> top > docs > PubMed:31319897 > annotations

PubMed:31319897 JSONTXT

Annnotations TAB JSON ListView MergeView

GoldHamster

Id Subject Object Predicate Lexical cue
T1 15-24 GO:0016236 denotes autophagy
T2 15-24 GO:0006914 denotes autophagy
T3 47-71 D018165 denotes Nelson Bay orthoreovirus
T4 47-71 118027 denotes Nelson Bay orthoreovirus
T6 85-109 D018165 denotes Nelson Bay orthoreovirus
T7 85-109 118027 denotes Nelson Bay orthoreovirus
T9 149-152 PR:Q9VZF4 denotes ago
T10 213-218 D006801 denotes human
T11 254-261 D013180 denotes strains
T12 254-261 D013180 denotes strains
T13 288-293 D006801 denotes human
T14 294-311 UBERON:0000072 denotes respiratory tract
T17 294-311 UBERON:0000065 denotes respiratory tract
T18 294-322 D012141 denotes respiratory tract infections
T19 294-322 D012141 denotes respiratory tract infections
T21 360-369 GO:0016236 denotes Autophagy
T22 360-369 GO:0006914 denotes Autophagy
T23 389-398 SO:0000856 denotes conserved
T24 437-450 GO:0005622 denotes intracellular
T25 502-511 UBERON:0004529 denotes processes
T26 527-547 GO:0019725 denotes cellular homeostasis
T28 562-571 GO:0016236 denotes autophagy
T29 562-571 GO:0006914 denotes autophagy
T30 598-613 GO:0016032 denotes viral infection
T31 598-613 D014777 denotes viral infection
T32 598-613 D014777 denotes viral infection
T35 676-693 UBERON:0000072 denotes respiratory tract
T38 676-693 UBERON:0000065 denotes respiratory tract
T39 676-703 D012141 denotes respiratory tract infection
T40 676-703 D012141 denotes respiratory tract infection
T44 805-812 SO:0001031 denotes reverse
T45 857-860 CVCL_1914 denotes BHK
T52 1040-1047 D014780 denotes viruses
T53 1110-1119 GO:0016236 denotes autophagy
T54 1110-1119 GO:0006914 denotes autophagy
T55 1151-1154 P82160 denotes LC3
T56 1160-1168 CHEBI:36080 denotes proteins
T57 1198-1207 D007239 denotes infection
T58 1198-1207 D007239 denotes infection
T59 1211-1214 CVCL_1914 denotes BHK
T60 1256-1265 CHEBI:9168 denotes rapamycin
T61 1256-1265 D020123 denotes rapamycin
T62 1256-1265 D020123 denotes rapamycin
T63 1267-1271 PR:P18613 denotes RAPA
T64 1267-1271 PR:Q96PN7 denotes RAPA
T65 1267-1271 PR:000016631 denotes RAPA
T66 1267-1271 PR:000023677 denotes RAPA
T67 1267-1271 PR:P60240 denotes RAPA
T68 1274-1289 CHEBI:38635 denotes 3-methyladenine
T69 1274-1289 C025946 denotes 3-methyladenine
T70 1274-1289 C025946 denotes 3-methyladenine
T74 1298-1309 2393 denotes chloroquine
T72 1298-1309 D002738 denotes chloroquine
T73 1298-1309 CHEBI:39254 denotes chloroquine
T75 1298-1309 CHEBI:48811 denotes chloroquine
T76 1298-1309 D002738 denotes chloroquine
T77 1298-1309 CHEBI:3638 denotes chloroquine
T79 1319-1326 SO:0000155 denotes plasmid
T78 1319-1326 45202 denotes plasmid
T80 1332-1335 P82160 denotes LC3
T81 1384-1387 P82160 denotes LC3
T82 1388-1392 SO:0000704 denotes gene
T83 1411-1414 P82160 denotes LC3
T88 1420-1427 SO:0000104 denotes protein
T87 1420-1427 PR:000000001 denotes protein
T84 1420-1427 GO:0003675 denotes protein
T85 1420-1427 CHEBI:36080 denotes protein
T86 1420-1427 CHEBI:11122 denotes protein
T89 1514-1517 CVCL_1914 denotes BHK
T90 1529-1534 CHEBI:23888 denotes drugs
T91 1609-1631 PR:000036838 denotes nonstructural proteins
T92 1623-1631 CHEBI:36080 denotes proteins
T94 1675-1684 D007239 denotes infection
T95 1675-1684 D007239 denotes infection
T96 1693-1702 GO:0016236 denotes autophagy
T97 1693-1702 GO:0006914 denotes autophagy
T98 1767-1784 GO:0019058 denotes viral replication
T99 1767-1784 GO:0019079 denotes viral replication
T100 1767-1784 GO:0008166 denotes viral replication
T101 1799-1808 GO:0016236 denotes autophagy
T102 1799-1808 GO:0006914 denotes autophagy
T103 1819-1836 GO:0019058 denotes viral replication
T104 1819-1836 GO:0019079 denotes viral replication
T105 1819-1836 GO:0008166 denotes viral replication
T106 1862-1871 GO:0016236 denotes autophagy
T107 1862-1871 GO:0006914 denotes autophagy
T112 1951-1958 SO:0000104 denotes protein
T108 1951-1958 GO:0003675 denotes protein
T109 1951-1958 CHEBI:36080 denotes protein
T110 1951-1958 CHEBI:11122 denotes protein
T115 1996-2005 GO:0016236 denotes autophagy
T116 1996-2005 GO:0006914 denotes autophagy
T117 2011-2026 GO:0016032 denotes viral infection
T118 2011-2026 D014777 denotes viral infection
T119 2011-2026 D014777 denotes viral infection
T122 2048-2057 D007239 denotes infection
T123 2048-2057 D007239 denotes infection
T124 2068-2077 GO:0016236 denotes autophagy
T125 2068-2077 GO:0006914 denotes autophagy
T130 2107-2114 SO:0000104 denotes protein
T126 2107-2114 GO:0003675 denotes protein
T127 2107-2114 CHEBI:36080 denotes protein
T128 2107-2114 CHEBI:11122 denotes protein
T133 2153-2162 GO:0016236 denotes autophagy
T134 2153-2162 GO:0006914 denotes autophagy
T135 2168-2183 GO:0016032 denotes viral infection
T136 2168-2183 D014777 denotes viral infection
T137 2168-2183 D014777 denotes viral infection

