PubMed:31147593
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 68-77 | Disease | denotes | carcinoma | http://purl.obolibrary.org/obo/MONDO_0004993 |
| T2 | 119-125 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T3 | 216-221 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 305-310 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 728-733 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T6 | 1199-1214 | Disease | denotes | colon carcinoma | http://purl.obolibrary.org/obo/MONDO_0002032 |
| T7 | 1251-1267 | Disease | denotes | breast carcinoma | http://purl.obolibrary.org/obo/MONDO_0004989 |
| T8 | 1308-1324 | Disease | denotes | kidney carcinoma | http://purl.obolibrary.org/obo/MONDO_0005206 |
| T9 | 1457-1462 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T10 | 1586-1591 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1199-1204 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
| T2 | 1308-1314 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/MAT_0000119 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 138-144 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 171-177 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 544-554 | Glycan | denotes | Tn-antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 544-554 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Tn-antigen | http://www.glycoepitope.jp/epitopes/EP0021 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 68-77 | Phenotype | denotes | carcinoma | HP:0030731 |
| T2 | 119-125 | Phenotype | denotes | cancer | HP:0002664 |
| T3 | 216-221 | Phenotype | denotes | tumor | HP:0002664 |
| T4 | 305-310 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 728-733 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 1205-1214 | Phenotype | denotes | carcinoma | HP:0030731 |
| T7 | 1251-1267 | Phenotype | denotes | breast carcinoma | HP:0003002 |
| T8 | 1315-1324 | Phenotype | denotes | carcinoma | HP:0030731 |
| T9 | 1457-1462 | Phenotype | denotes | tumor | HP:0002664 |
| T10 | 1586-1591 | Phenotype | denotes | tumor | HP:0002664 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 68-77 | Disease | denotes | carcinoma | http://purl.obolibrary.org/obo/MONDO_0004993 |
| T2 | 119-125 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T3 | 216-221 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 305-310 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 728-733 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T6 | 1199-1214 | Disease | denotes | colon carcinoma | http://purl.obolibrary.org/obo/MONDO_0002032 |
| T7 | 1251-1267 | Disease | denotes | breast carcinoma | http://purl.obolibrary.org/obo/MONDO_0004989 |
| T8 | 1308-1324 | Disease | denotes | kidney carcinoma | http://purl.obolibrary.org/obo/MONDO_0005206 |
| T9 | 1457-1462 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T10 | 1586-1591 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 9-14 | OrganismTaxon | denotes | human | 9606 |
| T2 | 664-669 | OrganismTaxon | denotes | human | 9606 |
| T3 | 734-739 | OrganismTaxon | denotes | human | 9606 |
| T4 | 1110-1115 | OrganismTaxon | denotes | human | 9606 |
| T5 | 1396-1401 | OrganismTaxon | denotes | human | 9606 |
| T6 | 1509-1514 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 119-131 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 670-676 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T2 | 1116-1122 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T3 | 1199-1204 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
| T4 | 1251-1257 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T5 | 1308-1314 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1199-1204 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
| T2 | 1308-1314 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/MAT_0000119 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-86 | Sentence | denotes | Purified human anti-Tn and anti-T antibodies specifically recognize carcinoma tissues. |
| T2 | 87-242 | Sentence | denotes | Described in several epithelial cancer cells, Tn- (GalNAcα1-O-Ser/Thr) and T- (Galβ3GalNAcα1-O-Ser/Thr) antigens are examples of tumor-associated antigens. |
| T3 | 243-448 | Sentence | denotes | Increased expression of Tn- and T-antigens is associated with tumor invasion and metastasis, and patients with high concentration of anti-Tn and anti-T antibodies have a more benign evolution of pathology. |
| T4 | 449-569 | Sentence | denotes | Asialofetuin (ASF) and ovine submaxillary mucin (OSM) are two glycoproteins that expose T- and Tn-antigen, respectively. |
| T5 | 570-748 | Sentence | denotes | In this work, using ASF or OSM we affinity-purified anti-T and anti-Tn antibodies from normal human plasma and tested their ability to specifically recognize tumor human tissues. |
| T6 | 749-993 | Sentence | denotes | Whereas purified anti-T antibodies (purity degree increase of 127-fold, and 22% recovery) were mainly IgG, for purified anti-Tn antibodies (purity degree enhancement of 125-fold, and 26% yield) the IgM fraction was predominant over the IgG one. |
| T7 | 994-1069 | Sentence | denotes | IgG2 subclass was significantly enriched in both purified antibody samples. |
| T8 | 1070-1361 | Sentence | denotes | Purified antibodies did not bind normal human tissue (0/42), although recognized malignant tissues from different origin such as colon carcinoma (11/77 by anti-Tn; 7/79 by anti-T), breast carcinoma (10/23 by anti-Tn; 7/23 by anti-T), and kidney carcinoma (45/51 by anti-Tn; 42/51 by anti-T). |
| T9 | 1362-1604 | Sentence | denotes | Our results suggest that purified human anti-Tn and anti-T antibodies have a potential as anti-tumor therapeutic agents; restoring their levels in human sera could positively affect the evolution of patients with epithelial tumor pathologies. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 138-144 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 171-177 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 544-554 | Glycan | denotes | Tn-antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 544-554 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Tn-antigen | http://www.glycoepitope.jp/epitopes/EP0021 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 9-14 | OrganismTaxon | denotes | human | 9606 |
| T2 | 664-669 | OrganismTaxon | denotes | human | 9606 |
| T3 | 734-739 | OrganismTaxon | denotes | human | 9606 |
| T4 | 1110-1115 | OrganismTaxon | denotes | human | 9606 |
| T5 | 1396-1401 | OrganismTaxon | denotes | human | 9606 |
| T6 | 1509-1514 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 670-676 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T2 | 1116-1122 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T3 | 1199-1204 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
| T4 | 1251-1257 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T5 | 1308-1314 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 68-77 | Phenotype | denotes | carcinoma | HP:0030731 |
| T2 | 119-125 | Phenotype | denotes | cancer | HP:0002664 |
| T3 | 216-221 | Phenotype | denotes | tumor | HP:0002664 |
| T4 | 305-310 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 728-733 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 1205-1214 | Phenotype | denotes | carcinoma | HP:0030731 |
| T7 | 1251-1267 | Phenotype | denotes | breast carcinoma | HP:0003002 |
| T8 | 1315-1324 | Phenotype | denotes | carcinoma | HP:0030731 |
| T9 | 1457-1462 | Phenotype | denotes | tumor | HP:0002664 |
| T10 | 1586-1591 | Phenotype | denotes | tumor | HP:0002664 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 119-131 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |