-218
T90 1600-1610 MPA denotes expression
T91 1620-1629 NEGREG denotes decreased
T92 1634-1640 GENE denotes Ctnnd
T93 1635-1641 GENE denotes Ctnnd2
T94 1642-1652 MPA denotes expression
T95 1657-1666 POSREG denotes increased
T96 1687-1715 DISEASE denotes allergic airway inflammatio
T97 1688-1716 CPA denotes allergic airway inflammation
T98 1731-1742 GENE denotes mmu-miR-21
T99 1744-1746 GENE denotes 5p
T100 1747-1761 VAR denotes overexpression
T101 1762-1772 NEGREG denotes suppressed
T102 1773-1799 CPA denotes airway hyperresponsiveness
T103 1779-1798 DISEASE denotes hyperresponsivenes
T104 1800-1832 DISEASE denotes eosinophilic airway inflammatio
T105 1801-1833 CPA denotes eosinophilic airway inflammation
T106 1837-1843 GENE denotes Ctnnd
T107 1838-1844 GENE denotes Ctnnd2
T108 1845-1858 POSREG denotes up-regulation
T109 1888-1900 VAR denotes perturbation
T110 1902-1909 GENE denotes f miR-2
T111 1904-1914 GENE denotes miR-218-5p
T112 1916-1922 GENE denotes r CTNN
T113 1918-1924 GENE denotes CTNND2
T114 1925-1935 MPA denotes expression
T115 1950-1957 REG denotes altered
T116 1966-1971 GENE denotes e CCL
T117 1974-1984 MPA denotes expression
T118 2073-2080 GENE denotes miR-21
T119 2074-2084 GENE denotes miR-218-5p
T120 2085-2090 REG denotes plays
T121 2093-2103 POSREG denotes protective
T122 2104-2108 REG denotes role
T123 2111-2143 DISEASE denotes eosinophilic airway inflammatio
T124 2112-2144 CPA denotes eosinophilic airway inflammation
T125 2149-2158 REG denotes targeting
T126 2158-2164 GENE denotes CTNND
T127 2159-2165 GENE denotes CTNND2
T128 2175-2182 GENE denotes catenin
T129 2185-2191 DISEASE denotes asthm
T130 2186-2192 DISEASE denotes asthma
T131 2198-2209 NEGREG denotes suppressing
T132 2219-2224 GENE denotes CCL2
T133 2226-2236 MPA denotes expression
R0 T0 T1 ThemeOf microRNA-218-5p,plays
R1 T0 T3 ThemeOf microRNA-218-5p,role
R2 T0 T6 ThemeOf microRNA-218-5p,targeting
R3 T2 T1 ThemeOf protective,plays
R4 T3 T1 ThemeOf role,plays
R5 T6 T1 CauseOf targeting,plays
R6 T3 T2 ThemeOf role,protective
R7 T6 T2 CauseOf targeting,protective
R8 T4 T3 ThemeOf eosinophilic airway inflammation,role
R9 T3 T6 ThemeOf role,targeting
R10 T4 T1 ThemeOf eosinophilic airway inflammation,plays
R11 T4 T2 ThemeOf eosinophilic airway inflammation,protective
R12 T4 T6 ThemeOf eosinophilic airway inflammation,targeting
R13 T8 T4 ThemeOf catenin,eosinophilic airway inflammation
R14 T9 T6 ThemeOf asthma,targeting
R15 T7 T2 ThemeOf δ-catenin,protective
R16 T7 T3 ThemeOf δ-catenin,role
R17 T7 T6 ThemeOf δ-catenin,targeting
R18 T7 T8 ThemeOf δ-catenin,catenin
R19 T8 T1 ThemeOf catenin,plays
R20 T8 T2 ThemeOf catenin,protective
R21 T8 T3 ThemeOf catenin,role
R22 T8 T6 ThemeOf catenin,targeting
R23 T9 T8 ThemeOf asthma,catenin
R24 T9 T1 ThemeOf asthma,plays
R25 T9 T2 ThemeOf asthma,protective
R26 T9 T3 ThemeOf asthma,role
R27 T9 T4 ThemeOf asthma,eosinophilic airway inflammation
R28 T9 T13 ThemeOf asthma,involved
R29 T9 T20 ThemeOf asthma,down-regulated
R30 T11 T13 ThemeOf (miR)-218-5p,involved
R31 T11 T14 ThemeOf (miR)-218-5p,airway inflammation
R32 T14 T13 ThemeOf airway inflammation,involved
