PubMed:31241704
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 125-226 | DRI_Background | denotes | DNA methylation is essential for spatiotemporally-regulated gene expression in embryonic development. |
| T2 | 227-408 | DRI_Approach | denotes | TBX22 (Chr X: 107667964-107688978) functioning as a transcriptional repressor affects DNA binding, sumoylation, and transcriptional repression associated with X-linked cleft palate. |
| T3 | 409-579 | DRI_Background | denotes | This study aimed to explore the relationship and potential mechanism between TBX22 exon 5 methylation and palatal shelf fusion induced by all-trans retinoic acid (ATRA). |
| T4 | 580-823 | DRI_Background | denotes | We performed DNA methylation profiling, using MethylRAD-seq, after high throughput sequencing of mouse embryos from control (n=9) and ATRA-treated (to induce cleft palate, n=9) C57BL/6J mice at embryonic gestation days(E) 13.5, 14.5 and 16.5. |
| T5 | 824-964 | DRI_Background | denotes | TBX22 exon 5 was hyper-methylated at the CpG site at E13.5 (P=0.025, log2FC=1.5) and E14.5 (P=0.011, log2FC:1.5) in ATRA-treated, whereas |
| T6 | 984-1104 | DRI_Background | denotes | exon 5 at the CpG site was not significantly different at E16.5 (P=0.808, log2FC=-0.2) between control and ATRA-treated. |
| T7 | 1183-1302 | DRI_Outcome | denotes | qPCR showed the change in TBX22 exon 5 expression level negatively correlated with its TBX22 exon 5 methylation level. |
| T8 | 1303-1538 | DRI_Background | denotes | These results indicate that changes in TBX22 exon 5 methylation might play an important regulatory role during palatal shelf fusion, and may enlighten the development of novel epigenetic biomarkers in the treatment of CP in the future. |
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 39-44 | PR:Q8K402 | denotes | TBX22 |
| T2 | 39-44 | PR:000016150 | denotes | TBX22 |
| T3 | 39-44 | PR:Q9Y458 | denotes | TBX22 |
| T5 | 45-49 | SO:0000147 | denotes | exon |
| T4 | 45-49 | PR:P33696 | denotes | exon |
| T7 | 52-63 | GO:0032259 | denotes | methylation |
| T6 | 52-63 | MOP:0000364 | denotes | methylation |
| T8 | 68-81 | UBERON:0005619 | denotes | palatal shelf |
| T10 | 82-88 | SO:0000806 | denotes | fusion |
| T12 | 111-123 | UBERON:0010426 | denotes | cleft palate |
| T11 | 111-123 | D002972 | denotes | cleft palate |
| T13 | 111-123 | D002972 | denotes | cleft palate |
| T14 | 111-123 | C566991 | denotes | cleft palate |
| T19 | 129-140 | GO:0032259 | denotes | methylation |
| T18 | 129-140 | MOP:0000364 | denotes | methylation |
| T20 | 175-184 | SO:0000119 | denotes | regulated |
| T21 | 185-189 | SO:0000704 | denotes | gene |
| T22 | 185-200 | GO:0010467 | denotes | gene expression |
| T23 | 204-213 | P02301 | denotes | embryonic |
| T24 | 204-213 | PR:000029532 | denotes | embryonic |
| T25 | 227-232 | PR:Q8K402 | denotes | TBX22 |
| T26 | 227-232 | PR:000016150 | denotes | TBX22 |
| T27 | 227-232 | PR:Q9Y458 | denotes | TBX22 |
| T30 | 313-316 | SO:0000352 | denotes | DNA |
| T28 | 313-316 | GO:0005574 | denotes | DNA |
| T29 | 313-316 | CHEBI:16991 | denotes | DNA |
| T31 | 313-316 | D004247 | denotes | DNA |
| T32 | 313-324 | GO:0003677 | denotes | DNA binding |
| T33 | 317-324 | SO:0100018 | denotes | binding |
| T34 | 317-324 | SO:0001091 | denotes | binding |
| T36 | 326-337 | GO:0016925 | denotes | sumoylation |
| T37 | 386-407 | C536426 | denotes | X-linked cleft palate |
| T38 | 386-407 | C536426 | denotes | X-linked cleft palate |
