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sonoma

Id Subject Object Predicate Lexical cue
T-0 28-41 NEGREG denotes Reversibility
T-1 45-53 DISEASE denotes Fibrosis
T-2 81-94 DISEASE denotes Heart Failure
T-3 121-129 DISEASE denotes fibrosis
T-4 184-195 REG denotes dysfunction
T-5 199-212 DISEASE denotes heart failure
T-6 214-216 DISEASE denotes HF
T-7 222-229 REG denotes depends
T-8 233-243 POSREG denotes activation
T-9 248-263 CPA denotes differentiation
T-10 361-363 DISEASE denotes HF
T-11 365-373 DISEASE denotes fibrosis
T-12 445-460 CPA denotes differentiation
T-13 491-493 DISEASE denotes HF
T-14 1046-1054 DISEASE denotes fibrosis
T-15 1073-1081 GENE denotes collagen
T-16 1085-1094 POSREG denotes prominent
T-17 1098-1100 DISEASE denotes HF
T-18 1151-1157 MPA denotes levels
T-19 1174-1196 GENE denotes growth factor (TGF)-β1
T-20 1198-1211 GENE denotes lysyl oxidase
T-21 1213-1222 GENE denotes periostin
T-22 1228-1239 GENE denotes osteopontin
T-23 1244-1252 POSREG denotes elevated
T-24 1287-1289 DISEASE denotes HF
T-25 1406-1408 DISEASE denotes HF
T-26 1423-1427 POSREG denotes high
T-27 1450-1459 GENE denotes cytokines
T-28 1468-1482 PATHWAY denotes TGF-β1 pathway
T-29 1486-1495 POSREG denotes activated
T-30 1497-1507 NEGREG denotes Inhibition
T-31 1511-1517 GENE denotes TGF-β1
T-32 1537-1539 DISEASE denotes HF
T-33 1546-1554 POSREG denotes promotes
T-34 1555-1572 CPA denotes dedifferentiation
T-35 1587-1591 NEGREG denotes loss
T-36 1611-1616 GENE denotes actin
T-37 1621-1654 MPA denotes depolymerization of stress fibers
T-38 1660-1667 NEGREG denotes reduces
T-39 1672-1682 MPA denotes expression
T-40 1774-1776 DISEASE denotes HF
T-41 1784-1792 REG denotes variable
T-42 1803-1818 CPA denotes differentiation
T-43 1823-1829 POSREG denotes retain
T-44 1858-1862 NEGREG denotes less
R-6 T-3 T-7 ThemeOf fibrosis,depends
R-7 T-9 T-7 ThemeOf differentiation,depends
R-8 T-8 T-7 ThemeOf activation,depends
R-9 T-13 T-12 ThemeOf HF,differentiation
R-10 T-14 T-16 ThemeOf fibrosis,prominent
R-11 T-16 T-17 CauseOf prominent,HF
R-12 T-19 T-18 ThemeOf growth factor (TGF)-β1,levels
R-13 T-19 T-23 ThemeOf growth factor (TGF)-β1,elevated
R-14 T-18 T-23 ThemeOf levels,elevated
R-15 T-20 T-23 ThemeOf lysyl oxidase,elevated
R-16 T-20 T-18 ThemeOf lysyl oxidase,levels
R-17 T-21 T-23 ThemeOf periostin,elevated
R-18 T-21 T-18 ThemeOf periostin,levels
R-19 T-22 T-23 ThemeOf osteopontin,elevated
R-0 T-1 T-0 ThemeOf Fibrosis,Reversibility
R-1 T-2 T-1 ThemeOf Heart Failure,Fibrosis
R-2 T-5 T-4 ThemeOf heart failure,dysfunction
R-3 T-6 T-4 ThemeOf HF,dysfunction
R-4 T-3 T-5 CauseOf fibrosis,heart failure
R-5 T-3 T-6 CauseOf fibrosis,HF
R-20 T-22 T-18 ThemeOf osteopontin,levels
R-21 T-28 T-29 ThemeOf TGF-β1 pathway,activated
R-22 T-30 T-38 CauseOf Inhibition,reduces
R-23 T-39 T-38 ThemeOf expression,reduces
R-24 T-41 T-43 CauseOf variable,retain
R-25 T-42 T-41 ThemeOf differentiation,variable

sonoma2

Id Subject Object Predicate Lexical cue
T0 0-23 CPA denotes Myofibroblast Phenotype
T1 28-41 REG denotes Reversibility
T2 45-53 DISEASE denotes Fibrosis
T3 71-94 DISEASE denotes End-Stage Heart Failure
T4 108-129 DISEASE denotes Interstitial fibrosis
T5 120-128 DISEASE denotes fibrosi
T6 183-211 DISEASE denotes dysfunction in heart failur
