PubMed:31213813 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/31213813","sourcedb":"PubMed","sourceid":"31213813","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/31213813","text":"A dual-functional HER2 aptamer-conjugated, pH-activated mesoporous silica nanocarrier-based drug delivery system provides in vitro synergistic cytotoxicity in HER2-positive breast cancer cells.\nPurpose: As well as functioning as a ligand that is selectively internalized by cells overexpressing human epidermal growth factor receptor-2 (HER2), HApt can exert cytotoxic effects by inducing cross-linking and subsequent translocation of HER2 to cytoplasmic vesicles, such downregulation of HER2 inhibits cell proliferation and induces apoptosis. We aimed to exploit the potential of HApt as both a targeting agent and antagonist to maximize the efficacy of mesoporous silica nanoparticle (MSN)-based drug release systems for HER2-positive breast cancer. Materials and methods: We fabricated novel HApt aptamer-functionalized pH-sensitive β-cyclodextrin (β-CD)-capped doxorubicin (DOX)-loaded mesoporous silica nanoparticles (termed MSN-BM/CD-HApt@DOX) for targeted delivery and selective targeting of HER2-positive cells. MSN-functionalized benzimidazole (MSN-BM) was used to load and achieve pH stimuli-responsive release of the chemotherapeutic agent doxorubicin (DOX). β-cyclodextrin was introduced as a gatekeeper for encapsulated DOX and HApt as a selective HER2-targeting moiety and biotherapeutic agent. Results: Physical and chemical characterizations (FT-IR, XRD, TEM and BET) confirmed successful construction of MSN-BM/CD-HApt@DOX nanoparticles. In vitro release assays verified pH-sensitive DOX release. MSN-BM/CD-HApt@DOX (relative DOX concentration, 3.6 μg/mL) underwent HER2-mediated endocytosis and was more cytotoxic to HER2-positive SKBR3 cells than HER2-negative MCF7 cells. MSN-BM/CD-HApt@DOX also exhibited better uptake and stronger growth inhibition in SKBR3 cells than the control MSN-BM/CD-NCApt@DOX functionalized with a scrambled nucleotide sequence on CD. Overall, intracellular delivery of DOX and the biotherapeutic agent HApt resulted in synergistic cytotoxic effects in HER2-positive cancer cells in comparison to either DOX or HApt alone. Conclusion: MSN-BM/CD-HApt@DOX enables HER2-mediated targeting and biotherapeutic effects as well as pH-responsive DOX drug release, resulting in synergistic cytotoxic effects in HER2-overexpressing cells in vitro. This novel nanocarrier could potentially enable specific targeting to improve the efficacy of chemotherapy for HER2-positive cancer.","tracks":[{"project":"GoldHamster","denotations":[{"id":"T1","span":{"begin":18,"end":21},"obj":"CVCL_1K15"},{"id":"T2","span":{"begin":18,"end":22},"obj":"PR:P04626"},{"id":"T3","span":{"begin":18,"end":22},"obj":"PR:000002082"},{"id":"T4","span":{"begin":18,"end":22},"obj":"PR:Q03557"},{"id":"T5","span":{"begin":18,"end":22},"obj":"PR:P34708"},{"id":"T6","span":{"begin":18,"end":22},"obj":"PR:Q5AK64"},{"id":"T8","span":{"begin":23,"end":30},"obj":"SO:0000031"},{"id":"T7","span":{"begin":23,"end":30},"obj":"CHEBI:140488"},{"id":"T9","span":{"begin":67,"end":73},"obj":"D012822"},{"id":"T10","span":{"begin":67,"end":73},"obj":"CHEBI:30563"},{"id":"T11","span":{"begin":67,"end":73},"obj":"D012822"},{"id":"T12","span":{"begin":92,"end":96},"obj":"CHEBI:23888"},{"id":"T13","span":{"begin":159,"end":162},"obj":"CVCL_1K15"},{"id":"T14","span":{"begin":159,"end":163},"obj":"PR:P04626"},{"id":"T15","span":{"begin":159,"end":163},"obj":"PR:000002082"},{"id":"T16","span":{"begin":159,"end":163},"obj":"PR:Q03557"},{"id":"T17","span":{"begin":159,"end":163},"obj":"PR:P34708"},{"id":"T18","span":{"begin":159,"end":163},"obj":"PR:Q5AK64"},{"id":"T19","span":{"begin":173,"end":179},"obj":"UBERON:0000310"},{"id":"T20","span":{"begin":173,"end":186},"obj":"D001943"},{"id":"T21","span":{"begin":173,"end":186},"obj":"D001943"},{"id":"T22","span":{"begin":231,"end":237},"obj":"CHEBI:52214"},{"id":"T23","span":{"begin":231,"end":237},"obj":"GO:0005488"},{"id":"T24","span":{"begin":295,"end":300},"obj":"D006801"},{"id":"T25","span":{"begin":295,"end":335},"obj":"C508053"},{"id":"T26","span":{"begin":295,"end":335},"obj":"C508053"},{"id":"T27","span":{"begin":301,"end":317},"obj":"UBERON:0000021"},{"id":"T31","span":{"begin":301,"end":324},"obj":"GO:0005154"},{"id":"T32","span":{"begin":301,"end":333},"obj":"Q01279"},{"id":"T33","span":{"begin":301,"end":333},"obj":"P0CY46"},{"id":"T34","span":{"begin":301,"end":333},"obj":"P55245"},{"id":"T35","span":{"begin":301,"end":333},"obj":"P00533"},{"id":"T36","span":{"begin":301,"end":333},"obj":"P04412"},{"id":"T38","span":{"begin":301,"end":333},"obj":"P13387"},{"id":"T39","span":{"begin":301,"end":333},"obj":"PR:000006933"},{"id":"T45","span":{"begin":337,"end":340},