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PubMed:31138793 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 110-198 DRI_Approach denotes Regulatory T cells (Tregs) have crucial functions in the inhibition of immune responses.
T2 199-367 DRI_Background denotes Their development and suppressive functions are controlled by the T cell receptor (TCR), but the TCR signaling mechanisms that mediate these effects remain ill-defined.
T3 368-560 DRI_Outcome denotes Here we show that CARD11-BCL10-MALT1 (CBM) signaling mediates TCR-induced NF-κB activation in Tregs and controls the conversion of resting Tregs to effector Tregs under homeostatic conditions.
T4 561-666 DRI_Approach denotes However, in inflammatory milieus, cytokines can bypass the CBM requirement for this differentiation step.
T5 667-699 DRI_Background denotes By contrast, CBM signaling, in a
T6 725-794 DRI_Background denotes manner, is essential for mediating the suppressive function of Tregs.
T7 795-961 DRI_Background denotes In malignant melanoma models, acute genetic blockade of BCL10 signaling selectively in Tregs or pharmacological MALT1 inhibition enhances anti-tumor immune responses.
T8 962-1155 DRI_Approach denotes Together, our data uncover a segregation of Treg differentiation and suppressive function at the CBM complex level, and provide a rationale to explore MALT1 inhibitors for cancer immunotherapy.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 35-43 CVCL_C410|Hybridoma|Mus musculus denotes activity
T2 373-375 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T3 442-444 CVCL_W770|Cancer_cell_line|Homo sapiens denotes NF
T4 446-447 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T5 448-458 CVCL_C410|Hybridoma|Mus musculus denotes activation
T6 698-699 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 989-990 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 1090-1091 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 1134-1140 CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens denotes cancer

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-5 PR:Q9Z0H7 denotes Bcl10
T2 0-5 PR:000004689 denotes Bcl10
T3 0-5 Q9QYN5 denotes Bcl10
T4 0-5 PR:O95999 denotes Bcl10
T5 0-5 Q9Z0H7 denotes Bcl10
T6 0-5 O95999 denotes Bcl10
T7 0-5 PR:Q9QYN5 denotes Bcl10
T10 17-21 UBERON:0001961 denotes Malt
T11 17-22 PR:Q9UDY8 denotes Malt1
T12 17-22 PR:Q2TBA3 denotes Malt1
T13 17-22 PR:000010096 denotes Malt1
T14 17-34 D000074884 denotes Malt1 paracaspase
T15 23-34 Q2TBA3 denotes paracaspase
T16 23-34 Q9GPM2 denotes paracaspase
T17 23-34 Q9UDY8 denotes paracaspase
T19 23-34 PR:000010096 denotes paracaspase
T20 265-271 CL:0000084 denotes T cell
T21 265-280 D011948 denotes T cell receptor
T22 282-285 PR:000015975 denotes TCR
T24 282-285 A2KF29 denotes TCR
T25 282-285 GO:0042101 denotes TCR
T23 282-285 GO:0006283 denotes TCR
T26 296-299 PR:000015975 denotes TCR
T28 296-299 A2KF29 denotes TCR
T29 296-299 GO:0042101 denotes TCR
T27 296-299 GO:0006283 denotes TCR
T30 300-309 GO:0023052 denotes signaling
T31 386-392 PR:Q9BXL7 denotes CARD11
T32 386-392 PR:Q8CIS0 denotes CARD11
T33 386-392 PR:000005034 denotes CARD11
T34 393-398 PR:Q9Z0H7 denotes BCL10
T35 393-398 PR:000004689 denotes BCL10
T36 393-398 Q9QYN5 denotes BCL10
T37 393-398 PR:O95999 denotes BCL10
T38 393-398 Q9Z0H7 denotes BCL10
T39 393-398 O95999 denotes BCL10
T40 393-398 PR:Q9QYN5 denotes BCL10
T43 399-403 UBERON:0001961 denotes MALT
T44 399-404 PR:Q9UDY8 denotes MALT1
T45 399-404 PR:Q2TBA3 denotes MALT1
T46 399-404 PR:000010096 denotes MALT1
T47 411-420 GO:0023052 denotes signaling
T48 430-433 PR:000015975 denotes TCR
T50 430-433 A2KF29 denotes TCR
