PubMed:3131282 JSONTXT

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{"project":"bc5cdr-valid-gpt-r-g-experiment","denotations":[{"id":"T1","span":{"begin":26,"end":41},"obj":"Chemical"},{"id":"T2","span":{"begin":103,"end":127},"obj":"Chemical"},{"id":"T3","span":{"begin":163,"end":178},"obj":"Chemical"},{"id":"T4","span":{"begin":180,"end":182},"obj":"Chemical"},{"id":"T5","span":{"begin":187,"end":211},"obj":"Chemical"},{"id":"T6","span":{"begin":213,"end":216},"obj":"Chemical"},{"id":"T7","span":{"begin":346,"end":349},"obj":"Chemical"},{"id":"T8","span":{"begin":415,"end":417},"obj":"Chemical"},{"id":"T9","span":{"begin":483,"end":486},"obj":"Chemical"},{"id":"T10","span":{"begin":504,"end":524},"obj":"Disease"},{"id":"T11","span":{"begin":612,"end":614},"obj":"Chemical"},{"id":"T12","span":{"begin":687,"end":693},"obj":"Disease"},{"id":"T13","span":{"begin":695,"end":718},"obj":"Disease"},{"id":"T14","span":{"begin":723,"end":732},"obj":"Disease"},{"id":"T15","span":{"begin":760,"end":769},"obj":"Disease"},{"id":"T16","span":{"begin":830,"end":832},"obj":"Chemical"},{"id":"T17","span":{"begin":862,"end":865},"obj":"Chemical"},{"id":"T18","span":{"begin":990,"end":993},"obj":"Chemical"},{"id":"T19","span":{"begin":1002,"end":1024},"obj":"Disease"},{"id":"T20","span":{"begin":1026,"end":1032},"obj":"Disease"},{"id":"T21","span":{"begin":1038,"end":1048},"obj":"Disease"},{"id":"T22","span":{"begin":1090,"end":1092},"obj":"Chemical"},{"id":"T23","span":{"begin":1125,"end":1127},"obj":"Chemical"},{"id":"T24","span":{"begin":1171,"end":1191},"obj":"Disease"},{"id":"T25","span":{"begin":1241,"end":1243},"obj":"Chemical"},{"id":"T26","span":{"begin":1276,"end":1279},"obj":"Chemical"}],"text":"Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole.\nThe potential modifying effect of retinyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach tumorigenesis was examined. Male F344 rats, 5 weeks of age, were maintained on diet containing 1% or 2% BHA by weight and simultaneously on drinking water supplemented with RA at various concentrations (w/v) for 52 weeks. In groups given 2% BHA, although marked hyperplastic changes of the forestomach epithelium were observed in all animals, co-administration of 0.25% RA significantly (P less than 0.05) increased the incidence of forestomach tumors (squamous cell papilloma and carcinoma) to 60% (9/15, 2 rats with carcinoma) from 15% (3/20, one rat with carcinoma) in the group given RA-free water. In rats given 1% BHA, RA co-administered at a dose of 0.05, 0.1, 0.2 or 0.25% showed a dose-dependent enhancing effect on the development of the BHA-induced epithelial hyperplasia. Tumors, all papillomas, were induced in 3 rats (17%) with 0.25% RA and in one rat (10%) with 0.05% RA co-administration. RA alone did not induce hyperplastic changes in the forestomach. These findings indicate that RA acted as a co-carcinogen in the BHA forestomach carcinogenesis of the rat."}