| T40 | 395-407 | UBERON:0010426 | denotes | cleft palate |
| T46 | 486-491 | PR:Q8K402 | denotes | TBX22 |
| T47 | 486-491 | PR:000016150 | denotes | TBX22 |
| T48 | 486-491 | PR:Q9Y458 | denotes | TBX22 |
| T50 | 492-496 | SO:0000147 | denotes | exon |
| T49 | 492-496 | PR:P33696 | denotes | exon |
| T52 | 499-510 | GO:0032259 | denotes | methylation |
| T51 | 499-510 | MOP:0000364 | denotes | methylation |
| T53 | 515-528 | UBERON:0005619 | denotes | palatal shelf |
| T55 | 529-535 | SO:0000806 | denotes | fusion |
| T56 | 548-571 | D014212 | denotes | all-trans retinoic acid |
| T57 | 548-571 | CHEBI:15367 | denotes | all-trans retinoic acid |
| T58 | 548-571 | D014212 | denotes | all-trans retinoic acid |
| T69 | 594-597 | SO:0000352 | denotes | DNA |
| T67 | 594-597 | GO:0005574 | denotes | DNA |
| T68 | 594-597 | CHEBI:16991 | denotes | DNA |
| T70 | 594-597 | D004247 | denotes | DNA |
| T71 | 594-609 | GO:0006306 | denotes | DNA methylation |
| T72 | 598-609 | MOP:0000364 | denotes | methylation |
| T74 | 678-683 | 10090 | denotes | mouse |
| T75 | 678-683 | D051379 | denotes | mouse |
| T77 | 739-751 | UBERON:0010426 | denotes | cleft palate |
| T76 | 739-751 | D002972 | denotes | cleft palate |
| T78 | 739-751 | D002972 | denotes | cleft palate |
| T79 | 739-751 | C566991 | denotes | cleft palate |
| T83 | 761-765 | CVCL_M564 | denotes | BL/6 |
| T84 | 761-765 | CVCL_0157 | denotes | BL/6 |
| T86 | 761-765 | CVCL_2637 | denotes | BL/6 |
| T85 | 761-765 | P12877 | denotes | BL/6 |
| T88 | 767-771 | D051379 | denotes | mice |
| T90 | 767-771 | 10095 | denotes | mice |
| T87 | 767-771 | PR:000005054 | denotes | mice |
| T89 | 767-771 | O89094 | denotes | mice |
| T91 | 775-784 | P02301 | denotes | embryonic |
| T92 | 775-784 | PR:000029532 | denotes | embryonic |
| T93 | 785-794 | GO:0007565 | denotes | gestation |
| T94 | 800-805 | PR:Q7TNS8 | denotes | E) 13 |
| T95 | 800-805 | Q38488 | denotes | E) 13 |
| T96 | 831-835 | PR:P33696 | denotes | exon |
| T97 | 831-835 | SO:0000147 | denotes | exon |
| T98 | 867-870 | CVCL_1G78 | denotes | CpG |
| T99 | 879-882 | PR:Q7TNS8 | denotes | E13 |
| T100 | 879-882 | Q38488 | denotes | E13 |
| T101 | 895-899 | PR:Q5BPS0 | denotes | log2 |
| T102 | 895-899 | PR:Q9S752 | denotes | log2 |
| T104 | 911-914 | PR:000011353 | denotes | E14 |
| T105 | 911-914 | PR:Q14207 | denotes | E14 |
| T106 | 911-914 | Q38490 | denotes | E14 |
| T107 | 911-914 | CVCL_C320 | denotes | E14 |
| T108 | 927-931 | PR:Q5BPS0 | denotes | log2 |
| T109 | 927-931 | PR:Q9S752 | denotes | log2 |
| T110 | 931-935 | PR:P42043 | denotes | FC:1 |
| T111 | 978-983 | PR:Q8K402 | denotes | TBX22 |
| T112 | 978-983 | PR:000016150 | denotes | TBX22 |
| T113 | 978-983 | PR:Q9Y458 | denotes | TBX22 |
| T114 | 984-988 | PR:P33696 | denotes | exon |
| T115 | 984-988 | SO:0000147 | denotes | exon |
| T116 | 989-993 | Q9ZWR8 | denotes | 5 at |
| T117 | 998-1001 | CVCL_1G78 | denotes | CpG |
| T118 | 1042-1045 | Q01650 | denotes | E16 |
| T119 | 1058-1062 | PR:Q5BPS0 | denotes | log2 |
| T120 | 1058-1062 | PR:Q9S752 | denotes | log2 |
| T121 | 1105-1108 | Q21244 | denotes | MSP |
| T122 | 1105-1108 | Q24K22 | denotes | MSP |
| T123 | 1105-1108 | P53020 | denotes | MSP |
| T124 | 1105-1108 | PR:P0A9Q1 | denotes | MSP |
| T125 | 1105-1108 | Q19832 | denotes | MSP |
| T126 | 1105-1108 | P13907 | denotes | MSP |
| T127 | 1105-1108 | P11472 | denotes | MSP |
| T128 | 1105-1108 | P53019 | denotes | MSP |
