
PubMed:31359737
Annnotations
GoldHamster
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 6-14 | CHEBI:25367 | denotes | Molecule |
T2 | 37-59 | D061205 | denotes | Vascular Calcification |
T3 | 37-59 | D061205 | denotes | Vascular Calcification |
T10 | 66-69 | SO:0001442 | denotes | Met |
T4 | 66-69 | PR:P16056 | denotes | Met |
T6 | 66-69 | PR:P97523 | denotes | Met |
T8 | 66-69 | PR:000014144 | denotes | Met |
T11 | 66-69 | PR:Q8CH25 | denotes | Met |
T5 | 66-69 | CHEBI:16044 | denotes | Met |
T7 | 66-69 | CHEBI:16643 | denotes | Met |
T9 | 66-69 | CHEBI:49037 | denotes | Met |
T12 | 66-69 | CHEBI:49038 | denotes | Met |
T13 | 66-69 | CHEBI:16811 | denotes | Met |
T15 | 70-76 | Q9R172 | denotes | Notch3 |
T16 | 70-76 | Q61982 | denotes | Notch3 |
T17 | 70-76 | PR:Q9UM47 | denotes | Notch3 |
T18 | 70-76 | PR:Q61982 | denotes | Notch3 |
T19 | 70-76 | Q9UM47 | denotes | Notch3 |
T20 | 70-76 | PR:Q9R172 | denotes | Notch3 |
T21 | 70-76 | PR:000011334 | denotes | Notch3 |
T22 | 77-80 | D017681 | denotes | HES |
T23 | 77-81 | PR:000008515 | denotes | HES1 |
T24 | 77-81 | PR:P35843 | denotes | HES1 |
T25 | 77-81 | PR:A0A0B4J2D5 | denotes | HES1 |
T26 | 77-81 | PR:Q04666 | denotes | HES1 |
T27 | 77-81 | PR:P35428 | denotes | HES1 |
T28 | 77-81 | PR:Q61658 | denotes | HES1 |
T30 | 77-81 | PR:000008523 | denotes | HES1 |
T31 | 77-81 | PR:Q14469 | denotes | HES1 |
T29 | 77-81 | CVCL_D092 | denotes | HES1 |
T32 | 82-92 | GO:0023052 | denotes | Signalling |
T33 | 111-133 | D061205 | denotes | Vascular calcification |
T34 | 111-133 | D061205 | denotes | Vascular calcification |
T35 | 281-291 | CL:0000182 | denotes | hepatocyte |
T37 | 281-305 | Q9BH09 | denotes | hepatocyte growth factor |
T39 | 281-305 | PR:000008534 | denotes | hepatocyte growth factor |
T40 | 281-305 | Q08048 | denotes | hepatocyte growth factor |
T41 | 281-305 | Q867B7 | denotes | hepatocyte growth factor |
T42 | 281-305 | Q76BS1 | denotes | hepatocyte growth factor |
T43 | 281-305 | P17945 | denotes | hepatocyte growth factor |
T45 | 281-305 | P14210 | denotes | hepatocyte growth factor |
T38 | 281-305 | D017228 | denotes | hepatocyte growth factor |
T44 | 281-305 | D017228 | denotes | hepatocyte growth factor |
T36 | 281-305 | GO:0005171 | denotes | hepatocyte growth factor |
T51 | 327-349 | D061205 | denotes | vascular calcification |
T52 | 327-349 | D061205 | denotes | vascular calcification |
T56 | 485-488 | 135300 | denotes | HGF |
T58 | 485-497 | Q00PJ8 | denotes | HGF-receptor |
T59 | 485-497 | P08581 | denotes | HGF-receptor |
T60 | 485-497 | Q108U6 | denotes | HGF-receptor |
T61 | 485-497 | Q2QLC0 | denotes | HGF-receptor |
T62 | 485-497 | Q2QLE0 | denotes | HGF-receptor |
T63 | 485-497 | A0M8S8 | denotes | HGF-receptor |
T64 | 485-497 | Q2IBA6 | denotes | HGF-receptor |
T65 | 485-497 | Q07E48 | denotes | HGF-receptor |
T66 | 485-497 | PR:000010335 | denotes | HGF-receptor |
T67 | 485-497 | Q09YN5 | denotes | HGF-receptor |
T68 | 485-497 | P16056 | denotes | HGF-receptor |
T69 | 485-497 | Q09YI9 | denotes | HGF-receptor |
T70 | 485-497 | A0M8R7 | denotes | HGF-receptor |
T71 | 485-497 | Q07DZ1 | denotes | HGF-receptor |
T72 | 485-497 | Q2IBF2 | denotes | HGF-receptor |
T73 | 485-497 | Q2IBC0 | denotes | HGF-receptor |