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{"project":"bc5cdr-valid-gemini-r-g","denotations":[{"id":"T1","span":{"begin":26,"end":41},"obj":"Chemical"},{"id":"T2","span":{"begin":103,"end":127},"obj":"Chemical"},{"id":"T3","span":{"begin":163,"end":178},"obj":"Chemical"},{"id":"T4","span":{"begin":180,"end":182},"obj":"Chemical"},{"id":"T5","span":{"begin":187,"end":211},"obj":"Chemical"},{"id":"T6","span":{"begin":213,"end":216},"obj":"Chemical"},{"id":"T7","span":{"begin":346,"end":349},"obj":"Chemical"},{"id":"T8","span":{"begin":415,"end":417},"obj":"Chemical"},{"id":"T9","span":{"begin":483,"end":486},"obj":"Chemical"},{"id":"T10","span":{"begin":504,"end":516},"obj":"Disease"},{"id":"T11","span":{"begin":612,"end":614},"obj":"Chemical"},{"id":"T12","span":{"begin":675,"end":693},"obj":"Disease"},{"id":"T13","span":{"begin":695,"end":718},"obj":"Disease"},{"id":"T14","span":{"begin":723,"end":732},"obj":"Disease"},{"id":"T15","span":{"begin":830,"end":832},"obj":"Chemical"},{"id":"T16","span":{"begin":862,"end":865},"obj":"Chemical"},{"id":"T17","span":{"begin":867,"end":869},"obj":"Chemical"},{"id":"T18","span":{"begin":990,"end":993},"obj":"Chemical"},{"id":"T19","span":{"begin":1002,"end":1024},"obj":"Disease"},{"id":"T20","span":{"begin":1026,"end":1032},"obj":"Disease"},{"id":"T21","span":{"begin":1038,"end":1048},"obj":"Disease"},{"id":"T22","span":{"begin":1090,"end":1092},"obj":"Chemical"},{"id":"T23","span":{"begin":1171,"end":1183},"obj":"Disease"}],"text":"Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole.\nThe potential modifying effect of retinyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach tumorigenesis was examined. Male F344 rats, 5 weeks of age, were maintained on diet containing 1% or 2% BHA by weight and simultaneously on drinking water supplemented with RA at various concentrations (w/v) for 52 weeks. In groups given 2% BHA, although marked hyperplastic changes of the forestomach epithelium were observed in all animals, co-administration of 0.25% RA significantly (P less than 0.05) increased the incidence of forestomach tumors (squamous cell papilloma and carcinoma) to 60% (9/15, 2 rats with carcinoma) from 15% (3/20, one rat with carcinoma) in the group given RA-free water. In rats given 1% BHA, RA co-administered at a dose of 0.05, 0.1, 0.2 or 0.25% showed a dose-dependent enhancing effect on the development of the BHA-induced epithelial hyperplasia. Tumors, all papillomas, were induced in 3 rats (17%) with 0.25% RA and in one rat (10%) with 0.05% RA co-administration. RA alone did not induce hyperplastic changes in the forestomach. These findings indicate that RA acted as a co-carcinogen in the BHA forestomach carcinogenesis of the rat."}

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{"project":"bc5cdr-valid-gemini-nr-g","denotations":[{"id":"T1","span":{"begin":26,"end":41},"obj":"Chemical"},{"id":"T2","span":{"begin":45,"end":71},"obj":"Disease"},{"id":"T3","span":{"begin":103,"end":127},"obj":"Chemical"},{"id":"T4","span":{"begin":163,"end":178},"obj":"Chemical"},{"id":"T5","span":{"begin":180,"end":182},"obj":"Chemical"},{"id":"T6","span":{"begin":187,"end":211},"obj":"Chemical"},{"id":"T7","span":{"begin":213,"end":216},"obj":"Chemical"},{"id":"T8","span":{"begin":226,"end":255},"obj":"Disease"},{"id":"T9","span":{"begin":346,"end":349},"obj":"Chemical"},{"id":"T10","span":{"begin":415,"end":417},"obj":"Chemical"},{"id":"T11","span":{"begin":483,"end":486},"obj":"Chemical"},{"id":"T12","span":{"begin":504,"end":524},"obj":"Disease"},{"id":"T13","span":{"begin":612,"end":614},"obj":"Chemical"},{"id":"T14","span":{"begin":675,"end":693},"obj":"Disease"},{"id":"T15","span":{"begin":695,"end":732},"obj":"Disease"},{"id":"T16","span":{"begin":830,"end":832},"obj":"Chemical"},{"id":"T17","span":{"begin":862,"end":865},"obj":"Chemical"},{"id":"T18","span":{"begin":990,"end":1001},"obj":"Disease"},{"id":"T19","span":{"begin":1002,"end":1024},"obj":"Disease"},{"id":"T20","span":{"begin":1026,"end":1032},"obj":"Disease"},{"id":"T21","span":{"begin":1038,"end":1048},"obj":"Disease"},{"id":"T22","span":{"begin":1090,"end":1092},"obj":"Chemical"},{"id":"T23","span":{"begin":1171,"end":1191},"obj":"Disease"},{"id":"T24","span":{"begin":1276,"end":1279},"obj":"Chemical"},{"id":"T25","span":{"begin":1280,"end":1306},"obj":"Disease"}],"text":"Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole.\nThe potential modifying effect of retinyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach tumorigenesis was examined. Male F344 rats, 5 weeks of age, were maintained on diet containing 1% or 2% BHA by weight and simultaneously on drinking water supplemented with RA at various concentrations (w/v) for 52 weeks. In groups given 2% BHA, although marked hyperplastic changes of the forestomach epithelium were observed in all animals, co-administration of 0.25% RA significantly (P less than 0.05) increased the incidence of forestomach tumors (squamous cell papilloma and carcinoma) to 60% (9/15, 2 rats with carcinoma) from 15% (3/20, one rat with carcinoma) in the group given RA-free water. In rats given 1% BHA, RA co-administered at a dose of 0.05, 0.1, 0.2 or 0.25% showed a dose-dependent enhancing effect on the development of the BHA-induced epithelial hyperplasia. Tumors, all papillomas, were induced in 3 rats (17%) with 0.25% RA and in one rat (10%) with 0.05% RA co-administration. RA alone did not induce hyperplastic changes in the forestomach. These findings indicate that RA acted as a co-carcinogen in the BHA forestomach carcinogenesis of the rat."}