| T129 | 1105-1108 | PR:000010683 | denotes | MSP |
| T130 | 1105-1108 | PR:Q5U405 | denotes | MSP |
| T131 | 1105-1108 | P26927 | denotes | MSP |
| T132 | 1105-1108 | P10549 | denotes | MSP |
| T133 | 1105-1108 | P26928 | denotes | MSP |
| T134 | 1105-1108 | PR:000022123 | denotes | MSP |
| T135 | 1105-1108 | PR:Q9BYE2 | denotes | MSP |
| T136 | 1105-1108 | P53017 | denotes | MSP |
| T137 | 1105-1108 | Q9TVW5 | denotes | MSP |
| T138 | 1105-1108 | P53018 | denotes | MSP |
| T139 | 1105-1108 | P0A431 | denotes | MSP |
| T140 | 1105-1108 | P0A432 | denotes | MSP |
| T141 | 1105-1108 | Q23519 | denotes | MSP |
| T142 | 1105-1108 | Q17856 | denotes | MSP |
| T143 | 1105-1108 | Q94053 | denotes | MSP |
| T144 | 1105-1108 | D0VWR2 | denotes | MSP |
| T145 | 1105-1108 | Q18461 | denotes | MSP |
| T146 | 1105-1108 | Q9R6W6 | denotes | MSP |
| T147 | 1105-1108 | P05634 | denotes | MSP |
| T148 | 1105-1108 | PR:000016455 | denotes | MSP |
| T149 | 1105-1108 | PR:Q86KP5 | denotes | MSP |
| T150 | 1209-1214 | PR:Q8K402 | denotes | TBX22 |
| T151 | 1209-1214 | PR:000016150 | denotes | TBX22 |
| T152 | 1209-1214 | PR:Q9Y458 | denotes | TBX22 |
| T153 | 1215-1219 | PR:P33696 | denotes | exon |
| T154 | 1215-1219 | SO:0000147 | denotes | exon |
| T155 | 1270-1275 | PR:Q8K402 | denotes | TBX22 |
| T156 | 1270-1275 | PR:000016150 | denotes | TBX22 |
| T157 | 1270-1275 | PR:Q9Y458 | denotes | TBX22 |
| T158 | 1277-1281 | PR:P33696 | denotes | exon |
| T159 | 1277-1281 | SO:0000147 | denotes | exon |
| T161 | 1284-1295 | GO:0032259 | denotes | methylation |
| T160 | 1284-1295 | MOP:0000364 | denotes | methylation |
| T162 | 1342-1347 | PR:Q8K402 | denotes | TBX22 |
| T163 | 1342-1347 | PR:000016150 | denotes | TBX22 |
| T164 | 1342-1347 | PR:Q9Y458 | denotes | TBX22 |
| T166 | 1348-1352 | SO:0000147 | denotes | exon |
| T165 | 1348-1352 | PR:P33696 | denotes | exon |
| T168 | 1355-1366 | GO:0032259 | denotes | methylation |
| T167 | 1355-1366 | MOP:0000364 | denotes | methylation |
| T169 | 1414-1427 | UBERON:0005619 | denotes | palatal shelf |
| T171 | 1428-1434 | SO:0000806 | denotes | fusion |
| T172 | 1490-1500 | D015415 | denotes | biomarkers |
| T173 | 1490-1500 | D015415 | denotes | biomarkers |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 277-278 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T2 | 581-583 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | We |
| T3 | 678-683 | CVCL_ZE35|Undefined_cell_line_type|Mus musculus | denotes | mouse |
| T4 | 706-709 | CVCL_0452|Transformed_cell_line|Mus musculus | denotes | n=9 |
| T5 | 753-756 | CVCL_0452|Transformed_cell_line|Mus musculus | denotes | n=9 |
| T6 | 867-870 | CVCL_1G78|Spontaneously_immortalized_cell_line|Channa punctata | denotes | CpG |
| T7 | 989-993 | CVCL_Y661|Cancer_cell_line|Rattus norvegicus | denotes | 5 at |
| T8 | 998-1001 | CVCL_1G78|Spontaneously_immortalized_cell_line|Channa punctata | denotes | CpG |
| T9 | 1124-1125 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T10 | 1199-1205 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | change |
| T11 | 1331-1338 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | changes |
| T12 | 1378-1380 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
| T13 | 1378-1380 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
| T14 | 1440-1443 | CVCL_E773|Transformed_cell_line|Homo sapiens | denotes | may |
| T15 | 1521-1523 | CVCL_6F78|Spontaneously_immortalized_cell_line|Anabas testudineus | denotes | CP |