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 85-614 BACKGROUND denotes Nelson Bay orthoreovirus (NBV) was first isolated over 40 years ago from a fruit bat in Australia. Normally, NBV does not cause human diseases, but recently several NBV strains have been associated with human respiratory tract infections, thus attracting clinical attention. Autophagy, an evolutionarily conserved process in eukaryotic cells, degrades intracellular substrates, participates in multiple physiological processes, and maintains cellular homeostasis. In addition, autophagy is intimately involved in viral infection.
T2 624-1658 METHODS denotes A new strain of NBV, isolated from a patient with a respiratory tract infection who returned to Japan from Bali, Indonesia, in 2007, was used in this study. NBV was rescued using a reverse genetics system involving cotransfection of BHK cells with 11 plasmids (pT7-L1 MB, pT7-L2 MB, pT7-L3 MB, pT7-M1 MB, pT7-M2 MB, pT7-M3 MB, pT7-S1 MB, pT7-S2 MB, pT7-S3 MB, pT7-S4 MB, and pcDNA3.1-T7), yielding NBV-MB. Recovered viruses were confirmed by immunofluorescence. The effect of NBV-MB on autophagy was evaluated by measuring the LC3-I/II proteins by immunoblot analysis after infection of BHK cells. Furthermore, after treatment with rapamycin (RAPA), 3-methyladenine (3-MA), chloroquine (CQ), or plasmid (GFP-LC3) transfection, the changes in expression of the LC3 gene and the amount of LC3-I/II protein were examined. In addition, variations in viral titer were assayed after treatment of BHK cells with drugs or after transfection with plasmids pCAGM3 and pCAGS3, which encode virus nonstructural proteins μNS and σNS, respectively.
T3 1668-2027 RESULTS denotes NBV-MB infection induced autophagy in host cells; however, the level of induction was dependent on viral replication. Induction of autophagy increased viral replication. By contrast, inhibiting autophagy suppressed NBV replication, albeit not significantly. The NBV-MB nonstructural protein μNS was involved in the induction of autophagy with viral infection.
T4 2041-2184 CONCLUSIONS denotes NBV-MB infection triggered autophagy. Also, the NBV nonstructural protein μNS may contribute to augmentation of autophagy upon viral infection.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 32-43 CVCL_XY58|Transformed_cell_line|Mus musculus denotes replication
T2 47-53 CVCL_ZU75|Cancer_cell_line|Homo sapiens denotes Nelson
T3 85-91 CVCL_ZU75|Cancer_cell_line|Homo sapiens denotes Nelson
T4 140-142 CVCL_IW90|Cancer_cell_line|Mus musculus denotes 40
T5 158-159 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 371-373 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T7 371-373 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T8 624-625 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T9 659-660 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T10 674-675 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T11 803-804 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 857-860 CVCL_1914|Spontaneously_immortalized_cell_line|Mesocricetus auratus denotes BHK
T13 872-874 CVCL_5986|Cancer_cell_line|Homo sapiens denotes 11
T14 889-891 CVCL_Z786|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes L1
T15 892-894 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T16 900-902 CVCL_0383|Spontaneously_immortalized_cell_line|Rattus norvegicus denotes L2
T17 900-902 CVCL_3534|Cancer_cell_line|Rattus norvegicus denotes L2