"obj":"CVCL_1K15"},{"id":"T46","span":{"begin":337,"end":341},"obj":"PR:P04626"},{"id":"T47","span":{"begin":337,"end":341},"obj":"PR:000002082"},{"id":"T48","span":{"begin":337,"end":341},"obj":"PR:Q03557"},{"id":"T49","span":{"begin":337,"end":341},"obj":"PR:P34708"},{"id":"T50","span":{"begin":337,"end":341},"obj":"PR:Q5AK64"},{"id":"T51","span":{"begin":418,"end":431},"obj":"SO:0000199"},{"id":"T52","span":{"begin":435,"end":438},"obj":"CVCL_1K15"},{"id":"T53","span":{"begin":435,"end":439},"obj":"PR:P04626"},{"id":"T54","span":{"begin":435,"end":439},"obj":"PR:000002082"},{"id":"T55","span":{"begin":435,"end":439},"obj":"PR:Q03557"},{"id":"T56","span":{"begin":435,"end":439},"obj":"PR:P34708"},{"id":"T57","span":{"begin":435,"end":439},"obj":"PR:Q5AK64"},{"id":"T58","span":{"begin":488,"end":491},"obj":"CVCL_1K15"},{"id":"T59","span":{"begin":488,"end":492},"obj":"PR:P04626"},{"id":"T60","span":{"begin":488,"end":492},"obj":"PR:000002082"},{"id":"T61","span":{"begin":488,"end":492},"obj":"PR:Q03557"},{"id":"T62","span":{"begin":488,"end":492},"obj":"PR:P34708"},{"id":"T63","span":{"begin":488,"end":492},"obj":"PR:Q5AK64"},{"id":"T64","span":{"begin":502,"end":520},"obj":"GO:0008283"},{"id":"T65","span":{"begin":507,"end":520},"obj":"UBERON:2000098"},{"id":"T66","span":{"begin":533,"end":542},"obj":"GO:0097194"},{"id":"T67","span":{"begin":533,"end":542},"obj":"GO:0006915"},{"id":"T68","span":{"begin":616,"end":626},"obj":"CHEBI:48706"},{"id":"T72","span":{"begin":666,"end":685},"obj":"CHEBI:50828"},{"id":"T74","span":{"begin":687,"end":690},"obj":"PR:O35763"},{"id":"T76","span":{"begin":687,"end":690},"obj":"PR:000003008"},{"id":"T77","span":{"begin":687,"end":690},"obj":"PR:P26041"},{"id":"T78","span":{"begin":687,"end":690},"obj":"PR:P26038"},{"id":"T75","span":{"begin":687,"end":690},"obj":"CVCL_9882"},{"id":"T79","span":{"begin":698,"end":702},"obj":"CHEBI:23888"},{"id":"T80","span":{"begin":723,"end":726},"obj":"CVCL_1K15"},{"id":"T81","span":{"begin":723,"end":727},"obj":"PR:P04626"},{"id":"T82","span":{"begin":723,"end":727},"obj":"PR:000002082"},{"id":"T83","span":{"begin":723,"end":727},"obj":"PR:Q03557"},{"id":"T84","span":{"begin":723,"end":727},"obj":"PR:P34708"},{"id":"T85","span":{"begin":723,"end":727},"obj":"PR:Q5AK64"},{"id":"T86","span":{"begin":737,"end":743},"obj":"UBERON:0000310"},{"id":"T87","span":{"begin":737,"end":750},"obj":"D001943"},{"id":"T88","span":{"begin":737,"end":750},"obj":"D001943"},{"id":"T90","span":{"begin":800,"end":807},"obj":"SO:0000031"},{"id":"T89","span":{"begin":800,"end":807},"obj":"CHEBI:140488"},{"id":"T91","span":{"begin":2,"end":14},"obj":"CHEBI:23456"},{"id":"T92","span":{"begin":858,"end":864},"obj":"SO:0000146"},{"id":"T95","span":{"begin":865,"end":876},"obj":"3639"},{"id":"T93","span":{"begin":865,"end":876},"obj":"D004317"},{"id":"T94","span":{"begin":865,"end":876},"obj":"CHEBI:64816"},{"id":"T96","span":{"begin":865,"end":876},"obj":"CHEBI:28748"},{"id":"T97","span":{"begin":865,"end":876},"obj":"D004317"},{"id":"T98","span":{"begin":901,"end":907},"obj":"D012822"},{"id":"T99","span":{"begin":901,"end":907},"obj":"CHEBI:30563"},{"id":"T100","span":{"begin":901,"end":907},"obj":"D012822"},{"id":"T101","span":{"begin":908,"end":921},"obj":"CHEBI:50803"},{"id":"T102","span":{"begin":930,"end":933},"obj":"PR:O35763"},{"id":"T104","span":{"begin":930,"end":933},"obj":"PR:000003008"},{"id":"T105","span":{"begin":930,"end":933},"obj":"PR:P26041"},{"id":"T106","span":{"begin":930,"end":933},"obj":"PR:P26038"},{"id":"T103","span":{"begin":930,"end":933},"obj":"CVCL_9882"},{"id":"T107","span":{"begin":999,"end":1002},"obj":"CVCL_1K15"},{"id":"T108","span":{"begin":999,"end":1003},"obj":"PR:P04626"},{"id":"T109","span":{"begin":999,"end":1003},"obj":"PR:000002082"},{"id":"T110","span":{"begin":999,"end":1003},"obj":"PR:Q03557"},{"id":"T111","span":{"begin":999,"end":1003},"obj":"PR:P34708"},{"id":"T112","span":{"begin":999,"end":1003},"obj":"PR:Q5AK64"},{"id":"T113","span":{"begin":1020,"end":1023},"obj":"PR:O35763"},{"id":"T115","span":{"begin":1020,"end":1023},"obj":"PR:000003008"},{"id":"T116","span":{"begin":1020,"end":1023},"obj":"PR:P26041"},{"id":"T117","span":{"begin":1020,"end":1023},"obj":"PR:P26038"},{"id":"T114","span":{"begin":1020,"end":1023},"obj":"CVCL_9882"},{"id":"T118","span":{"begin":1039,"end":1052},"obj":"C031000"},{"id":"T119","span":{"begin":1039,"end":1052},"obj":"C031000"},{"id":"T120","span":{"begin":1039,"end":1052},"obj":"CHEBI:41275"},{"id":"T121","span":{"begin":1039,"end":1052},"obj":"CHEBI:36622"},{"id":"T122","span":{"begin":1054,"end":1057},"obj":"PR:O35763"},{"id":"T124","span":{"begin":1054,"end":1057},"obj":"PR:000003008"},{"id":"T125","span":{"begin":1054,"end":1057},"obj":"PR:P26041"},{"id":"T126","span":{"begin":1054,"end":1057},"obj":"PR:P26038"},{"id":"T123