R33 T14 T20 ThemeOf airway inflammation,down-regulated
R34 T16 T6 ThemeOf asthma,targeting
R35 T16 T13 ThemeOf asthma,involved
R36 T16 T20 ThemeOf asthma,down-regulated
R37 T18 T20 ThemeOf miR-218-5p,down-regulated
R38 T21 T23 ThemeOf miR-218-5p,plays
R39 T21 T24 ThemeOf miR-218-5p,role
R40 T21 T27 ThemeOf miR-218-5p,airway inflammation
R41 T24 T23 ThemeOf role,plays
R42 T27 T23 ThemeOf airway inflammation,plays
R43 T25 T24 ThemeOf asthma,role
R44 T27 T24 ThemeOf airway inflammation,role
R45 T25 T20 ThemeOf asthma,down-regulated
R46 T25 T23 ThemeOf asthma,plays
R47 T25 T27 ThemeOf asthma,airway inflammation
R48 T25 T28 ThemeOf asthma,role
R49 T29 T28 ThemeOf miR-218-5p,role
R50 T33 T28 ThemeOf airway inflammation,role
R51 T29 T33 ThemeOf miR-218-5p,airway inflammation
R52 T31 T20 ThemeOf asthma,down-regulated
R53 T31 T28 ThemeOf asthma,role
R54 T31 T33 ThemeOf asthma,airway inflammation
R55 T31 T34 ThemeOf asthma,measured
R56 T37 T34 ThemeOf expression,measured
R57 T35 T34 ThemeOf miR-218-5p,measured
R58 T35 T37 ThemeOf miR-218-5p,expression
R59 T38 T37 ThemeOf asthma,expression
R60 T37 T39 ThemeOf expression,correlations
R61 T38 T20 ThemeOf asthma,down-regulated
R62 T38 T34 ThemeOf asthma,measured
R63 T38 T39 ThemeOf asthma,correlations
R64 T38 T42 ThemeOf asthma,expression
R65 T40 T39 ThemeOf miR-218-5p,correlations
R66 T42 T39 ThemeOf expression,correlations
R67 T43 T39 ThemeOf airway eosinophilia,correlations
R68 T40 T42 ThemeOf miR-218-5p,expression
R69 T42 T34 ThemeOf expression,measured
R70 T43 T42 ThemeOf airway eosinophilia,expression
R71 T43 T34 ThemeOf airway eosinophilia,measured
R72 T45 T46 ThemeOf CTNND2,target
R73 T45 T49 ThemeOf CTNND2,expression
R74 T47 T46 ThemeOf miR-218-5p,target
R75 T49 T46 ThemeOf expression,target
R76 T47 T49 ThemeOf miR-218-5p,expression
R77 T50 T49 ThemeOf catenin,expression
R78 T50 T46 ThemeOf catenin,target
R79 T52 T51 ThemeOf miR-218,role
R80 T53 T51 ThemeOf 5p-CTNND2 pathway,role
R81 T55 T51 ThemeOf allergic airway inflammation,role
R82 T52 T53 ThemeOf miR-218,5p-CTNND2 pathway
R83 T55 T53 ThemeOf allergic airway inflammation,5p-CTNND2 pathway
R84 T55 T60 ThemeOf allergic airway inflammation,decreased
R85 T55 T61 ThemeOf allergic airway inflammation,negatively
R86 T58 T59 ThemeOf miR-218-5p,expression
R87 T58 T60 ThemeOf miR-218-5p,decreased
R88 T59 T60 ThemeOf expression,decreased
R89 T59 T61 ThemeOf expression,negatively
R90 T59 T62 ThemeOf expression,correlated
R91 T62 T61 ThemeOf correlated,negatively
R92 T63 T62 ThemeOf eosinophils,correlated
R93 T64 T62 ThemeOf induced sputum,correlated
R94 T65 T62 ThemeOf type 2 biomarkers,correlated
R95 T63 T60 ThemeOf eosinophils,decreased
R96 T63 T61 ThemeOf eosinophils,negatively
R97 T63 T64 ThemeOf eosinophils,induced sputum
R98 T65 T63 ThemeOf type 2 biomarkers,eosinophils
R99 T64 T60 ThemeOf induced sputum,decreased
R100 T64 T61 ThemeOf induced sputum,negatively
R101 T65 T64 ThemeOf type 2 biomarkers,induced sputum
R102 T65 T60 ThemeOf type 2 biomarkers,decreased
R103 T65 T61 ThemeOf type 2 biomarkers,negatively
R104 T67 T65 ThemeOf asthma,type 2 biomarkers