T74 | 485-497 | Q07E01 | denotes | HGF-receptor |
T75 | 485-497 | P97523 | denotes | HGF-receptor |
T76 | 485-497 | Q07E37 | denotes | HGF-receptor |
T77 | 485-497 | Q07DY1 | denotes | HGF-receptor |
T78 | 485-497 | Q09YH7 | denotes | HGF-receptor |
T79 | 485-497 | Q75ZY9 | denotes | HGF-receptor |
T80 | 485-497 | Q2QLA9 | denotes | HGF-receptor |
T81 | 485-497 | Q09YL1 | denotes | HGF-receptor |
T82 | 485-497 | Q09YK0 | denotes | HGF-receptor |
T83 | 485-497 | Q2QL89 | denotes | HGF-receptor |
T84 | 485-497 | Q07DV8 | denotes | HGF-receptor |
T85 | 485-497 | Q2QLG5 | denotes | HGF-receptor |
T86 | 485-497 | Q2QLF1 | denotes | HGF-receptor |
T87 | 485-497 | Q2IBG7 | denotes | HGF-receptor |
T88 | 485-497 | Q2IBD8 | denotes | HGF-receptor |
T90 | 485-497 | Q2QLH6 | denotes | HGF-receptor |
T91 | 485-497 | Q07E24 | denotes | HGF-receptor |
T92 | 485-497 | Q769I5 | denotes | HGF-receptor |
T93 | 485-497 | A1X150 | denotes | HGF-receptor |
T89 | 485-497 | D019859 | denotes | HGF-receptor |
T94 | 498-508 | GO:0023052 | denotes | signalling |
T95 | 592-602 | GO:0023052 | denotes | signalling |
T96 | 607-629 | D061205 | denotes | vascular calcification |
T97 | 607-629 | D061205 | denotes | vascular calcification |
T98 | 657-662 | D006801 | denotes | human |
T99 | 663-685 | UBERON:0004237 | denotes | vascular smooth muscle |
T107 | 787-791 | CVCL_KT16 | denotes | 1-C4 |
T108 | 818-822 | CVCL_KT16 | denotes | 1-C4 |
T109 | 826-846 | P19147 | denotes | alkaline phosphatase |
T110 | 826-846 | P83456 | denotes | alkaline phosphatase |
T112 | 826-846 | PR:000023540 | denotes | alkaline phosphatase |
T113 | 826-846 | O60109 | denotes | alkaline phosphatase |
T114 | 826-846 | P21948 | denotes | alkaline phosphatase |
T115 | 826-846 | P00634 | denotes | alkaline phosphatase |
T116 | 826-846 | P86348 | denotes | alkaline phosphatase |
T117 | 826-846 | P81800 | denotes | alkaline phosphatase |
T118 | 826-846 | Q05205 | denotes | alkaline phosphatase |
T111 | 826-846 | D000469 | denotes | alkaline phosphatase |
T119 | 835-846 | GO:0016791 | denotes | phosphatase |
T121 | 848-851 | PR:Q53GG5 | denotes | ALP |
T122 | 848-851 | Q9Z1X0 | denotes | ALP |
T123 | 848-851 | Q6V9X0 | denotes | ALP |
T124 | 848-851 | PR:000022085 | denotes | ALP |
T125 | 848-851 | PR:000004502 | denotes | ALP |
T126 | 848-851 | PR:Q7L266 | denotes | ALP |
T127 | 848-851 | PR:000004385 | denotes | ALP |
T128 | 848-851 | A1CIA7 | denotes | ALP |
T129 | 848-851 | PR:000012510 | denotes | ALP |
T130 | 848-851 | Q00208 | denotes | ALP |
T131 | 848-851 | Q03420 | denotes | ALP |
T132 | 848-851 | PR:000015248 | denotes | ALP |
T133 | 848-851 | PR:Q8VI04 | denotes | ALP |
T134 | 848-851 | PR:Q6A051 | denotes | ALP |
T135 | 848-851 | PR:Q9PU47 | denotes | ALP |
T136 | 848-851 | P12547 | denotes | ALP |
T137 | 848-851 | P29118 | denotes | ALP |
T138 | 848-851 | P03973 | denotes | ALP |
T139 | 848-851 | PR:P33997 | denotes | ALP |
T140 | 848-851 | PR:000001802 | denotes | ALP |
T141 | 848-851 | PR:Q66HS7 | denotes | ALP |
T142 | 848-851 | PR:Q9H0A0 | denotes | ALP |
T143 | 848-851 | A1CWF3 | denotes | ALP |
T145 | 848-851 | P97430 | denotes | ALP |
T146 | 848-851 | P22298 | denotes | ALP |
T147 | 848-851 | B0Y708 | denotes | ALP |
T148 | 848-851 | P35211 | denotes | ALP |