","span":{"begin":1054,"end":1057},"obj":"CVCL_9882"},{"id":"T127","span":{"begin":1151,"end":1162},"obj":"D004317"},{"id":"T128","span":{"begin":1151,"end":1162},"obj":"CHEBI:64816"},{"id":"T130","span":{"begin":1151,"end":1162},"obj":"CHEBI:28748"},{"id":"T131","span":{"begin":1151,"end":1162},"obj":"D004317"},{"id":"T129","span":{"begin":1151,"end":1162},"obj":"3639"},{"id":"T132","span":{"begin":1172,"end":1184},"obj":"CHEBI:23456"},{"id":"T133","span":{"begin":1205,"end":1215},"obj":"111938"},{"id":"T134","span":{"begin":1261,"end":1264},"obj":"CVCL_1K15"},{"id":"T135","span":{"begin":1261,"end":1265},"obj":"PR:P04626"},{"id":"T136","span":{"begin":1261,"end":1265},"obj":"PR:000002082"},{"id":"T137","span":{"begin":1261,"end":1265},"obj":"PR:Q03557"},{"id":"T138","span":{"begin":1261,"end":1265},"obj":"PR:P34708"},{"id":"T139","span":{"begin":1261,"end":1265},"obj":"PR:Q5AK64"},{"id":"T140","span":{"begin":1371,"end":1374},"obj":"PR:000016500"},{"id":"T141","span":{"begin":1371,"end":1374},"obj":"Q9H2S6"},{"id":"T144","span":{"begin":1371,"end":1374},"obj":"Q9EP64"},{"id":"T145","span":{"begin":1371,"end":1374},"obj":"Q9ESC2"},{"id":"T142","span":{"begin":1371,"end":1374},"obj":"CVCL_E844"},{"id":"T143","span":{"begin":1371,"end":1374},"obj":"GO:0097197"},{"id":"T146","span":{"begin":1371,"end":1374},"obj":"CHEBI:27919"},{"id":"T147","span":{"begin":1379,"end":1382},"obj":"PR:Q8JZM4"},{"id":"T148","span":{"begin":1379,"end":1382},"obj":"PR:Q8NFT8"},{"id":"T149","span":{"begin":1379,"end":1382},"obj":"PR:000006599"},{"id":"T150","span":{"begin":1379,"end":1382},"obj":"CHEBI:17750"},{"id":"T151","span":{"begin":1421,"end":1424},"obj":"PR:O35763"},{"id":"T153","span":{"begin":1421,"end":1424},"obj":"PR:000003008"},{"id":"T154","span":{"begin":1421,"end":1424},"obj":"PR:P26041"},{"id":"T155","span":{"begin":1421,"end":1424},"obj":"PR:P26038"},{"id":"T152","span":{"begin":1421,"end":1424},"obj":"CVCL_9882"},{"id":"T156","span":{"begin":1440,"end":1453},"obj":"CHEBI:50803"},{"id":"T157","span":{"begin":1514,"end":1517},"obj":"PR:O35763"},{"id":"T159","span":{"begin":1514,"end":1517},"obj":"PR:000003008"},{"id":"T160","span":{"begin":1514,"end":1517},"obj":"PR:P26041"},{"id":"T161","span":{"begin":1514,"end":1517},"obj":"PR:P26038"},{"id":"T158","span":{"begin":1514,"end":1517},"obj":"CVCL_9882"},{"id":"T167","span":{"begin":1583,"end":1586},"obj":"CVCL_1K15"},{"id":"T168","span":{"begin":1583,"end":1587},"obj":"PR:P04626"},{"id":"T169","span":{"begin":1583,"end":1587},"obj":"PR:000002082"},{"id":"T170","span":{"begin":1583,"end":1587},"obj":"PR:Q03557"},{"id":"T171","span":{"begin":1583,"end":1587},"obj":"PR:P34708"},{"id":"T172","span":{"begin":1583,"end":1587},"obj":"PR:Q5AK64"},{"id":"T173","span":{"begin":1597,"end":1608},"obj":"GO:0006897"},{"id":"T174","span":{"begin":1635,"end":1638},"obj":"CVCL_1K15"},{"id":"T175","span":{"begin":1635,"end":1639},"obj":"PR:P04626"},{"id":"T176","span":{"begin":1635,"end":1639},"obj":"PR:000002082"},{"id":"T177","span":{"begin":1635,"end":1639},"obj":"PR:Q03557"},{"id":"T178","span":{"begin":1635,"end":1639},"obj":"PR:P34708"},{"id":"T179","span":{"begin":1635,"end":1639},"obj":"PR:Q5AK64"},{"id":"T180","span":{"begin":1649,"end":1654},"obj":"CVCL_0033"},{"id":"T181","span":{"begin":1666,"end":1669},"obj":"CVCL_1K15"},{"id":"T182","span":{"begin":1666,"end":1670},"obj":"PR:P04626"},{"id":"T183","span":{"begin":1666,"end":1670},"obj":"PR:000002082"},{"id":"T184","span":{"begin":1666,"end":1670},"obj":"PR:Q03557"},{"id":"T185","span":{"begin":1666,"end":1670},"obj":"PR:P34708"},{"id":"T186","span":{"begin":1666,"end":1670},"obj":"PR:Q5AK64"},{"id":"T188","span":{"begin":1680,"end":1684},"obj":"CVCL_0031"},{"id":"T189","span":{"begin":1692,"end":1695},"obj":"PR:O35763"},{"id":"T191","span":{"begin":1692,"end":1695},"obj":"PR:000003008"},{"id":"T192","span":{"begin":1692,"end":1695},"obj":"PR:P26041"},{"id":"T193","span":{"begin":1692,"end":1695},"obj":"PR:P26038"},{"id":"T190","span":{"begin":1692,"end":1695},"obj":"CVCL_9882"},{"id":"T194","span":{"begin":1733,"end":1739},"obj":"GO:0098657"},{"id":"T195","span":{"begin":1733,"end":1739},"obj":"GO:0098739"},{"id":"T196","span":{"begin":1774,"end":1779},"obj":"CVCL_0033"},{"id":"T197","span":{"begin":1803,"end":1806},"obj":"PR:O35763"},{"id":"T199","span":{"begin":1803,"end":1806},"obj":"PR:000003008"},{"id":"T200","span":{"begin":1803,"end":1806},"obj":"PR:P26041"},{"id":"T201","span":{"begin":1803,"end":1806},"obj":"PR:P26038"},{"id":"T198","span":{"begin":1803,"end":1806},"obj":"CVCL_9882"},{"id":"T202","span":{"begin":1855,"end":1865},"obj":"CHEBI:36976"},{"id":"T203","span":{"begin":1866,"end":1874},"obj":"SO:0000001"},{"id":"T204","span":{"begin":1891,"end":1904},"obj":"GO:0005622"},{"id":"T205","span":{"begin":2000,"end":2003},"obj":"CVCL_1K15"},{"id":"T206","span