PubMed:31110314
Annnotations
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 71-180 | DRI_Challenge | denotes | epresents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections. |
T2 | 181-306 | DRI_Background | denotes | Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC). |
T3 | 307-463 | DRI_Challenge | denotes | In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC. |
T4 | 464-537 | DRI_Background | denotes | Cytokines linked to cancer-associated cachexia did not contribute to IAC. |
T5 | 538-546 | DRI_Background | denotes | Instead, |
T6 | 567-678 | DRI_Background | denotes | T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores. |
T7 | 679-856 | DRI_Approach | denotes | These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming. |
T8 | 857-998 | DRI_Outcome | denotes | Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC. |
Goldhamster2_Cellosaurus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 81-82 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T2 | 135-142 | CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens | denotes | cancers |
T3 | 233-236 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
T4 | 233-236 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
T5 | 301-304 | CVCL_X373|Transformed_cell_line|Rattus norvegicus | denotes | IAC |
T6 | 328-330 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
T7 | 340-341 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T8 | 421-423 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T9 | 421-423 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T10 | 459-462 | CVCL_X373|Transformed_cell_line|Rattus norvegicus | denotes | IAC |
T11 | 484-490 | CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens | denotes | cancer |
T12 | 533-536 | CVCL_X373|Transformed_cell_line|Rattus norvegicus | denotes | IAC |
T13 | 608-615 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | changes |
T14 | 685-692 | CVCL_0238|Cancer_cell_line|Homo sapiens | denotes | changes |
T15 | 705-706 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
T16 | 707-711 | CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens | denotes | time |
T17 | 736-740 | CVCL_3772|Transformed_cell_line|Homo sapiens | denotes | peak |
T18 | 950-952 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
T19 | 950-952 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
T20 | 994-997 | CVCL_X373|Transformed_cell_line|Rattus norvegicus | denotes | IAC |
Inflammaging
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-60 | Sentence | denotes | CD8+ T cells induce cachexia during chronic viral infection. |
T2 | 61-180 | Sentence | denotes | Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections. |
T3 | 181-306 | Sentence | denotes | Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC). |
T4 | 307-463 | Sentence | denotes | In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC. |
T5 | 464-537 | Sentence | denotes | Cytokines linked to cancer-associated cachexia did not contribute to IAC. |
T6 | 538-678 | Sentence | denotes | Instead, virus-specific CD8+ T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores. |
T7 | 679-856 | Sentence | denotes | These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming. |
T8 | 857-998 | Sentence | denotes | Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC. |
T1 | 0-60 | Sentence | denotes | CD8+ T cells induce cachexia during chronic viral infection. |
T2 | 61-180 | Sentence | denotes | Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections. |
T3 | 181-306 | Sentence | denotes | Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC). |
T4 | 307-463 | Sentence | denotes | In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC. |
T5 | 464-537 | Sentence | denotes | Cytokines linked to cancer-associated cachexia did not contribute to IAC. |
T6 | 538-678 | Sentence | denotes | Instead, virus-specific CD8+ T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores. |
T7 | 679-856 | Sentence | denotes | These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming. |
T8 | 857-998 | Sentence | denotes | Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC. |
GoldHamster
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 20-28 | D002100 | denotes | cachexia |
T2 | 20-28 | D002100 | denotes | cachexia |
T3 | 44-59 | GO:0016032 | denotes | viral infection |
T4 | 44-59 | D014777 | denotes | viral infection |
T5 | 44-59 | D014777 | denotes | viral infection |
T8 | 135-142 | D009369 | denotes | cancers |
T9 | 135-142 | D009369 | denotes | cancers |
T10 | 152-164 | GO:0006954 | denotes | inflammation |
T11 | 152-164 | D007249 | denotes | inflammation |
T12 | 152-164 | D007249 | denotes | inflammation |
T13 | 224-232 | D002100 | denotes | cachexia |
T14 | 224-232 | D002100 | denotes | cachexia |
T15 | 270-279 | D007239 | denotes | infection |
T16 | 270-279 | D007239 | denotes | infection |
T17 | 291-299 | D002100 | denotes | cachexia |
T18 | 291-299 | D002100 | denotes | cachexia |
T20 | 301-304 | CVCL_X373 | denotes | IAC |
T19 | 301-304 | UBERON:2002269 | denotes | IAC |
T21 | 362-370 | D002100 | denotes | cachexia |
T22 | 362-370 | D002100 | denotes | cachexia |
T23 | 374-378 | PR:000005054 | denotes | mice |
T25 | 374-378 | O89094 | denotes | mice |
T24 | 374-378 | D051379 | denotes | mice |
T26 | 374-378 | 10095 | denotes | mice |
T27 | 392-407 | GO:0016032 | denotes | viral infection |
T28 | 392-407 | D014777 | denotes | viral infection |
T29 | 392-407 | D014777 | denotes | viral infection |
T33 | 459-462 | CVCL_X373 | denotes | IAC |
T32 | 459-462 | UBERON:2002269 | denotes | IAC |
T34 | 464-473 | D016207 | denotes | Cytokines |
T35 | 464-473 | D016207 | denotes | Cytokines |
T36 | 502-510 | D002100 | denotes | cachexia |
T37 | 502-510 | D002100 | denotes | cachexia |
T39 | 533-536 | CVCL_X373 | denotes | IAC |
T38 | 533-536 | UBERON:2002269 | denotes | IAC |
T41 | 623-637 | UBERON:0001013 | denotes | adipose tissue |
T43 | 665-670 | CHEBI:18059 | denotes | lipid |
T44 | 753-759 | CL:0000084 | denotes | T cell |
T45 | 782-788 | CL:0000084 | denotes | T cell |
T48 | 799-816 | PR:000025848 | denotes | type I interferon |
T46 | 799-816 | D007370 | denotes | type I interferon |
T47 | 799-816 | D007370 | denotes | type I interferon |
T54 | 817-826 | GO:0023052 | denotes | signaling |
T55 | 831-838 | D000941 | denotes | antigen |
T56 | 831-838 | CHEBI:59132 | denotes | antigen |
T57 | 831-838 | D000941 | denotes | antigen |
T58 | 883-892 | CHEBI:22587 | denotes | antiviral |
T60 | 913-927 | UBERON:0001013 | denotes | adipose-tissue |
T62 | 921-938 | GO:0048771 | denotes | tissue remodeling |
T64 | 994-997 | CVCL_X373 | denotes | IAC |
T63 | 994-997 | UBERON:2002269 | denotes | IAC |