T149 | 848-851 | B8N106 | denotes | ALP |
T150 | 848-851 | P83610 | denotes | ALP |
T151 | 848-851 | P28296 | denotes | ALP |
T152 | 848-851 | PR:000010995 | denotes | ALP |
T144 | 848-851 | D050197 | denotes | ALP |
T159 | 879-882 | SO:0001442 | denotes | Met |
T153 | 879-882 | PR:P16056 | denotes | Met |
T155 | 879-882 | PR:P97523 | denotes | Met |
T157 | 879-882 | PR:000014144 | denotes | Met |
T160 | 879-882 | PR:Q8CH25 | denotes | Met |
T154 | 879-882 | CHEBI:16044 | denotes | Met |
T156 | 879-882 | CHEBI:16643 | denotes | Met |
T158 | 879-882 | CHEBI:49037 | denotes | Met |
T161 | 879-882 | CHEBI:49038 | denotes | Met |
T162 | 879-882 | CHEBI:16811 | denotes | Met |
T164 | 883-889 | Q9R172 | denotes | Notch3 |
T165 | 883-889 | Q61982 | denotes | Notch3 |
T166 | 883-889 | PR:Q9UM47 | denotes | Notch3 |
T167 | 883-889 | PR:Q61982 | denotes | Notch3 |
T168 | 883-889 | Q9UM47 | denotes | Notch3 |
T169 | 883-889 | PR:Q9R172 | denotes | Notch3 |
T170 | 883-889 | PR:000011334 | denotes | Notch3 |
T171 | 890-893 | D017681 | denotes | HES |
T172 | 890-894 | PR:000008515 | denotes | HES1 |
T173 | 890-894 | PR:P35843 | denotes | HES1 |
T174 | 890-894 | PR:A0A0B4J2D5 | denotes | HES1 |
T175 | 890-894 | PR:Q04666 | denotes | HES1 |
T176 | 890-894 | PR:P35428 | denotes | HES1 |
T177 | 890-894 | PR:Q61658 | denotes | HES1 |
T179 | 890-894 | PR:000008523 | denotes | HES1 |
T180 | 890-894 | PR:Q14469 | denotes | HES1 |
T178 | 890-894 | CVCL_D092 | denotes | HES1 |
T181 | 895-905 | GO:0023052 | denotes | signalling |
T182 | 952-955 | Q41249 | denotes | PCR |
T183 | 952-955 | O66148 | denotes | PCR |
T184 | 952-955 | Q59987 | denotes | PCR |
T185 | 952-955 | Q01289 | denotes | PCR |
T186 | 952-955 | O80333 | denotes | PCR |
T187 | 952-955 | P15904 | denotes | PCR |
T188 | 952-955 | Q9SDT1 | denotes | PCR |
T189 | 952-955 | Q39617 | denotes | PCR |
T190 | 1001-1005 | CVCL_KT16 | denotes | 1-C4 |
T199 | 1071-1085 | CHEBI:40863 | denotes | Alizarin Red S |
T200 | 1071-1085 | C004468 | denotes | Alizarin Red S |
T201 | 1071-1085 | C004468 | denotes | Alizarin Red S |
T202 | 1071-1085 | CHEBI:87358 | denotes | Alizarin Red S |
T203 | 1080-1083 | PR:Q9Z1M8 | denotes | Red |
T204 | 1080-1085 | D000080822 | denotes | Red S |
T205 | 1099-1106 | 1895 | denotes | calcium |
T206 | 1099-1106 | CHEBI:29320 | denotes | calcium |
T207 | 1099-1106 | CHEBI:22984 | denotes | calcium |
T208 | 1140-1144 | CVCL_KT16 | denotes | 1-C4 |
T209 | 1153-1156 | PR:Q53GG5 | denotes | ALP |
T210 | 1153-1156 | Q9Z1X0 | denotes | ALP |
T211 | 1153-1156 | Q6V9X0 | denotes | ALP |
T212 | 1153-1156 | PR:000022085 | denotes | ALP |
T213 | 1153-1156 | PR:000004502 | denotes | ALP |
T214 | 1153-1156 | PR:Q7L266 | denotes | ALP |
T215 | 1153-1156 | PR:000004385 | denotes | ALP |
T216 | 1153-1156 | A1CIA7 | denotes | ALP |
T217 | 1153-1156 | PR:000012510 | denotes | ALP |
T218 | 1153-1156 | Q00208 | denotes | ALP |
T219 | 1153-1156 | Q03420 | denotes | ALP |
T220 | 1153-1156 | PR:000015248 | denotes | ALP |
T221 | 1153-1156 | PR:Q8VI04 | denotes | ALP |
T222 | 1153-1156 | PR:Q6A051 | denotes | ALP |
T223 | 1153-1156 | PR:Q9PU47 | denotes | ALP |
T224 | 1153-1156 | P12547 | denotes | ALP |
T225 | 1153-1156 | P29118 | denotes | ALP |
