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PubMed:31341019 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 154-319 DRI_Background denotes The triple-negative phenotype is the most prevalent form of human breast cancer worldwide and is characterized by poor survival, high aggressiveness, and recurrence.
T2 320-483 DRI_Background denotes Microvesicles (MV) are shredded plasma membrane components and critically mediate cell-cell communication, but can also induce cancer proliferation and metastasis.
T3 484-725 DRI_Background denotes Previous studies have revealed that protease-activated receptor 2 (PAR2) contributes significantly to human triple-negative breast cancer (TNBC) progression by releasing nano-size MV and promoting cell proliferation, migration, and invasion.
T4 726-829 DRI_Background denotes MV isolated from highly aggressive human TNBC cells impart metastatic potential to nonmetastatic cells.
T5 830-1000 DRI_Background denotes Over-expression of microRNA221 (miR221) has also been reported to enhance the metastatic potential of human TNBC, but miR221's relationship to PAR2-induced MV is unclear.
T6 1001-1342 DRI_Outcome denotes Here, using isolated MV, immunoblotting, quantitative RT-PCR, FACS analysis, and enzymatic assays, we show that miR221 is translocated via human TNBC-derived MV, which upon fusion with recipient cells, enhance their proliferation, survival, and metastasis both in vitro and in vivo by inducing the epithelial-to-mesenchymal transition (EMT).
T7 1343-1572 DRI_Background denotes Administration of anti-miR221 significantly impaired MV-induced expression of the mesenchymal markers Snail, Slug, N-cadherin, and vimentin in the recipient cells, whereas restoring expression of the epithelial marker E-cadherin.
T8 1573-1597 DRI_Outcome denotes We also demonstrate that
T9 1619-1763 DRI_Outcome denotes targets phosphatase and tensin homolog (PTEN) in the recipient cells, followed by AKT Ser/Thr kinase (AKT)/NF-κB activation, which promotes EMT.
T10 1764-1909 DRI_Background denotes Moreover, elevated miR221 levels in MV derived from human TNBC patients' blood could induce cell proliferation and metastasis in recipient cells.
T11 1910-2042 DRI_Approach denotes In summary, miR221 transfer from TNBC cells via PAR2-derived MV induces EMT and enhances the malignant potential of recipient cells.

sentences

Id Subject Object Predicate Lexical cue
T1 0-153 Sentence denotes Triple-negative breast cancer-derived microvesicles transfer microRNA221 to the recipient cells and thereby promote epithelial-to-mesenchymal transition.
T2 154-319 Sentence denotes The triple-negative phenotype is the most prevalent form of human breast cancer worldwide and is characterized by poor survival, high aggressiveness, and recurrence.
T3 320-483 Sentence denotes Microvesicles (MV) are shredded plasma membrane components and critically mediate cell-cell communication, but can also induce cancer proliferation and metastasis.
T4 484-725 Sentence denotes Previous studies have revealed that protease-activated receptor 2 (PAR2) contributes significantly to human triple-negative breast cancer (TNBC) progression by releasing nano-size MV and promoting cell proliferation, migration, and invasion.
T5 726-829 Sentence denotes MV isolated from highly aggressive human TNBC cells impart metastatic potential to nonmetastatic cells.
T6 830-1000 Sentence denotes Over-expression of microRNA221 (miR221) has also been reported to enhance the metastatic potential of human TNBC, but miR221's relationship to PAR2-induced MV is unclear.
T7 1001-1342 Sentence denotes Here, using isolated MV, immunoblotting, quantitative RT-PCR, FACS analysis, and enzymatic assays, we show that miR221 is translocated via human TNBC-derived MV, which upon fusion with recipient cells, enhance their proliferation, survival, and metastasis both in vitro and in vivo by inducing the epithelial-to-mesenchymal transition (EMT).
T8 1343-1572 Sentence denotes Administration of anti-miR221 significantly impaired MV-induced expression of the mesenchymal markers Snail, Slug, N-cadherin, and vimentin in the recipient cells, whereas restoring expression of the epithelial marker E-cadherin.
T9 1573-1763 Sentence denotes We also demonstrate that MV-associated miR221 targets phosphatase and tensin homolog (PTEN) in the recipient cells, followed by AKT Ser/Thr kinase (AKT)/NF-κB activation, which promotes EMT.
T10 1764-1909 Sentence denotes Moreover, elevated miR221 levels in MV derived from human TNBC patients' blood could induce cell proliferation and metastasis in recipient cells.
T11 1910-2042 Sentence denotes In summary, miR221 transfer from TNBC cells via PAR2-derived MV induces EMT and enhances the malignant potential of recipient cells.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1837-1842 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 1837-1842 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 16-29 Phenotype denotes breast cancer HP:0003002
T2 220-233 Phenotype denotes breast cancer HP:0003002
T3 288-302 Phenotype denotes aggressiveness HP:0000718
T4 447-453 Phenotype denotes cancer HP:0002664
T5 608-621 Phenotype denotes breast cancer HP:0003002
T6 750-760 Phenotype denotes aggressive HP:0000718

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 0-29 Disease denotes Triple-negative breast cancer http://purl.obolibrary.org/obo/MONDO_0005494
T2 220-233 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 447-453 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 592-621 Disease denotes triple-negative breast cancer http://purl.obolibrary.org/obo/MONDO_0005494
T5 623-627 Disease denotes TNBC http://purl.obolibrary.org/obo/MONDO_0005494
T6 767-771 Disease denotes TNBC http://purl.obolibrary.org/obo/MONDO_0005494
T7 938-942 Disease denotes TNBC http://purl.obolibrary.org/obo/MONDO_0005494
T8 1063-1067 Disease denotes FACS http://purl.obolibrary.org/obo/MONDO_0018262
T9 1146-1150 Disease denotes TNBC http://purl.obolibrary.org/obo/MONDO_0005494
T10 1822-1826 Disease denotes TNBC http://purl.obolibrary.org/obo/MONDO_0005494
T11 1943-1947 Disease denotes TNBC http://purl.obolibrary.org/obo/MONDO_0005494

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 214-219 OrganismTaxon denotes human 9606
T2 586-591 OrganismTaxon denotes human 9606
T3 761-766 OrganismTaxon denotes human 9606
T4 932-937 OrganismTaxon denotes human 9606
T5 1140-1145 OrganismTaxon denotes human 9606
T6 1816-1821 OrganismTaxon denotes human 9606

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1837-1842 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 16-22 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 220-226 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 352-367 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T4 608-614 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 1837-1842 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178