T7 184-195 REG denotes dysfunction
T8 199-212 DISEASE denotes heart failure
T9 214-216 DISEASE denotes HF
T10 222-229 REG denotes depends
T11 233-243 POSREG denotes activation
T12 248-263 CPA denotes differentiation
T13 361-363 DISEASE denotes HF
T14 364-372 DISEASE denotes fibrosi
T15 365-373 DISEASE denotes fibrosis
T16 381-391 REG denotes reversible
T17 445-460 CPA denotes differentiation
T18 481-493 DISEASE denotes end-stage HF
T19 533-546 REG denotes reversibility
T20 654-662 DISEASE denotes s (ische
T21 667-689 DISEASE denotes nd dilated cardiomyopa
T22 670-692 DISEASE denotes dilated cardiomyopathy
T23 1033-1054 DISEASE denotes Interstitial fibrosis
T24 1042-1050 DISEASE denotes ial fibr
T25 1060-1072 REG denotes cross-linked
T26 1073-1081 GENE denotes collagen
T27 1085-1094 POSREG denotes prominent
T28 1098-1100 DISEASE denotes HF
T29 1126-1135 POSREG denotes activated
T30 1151-1157 MPA denotes levels
T31 1157-1195 GENE denotes of transforming growth factor (TGF)-β
T32 1161-1196 GENE denotes transforming growth factor (TGF)-β1
T33 1198-1211 GENE denotes lysyl oxidase
T34 1212-1221 GENE denotes periosti
T35 1213-1222 GENE denotes periostin
T36 1227-1238 GENE denotes osteoponti
T37 1228-1239 GENE denotes osteopontin
T38 1244-1252 POSREG denotes elevated
T39 1287-1289 DISEASE denotes HF
T40 1362-1368 NEGREG denotes mature
T41 1369-1377 GENE denotes α-smooth
T42 1406-1408 DISEASE denotes HF
T43 1423-1427 POSREG denotes high
T44 1428-1434 MPA denotes levels
T45 1438-1459 GENE denotes profibrotic cytokines
T46 1468-1474 GENE denotes TGF-β1
T47 1471-1480 GENE denotes -β1 pathw
T48 1486-1495 POSREG denotes activated
T49 1497-1507 NEGREG denotes Inhibition
T50 1511-1517 GENE denotes TGF-β1
T51 1517-1526 GENE denotes receptor
T52 1537-1539 DISEASE denotes HF
T53 1546-1554 POSREG denotes promotes
T54 1555-1572 CPA denotes dedifferentiation
T55 1587-1591 NEGREG denotes loss
T56 1595-1616 GENE denotes α-smooth muscle actin
T57 1621-1654 MPA denotes depolymerization of stress fibers
T58 1660-1667 NEGREG denotes reduces
T59 1672-1682 MPA denotes expression
T60 1686-1697 GENE denotes profibrotic
T61 1708-1724 MPA denotes cytokines levels
T62 1764-1776 DISEASE denotes end-stage HF
T63 1784-1792 REG denotes variable
T64 1803-1818 CPA denotes differentiation
T65 1823-1829 POSREG denotes retain
T66 1858-1862 NEGREG denotes less
T67 1920-1940 DISEASE denotes antifibrotic therapy
R8 T11 T7 CauseOf activation,dysfunction
R9 T11 T10 ThemeOf activation,depends
R10 T12 T10 ThemeOf differentiation,depends
R11 T13 T16 ThemeOf HF,reversible
R12 T15 T16 ThemeOf fibrosis,reversible
R13 T18 T17 ThemeOf end-stage HF,differentiation
R14 T18 T19 ThemeOf end-stage HF,reversibility
R15 T23 T25 ThemeOf Interstitial fibrosis,cross-linked
R0 T2 T1 ThemeOf Fibrosis,Reversibility
R1 T3 T1 ThemeOf End-Stage Heart Failure,Reversibility
R2 T4 T10 ThemeOf Interstitial fibrosis,depends
R3 T7 T10 ThemeOf dysfunction,depends
R4 T8 T7 ThemeOf heart failure,dysfunction
R5 T8 T10 ThemeOf heart failure,depends
R6 T9 T7 ThemeOf HF,dysfunction
R7 T9 T10 ThemeOf HF,depends
R16 T23 T27 ThemeOf Interstitial fibrosis,prominent
R17 T26 T27 ThemeOf collagen,prominent
R18 T28 T25 ThemeOf HF,cross-linked
R19 T28 T27 ThemeOf HF,prominent