T51 430-433 GO:0042101 denotes TCR
T49 430-433 GO:0006283 denotes TCR
T54 516-524 CHEBI:35224 denotes effector
T55 595-604 D016207 denotes cytokines
T56 595-604 D016207 denotes cytokines
T57 684-693 GO:0023052 denotes signaling
T60 700-704 UBERON:0001961 denotes MALT
T61 700-705 PR:Q9UDY8 denotes MALT1
T62 700-705 PR:Q2TBA3 denotes MALT1
T63 700-705 PR:000010096 denotes MALT1
T64 706-714 P68985 denotes protease
T65 706-714 P30202 denotes protease
T66 706-714 P42672 denotes protease
T67 706-714 P11826 denotes protease
T68 706-714 Q5TJ03 denotes protease
T69 706-714 O71070 denotes protease
T70 706-714 P63122 denotes protease
T71 706-714 P63131 denotes protease
T72 706-714 Q9IIH4 denotes protease
T73 706-714 P10270 denotes protease
T74 706-714 Q8JN66 denotes protease
T75 706-714 O40958 denotes protease
T76 706-714 P10265 denotes protease
T77 706-714 Q9QM72 denotes protease
T78 706-714 P63119 denotes protease
T79 706-714 Q9WF19 denotes protease
T80 706-714 P63120 denotes protease
T81 706-714 P63125 denotes protease
T82 706-714 P63124 denotes protease
T83 706-714 P68986 denotes protease
T84 706-714 Q96629 denotes protease
T85 706-714 P63121 denotes protease
T86 706-714 P09569 denotes protease
T87 706-714 P03253 denotes protease
T88 706-714 P63129 denotes protease
T89 706-714 P10381 denotes protease
T90 706-714 P07885 denotes protease
T91 706-714 Q83906 denotes protease
T92 706-714 P19119 denotes protease
T93 706-714 P63127 denotes protease
T94 706-714 Q84177 denotes protease
T95 706-714 P19151 denotes protease
T96 706-714 Q9Y6I0 denotes protease
T97 706-714 P63123 denotes protease
T98 706-714 P68984 denotes protease
T99 706-714 P87563 denotes protease
T100 706-714 P03252 denotes protease
T101 706-714 O71150 denotes protease
T102 706-714 P11825 denotes protease
T103 798-816 D008545 denotes malignant melanoma
T104 798-816 D008545 denotes malignant melanoma
T107 851-856 PR:Q9Z0H7 denotes BCL10
T108 851-856 PR:000004689 denotes BCL10
T109 851-856 Q9QYN5 denotes BCL10
T110 851-856 PR:O95999 denotes BCL10
T111 851-856 Q9Z0H7 denotes BCL10
T112 851-856 O95999 denotes BCL10
T113 851-856 PR:Q9QYN5 denotes BCL10
T114 857-866 GO:0023052 denotes signaling
T117 907-911 UBERON:0001961 denotes MALT
T118 907-912 PR:Q9UDY8 denotes MALT1
T119 907-912 PR:Q2TBA3 denotes MALT1
T120 907-912 PR:000010096 denotes MALT1
T121 938-943 D009369 denotes tumor
T122 938-943 D009369 denotes tumor
T123 1006-1010 CL:0000792 denotes Treg
T124 1006-1010 CL:0000815 denotes Treg
T125 1059-1070 GO:0032449 denotes CBM complex
T128 1113-1117 UBERON:0001961 denotes MALT
T129 1113-1118 PR:Q9UDY8 denotes MALT1
T130 1113-1118 PR:Q2TBA3 denotes MALT1
T131 1113-1118 PR:000010096 denotes MALT1
T132 1119-1129 CHEBI:35222 denotes inhibitors

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 798-816 Phenotype denotes malignant melanoma HP:0002861
T2 938-943 Phenotype denotes tumor HP:0002664
T3 1134-1140 Phenotype denotes cancer HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 59-77 Disease denotes immune suppressive http://purl.obolibrary.org/obo/MONDO_0007816
T2 798-816 Disease denotes malignant melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T3 938-943 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T4 1134-1140 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 265-271 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 90-108 Cell denotes regulatory T cells http://purl.obolibrary.org/obo/CL:0000815
T2 110-128 Cell denotes Regulatory T cells http://purl.obolibrary.org/obo/CL:0000815
T3 265-271 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T4 1006-1010 Cell denotes Treg http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815