R105 T65 T76 ThemeOf type 2 biomarkers,up-regulated
R106 T67 T59 ThemeOf asthma,expression
R107 T67 T60 ThemeOf asthma,decreased
R108 T67 T61 ThemeOf asthma,negatively
R109 T67 T62 ThemeOf asthma,correlated
R110 T67 T63 ThemeOf asthma,eosinophils
R111 T67 T64 ThemeOf asthma,induced sputum
R112 T67 T71 ThemeOf asthma,target
R113 T67 T76 ThemeOf asthma,up-regulated
R114 T69 T71 ThemeOf CTNND2,target
R115 T70 T69 ThemeOf δ-catenin,CTNND2
R116 T70 T71 ThemeOf δ-catenin,target
R117 T70 T72 ThemeOf δ-catenin,miR-218-5p
R118 T70 T76 ThemeOf δ-catenin,up-regulated
R119 T72 T71 ThemeOf miR-218-5p,target
R120 T74 T76 ThemeOf CTNND2,up-regulated
R121 T77 T76 ThemeOf catenin,up-regulated
R122 T78 T76 ThemeOf catenin,up-regulated
R123 T78 T77 ThemeOf catenin,catenin
R124 T79 T76 ThemeOf asthma,up-regulated
R125 T79 T80 ThemeOf asthma,IL-13-stimulated
R126 T80 T76 ThemeOf IL-13-stimulated,up-regulated
R127 T82 T83 ThemeOf CTNND2,expression
R128 T82 T84 ThemeOf CTNND2,positively
R129 T82 T85 ThemeOf CTNND2,correlated
R130 T83 T84 ThemeOf expression,positively
R131 T83 T85 ThemeOf expression,correlated
R132 T85 T84 ThemeOf correlated,positively
R133 T86 T85 ThemeOf airway eosinophilia,correlated
R134 T86 T83 ThemeOf airway eosinophilia,expression
R135 T86 T84 ThemeOf airway eosinophilia,positively
R136 T88 T86 ThemeOf asthma,airway eosinophilia
R137 T88 T76 ThemeOf asthma,up-regulated
R138 T88 T83 ThemeOf asthma,expression
R139 T88 T84 ThemeOf asthma,positively
R140 T88 T85 ThemeOf asthma,correlated
R141 T88 T91 ThemeOf asthma,decreased
R142 T88 T95 ThemeOf asthma,increased
R143 T90 T91 ThemeOf expression,decreased
R144 T90 T95 ThemeOf expression,increased
R145 T93 T94 ThemeOf Ctnnd2,expression
R146 T93 T95 ThemeOf Ctnnd2,increased
R147 T94 T91 ThemeOf expression,decreased
R148 T94 T95 ThemeOf expression,increased
R149 T97 T91 ThemeOf allergic airway inflammation,decreased
R150 T97 T94 ThemeOf allergic airway inflammation,expression
R151 T97 T95 ThemeOf allergic airway inflammation,increased
R152 T99 T100 ThemeOf 5p,overexpression
R153 T100 T101 CauseOf overexpression,suppressed
R154 T102 T100 ThemeOf airway hyperresponsiveness,overexpression
R155 T105 T100 ThemeOf eosinophilic airway inflammation,overexpression
R156 T105 T101 ThemeOf eosinophilic airway inflammation,suppressed
R157 T108 T101 ThemeOf up-regulation,suppressed
R158 T102 T101 ThemeOf airway hyperresponsiveness,suppressed
R159 T102 T108 ThemeOf airway hyperresponsiveness,up-regulation
R160 T105 T108 ThemeOf eosinophilic airway inflammation,up-regulation
R161 T107 T100 ThemeOf Ctnnd2,overexpression
R162 T107 T101 ThemeOf Ctnnd2,suppressed
R163 T107 T102 ThemeOf Ctnnd2,airway hyperresponsiveness
R164 T107 T108 ThemeOf Ctnnd2,up-regulation
R165 T114 T109 ThemeOf expression,perturbation
R166 T109 T115 CauseOf perturbation,altered
R167 T109 T117 CauseOf perturbation,expression
R168 T111 T109 ThemeOf miR-218-5p,perturbation
R169 T111 T114 ThemeOf miR-218-5p,expression
R170 T113 T109 ThemeOf CTNND2,perturbation
R171 T113 T114 ThemeOf CTNND2,expression
R172 T117 T114 ThemeOf expression,expression