":{"begin":2000,"end":2004},"obj":"PR:P04626"},{"id":"T207","span":{"begin":2000,"end":2004},"obj":"PR:000002082"},{"id":"T208","span":{"begin":2000,"end":2004},"obj":"PR:Q03557"},{"id":"T209","span":{"begin":2000,"end":2004},"obj":"PR:P34708"},{"id":"T210","span":{"begin":2000,"end":2004},"obj":"PR:Q5AK64"},{"id":"T211","span":{"begin":2082,"end":2085},"obj":"PR:O35763"},{"id":"T213","span":{"begin":2082,"end":2085},"obj":"PR:000003008"},{"id":"T214","span":{"begin":2082,"end":2085},"obj":"PR:P26041"},{"id":"T215","span":{"begin":2082,"end":2085},"obj":"PR:P26038"},{"id":"T212","span":{"begin":2082,"end":2085},"obj":"CVCL_9882"},{"id":"T216","span":{"begin":2109,"end":2112},"obj":"CVCL_1K15"},{"id":"T217","span":{"begin":2109,"end":2113},"obj":"PR:P04626"},{"id":"T218","span":{"begin":2109,"end":2113},"obj":"PR:000002082"},{"id":"T219","span":{"begin":2109,"end":2113},"obj":"PR:Q03557"},{"id":"T220","span":{"begin":2109,"end":2113},"obj":"PR:P34708"},{"id":"T221","span":{"begin":2109,"end":2113},"obj":"PR:Q5AK64"},{"id":"T222","span":{"begin":2189,"end":2193},"obj":"CHEBI:23888"},{"id":"T223","span":{"begin":2249,"end":2252},"obj":"CVCL_1K15"},{"id":"T224","span":{"begin":2249,"end":2253},"obj":"PR:P04626"},{"id":"T225","span":{"begin":2249,"end":2253},"obj":"PR:000002082"},{"id":"T226","span":{"begin":2249,"end":2253},"obj":"PR:Q03557"},{"id":"T227","span":{"begin":2249,"end":2253},"obj":"PR:P34708"},{"id":"T228","span":{"begin":2249,"end":2253},"obj":"PR:Q5AK64"},{"id":"T229","span":{"begin":2396,"end":2399},"obj":"CVCL_1K15"},{"id":"T230","span":{"begin":2396,"end":2400},"obj":"PR:P04626"},{"id":"T231","span":{"begin":2396,"end":2400},"obj":"PR:000002082"},{"id":"T232","span":{"begin":2396,"end":2400},"obj":"PR:Q03557"},{"id":"T233","span":{"begin":2396,"end":2400},"obj":"PR:P34708"},{"id":"T234","span":{"begin":2396,"end":2400},"obj":"PR:Q5AK64"}],"attributes":[{"subj":"T1","pred":"source","obj":"GoldHamster"},{"subj":"T2","pred":"source","obj":"GoldHamster"},{"subj":"T3","pred":"source","obj":"GoldHamster"},{"subj":"T4","pred":"source","obj":"GoldHamster"},{"subj":"T5","pred":"source","obj":"GoldHamster"},{"subj":"T6","pred":"source","obj":"GoldHamster"},{"subj":"T8","pred":"source","obj":"GoldHamster"},{"subj":"T7","pred":"source","obj":"GoldHamster"},{"subj":"T9","pred":"source","obj":"GoldHamster"},{"subj":"T10","pred":"source","obj":"GoldHamster"},{"subj":"T11","pred":"source","obj":"GoldHamster"},{"subj":"T12","pred":"source","obj":"GoldHamster"},{"subj":"T13","pred":"source","obj":"GoldHamster"},{"subj":"T14","pred":"source","obj":"GoldHamster"},{"subj":"T15","pred":"source","obj":"GoldHamster"},{"subj":"T16","pred":"source","obj":"GoldHamster"},{"subj":"T17","pred":"source","obj":"GoldHamster"},{"subj":"T18","pred":"source","obj":"GoldHamster"},{"subj":"T19","pred":"source","obj":"GoldHamster"},{"subj":"T20","pred":"source","obj":"GoldHamster"},{"subj":"T21","pred":"source","obj":"GoldHamster"},{"subj":"T22","pred":"source","obj":"GoldHamster"},{"subj":"T23","pred":"source","obj":"GoldHamster"},{"subj":"T24","pred":"source","obj":"GoldHamster"},{"subj":"T25","pred":"source","obj":"GoldHamster"},{"subj":"T26","pred":"source","obj":"GoldHamster"},{"subj":"T27","pred":"source","obj":"GoldHamster"},{"subj":"T31","pred":"source","obj":"GoldHamster"},{"subj":"T32","pred":"source","obj":"GoldHamster"},{"subj":"T33","pred":"source","obj":"GoldHamster"},{"subj":"T34","pred":"source","obj":"GoldHamster"},{"subj":"T35","pred":"source","obj":"GoldHamster"},{"subj":"T36","pred":"source","obj":"GoldHamster"},{"subj":"T38","pred":"source","obj":"GoldHamster"},{"subj":"T39","pred":"source","obj":"GoldHamster"},{"subj":"T45","pred":"source","obj":"GoldHamster"},{"subj":"T46","pred":"source","obj":"GoldHamster"},{"subj":"T47","pred":"source","obj":"GoldHamster"},{"subj":"T48","pred":"source","obj":"GoldHamster"},{"subj":"T49","pred":"source","obj":"GoldHamster"},{"subj":"T50","pred":"source","obj":"GoldHamster"},{"subj":"T51","pred":"source","obj":"GoldHamster"},{"subj":"T52","pred":"source","obj":"GoldHamster"},{"subj":"T53","pred":"source","obj":"GoldHamster"},{"subj":"T54","pred":"source","obj":"GoldHamster"},{"subj":"T55","pred":"source","obj":"GoldHamster"},{"subj":"T56","pred":"source","obj":"GoldHamster"},{"subj":"T57","pred":"source","obj":"GoldHamster"},{"subj":"T58","pred":"source","obj":"GoldHamster"},{"subj":"T59","pred":"source","obj":"GoldHamster"},{"subj":"T60","pred":"source","obj":"GoldHamster"},{"subj":"T61","pred":"source","obj":"GoldHamster"},{"subj":"T62","pred":"source","obj":"GoldHamster"},{"subj":"T63","pred":"source","obj":"GoldHamster"},{"subj":"T64","pred":"source","obj":"GoldHamster"},{"subj":"T65","pred":"source","obj":"GoldHamster"},{"subj":"T66","pred":"source","obj":"GoldHamster"},{"subj":"T67","pred":"source","obj":"GoldHamster"},{"subj":"T68","pred":"source","obj":"GoldHamster"},{"subj":"T72","pred":"source","obj":"GoldHamster"},{"subj":"T74","pred":"source","obj":"GoldHamster"},{"subj":"T76","pred":"source","obj":"GoldHamster"},{"subj":"T77","pred":"source","obj":"GoldHamster"},{"subj":"T78","pred":"source","obj":"GoldHamster"},{"subj":"T75","pred":"source","obj":"GoldHamster"},{"subj":"T79","pred":"source","obj":"GoldHamster"},{"subj":"T80","pred":"source","obj":"GoldHamster"},{"subj":"T81","pred":"source","obj":"GoldHamster"},{"subj":"T82","pred":"source","obj":"GoldHamster"},{"subj":"T83","pred":"source","obj":"GoldHamster"},{"subj":"T84","pred":"source","obj":"GoldHamster"},{"subj":"T85","pred":"source","obj":"GoldHamster"},{"subj":"T86","pred":"source","obj":"GoldHamster"},{"subj":"T87","pred":"source","obj":"GoldHamster"},{"subj":"T88","pred":"source","obj":"GoldHamster"},{"subj":"T90","pred":"source","obj":"GoldHamster"},{"subj":"T89","pred":"source","obj":"GoldHamster"},{"subj":"T91","pred":"source","obj":"GoldHamster"},{"subj":"T92","pred":"source","obj":"GoldHamster"},{"subj":"T95","pred":"source","obj":"GoldHamster"},{"subj":"T93","pred":"source","obj":"GoldHamster"},{"subj":"T94","pred":"source","obj":"GoldHamster"},{"subj":"T96","pred":"source","obj":"GoldHamster"},{"subj":"T97","pred":"source","obj":"GoldHamster"},{"subj":"T98","pred":"source","obj":"GoldHamster"},{"subj":"T99","pred":"source","obj":"GoldHamster"},{"subj":"T100","pred":"source","obj":"GoldHamster"},{"subj":"T101","pred":"source","obj":"GoldHamster"},{"subj":"T102","pred":"source","obj":"GoldHamster"},{"subj":"T104","pred":"source","obj":"GoldHamster"},{"subj":"T105","pred":"source","obj":"GoldHamster"},{"subj":"T106","pred":"source","obj":"GoldHamster"},{"subj":"T103","pred":"source","obj":"GoldHamster"},{"subj":"T107","pred":"source","obj":"GoldHamster"},{"subj":"T108","pred":"source","obj":"GoldHamster"},{"subj":"T109","pred":"source","obj":"GoldHamster"},{"subj":"T110","pred":"source","obj":"GoldHamster"},{"subj":"T111","pred":"source","obj":"GoldHamster"},{"subj":"T112","pred":"source","obj":"GoldHamster"},{"subj":"T113","pred":"source","obj":"GoldHamster"},{"subj":"T115","pred":"source","obj":"GoldHamster"},{"subj":"T116","pred":"source","obj":"GoldHamster"},{"subj":"T117","pred":"source","obj":"GoldHamster"},{"subj":"T114","pred":"source","obj":"GoldHamster"},{"subj":"T118","pred":"source","obj":"GoldHamster"},{"subj":"T119","pred":"source","obj":"GoldHamster"},{"subj":"T120","pred":"source","obj":"GoldHamster"},{"subj":"T121","pred":"source","obj":"GoldHamster"},{"subj":"T122","pred":"source","obj":"GoldHamster"},{"subj":"T124","pred":"source","obj":"GoldHamster"},{"subj":"T125","pred":"source","obj":"GoldHamster"},{"subj":"T126","pred":"source","obj":"GoldHamster"},{"subj":"T123","pred":"source","obj":"GoldHamster"},{"subj":"T127","pred":"source","obj":"GoldHamster"},{"subj":"T128","pred":"source","obj":"GoldHamster"},{"subj":"T130","pred":"source","obj":"GoldHamster"},{"subj":"T131","pred":"source","obj":"GoldHamster"},{"subj":"T129","pred":"source","obj":"GoldHamster"},{"subj":"T132","pred":"source","obj":"GoldHamster"},{"subj":"T133","pred":"source","obj":"GoldHamster"},{"subj":"T134","pred":"source","obj":"GoldHamster"},{"subj":"T135","pred":"source","obj":"GoldHamster"},{"subj":"T136","pred":"source","obj":"GoldHamster"},{"subj":"T137","pred":"source","obj":"GoldHamster"},{"subj":"T138","pred":"source","obj":"GoldHamster"},{"subj":"T139","pred":"source","obj":"GoldHamster"},{"subj":"T140","pred":"source","obj":"GoldHamster"},{"subj":"T141","pred":"source","obj":"GoldHamster"},{"subj":"T144","pred":"source","obj":"GoldHamster"},{"subj":"T145","pred":"source","obj":"GoldHamster"},{"subj":"T142","pred":"source","obj":"GoldHamster"},{"subj":"T143","pred":"source","obj":"GoldHamster"},{"subj":"T146","pred":"source","obj":"GoldHamster"},{"subj":"T147","pred":"source","obj":"GoldHamster"},{"subj":"T148","pred":"source","obj":"GoldHamster"},{"subj":"T149","pred":"source","obj":"GoldHamster"},{"subj":"T150","pred":"source","obj":"GoldHamster"},{"subj":"T151","pred":"source","obj":"GoldHamster"},{"subj":"T153","pred":"source","obj":"GoldHamster"},{"subj":"T154","pred":"source","obj":"GoldHamster"},{"subj":"T155","pred":"source","obj":"GoldHamster"},{"subj":"T152","pred":"source","obj":"GoldHamster"},{"subj":"T156","pred":"source","obj":"GoldHamster"},{"subj":"T157","pred":"source","obj":"GoldHamster"},{"subj":"T159","pred":"source","obj":"GoldHamster"},{"subj":"T160","pred":"source","obj":"GoldHamster"},{"subj":"T161","pred":"source","obj":"GoldHamster"},{"subj":"T158","pred":"source","obj":"GoldHamster"},{"subj":"T167","pred":"source","obj":"GoldHamster"},{"subj":"T168","pred":"source","obj":"GoldHamster"},{"subj":"T169","pred":"source","obj":"GoldHamster"},{"subj":"T170","pred":"source