PubMed:31213813 / 0-349 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/31213813","sourcedb":"PubMed","sourceid":"31213813","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/31213813","text":"A dual-functional HER2 aptamer-conjugated, pH-activated mesoporous silica nanocarrier-based drug delivery system provides in vitro synergistic cytotoxicity in HER2-positive breast cancer cells.\nPurpose: As well as functioning as a ligand that is selectively internalized by cells overexpressing human epidermal growth factor receptor-2 (HER2), HApt ","tracks":[{"project":"GoldHamster","denotations":[{"id":"T1","span":{"begin":18,"end":21},"obj":"CVCL_1K15"},{"id":"T2","span":{"begin":18,"end":22},"obj":"PR:P04626"},{"id":"T3","span":{"begin":18,"end":22},"obj":"PR:000002082"},{"id":"T4","span":{"begin":18,"end":22},"obj":"PR:Q03557"},{"id":"T5","span":{"begin":18,"end":22},"obj":"PR:P34708"},{"id":"T6","span":{"begin":18,"end":22},"obj":"PR:Q5AK64"},{"id":"T8","span":{"begin":23,"end":30},"obj":"SO:0000031"},{"id":"T7","span":{"begin":23,"end":30},"obj":"CHEBI:140488"},{"id":"T9","span":{"begin":67,"end":73},"obj":"D012822"},{"id":"T10","span":{"begin":67,"end":73},"obj":"CHEBI:30563"},{"id":"T11","span":{"begin":67,"end":73},"obj":"D012822"},{"id":"T12","span":{"begin":92,"end":96},"obj":"CHEBI:23888"},{"id":"T13","span":{"begin":159,"end":162},"obj":"CVCL_1K15"},{"id":"T14","span":{"begin":159,"end":163},"obj":"PR:P04626"},{"id":"T15","span":{"begin":159,"end":163},"obj":"PR:000002082"},{"id":"T16","span":{"begin":159,"end":163},"obj":"PR:Q03557"},{"id":"T17","span":{"begin":159,"end":163},"obj":"PR:P34708"},{"id":"T18","span":{"begin":159,"end":163},"obj":"PR:Q5AK64"},{"id":"T19","span":{"begin":173,"end":179},"obj":"UBERON:0000310"},{"id":"T20","span":{"begin":173,"end":186},"obj":"D001943"},{"id":"T21","span":{"begin":173,"end":186},"obj":"D001943"},{"id":"T22","span":{"begin":231,"end":237},"obj":"CHEBI:52214"},{"id":"T23","span":{"begin":231,"end":237},"obj":"GO:0005488"},{"id":"T24","span":{"begin":295,"end":300},"obj":"D006801"},{"id":"T25","span":{"begin":295,"end":335},"obj":"C508053"},{"id":"T26","span":{"begin":295,"end":335},"obj":"C508053"},{"id":"T27","span":{"begin":301,"end":317},"obj":"UBERON:0000021"},{"id":"T31","span":{"begin":301,"end":324},"obj":"GO:0005154"},{"id":"T32","span":{"begin":301,"end":333},"obj":"Q01279"},{"id":"T33","span":{"begin":301,"end":333},"obj":"P0CY46"},{"id":"T34","span":{"begin":301,"end":333},"obj":"P55245"},{"id":"T35","span":{"begin":301,"end":333},"obj":"P00533"},{"id":"T36","span":{"begin":301,"end":333},"obj":"P04412"},{"id":"T38","span":{"begin":301,"end":333},"obj":"P13387"},{"id":"T39","span":{"begin":301,"end":333},"obj":"PR:000006933"},{"id":"T45","span":{"begin":337,"end":340},"obj":"CVCL_1K15"},{"id":"T46","span":{"begin":337,"end":341},"obj":"PR:P04626"},{"id":"T47","span":{"begin":337,"end":341},"obj":"PR:000002082"},{"id":"T48","span":{"begin":337,"end":341},"obj":"PR:Q03557"},{"id":"T49","span":{"begin":337,"end":341},"obj":"PR:P34708"},{"id":"T50","span":{"begin":337,"end":341},"obj":"PR:Q5AK64"},{"id":"T91","span":{"begin":2,"end":14},"obj":"CHEBI:23456"}],"attributes":[{"subj":"T1","pred":"source","obj":"GoldHamster"},{"subj":"T2","pred":"source","obj":"GoldHamster"},{"subj":"T3","pred":"source","obj":"GoldHamster"},{"subj":"T4","pred":"source","obj":"GoldHamster"},{"subj":"T5","pred":"source","obj":"GoldHamster"},{"subj":"T6","pred":"source","obj":"GoldHamster"},{"subj":"T8","pred":"source","obj":"GoldHamster"},{"subj":"T7","pred":"source","obj":"GoldHamster"},{"subj":"T9","pred":"source","obj":"GoldHamster"},{"subj":"T10","pred":"source","obj":"GoldHamster"},{"subj":"T11","pred":"source","obj":"GoldHamster"},{"subj":"T12","pred":"source","obj":"GoldHamster"},{"subj":"T13","pred":"source","obj":"GoldHamster"},{"subj":"T14","pred":"source","obj":"GoldHamster"},{"subj":"T15","pred":"source","obj":"GoldHamster"},{"subj":"T16","pred":"source","obj":"GoldHamster"},{"subj":"T17","pred":"source","obj":"GoldHamster"},{"subj":"T18","pred":"source","obj":"GoldHamster"},{"subj":"T19","pred":"source","obj":"GoldHamster"},{"subj":"T20","pred":"source","obj":"GoldHamster"},{"subj":"T21","pred":"source","obj":"GoldHamster"},{"subj":"T22","pred":"source","obj":"GoldHamster"},{"subj":"T23","pred":"source","obj":"GoldHamster"},{"subj":"T24","pred":"source","obj":"GoldHamster"},{"subj":"T25","pred":"source","obj":"GoldHamster"},{"subj":"T26","pred":"source","obj":"GoldHamster"},{"subj":"T27","pred":"source","obj":"GoldHamster"},{"subj":"T31","pred":"source","obj":"GoldHamster"},{"subj":"T32","pred":"source","obj":"GoldHamster"},{"subj":"T33","pred":"source","obj":"GoldHamster"},{"subj":"T34","pred":"source","obj":"GoldHamster"},{"subj":"T35","pred":"source","obj":"GoldHamster"},{"subj":"T36","pred":"source","obj":"GoldHamster"},{"subj":"T38","pred":"source","obj":"GoldHamster"},{"subj":"T39","pred":"source","obj":"GoldHamster"},{"subj":"T45","pred":"source","obj":"GoldHamster"},{"subj":"T46","pred":"source","obj":"GoldHamster"},{"subj":"T47","pred":"source","obj":"GoldHamster"},{"subj":"T48","pred":"source","obj":"GoldHamster"},{"subj":"T49","pred":"source","obj":"GoldHamster"},{"subj":"T50","pred":"source","obj":"GoldHamster"},{"subj":"T91","pred":"source","obj":"GoldHamster"}]},{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":0,"end":1},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T2","span":{"begin":46,"end":55},"obj":"CVCL_C410|Hybridoma|Mus musculus"},{"id":"T3","span":{"begin":180,"end":186},"obj":"CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T4","span":{"begin":229,"end":230},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"}],"attributes":[{"subj":"T1","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T2","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T3","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T4","pred":"source","obj":"Goldhamster2_Cellosaurus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"GoldHamster","color":"#e2ec93","default":true},{"id":"Goldhamster2_Cellosaurus","color":"#db93ec"}]}]}}