T18 900-902 CVCL_XK47|Hybridoma|Mus musculus denotes L2
T19 900-902 CVCL_Z788|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes L2
T20 903-905 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T21 911-913 CVCL_UU62|Transformed_cell_line|Homo sapiens denotes L3
T22 911-913 CVCL_XX36|Spontaneously_immortalized_cell_line|Mus musculus denotes L3
T23 914-916 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T24 922-924 CVCL_2107|Cancer_cell_line|Mus musculus denotes M1
T25 922-924 CVCL_2H39|Cancer_cell_line|Homo sapiens denotes M1
T26 922-924 CVCL_W290|Cancer_cell_line|Homo sapiens denotes M1
T27 922-924 CVCL_YT16|Induced_pluripotent_stem_cell|Homo sapiens denotes M1
T28 922-924 CVCL_ZU44|Transformed_cell_line|Homo sapiens denotes M1
T29 925-927 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T30 933-935 CVCL_M543|Cancer_cell_line|Homo sapiens denotes M2
T31 933-935 CVCL_W291|Cancer_cell_line|Homo sapiens denotes M2
T32 933-935 CVCL_XD77|Embryonic_stem_cell|Homo sapiens denotes M2
T33 936-938 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T34 944-946 CVCL_4Y25|Cancer_cell_line|Mus musculus denotes M3
T35 944-946 CVCL_8336|Cancer_cell_line|Homo sapiens denotes M3
T36 944-946 CVCL_C506|Hybridoma|Mus musculus denotes M3
T37 944-946 CVCL_U046|Hybridoma|Mus musculus denotes M3
T38 944-946 CVCL_XX81|Hybridoma|Mus musculus denotes M3
T39 947-949 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T40 955-957 CVCL_0H88|Cancer_cell_line|Homo sapiens denotes S1
T41 955-957 CVCL_2499|Cancer_cell_line|Homo sapiens denotes S1
T42 955-957 CVCL_B374|Cancer_cell_line|Homo sapiens denotes S1
T43 955-957 CVCL_Z231|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes S1
T44 958-960 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T45 966-968 CVCL_2500|Cancer_cell_line|Homo sapiens denotes S2
T46 966-968 CVCL_4698|Hybridoma|Mus musculus denotes S2
T47 966-968 CVCL_4719|Cancer_cell_line|Homo sapiens denotes S2
T48 966-968 CVCL_Z232|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes S2
T49 969-971 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T50 977-979 CVCL_GY00|Spontaneously_immortalized_cell_line|Xenopus laevis denotes S3
T51 977-979 CVCL_Z233|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes S3
T52 980-982 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T53 988-990 CVCL_RX85|Cancer_cell_line|Homo sapiens denotes S4
T54 991-993 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T55 1008-1010 CVCL_4314|Conditionally_immortalized_cell_line|Mus musculus denotes T7
T56 1026-1028 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T57 1104-1106 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T58 1211-1214 CVCL_1914|Spontaneously_immortalized_cell_line|Mesocricetus auratus denotes BHK
T59 1293-1295 CVCL_Z027|Cancer_cell_line|Homo sapiens denotes MA
T60 1355-1362 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T61 1514-1517 CVCL_1914|Spontaneously_immortalized_cell_line|Mesocricetus auratus denotes BHK
T62 1672-1674 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T63 1773-1784 CVCL_XY58|Transformed_cell_line|Mus musculus denotes replication
T64 1825-1836 CVCL_XY58|Transformed_cell_line|Mus musculus denotes replication
T65 1887-1898 CVCL_XY58|Transformed_cell_line|Mus musculus denotes replication
T66 1934-1936 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T67 2045-2047 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T68 2119-2122 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may