PubMed:31366827
Annnotations
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 69-72 | PR:P70372 | denotes | Hua |
| T2 | 69-72 | PR:000007016 | denotes | Hua |
| T3 | 87-91 | CVCL_V640 | denotes | Tong |
| T4 | 95-99 | CVCL_D965 | denotes | Fang |
| T5 | 95-99 | UBERON:0003674 | denotes | Fang |
| T6 | 95-99 | UBERON:0013078 | denotes | Fang |
| T7 | 149-157 | CHEBI:23888 | denotes | medicine |
| T8 | 285-304 | D045506 | denotes | therapeutic effects |
| T9 | 285-304 | D045506 | denotes | therapeutic effects |
| T10 | 421-424 | PR:P70372 | denotes | Hua |
| T11 | 421-424 | PR:000007016 | denotes | Hua |
| T12 | 439-443 | CVCL_V640 | denotes | Tong |
| T13 | 447-451 | CVCL_D965 | denotes | Fang |
| T14 | 447-451 | UBERON:0003674 | denotes | Fang |
| T15 | 447-451 | UBERON:0013078 | denotes | Fang |
| T16 | 488-496 | CHEBI:23888 | denotes | medicine |
| T17 | 525-545 | D001172 | denotes | rheumatoid arthritis |
| T18 | 525-545 | D001172 | denotes | rheumatoid arthritis |
| T21 | 661-670 | SO:0000732 | denotes | predicted |
| T22 | 801-815 | D064209 | denotes | phytochemicals |
| T23 | 801-815 | D064209 | denotes | phytochemicals |
| T24 | 1319-1322 | CVCL_AV82 | denotes | AUC |
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 101-166 | DRI_Background | denotes | Herbal formulae have a long history in clinical medicine in Asia. |
| T2 | 167-403 | DRI_Challenge | denotes | While the complexity of the formulae leads to the complex compound-target interactions and the resultant multi-target therapeutic effects, it is difficult to elucidate the molecular/therapeutic mechanism of action for the many formulae. |
| T3 | 404-546 | DRI_Background | denotes | For example, the Hua-Yu-Qiang-Shen-Tong-Bi-Fang (TBF), an herbal formula of Chinese medicine, has been used for treating rheumatoid arthritis. |
| T4 | 547-642 | DRI_Approach | denotes | However, the target information of a great number of compounds from the TBF formula is missing. |
| T5 | 643-766 | DRI_Approach | denotes | In this study, we predicted the targets of the compounds from the TBF formula via network analysis and in silico computing. |
| T6 | 767-989 | DRI_Outcome | denotes | Initially, the information of the phytochemicals contained in the plants of the herbal formula was collected, and subsequently computed to their corresponding fingerprints for the sake of structural similarity calculation. |
| T7 | 990-1094 | DRI_Background | denotes | Then a compound structural similarity network infused with available target information was constructed. |
| T8 | 1095-1227 | DRI_Background | denotes | Five local similarity indices were used and compared for their performance on predicting the potential new targets of the compounds. |
| T9 | 1228-1425 | DRI_Outcome | denotes | Finally, the Preferential Attachment Index was selected for it having an area under curve (AUC) of 0.886, which outperforms the other four algorithms in predicting the compound-target interactions. |
| T10 | 1426-1552 | DRI_Background | denotes | This method could provide a promising direction for identifying the compound-target interactions of herbal formulae in silico. |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 87-91 | CVCL_V640|Cancer_cell_line|Homo sapiens | denotes | Tong |
| T2 | 92-94 | CVCL_LI17|Cancer_cell_line|Homo sapiens | denotes | Bi |
| T3 | 95-99 | CVCL_D965|Induced_pluripotent_stem_cell|Homo sapiens | denotes | Fang |
| T4 | 122-123 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T5 | 439-443 | CVCL_V640|Cancer_cell_line|Homo sapiens | denotes | Tong |
| T6 | 444-446 | CVCL_LI17|Cancer_cell_line|Homo sapiens | denotes | Bi |
| T7 | 447-451 | CVCL_D965|Induced_pluripotent_stem_cell|Homo sapiens | denotes | Fang |
| T8 | 459-461 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
| T9 | 459-461 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
| T10 | 498-501 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
| T11 | 498-501 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
| T12 | 582-583 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T13 | 658-660 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
| T14 | 995-996 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T15 | 1298-1300 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
| T16 | 1298-1300 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
| T17 | 1319-1322 | CVCL_AV82|Finite_cell_line|Homo sapiens | denotes | AUC |
| T18 | 1452-1453 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |