PubMed:31374360 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/31374360","sourcedb":"PubMed","sourceid":"31374360","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/31374360","text":"Effects of nanoparticles exposure and PON1 genotype on heart rate variability.\nOBJECTIVES: This study was to assess the association between different NPs exposure and PON1 genotype on Heart Rate Variability (HRV) parameters among workers.\nMETHODS: This study included 235 non-CVD subjects handled to nanomaterials (NM) and 185 non-exposed controls without CVD from 14 NM plants. All participants completed short-term HRV measurements, and were collected blood specimens to measure PON1 activities and the genotype of the PON1 Q192R polymorphism.\nRESULTS: In a multivariate regression model, this study observed a positive relationship between nano-Ag exposure and HRV time-domain (RMSSD) and frequency-domain (HF). After adjusting for confounders, the results showed positive associations between RR homozygosity, PON1 paraoxonase/arylesterase activities with HRV, and was particularly noteworthy in RMSSD and HF.\nCONCLUSIONS: This study shows a significant increment of RMSSD and HF among workers who handled Nano-Ag materials. These results imply that Nano-Ag and PON1 Q192R genotype can trigger ANS reflexes and alter cardiac frequency and function.","tracks":[{"project":"PubTator4TogoVar","denotations":[{"id":"31374360_0","span":{"begin":526,"end":531},"obj":"ProteinMutation"},{"id":"31374360_1","span":{"begin":1071,"end":1076},"obj":"ProteinMutation"}],"attributes":[{"id":"31374360_0_ProteinMutation","pred":"proteinmutation","subj":"31374360_0","obj":"rs662"},{"id":"31374360_1_ProteinMutation","pred":"proteinmutation","subj":"31374360_1","obj":"rs662"},{"subj":"31374360_0","pred":"source","obj":"PubTator4TogoVar"},{"subj":"31374360_1","pred":"source","obj":"PubTator4TogoVar"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubTator4TogoVar","color":"#ecb293","default":true}]}]}}