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{"project":"bc5cdr-valid-deepseek-r-g","denotations":[{"id":"T1","span":{"begin":26,"end":41},"obj":"Chemical"},{"id":"T2","span":{"begin":103,"end":127},"obj":"Chemical"},{"id":"T3","span":{"begin":180,"end":182},"obj":"Chemical"},{"id":"T4","span":{"begin":213,"end":216},"obj":"Chemical"},{"id":"T5","span":{"begin":695,"end":718},"obj":"Disease"},{"id":"T6","span":{"begin":723,"end":732},"obj":"Disease"},{"id":"T7","span":{"begin":1002,"end":1024},"obj":"Disease"},{"id":"T8","span":{"begin":1038,"end":1048},"obj":"Disease"}],"text":"Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole.\nThe potential modifying effect of retinyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach tumorigenesis was examined. Male F344 rats, 5 weeks of age, were maintained on diet containing 1% or 2% BHA by weight and simultaneously on drinking water supplemented with RA at various concentrations (w/v) for 52 weeks. In groups given 2% BHA, although marked hyperplastic changes of the forestomach epithelium were observed in all animals, co-administration of 0.25% RA significantly (P less than 0.05) increased the incidence of forestomach tumors (squamous cell papilloma and carcinoma) to 60% (9/15, 2 rats with carcinoma) from 15% (3/20, one rat with carcinoma) in the group given RA-free water. In rats given 1% BHA, RA co-administered at a dose of 0.05, 0.1, 0.2 or 0.25% showed a dose-dependent enhancing effect on the development of the BHA-induced epithelial hyperplasia. Tumors, all papillomas, were induced in 3 rats (17%) with 0.25% RA and in one rat (10%) with 0.05% RA co-administration. RA alone did not induce hyperplastic changes in the forestomach. These findings indicate that RA acted as a co-carcinogen in the BHA forestomach carcinogenesis of the rat."}

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{"project":"bc5cdr-valid-deepseek-r-m","denotations":[{"id":"T1","span":{"begin":26,"end":41},"obj":"Chemical"},{"id":"T2","span":{"begin":103,"end":127},"obj":"Chemical"},{"id":"T3","span":{"begin":163,"end":178},"obj":"Chemical"},{"id":"T4","span":{"begin":180,"end":182},"obj":"Chemical"},{"id":"T5","span":{"begin":187,"end":211},"obj":"Chemical"},{"id":"T6","span":{"begin":213,"end":216},"obj":"Chemical"},{"id":"T7","span":{"begin":346,"end":349},"obj":"Chemical"},{"id":"T8","span":{"begin":415,"end":417},"obj":"Chemical"},{"id":"T9","span":{"begin":504,"end":516},"obj":"Disease"},{"id":"T10","span":{"begin":687,"end":693},"obj":"Disease"},{"id":"T11","span":{"begin":695,"end":718},"obj":"Disease"},{"id":"T12","span":{"begin":723,"end":732},"obj":"Disease"},{"id":"T13","span":{"begin":1013,"end":1024},"obj":"Disease"},{"id":"T14","span":{"begin":1026,"end":1032},"obj":"Disease"},{"id":"T15","span":{"begin":1038,"end":1048},"obj":"Disease"}],"text":"Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole.\nThe potential modifying effect of retinyl acetate (RA) on butylated hydroxyanisole (BHA)-induced rat forestomach tumorigenesis was examined. Male F344 rats, 5 weeks of age, were maintained on diet containing 1% or 2% BHA by weight and simultaneously on drinking water supplemented with RA at various concentrations (w/v) for 52 weeks. In groups given 2% BHA, although marked hyperplastic changes of the forestomach epithelium were observed in all animals, co-administration of 0.25% RA significantly (P less than 0.05) increased the incidence of forestomach tumors (squamous cell papilloma and carcinoma) to 60% (9/15, 2 rats with carcinoma) from 15% (3/20, one rat with carcinoma) in the group given RA-free water. In rats given 1% BHA, RA co-administered at a dose of 0.05, 0.1, 0.2 or 0.25% showed a dose-dependent enhancing effect on the development of the BHA-induced epithelial hyperplasia. Tumors, all papillomas, were induced in 3 rats (17%) with 0.25% RA and in one rat (10%) with 0.05% RA co-administration. RA alone did not induce hyperplastic changes in the forestomach. These findings indicate that RA acted as a co-carcinogen in the BHA forestomach carcinogenesis of the rat."}

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