","obj":"GoldHamster"},{"subj":"T171","pred":"source","obj":"GoldHamster"},{"subj":"T172","pred":"source","obj":"GoldHamster"},{"subj":"T173","pred":"source","obj":"GoldHamster"},{"subj":"T174","pred":"source","obj":"GoldHamster"},{"subj":"T175","pred":"source","obj":"GoldHamster"},{"subj":"T176","pred":"source","obj":"GoldHamster"},{"subj":"T177","pred":"source","obj":"GoldHamster"},{"subj":"T178","pred":"source","obj":"GoldHamster"},{"subj":"T179","pred":"source","obj":"GoldHamster"},{"subj":"T180","pred":"source","obj":"GoldHamster"},{"subj":"T181","pred":"source","obj":"GoldHamster"},{"subj":"T182","pred":"source","obj":"GoldHamster"},{"subj":"T183","pred":"source","obj":"GoldHamster"},{"subj":"T184","pred":"source","obj":"GoldHamster"},{"subj":"T185","pred":"source","obj":"GoldHamster"},{"subj":"T186","pred":"source","obj":"GoldHamster"},{"subj":"T188","pred":"source","obj":"GoldHamster"},{"subj":"T189","pred":"source","obj":"GoldHamster"},{"subj":"T191","pred":"source","obj":"GoldHamster"},{"subj":"T192","pred":"source","obj":"GoldHamster"},{"subj":"T193","pred":"source","obj":"GoldHamster"},{"subj":"T190","pred":"source","obj":"GoldHamster"},{"subj":"T194","pred":"source","obj":"GoldHamster"},{"subj":"T195","pred":"source","obj":"GoldHamster"},{"subj":"T196","pred":"source","obj":"GoldHamster"},{"subj":"T197","pred":"source","obj":"GoldHamster"},{"subj":"T199","pred":"source","obj":"GoldHamster"},{"subj":"T200","pred":"source","obj":"GoldHamster"},{"subj":"T201","pred":"source","obj":"GoldHamster"},{"subj":"T198","pred":"source","obj":"GoldHamster"},{"subj":"T202","pred":"source","obj":"GoldHamster"},{"subj":"T203","pred":"source","obj":"GoldHamster"},{"subj":"T204","pred":"source","obj":"GoldHamster"},{"subj":"T205","pred":"source","obj":"GoldHamster"},{"subj":"T206","pred":"source","obj":"GoldHamster"},{"subj":"T207","pred":"source","obj":"GoldHamster"},{"subj":"T208","pred":"source","obj":"GoldHamster"},{"subj":"T209","pred":"source","obj":"GoldHamster"},{"subj":"T210","pred":"source","obj":"GoldHamster"},{"subj":"T211","pred":"source","obj":"GoldHamster"},{"subj":"T213","pred":"source","obj":"GoldHamster"},{"subj":"T214","pred":"source","obj":"GoldHamster"},{"subj":"T215","pred":"source","obj":"GoldHamster"},{"subj":"T212","pred":"source","obj":"GoldHamster"},{"subj":"T216","pred":"source","obj":"GoldHamster"},{"subj":"T217","pred":"source","obj":"GoldHamster"},{"subj":"T218","pred":"source","obj":"GoldHamster"},{"subj":"T219","pred":"source","obj":"GoldHamster"},{"subj":"T220","pred":"source","obj":"GoldHamster"},{"subj":"T221","pred":"source","obj":"GoldHamster"},{"subj":"T222","pred":"source","obj":"GoldHamster"},{"subj":"T223","pred":"source","obj":"GoldHamster"},{"subj":"T224","pred":"source","obj":"GoldHamster"},{"subj":"T225","pred":"source","obj":"GoldHamster"},{"subj":"T226","pred":"source","obj":"GoldHamster"},{"subj":"T227","pred":"source","obj":"GoldHamster"},{"subj":"T228","pred":"source","obj":"GoldHamster"},{"subj":"T229","pred":"source","obj":"GoldHamster"},{"subj":"T230","pred":"source","obj":"GoldHamster"},{"subj":"T231","pred":"source","obj":"GoldHamster"},{"subj":"T232","pred":"source","obj":"GoldHamster"},{"subj":"T233","pred":"source","obj":"GoldHamster"},{"subj":"T234","pred":"source","obj":"GoldHamster"}]},{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":194,"end":543},"obj":"DRI_Outcome"},{"id":"T2","span":{"begin":544,"end":751},"obj":"DRI_Challenge"},{"id":"T3","span":{"begin":752,"end":794},"obj":"DRI_Background"},{"id":"T4","span":{"begin":851,"end":1019},"obj":"DRI_Background"},{"id":"T5","span":{"begin":1020,"end":1038},"obj":"REPLACED"},{"id":"T6","span":{"begin":1053,"end":1169},"obj":"DRI_Background"},{"id":"T7","span":{"begin":1170,"end":1308},"obj":"DRI_Approach"},{"id":"T8","span":{"begin":1455,"end":1513},"obj":"DRI_Background"},{"id":"T9","span":{"begin":1514,"end":1665},"obj":"DRI_Background"},{"id":"T10","span":{"begin":1685,"end":1691},"obj":"DRI_Background"},{"id":"T11","span":{"begin":1692,"end":1881},"obj":"DRI_Outcome"},{"id":"T12","span":{"begin":1882,"end":2069},"obj":"DRI_Background"},{"id":"T13","span":{"begin":2070,"end":2284},"obj":"DRI_Outcome"},{"id":"T14","span":{"begin":2285,"end":2417},"obj":"DRI_Outcome"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T7","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T8","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T9","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T10","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T11","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T12","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T13","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T14","pred":"source","obj":"PubMed_ArguminSci"}]},{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":0,"end":1},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T2","span":{"begin":46,"end":55},"obj":"CVCL_C410|Hybridoma|Mus