R173 T117 T115 ThemeOf expression,altered
R174 T119 T121 CauseOf miR-218-5p,protective
R175 T120 T121 ThemeOf plays,protective
R176 T122 T120 ThemeOf role,plays
R177 T125 T120 CauseOf targeting,plays
R178 T122 T121 ThemeOf role,protective
R179 T125 T121 CauseOf targeting,protective
R180 T124 T122 ThemeOf eosinophilic airway inflammation,role
R181 T122 T125 ThemeOf role,targeting
R182 T124 T120 ThemeOf eosinophilic airway inflammation,plays
R183 T124 T121 ThemeOf eosinophilic airway inflammation,protective
R184 T124 T125 ThemeOf eosinophilic airway inflammation,targeting
R185 T124 T131 ThemeOf eosinophilic airway inflammation,suppressing
R186 T130 T125 ThemeOf asthma,targeting
R187 T125 T131 CauseOf targeting,suppressing
R188 T127 T121 ThemeOf CTNND2,protective
R189 T127 T122 ThemeOf CTNND2,role
R190 T127 T125 ThemeOf CTNND2,targeting
R191 T127 T128 ThemeOf CTNND2,catenin
R192 T128 T121 ThemeOf catenin,protective
R193 T128 T122 ThemeOf catenin,role
R194 T128 T124 ThemeOf catenin,eosinophilic airway inflammation
R195 T128 T125 ThemeOf catenin,targeting
R196 T130 T128 ThemeOf asthma,catenin
R197 T128 T131 ThemeOf catenin,suppressing
R198 T128 T133 ThemeOf catenin,expression
R199 T130 T120 ThemeOf asthma,plays
R200 T130 T121 ThemeOf asthma,protective
R201 T130 T122 ThemeOf asthma,role
R202 T130 T124 ThemeOf asthma,eosinophilic airway inflammation
R203 T130 T131 ThemeOf asthma,suppressing
R204 T130 T133 ThemeOf asthma,expression
R205 T133 T131 ThemeOf expression,suppressing
R206 T133 T125 ThemeOf expression,targeting

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting δ-catenin, a novel catenin in asthma.
T2 128-221 Sentence denotes BACKGROUND: microRNA (miR)-218-5p is involved in cigarette smoke-induced airway inflammation.
T3 222-323 Sentence denotes In our earlier asthma epithelial miRNA profiling data, miR-218-5p was the top 2 down-regulated miRNA.
T4 324-398 Sentence denotes We hypothesize that miR-218-5p plays a role in asthma airway inflammation.
T5 399-409 Sentence denotes OBJECTIVE:
T6 410-493 Sentence denotes To unveil the role of miR-218-5p and its target gene in asthma airway inflammation.
T7 494-502 Sentence denotes METHODS:
T8 503-703 Sentence denotes We measured miR-218-5p expression in bronchial brushings of asthma patients (n = 50) and healthy controls (n = 15), and analysed the correlations between miR-218-5p expression and airway eosinophilia.
T9 704-900 Sentence denotes We examined whether CTNND2 was a target of miR-218-5p, and the expression of 12 catenin family members in bronchial brushings, in cultured human bronchial epithelial (HBE) cells and BEAS-2B cells.
T10 901-1004 Sentence denotes We explored the role of miR-218-5p-CTNND2 pathway using a murine model of allergic airway inflammation.
T11 1005-1013 Sentence denotes RESULTS:
T12 1014-1207 Sentence denotes Epithelial miR-218-5p expression was significantly decreased and negatively correlated with eosinophils in induced sputum and bronchial biopsies, and other type 2 biomarkers in asthma patients.
T13 1208-1280 Sentence denotes We verified that CTNND2 (encoding δ-catenin) was a target of miR-218-5p.