T226 | 1153-1156 | P03973 | denotes | ALP |
T227 | 1153-1156 | PR:P33997 | denotes | ALP |
T228 | 1153-1156 | PR:000001802 | denotes | ALP |
T229 | 1153-1156 | PR:Q66HS7 | denotes | ALP |
T230 | 1153-1156 | PR:Q9H0A0 | denotes | ALP |
T231 | 1153-1156 | A1CWF3 | denotes | ALP |
T233 | 1153-1156 | P97430 | denotes | ALP |
T234 | 1153-1156 | P22298 | denotes | ALP |
T235 | 1153-1156 | B0Y708 | denotes | ALP |
T236 | 1153-1156 | P35211 | denotes | ALP |
T237 | 1153-1156 | B8N106 | denotes | ALP |
T238 | 1153-1156 | P83610 | denotes | ALP |
T239 | 1153-1156 | P28296 | denotes | ALP |
T240 | 1153-1156 | PR:000010995 | denotes | ALP |
T232 | 1153-1156 | D050197 | denotes | ALP |
T241 | 1220-1223 | CHEBI:60815 | denotes | BMP |
T244 | 1220-1225 | PR:P49001 | denotes | BMP-2 |
T245 | 1220-1225 | PR:P21274 | denotes | BMP-2 |
T246 | 1220-1225 | Q804S2 | denotes | BMP-2 |
T247 | 1220-1225 | P49001 | denotes | BMP-2 |
T248 | 1220-1225 | P12643 | denotes | BMP-2 |
T249 | 1220-1225 | P21274 | denotes | BMP-2 |
T250 | 1220-1225 | Q90751 | denotes | BMP-2 |
T251 | 1220-1225 | O46564 | denotes | BMP-2 |
T252 | 1220-1225 | PR:P12643 | denotes | BMP-2 |
T253 | 1220-1225 | PR:000000164 | denotes | BMP-2 |
T254 | 1220-1225 | O19006 | denotes | BMP-2 |
T255 | 1227-1232 | PR:Q13950 | denotes | Runx2 |
T256 | 1227-1232 | PR:Q08775 | denotes | Runx2 |
T257 | 1227-1232 | PR:000014364 | denotes | Runx2 |
T258 | 1234-1238 | PR:P35548 | denotes | Msx2 |
T259 | 1234-1238 | PR:Q03358 | denotes | Msx2 |
T260 | 1234-1238 | PR:000010687 | denotes | Msx2 |
T261 | 1234-1238 | PR:P28362 | denotes | Msx2 |
T262 | 1243-1246 | PR:000015561 | denotes | OPN |
T263 | 1243-1246 | PR:P10451 | denotes | OPN |
T264 | 1278-1281 | PR:P16056 | denotes | Met |
T266 | 1278-1281 | PR:P97523 | denotes | Met |
T268 | 1278-1281 | PR:000014144 | denotes | Met |
T271 | 1278-1281 | PR:Q8CH25 | denotes | Met |
T270 | 1278-1281 | SO:0001442 | denotes | Met |
T265 | 1278-1281 | CHEBI:16044 | denotes | Met |
T267 | 1278-1281 | CHEBI:16643 | denotes | Met |
T269 | 1278-1281 | CHEBI:49037 | denotes | Met |
T272 | 1278-1281 | CHEBI:49038 | denotes | Met |
T273 | 1278-1281 | CHEBI:16811 | denotes | Met |
T274 | 1282-1297 | GO:0016310 | denotes | phosphorylation |
T275 | 1352-1367 | CHEBI:90199 | denotes | c-Met inhibitor |
T276 | 1354-1357 | PR:P16056 | denotes | Met |
T278 | 1354-1357 | PR:P97523 | denotes | Met |
T280 | 1354-1357 | PR:000014144 | denotes | Met |
T283 | 1354-1357 | PR:Q8CH25 | denotes | Met |
T282 | 1354-1357 | SO:0001442 | denotes | Met |
T291 | 1369-1379 | 1148495 | denotes | crizotinib |
T288 | 1369-1379 | CHEBI:64310 | denotes | crizotinib |
T289 | 1369-1379 | CHEBI:77563 | denotes | crizotinib |
T290 | 1369-1379 | D000077547 | denotes | crizotinib |
T292 | 1369-1379 | D000077547 | denotes | crizotinib |
T293 | 1421-1426 | PR:P46530 | denotes | Notch |
T294 | 1427-1436 | CHEBI:35222 | denotes | inhibitor |
T295 | 1437-1441 | C028145 | denotes | DAPT |
T296 | 1437-1441 | C028145 | denotes | DAPT |
T298 | 1437-1441 | CHEBI:86193 | denotes | DAPT |
T297 | 1437-1441 | CVCL_D279 | denotes | DAPT |
T299 | 1481-1490 | SO:0000119 | denotes | regulated |
T301 | 1491-1497 | Q9R172 | denotes | Notch3 |
T302 | 1491-1497 | Q61982 | denotes | Notch3 |
