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PubMed:31110314 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 71-180 DRI_Challenge denotes epresents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections.
T2 181-306 DRI_Background denotes Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC).
T3 307-463 DRI_Challenge denotes In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC.
T4 464-537 DRI_Background denotes Cytokines linked to cancer-associated cachexia did not contribute to IAC.
T5 538-546 DRI_Background denotes Instead,
T6 567-678 DRI_Background denotes T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores.
T7 679-856 DRI_Approach denotes These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming.
T8 857-998 DRI_Outcome denotes Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 81-82 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 135-142 CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens denotes cancers
T3 233-236 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T4 233-236 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T5 301-304 CVCL_X373|Transformed_cell_line|Rattus norvegicus denotes IAC
T6 328-330 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T7 340-341 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 421-423 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T9 421-423 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T10 459-462 CVCL_X373|Transformed_cell_line|Rattus norvegicus denotes IAC
T11 484-490 CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens denotes cancer
T12 533-536 CVCL_X373|Transformed_cell_line|Rattus norvegicus denotes IAC
T13 608-615 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T14 685-692 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T15 705-706 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T16 707-711 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T17 736-740 CVCL_3772|Transformed_cell_line|Homo sapiens denotes peak
T18 950-952 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T19 950-952 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T20 994-997 CVCL_X373|Transformed_cell_line|Rattus norvegicus denotes IAC

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes CD8+ T cells induce cachexia during chronic viral infection.
T2 61-180 Sentence denotes Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections.
T3 181-306 Sentence denotes Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC).
T4 307-463 Sentence denotes In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC.
T5 464-537 Sentence denotes Cytokines linked to cancer-associated cachexia did not contribute to IAC.
T6 538-678 Sentence denotes Instead, virus-specific CD8+ T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores.
T7 679-856 Sentence denotes These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming.
T8 857-998 Sentence denotes Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC.
T1 0-60 Sentence denotes CD8+ T cells induce cachexia during chronic viral infection.
T2 61-180 Sentence denotes Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic inflammation and infections.
T3 181-306 Sentence denotes Understanding of the mechanisms that drive cachexia has remained limited, especially for infection-associated cachexia (IAC).
T4 307-463 Sentence denotes In the present paper we describe a model of reversible cachexia in mice with chronic viral infection and identify an essential role for CD8+ T cells in IAC.
T5 464-537 Sentence denotes Cytokines linked to cancer-associated cachexia did not contribute to IAC.
T6 538-678 Sentence denotes Instead, virus-specific CD8+ T cells caused morphologic and molecular changes in the adipose tissue, which led to depletion of lipid stores.
T7 679-856 Sentence denotes These changes occurred at a time point that preceded the peak of the CD8+ T cell response and required T cell-intrinsic type I interferon signaling and antigen-specific priming.
T8 857-998 Sentence denotes Our results link systemic antiviral immune responses to adipose-tissue remodeling and reveal an underappreciated role of CD8+ T cells in IAC.

GoldHamster

Id Subject Object Predicate Lexical cue
T1 20-28 D002100 denotes cachexia
T2 20-28 D002100 denotes cachexia
T3 44-59 GO:0016032 denotes viral infection
T4 44-59 D014777 denotes viral infection
T5 44-59 D014777 denotes viral infection
T8 135-142 D009369 denotes cancers
T9 135-142 D009369 denotes cancers
T10 152-164 GO:0006954 denotes inflammation
T11 152-164 D007249 denotes inflammation
T12 152-164 D007249 denotes inflammation
T13 224-232 D002100 denotes cachexia
T14 224-232 D002100 denotes cachexia
T15 270-279 D007239 denotes infection
T16 270-279 D007239 denotes infection
T17 291-299 D002100 denotes cachexia
T18 291-299 D002100 denotes cachexia
T20 301-304 CVCL_X373 denotes IAC
T19 301-304 UBERON:2002269 denotes IAC
T21 362-370 D002100 denotes cachexia
T22 362-370 D002100 denotes cachexia
T23 374-378 PR:000005054 denotes mice
T25 374-378 O89094 denotes mice
T24 374-378 D051379 denotes mice
T26 374-378 10095 denotes mice
T27 392-407 GO:0016032 denotes viral infection
T28 392-407 D014777 denotes viral infection
T29 392-407 D014777 denotes viral infection
T33 459-462 CVCL_X373 denotes IAC
T32 459-462 UBERON:2002269 denotes IAC
T34 464-473 D016207 denotes Cytokines
T35 464-473 D016207 denotes Cytokines
T36 502-510 D002100 denotes cachexia
T37 502-510 D002100 denotes cachexia
T39 533-536 CVCL_X373 denotes IAC
T38 533-536 UBERON:2002269 denotes IAC
T41 623-637 UBERON:0001013 denotes adipose tissue
T43 665-670 CHEBI:18059 denotes lipid
T44 753-759 CL:0000084 denotes T cell
T45 782-788 CL:0000084 denotes T cell
T48 799-816 PR:000025848 denotes type I interferon
T46 799-816 D007370 denotes type I interferon
T47 799-816 D007370 denotes type I interferon
T54 817-826 GO:0023052 denotes signaling
T55 831-838 D000941 denotes antigen
T56 831-838 CHEBI:59132 denotes antigen
T57 831-838 D000941 denotes antigen
T58 883-892 CHEBI:22587 denotes antiviral
T60 913-927 UBERON:0001013 denotes adipose-tissue
T62 921-938 GO:0048771 denotes tissue remodeling
T64 994-997 CVCL_X373 denotes IAC
T63 994-997 UBERON:2002269 denotes IAC