musculus"},{"id":"T3","span":{"begin":180,"end":186},"obj":"CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T4","span":{"begin":229,"end":230},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T5","span":{"begin":544,"end":546},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"},{"id":"T6","span":{"begin":594,"end":595},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T7","span":{"begin":687,"end":690},"obj":"CVCL_9882|Cancer_cell_line|Homo sapiens"},{"id":"T8","span":{"begin":744,"end":750},"obj":"CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T9","span":{"begin":775,"end":777},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"},{"id":"T10","span":{"begin":854,"end":856},"obj":"CVCL_5731|Spontaneously_immortalized_cell_line|Mus musculus"},{"id":"T11","span":{"begin":854,"end":856},"obj":"CVCL_W955|Cancer_cell_line|Homo sapiens"},{"id":"T12","span":{"begin":930,"end":933},"obj":"CVCL_9882|Cancer_cell_line|Homo sapiens"},{"id":"T13","span":{"begin":934,"end":936},"obj":"CVCL_E481|Transformed_cell_line|Homo sapiens"},{"id":"T14","span":{"begin":934,"end":936},"obj":"CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer"},{"id":"T15","span":{"begin":937,"end":939},"obj":"CVCL_5731|Spontaneously_immortalized_cell_line|Mus musculus"},{"id":"T16","span":{"begin":937,"end":939},"obj":"CVCL_W955|Cancer_cell_line|Homo sapiens"},{"id":"T17","span":{"begin":1020,"end":1023},"obj":"CVCL_9882|Cancer_cell_line|Homo sapiens"},{"id":"T18","span":{"begin":1054,"end":1057},"obj":"CVCL_9882|Cancer_cell_line|Homo sapiens"},{"id":"T19","span":{"begin":1058,"end":1060},"obj":"CVCL_E481|Transformed_cell_line|Homo sapiens"},{"id":"T20","span":{"begin":1058,"end":1060},"obj":"CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer"},{"id":"T21","span":{"begin":1203,"end":1204},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T22","span":{"begin":1249,"end":1250},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T23","span":{"begin":1359,"end":1361},"obj":"CVCL_4203|Spontaneously_immortalized_cell_line|Lithobates catesbeiana"},{"id":"T24","span":{"begin":1362,"end":1364},"obj":"CVCL_ZD54|Transformed_cell_line|Homo sapiens"},{"id":"T25","span":{"begin":1371,"end":1374},"obj":"CVCL_E844|Transformed_cell_line|Homo sapiens"},{"id":"T26","span":{"begin":1421,"end":1424},"obj":"CVCL_9882|Cancer_cell_line|Homo sapiens"},{"id":"T27","span":{"begin":1425,"end":1427},"obj":"CVCL_E481|Transformed_cell_line|Homo sapiens"},{"id":"T28","span":{"begin":1425,"end":1427},"obj":"CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer"},{"id":"T29","span":{"begin":1428,"end":1430},"obj":"CVCL_5731|Spontaneously_immortalized_cell_line|Mus musculus"},{"id":"T30","span":{"begin":1428,"end":1430},"obj":"CVCL_W955|Cancer_cell_line|Homo sapiens"},{"id":"T31","span":{"begin":1514,"end":1517},"obj":"CVCL_9882|Cancer_cell_line|Homo sapiens"},{"id":"T32","span":{"begin":1518,"end":1520},"obj":"CVCL_E481|Transformed_cell_line|Homo sapiens"},{"id":"T33","span":{"begin":1518,"end":1520},"obj":"CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer"},{"id":"T34","span":{"begin":1521,"end":1523},"obj":"CVCL_5731|Spontaneously_immortalized_cell_line|Mus musculus"},{"id":"T35","span":{"begin":1521,"end":1523},"obj":"CVCL_W955|Cancer_cell_line|Homo sapiens"},{"id":"T36","span":{"begin":1569,"end":1571},"obj":"CVCL_F566|Transformed_cell_line|Homo sapiens"},{"id":"T37","span":{"begin":1569,"end":1571},"obj":"CVCL_W799|Cancer_cell_line|Homo sapiens"},{"id":"T38","span":{"begin":1649,"end":1654},"obj":"CVCL_0033|Cancer_cell_line|Homo sapiens"},{"id":"T39","span":{"begin":1680,"end":1684},"obj":"CVCL_0031|Cancer_cell_line|Homo sapiens"},{"id":"T40","span":{"begin":1692,"end":1695},"obj":"CVCL_9882|Cancer_cell_line|Homo sapiens"},{"id":"T41","span":{"begin":1696,"end":1698},"obj":"CVCL_E481|Transformed_cell_line|Homo sapiens"},{"id":"T42","span":{"begin":1696,"end":1698},"obj":"CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer"},{"id":"T43","span":{"begin":1699,"end":1701},"obj":"CVCL_5731|Spontaneously_immortalized_cell_line|Mus musculus"},{"id":"T44","span":{"begin":1699,"end":1701},"obj":"CVCL_W955|Cancer_cell_line|Homo sapiens"},{"id":"T45","span":{"begin":1774,"end":1779},"obj":"CVCL_0033|Cancer_cell_line|Homo sapiens"},{"id":"T46","span":{"begin":1803,"end":1806},"obj":"CVCL_9882|Cancer_cell_line|Homo sapiens"},{"id":"T47","span":{"begin":1807,"end":1809},"obj":"CVCL_E481|Transformed_cell_line|Homo sapiens"},{"id":"T48","span":{"begin":1807,"end":1809},"obj":"CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer"},{"id":"T49","span":{"begin":1810,"end":1812},"obj":"CVCL_5731|Spontaneously_immortalized_cell_line|Mus