T303 | 1491-1497 | PR:Q9UM47 | denotes | Notch3 |
T304 | 1491-1497 | PR:Q61982 | denotes | Notch3 |
T305 | 1491-1497 | Q9UM47 | denotes | Notch3 |
T306 | 1491-1497 | PR:Q9R172 | denotes | Notch3 |
T307 | 1491-1497 | PR:000011334 | denotes | Notch3 |
T308 | 1491-1505 | D000071656 | denotes | Notch3 protein |
T313 | 1498-1505 | SO:0000104 | denotes | protein |
T312 | 1498-1505 | PR:000000001 | denotes | protein |
T309 | 1498-1505 | GO:0003675 | denotes | protein |
T314 | 1513-1517 | C028145 | denotes | DAPT |
T315 | 1513-1517 | C028145 | denotes | DAPT |
T317 | 1513-1517 | CHEBI:86193 | denotes | DAPT |
T316 | 1513-1517 | CVCL_D279 | denotes | DAPT |
T321 | 1522-1532 | 1148495 | denotes | crizotinib |
T318 | 1522-1532 | CHEBI:64310 | denotes | crizotinib |
T319 | 1522-1532 | CHEBI:77563 | denotes | crizotinib |
T320 | 1522-1532 | D000077547 | denotes | crizotinib |
T322 | 1522-1532 | D000077547 | denotes | crizotinib |
T323 | 1555-1558 | D017681 | denotes | Hes |
T324 | 1555-1560 | PR:000008515 | denotes | Hes-1 |
T325 | 1555-1560 | PR:P35843 | denotes | Hes-1 |
T326 | 1555-1560 | PR:A0A0B4J2D5 | denotes | Hes-1 |
T327 | 1555-1560 | PR:Q04666 | denotes | Hes-1 |
T328 | 1555-1560 | PR:P35428 | denotes | Hes-1 |
T329 | 1555-1560 | PR:Q61658 | denotes | Hes-1 |
T331 | 1555-1560 | PR:000008523 | denotes | Hes-1 |
T332 | 1555-1560 | PR:Q14469 | denotes | Hes-1 |
T330 | 1555-1560 | CVCL_D092 | denotes | Hes-1 |
T333 | 1561-1568 | GO:0003675 | denotes | protein |
T337 | 1561-1568 | SO:0000104 | denotes | protein |
T336 | 1561-1568 | PR:000000001 | denotes | protein |
T334 | 1561-1568 | CHEBI:36080 | denotes | protein |
T335 | 1561-1568 | CHEBI:11122 | denotes | protein |
T340 | 1638-1642 | CVCL_D279 | denotes | DAPT |
T338 | 1638-1642 | C028145 | denotes | DAPT |
T339 | 1638-1642 | C028145 | denotes | DAPT |
T341 | 1638-1642 | CHEBI:86193 | denotes | DAPT |
T343 | 1644-1648 | 1311190 | denotes | GOLD |
T342 | 1644-1648 | CHEBI:59965 | denotes | GOLD |
T344 | 1689-1696 | SO:0100018 | denotes | binding |
T345 | 1689-1696 | SO:0001091 | denotes | binding |
T346 | 1689-1696 | GO:0005488 | denotes | binding |
T347 | 1713-1717 | CVCL_KT16 | denotes | 1-C4 |
T348 | 1721-1724 | PR:Q08048 | denotes | HGF |
T349 | 1721-1724 | PR:P17945 | denotes | HGF |
T350 | 1721-1724 | PR:000008534 | denotes | HGF |
T352 | 1721-1724 | PR:P14210 | denotes | HGF |
T351 | 1721-1724 | 135300 | denotes | HGF |
T353 | 1872-1875 | PR:Q08048 | denotes | HGF |
T354 | 1872-1875 | PR:P17945 | denotes | HGF |
T355 | 1872-1875 | PR:000008534 | denotes | HGF |
T357 | 1872-1875 | PR:P14210 | denotes | HGF |
T356 | 1872-1875 | 135300 | denotes | HGF |
T364 | 1878-1881 | SO:0001442 | denotes | Met |
T358 | 1878-1881 | PR:P16056 | denotes | Met |
T360 | 1878-1881 | PR:P97523 | denotes | Met |
T362 | 1878-1881 | PR:000014144 | denotes | Met |
T365 | 1878-1881 | PR:Q8CH25 | denotes | Met |
T359 | 1878-1881 | CHEBI:16044 | denotes | Met |
T361 | 1878-1881 | CHEBI:16643 | denotes | Met |
T363 | 1878-1881 | CHEBI:49037 | denotes | Met |
T366 | 1878-1881 | CHEBI:49038 | denotes | Met |
T367 | 1878-1881 | CHEBI:16811 | denotes | Met |
T368 | 1886-1891 | PR:P46530 | denotes | Notch |
T369 | 1892-1902 | GO:0023052 | denotes | signalling |
PubMed_Structured_Abstracts