T14 1281-1480 Sentence denotes Remarkably, CTNND2 was the most significantly up-regulated catenin compared with the other 11 catenin family members in bronchial brushings of asthma patients, IL-13-stimulated HBE and BEAS-2B cells.
T15 1481-1577 Sentence denotes Moreover, epithelial CTNND2 expression positively correlated with airway eosinophilia in asthma.
T16 1578-1717 Sentence denotes Airway mmu-miR-218-5p expression was also decreased, and Ctnnd2 expression was increased in a murine model of allergic airway inflammation.
T17 1718-1878 Sentence denotes Intriguingly, mmu-miR-218-5p overexpression suppressed airway hyperresponsiveness, eosinophilic airway inflammation and Ctnnd2 up-regulation in the mouse model.
T18 1879-2026 Sentence denotes Finally, perturbation of miR-218-5p or CTNND2 expression significantly altered chemokine CCL26 expression in the cell cultures and the mouse model.
T19 2027-2062 Sentence denotes CONCLUSIONS AND CLINICAL RELEVANCE:
T20 2063-2237 Sentence denotes Epithelial miR-218-5p plays a protective role in eosinophilic airway inflammation via targeting CTNND2, a novel catenin in asthma, and suppressing chemokine CCL26 expression.
T1 0-127 Sentence denotes microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting δ-catenin, a novel catenin in asthma.
T2 128-221 Sentence denotes BACKGROUND: microRNA (miR)-218-5p is involved in cigarette smoke-induced airway inflammation.
T3 222-323 Sentence denotes In our earlier asthma epithelial miRNA profiling data, miR-218-5p was the top 2 down-regulated miRNA.
T4 324-398 Sentence denotes We hypothesize that miR-218-5p plays a role in asthma airway inflammation.
T5 399-409 Sentence denotes OBJECTIVE:
T6 410-493 Sentence denotes To unveil the role of miR-218-5p and its target gene in asthma airway inflammation.
T7 494-502 Sentence denotes METHODS:
T8 503-703 Sentence denotes We measured miR-218-5p expression in bronchial brushings of asthma patients (n = 50) and healthy controls (n = 15), and analysed the correlations between miR-218-5p expression and airway eosinophilia.
T9 704-900 Sentence denotes We examined whether CTNND2 was a target of miR-218-5p, and the expression of 12 catenin family members in bronchial brushings, in cultured human bronchial epithelial (HBE) cells and BEAS-2B cells.
T10 901-1004 Sentence denotes We explored the role of miR-218-5p-CTNND2 pathway using a murine model of allergic airway inflammation.
T11 1005-1013 Sentence denotes RESULTS:
T12 1014-1207 Sentence denotes Epithelial miR-218-5p expression was significantly decreased and negatively correlated with eosinophils in induced sputum and bronchial biopsies, and other type 2 biomarkers in asthma patients.
T13 1208-1280 Sentence denotes We verified that CTNND2 (encoding δ-catenin) was a target of miR-218-5p.
T14 1281-1480 Sentence denotes Remarkably, CTNND2 was the most significantly up-regulated catenin compared with the other 11 catenin family members in bronchial brushings of asthma patients, IL-13-stimulated HBE and BEAS-2B cells.
T15 1481-1577 Sentence denotes Moreover, epithelial CTNND2 expression positively correlated with airway eosinophilia in asthma.
T16 1578-1717 Sentence denotes Airway mmu-miR-218-5p expression was also decreased, and Ctnnd2 expression was increased in a murine model of allergic airway inflammation.
T17 1718-1878 Sentence denotes Intriguingly, mmu-miR-218-5p overexpression suppressed airway hyperresponsiveness, eosinophilic airway inflammation and Ctnnd2 up-regulation in the mouse model.
T18 1879-2026 Sentence denotes Finally, perturbation of miR-218-5p or CTNND2 expression significantly altered chemokine CCL26 expression in the cell cultures and the mouse model.
T19 2027-2062 Sentence denotes CONCLUSIONS AND CLINICAL RELEVANCE:
T20 2063-2237 Sentence denotes Epithelial miR-218-5p plays a protective role in eosinophilic airway inflammation via targeting CTNND2, a novel catenin in asthma, and suppressing chemokine CCL26 expression.