musculus"},{"id":"T50","span":{"begin":1810,"end":1812},"obj":"CVCL_W955|Cancer_cell_line|Homo sapiens"},{"id":"T51","span":{"begin":1843,"end":1844},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T52","span":{"begin":1878,"end":1880},"obj":"CVCL_5731|Spontaneously_immortalized_cell_line|Mus musculus"},{"id":"T53","span":{"begin":1878,"end":1880},"obj":"CVCL_W955|Cancer_cell_line|Homo sapiens"},{"id":"T54","span":{"begin":2014,"end":2020},"obj":"CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T55","span":{"begin":2082,"end":2085},"obj":"CVCL_9882|Cancer_cell_line|Homo sapiens"},{"id":"T56","span":{"begin":2086,"end":2088},"obj":"CVCL_E481|Transformed_cell_line|Homo sapiens"},{"id":"T57","span":{"begin":2086,"end":2088},"obj":"CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer"},{"id":"T58","span":{"begin":2089,"end":2091},"obj":"CVCL_5731|Spontaneously_immortalized_cell_line|Mus musculus"},{"id":"T59","span":{"begin":2089,"end":2091},"obj":"CVCL_W955|Cancer_cell_line|Homo sapiens"},{"id":"T60","span":{"begin":2410,"end":2416},"obj":"CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens"}],"attributes":[{"subj":"T1","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T2","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T3","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T4","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T5","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T6","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T7","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T8","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T9","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T10","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T11","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T12","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T13","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T14","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T15","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T16","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T17","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T18","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T19","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T20","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T21","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T22","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T23","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T24","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T25","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T26","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T27","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T28","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T29","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T30","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T31","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T32","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T33","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T34","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T35","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T36","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T37","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T38","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T39","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T40","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T41","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T42","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T43","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T44","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T45","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T46","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T47","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T48","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T49","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T50","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T51","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T52","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T53","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T54","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T55","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T56","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T57","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T58","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T59","pred":"source","obj":"Goldhamster2_Cellosaurus"},{"subj":"T60","pred":"source","obj":"Goldhamster2_Cellosaurus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"GoldHamster","color":"#a1ec93","default":true},{"id":"PubMed_ArguminSci","color":"#ec93bb"},{"id":"Goldhamster2_Cellosaurus","color":"#93d5ec"}]}]}}