PubMed:31186474
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 57-76 | Disease | denotes | Alzheimer's disease | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T2 | 114-121 | Disease | denotes | amyloid | http://purl.obolibrary.org/obo/MONDO_0019065 |
| T3 | 234-253 | Disease | denotes | Alzheimer's disease | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T4 | 255-257 | Disease | denotes | AD | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T5 | 469-471 | Disease | denotes | AD | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T6 | 765-767 | Disease | denotes | AD | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T7 | 786-788 | Disease | denotes | AD | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T8 | 809-811 | Disease | denotes | AD | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T9 | 922-924 | Disease | denotes | AD | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T10 | 1010-1012 | Disease | denotes | AD | http://purl.obolibrary.org/obo/MONDO_0004975 |
| T11 | 1268-1270 | Disease | denotes | AD | http://purl.obolibrary.org/obo/MONDO_0004975 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 29-50 | Phenotype | denotes | cognitive impairments | HP:0100543 |
| T2 | 57-76 | Phenotype | denotes | Alzheimer's disease | HP:0002511 |
| T3 | 205-223 | Phenotype | denotes | memory impairments | HP:0002354 |
| T4 | 234-253 | Phenotype | denotes | Alzheimer's disease | HP:0002511 |
| T5 | 255-257 | Phenotype | denotes | AD | HP:0002511 |
| T6 | 469-471 | Phenotype | denotes | AD | HP:0002511 |
| T7 | 721-739 | Phenotype | denotes | cognitive deficits | HP:0100543 |
| T8 | 765-767 | Phenotype | denotes | AD | HP:0002511 |
| T9 | 786-788 | Phenotype | denotes | AD | HP:0002511 |
| T10 | 809-811 | Phenotype | denotes | AD | HP:0002511 |
| T11 | 922-924 | Phenotype | denotes | AD | HP:0002511 |
| T12 | 1010-1012 | Phenotype | denotes | AD | HP:0002511 |
| T13 | 1268-1270 | Phenotype | denotes | AD | HP:0002511 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 141-146 | Body_part | denotes | Brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T2 | 697-708 | Body_part | denotes | hippocampus | http://purl.obolibrary.org/obo/MAT_0000114 |
| T3 | 882-901 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/MAT_0000499 |
| T4 | 990-1001 | Body_part | denotes | hippocampus | http://purl.obolibrary.org/obo/MAT_0000114 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 12-16 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T2 | 318-322 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T3 | 456-460 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T4 | 551-555 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T5 | 683-687 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T6 | 791-795 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T7 | 965-969 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T8 | 1221-1225 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 12-16 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T2 | 318-322 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T3 | 456-460 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T4 | 551-555 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T5 | 683-687 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T6 | 791-795 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T7 | 965-969 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T8 | 1221-1225 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 29-50 | Phenotype | denotes | cognitive impairments | HP:0100543 |
| T2 | 57-76 | Phenotype | denotes | Alzheimer's disease | HP:0002511 |
| T3 | 205-223 | Phenotype | denotes | memory impairments | HP:0002354 |
| T4 | 234-253 | Phenotype | denotes | Alzheimer's disease | HP:0002511 |
| T5 | 255-257 | Phenotype | denotes | AD | HP:0002511 |
| T6 | 469-471 | Phenotype | denotes | AD | HP:0002511 |
| T7 | 721-739 | Phenotype | denotes | cognitive deficits | HP:0100543 |
| T8 | 765-767 | Phenotype | denotes | AD | HP:0002511 |
| T9 | 786-788 | Phenotype | denotes | AD | HP:0002511 |
| T10 | 809-811 | Phenotype | denotes | AD | HP:0002511 |
| T11 | 922-924 | Phenotype | denotes | AD | HP:0002511 |
| T12 | 1010-1012 | Phenotype | denotes | AD | HP:0002511 |
| T13 | 1268-1270 | Phenotype | denotes | AD | HP:0002511 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 77-82 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T3 | 697-708 | OrganismTaxon | denotes | hippocampus | 72046 |
| T4 | 768-773 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T6 | 812-816 | OrganismTaxon | denotes | mice | 10088 |
| T7 | 925-929 | OrganismTaxon | denotes | mice | 10088 |
| T8 | 990-1001 | OrganismTaxon | denotes | hippocampus | 72046 |
| T9 | 1013-1017 | OrganismTaxon | denotes | mice | 10088 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 643-659 | Cell | denotes | cortical neurons | http://purl.obolibrary.org/obo/CL:0010012 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 141-146 | Body_part | denotes | Brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T3 | 643-659 | Body_part | denotes | cortical neurons | http://purl.obolibrary.org/obo/CL_0010012 |
| T4 | 697-708 | Body_part | denotes | hippocampus | http://purl.obolibrary.org/obo/UBERON_0001954|http://purl.obolibrary.org/obo/UBERON_0002421|http://purl.obolibrary.org/obo/UBERON_0002961 |
| T7 | 882-901 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/UBERON_0001359 |
| T8 | 990-1001 | Body_part | denotes | hippocampus | http://purl.obolibrary.org/obo/UBERON_0001954|http://purl.obolibrary.org/obo/UBERON_0002421|http://purl.obolibrary.org/obo/UBERON_0002961 |