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 111-639 | OBJECTIVE | denotes | Vascular calcification represents a huge clinical problem contributing to adverse cardiovascular events, with no effective treatment currently available. Upregulation of hepatocyte growth factor has been linked with vascular calcification, and thus, represent a potential target in the development of a novel therapeutic strategy. Glycomimetics have been shown to interrupt HGF-receptor signalling, therefore this study investigated the effect of novel glycomimetics on osteogenic signalling and vascular calcification in vitro. |
T2 | 649-990 | METHODS | denotes | Primary human vascular smooth muscle cells (HVSMCs) were induced by β-glycerophosphate (β-GP) and treated with 4 glycomimetic compounds (C1-C4). The effect of β-GP and C1-C4 on alkaline phosphatase (ALP), osteogenic markers and c-Met/Notch3/HES1 signalling was determined using colorimetric assays, qRT-PCR and western blotting respectively. |
T3 | 1000-1760 | RESULTS | denotes | C1-C4 significantly attenuated β-GP-induced calcification, as shown by Alizarin Red S staining and calcium content by day 14. In addition, C1-C4 reduced ALP activity and prevented upregulation of the osteogenic markers, BMP-2, Runx2, Msx2 and OPN. Furthermore, β-GP increased c-Met phosphorylation at day 21, an effect ameliorated by C2 and C4 and the c-Met inhibitor, crizotinib. We next interrogated the effects of the Notch inhibitor DAPT and confirmed an inhibition of β-GP up-regulated Notch3 protein by C2, DAPT and crizotinib compared to controls. Hes-1 protein upregulation by β-GP, was also significantly downregulated by C2 and DAPT. GOLD docking analysis identified a potential binding interaction of C1-C4 to HGF which will be investigated further. |
T4 | 1773-1903 | CONCLUSIONS | denotes | These findings demonstrate that glycomimetics have potent anti-calcification properties acting via HGF/c-Met and Notch signalling. |
Goldhamster2_Cellosaurus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 64-65 | CVCL_S361|Finite_cell_line|Mus musculus | denotes | c |
T2 | 77-81 | CVCL_D092|Embryonic_stem_cell|Homo sapiens | denotes | HES1 |
T3 | 145-146 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T4 | 306-309 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
T5 | 306-309 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
T6 | 371-372 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T7 | 412-413 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T8 | 739-741 | CVCL_S009|Spontaneously_immortalized_cell_line|Epinephelus tauvina | denotes | GP |
T9 | 786-788 | CVCL_1G30|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C1 |
T10 | 786-788 | CVCL_L326|Cancer_cell_line|Canis lupus familiaris | denotes | C1 |
T11 | 786-788 | CVCL_RG57|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T12 | 786-788 | CVCL_WT75|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T13 | 789-791 | CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C4 |
T14 | 789-791 | CVCL_4783|Cancer_cell_line|Homo sapiens | denotes | C4 |
T15 | 789-791 | CVCL_5111|Cancer_cell_line|Homo sapiens | denotes | C4 |
T16 | 789-791 | CVCL_7311|Finite_cell_line|Homo sapiens | denotes | C4 |
T17 | 789-791 | CVCL_H536|Cancer_cell_line|Rattus norvegicus | denotes | C4 |
T18 | 789-791 | CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C4 |
T19 | 810-812 | CVCL_S009|Spontaneously_immortalized_cell_line|Epinephelus tauvina | denotes | GP |
T20 | 817-819 | CVCL_1G30|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C1 |
T21 | 817-819 | CVCL_L326|Cancer_cell_line|Canis lupus familiaris | denotes | C1 |
T22 | 817-819 | CVCL_RG57|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T23 | 817-819 | CVCL_WT75|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T24 | 820-822 | CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C4 |
T25 | 820-822 | CVCL_4783|Cancer_cell_line|Homo sapiens | denotes | C4 |
T26 | 820-822 | CVCL_5111|Cancer_cell_line|Homo sapiens | denotes | C4 |
T27 | 820-822 | CVCL_7311|Finite_cell_line|Homo sapiens | denotes | C4 |
T28 | 820-822 | CVCL_H536|Cancer_cell_line|Rattus norvegicus | denotes | C4 |
T29 | 820-822 | CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C4 |
T30 | 877-878 | CVCL_S361|Finite_cell_line|Mus musculus | denotes | c |
T31 | 890-894 | CVCL_D092|Embryonic_stem_cell|Homo sapiens | denotes | HES1 |
T32 | 1000-1002 | CVCL_1G30|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C1 |
T33 | 1000-1002 | CVCL_L326|Cancer_cell_line|Canis lupus familiaris | denotes | C1 |
T34 | 1000-1002 | CVCL_RG57|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T35 | 1000-1002 | CVCL_WT75|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T36 | 1003-1005 | CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C4 |
T37 | 1003-1005 | CVCL_4783|Cancer_cell_line|Homo sapiens | denotes | C4 |
T38 | 1003-1005 | CVCL_5111|Cancer_cell_line|Homo sapiens | denotes | C4 |
T39 | 1003-1005 | CVCL_7311|Finite_cell_line|Homo sapiens | denotes | C4 |
T40 | 1003-1005 | CVCL_H536|Cancer_cell_line|Rattus norvegicus | denotes | C4 |
T41 | 1003-1005 | CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C4 |
T42 | 1033-1035 | CVCL_S009|Spontaneously_immortalized_cell_line|Epinephelus tauvina | denotes | GP |
T43 | 1122-1124 | CVCL_ZS48|Finite_cell_line|Homo sapiens | denotes | 14 |
T44 | 1139-1141 | CVCL_1G30|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C1 |
T45 | 1139-1141 | CVCL_L326|Cancer_cell_line|Canis lupus familiaris | denotes | C1 |
T46 | 1139-1141 | CVCL_RG57|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T47 | 1139-1141 | CVCL_WT75|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T48 | 1142-1144 | CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C4 |
T49 | 1142-1144 | CVCL_4783|Cancer_cell_line|Homo sapiens | denotes | C4 |
T50 | 1142-1144 | CVCL_5111|Cancer_cell_line|Homo sapiens | denotes | C4 |
T51 | 1142-1144 | CVCL_7311|Finite_cell_line|Homo sapiens | denotes | C4 |
T52 | 1142-1144 | CVCL_H536|Cancer_cell_line|Rattus norvegicus | denotes | C4 |
T53 | 1142-1144 | CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C4 |
T54 | 1157-1165 | CVCL_C410|Hybridoma|Mus musculus | denotes | activity |
T55 | 1263-1265 | CVCL_S009|Spontaneously_immortalized_cell_line|Epinephelus tauvina | denotes | GP |
T56 | 1276-1277 | CVCL_S361|Finite_cell_line|Mus musculus | denotes | c |