| T11 | 1029-1035 | Body_part | denotes | plaque | http://purl.obolibrary.org/obo/UBERON_0016482 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 141-146 | Body_part | denotes | Brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T2 | 697-708 | Body_part | denotes | hippocampus | http://purl.obolibrary.org/obo/MAT_0000114 |
| T3 | 882-901 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/MAT_0000499 |
| T4 | 990-1001 | Body_part | denotes | hippocampus | http://purl.obolibrary.org/obo/MAT_0000114 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-140 | Sentence | denotes | Ganglioside GQ1b ameliorates cognitive impairments in an Alzheimer's disease mouse model, and causes reduction of amyloid precursor protein. |
| T2 | 141-259 | Sentence | denotes | Brain-derived neurotrophic factor (BDNF) plays crucial roles in memory impairments including Alzheimer's disease (AD). |
| T3 | 260-412 | Sentence | denotes | Previous studies have reported that tetrasialoganglioside GQ1b is involved in long-term potentiation and cognitive functions as well as BDNF expression. |
| T4 | 413-497 | Sentence | denotes | However, in vitro and in vivo functions of GQ1b against AD has not investigated yet. |
| T5 | 498-660 | Sentence | denotes | Consequently, treatment of oligomeric Aβ followed by GQ1b significantly restores Aβ1-42-induced cell death through BDNF up-regulation in primary cortical neurons. |
| T6 | 661-790 | Sentence | denotes | Bilateral infusion of GQ1b into the hippocampus ameliorates cognitive deficits in the triple-transgenic AD mouse model (3xTg-AD). |
| T7 | 791-930 | Sentence | denotes | GQ1b-infused 3xTg-AD mice had substantially increased BDNF levels compared with artificial cerebrospinal fluid (aCSF)-treated 3xTg-AD mice. |
| T8 | 931-1162 | Sentence | denotes | Interestingly, we also found that GQ1b administration into hippocampus of 3xTg-AD mice reduces Aβ plaque deposition and tau phosphorylation, which correlate with APP protein reduction and phospho-GSK3β level increase, respectively. |
| T9 | 1163-1281 | Sentence | denotes | These findings demonstrate that the tetrasialoganglioside GQ1b may contribute to a potential strategy of AD treatment. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 12-16 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T2 | 318-322 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T3 | 456-460 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T4 | 551-555 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T5 | 683-687 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T6 | 791-795 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T7 | 965-969 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
| T8 | 1221-1225 | Glycan | denotes | GQ1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G18625KA |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 12-16 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T2 | 318-322 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T3 | 456-460 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T4 | 551-555 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T5 | 683-687 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T6 | 791-795 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T7 | 965-969 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
| T8 | 1221-1225 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1b | http://www.glycoepitope.jp/epitopes/EP0069 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 57-76 | Disease | denotes | Alzheimer's disease | MONDO:0004975 |
| T2 | 114-121 | Disease | denotes | amyloid | MONDO:0019065 |
| T3 | 234-253 | Disease | denotes | Alzheimer's disease | MONDO:0004975 |
| T4 | 255-257 | Disease | denotes | AD | MONDO:0004975 |
| T5 | 469-471 | Disease | denotes | AD | MONDO:0004975 |
| T6 | 765-767 | Disease | denotes | AD | MONDO:0004975 |
| T7 | 786-788 | Disease | denotes | AD | MONDO:0004975 |
| T8 | 809-811 | Disease | denotes | AD | MONDO:0004975 |
| T9 | 922-924 | Disease | denotes | AD | MONDO:0004975 |
| T10 | 1010-1012 | Disease | denotes | AD | MONDO:0004975 |
| T11 | 1268-1270 | Disease | denotes | AD | MONDO:0004975 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 77-82 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T3 | 697-708 | OrganismTaxon | denotes | hippocampus | 72046 |
| T4 | 768-773 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T6 | 812-816 | OrganismTaxon | denotes | mice | 10088 |
| T7 | 925-929 | OrganismTaxon | denotes | mice | 10088 |
| T8 | 990-1001 | OrganismTaxon | denotes | hippocampus | 72046 |
| T9 | 1013-1017 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 141-146 | Body_part | denotes | Brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T3 | 643-659 | Body_part | denotes | cortical neurons | http://purl.obolibrary.org/obo/CL_0010012 |
| T4 | 697-708 | Body_part | denotes | hippocampus | http://purl.obolibrary.org/obo/UBERON_0001954|http://purl.obolibrary.org/obo/UBERON_0002421|http://purl.obolibrary.org/obo/UBERON_0002961 |
| T7 | 882-901 | Body_part | denotes | cerebrospinal fluid | http://purl.obolibrary.org/obo/UBERON_0001359 |
| T8 | 990-1001 | Body_part | denotes | hippocampus | http://purl.obolibrary.org/obo/UBERON_0001954|http://purl.obolibrary.org/obo/UBERON_0002421|http://purl.obolibrary.org/obo/UBERON_0002961 |
| T11 | 1029-1035 | Body_part | denotes | plaque | http://purl.obolibrary.org/obo/UBERON_0016482 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 643-659 | Cell | denotes | cortical neurons | http://purl.obolibrary.org/obo/CL:0010012 |