T57 | 1309-1311 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T58 | 1309-1311 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T59 | 1334-1336 | CVCL_1G31|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C2 |
T60 | 1334-1336 | CVCL_4722|Cancer_cell_line|Rattus norvegicus | denotes | C2 |
T61 | 1334-1336 | CVCL_7426|Finite_cell_line|Homo sapiens | denotes | C2 |
T62 | 1334-1336 | CVCL_L327|Cancer_cell_line|Canis lupus familiaris | denotes | C2 |
T63 | 1341-1343 | CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C4 |
T64 | 1341-1343 | CVCL_4783|Cancer_cell_line|Homo sapiens | denotes | C4 |
T65 | 1341-1343 | CVCL_5111|Cancer_cell_line|Homo sapiens | denotes | C4 |
T66 | 1341-1343 | CVCL_7311|Finite_cell_line|Homo sapiens | denotes | C4 |
T67 | 1341-1343 | CVCL_H536|Cancer_cell_line|Rattus norvegicus | denotes | C4 |
T68 | 1341-1343 | CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C4 |
T69 | 1352-1353 | CVCL_S361|Finite_cell_line|Mus musculus | denotes | c |
T70 | 1381-1383 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
T71 | 1437-1441 | CVCL_D279|Cancer_cell_line|Homo sapiens | denotes | DAPT |
T72 | 1456-1458 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T73 | 1456-1458 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T74 | 1475-1477 | CVCL_S009|Spontaneously_immortalized_cell_line|Epinephelus tauvina | denotes | GP |
T75 | 1509-1511 | CVCL_1G31|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C2 |
T76 | 1509-1511 | CVCL_4722|Cancer_cell_line|Rattus norvegicus | denotes | C2 |
T77 | 1509-1511 | CVCL_7426|Finite_cell_line|Homo sapiens | denotes | C2 |
T78 | 1509-1511 | CVCL_L327|Cancer_cell_line|Canis lupus familiaris | denotes | C2 |
T79 | 1513-1517 | CVCL_D279|Cancer_cell_line|Homo sapiens | denotes | DAPT |
T80 | 1555-1560 | CVCL_D092|Embryonic_stem_cell|Homo sapiens | denotes | Hes-1 |
T81 | 1587-1589 | CVCL_S009|Spontaneously_immortalized_cell_line|Epinephelus tauvina | denotes | GP |
T82 | 1631-1633 | CVCL_1G31|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C2 |
T83 | 1631-1633 | CVCL_4722|Cancer_cell_line|Rattus norvegicus | denotes | C2 |
T84 | 1631-1633 | CVCL_7426|Finite_cell_line|Homo sapiens | denotes | C2 |
T85 | 1631-1633 | CVCL_L327|Cancer_cell_line|Canis lupus familiaris | denotes | C2 |
T86 | 1638-1642 | CVCL_D279|Cancer_cell_line|Homo sapiens | denotes | DAPT |
T87 | 1677-1678 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T88 | 1712-1714 | CVCL_1G30|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C1 |
T89 | 1712-1714 | CVCL_L326|Cancer_cell_line|Canis lupus familiaris | denotes | C1 |
T90 | 1712-1714 | CVCL_RG57|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T91 | 1712-1714 | CVCL_WT75|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C1 |
T92 | 1715-1717 | CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes | denotes | C4 |
T93 | 1715-1717 | CVCL_4783|Cancer_cell_line|Homo sapiens | denotes | C4 |
T94 | 1715-1717 | CVCL_5111|Cancer_cell_line|Homo sapiens | denotes | C4 |
T95 | 1715-1717 | CVCL_7311|Finite_cell_line|Homo sapiens | denotes | C4 |
T96 | 1715-1717 | CVCL_H536|Cancer_cell_line|Rattus norvegicus | denotes | C4 |
T97 | 1715-1717 | CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens | denotes | C4 |
T98 | 1876-1877 | CVCL_S361|Finite_cell_line|Mus musculus | denotes | c |