R20 T28 T38 ThemeOf HF,elevated
R21 T30 T38 ThemeOf levels,elevated
R22 T32 T30 ThemeOf transforming growth factor (TGF)-β1,levels
R23 T32 T38 ThemeOf transforming growth factor (TGF)-β1,elevated
R24 T33 T30 ThemeOf lysyl oxidase,levels
R25 T33 T38 ThemeOf lysyl oxidase,elevated
R26 T35 T30 ThemeOf periostin,levels
R27 T35 T38 ThemeOf periostin,elevated
R28 T37 T30 ThemeOf osteopontin,levels
R29 T37 T38 ThemeOf osteopontin,elevated
R30 T42 T43 ThemeOf HF,high
R31 T42 T44 ThemeOf HF,levels
R32 T42 T48 ThemeOf HF,activated
R33 T44 T43 ThemeOf levels,high
R34 T45 T44 ThemeOf profibrotic cytokines,levels
R35 T44 T48 ThemeOf levels,activated
R36 T45 T43 ThemeOf profibrotic cytokines,high
R37 T45 T48 ThemeOf profibrotic cytokines,activated
R38 T46 T44 ThemeOf TGF-β1,levels
R39 T46 T48 ThemeOf TGF-β1,activated
R40 T52 T49 ThemeOf HF,Inhibition
R41 T49 T53 CauseOf Inhibition,promotes
R42 T49 T54 CauseOf Inhibition,dedifferentiation
R43 T49 T55 CauseOf Inhibition,loss
R44 T49 T58 CauseOf Inhibition,reduces
R45 T50 T49 ThemeOf TGF-β1,Inhibition
R46 T52 T53 ThemeOf HF,promotes
R47 T54 T53 ThemeOf dedifferentiation,promotes
R48 T56 T55 ThemeOf α-smooth muscle actin,loss
R49 T57 T55 ThemeOf depolymerization of stress fibers,loss
R50 T59 T58 ThemeOf expression,reduces
R51 T60 T59 ThemeOf profibrotic,expression
R52 T61 T59 ThemeOf cytokines levels,expression
R53 T61 T58 ThemeOf cytokines levels,reduces
R54 T62 T63 ThemeOf end-stage HF,variable
R55 T62 T64 ThemeOf end-stage HF,differentiation
R56 T62 T65 ThemeOf end-stage HF,retain
R57 T63 T65 CauseOf variable,retain
R58 T64 T63 ThemeOf differentiation,variable

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure.
T2 96-107 Sentence denotes BACKGROUND:
T3 108-307 Sentence denotes Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts into myofibroblasts (MyoFb).
T4 308-392 Sentence denotes Recent clinical evidence suggests that in late-stage HF, fibrosis is not reversible.
T5 393-404 Sentence denotes OBJECTIVES:
T6 405-547 Sentence denotes The study aims to examine the degree of differentiation of cardiac MyoFb in end-stage HF and the potential for their phenotypic reversibility.
T7 548-556 Sentence denotes METHODS:
T8 557-725 Sentence denotes Fibroblasts were isolated from the left ventricle of the explanted hearts of transplant recipients (ischemic and dilated cardiomyopathy), and from nonused donor hearts.
T9 726-819 Sentence denotes Fibroblasts were maintained in culture without passaging for 4 or 8 days (treatment studies).
T10 820-931 Sentence denotes Phenotyping included functional testing, immunostaining, and expression studies for markers of differentiation.
T11 932-1023 Sentence denotes These data were complemented with immunohistology and expression studies in tissue samples.
T12 1024-1032 Sentence denotes RESULTS:
T13 1033-1143 Sentence denotes Interstitial fibrosis with cross-linked collagen is prominent in HF hearts, with presence of activated MyoFbs.
T14 1144-1253 Sentence denotes Tissue levels of transforming growth factor (TGF)-β1, lysyl oxidase, periostin, and osteopontin are elevated.
T15 1254-1405 Sentence denotes Fibroblastic cells isolated from HF hearts are predominantly MyoFb, proliferative or nonproliferative, with mature α-smooth muscle actin stress fibers.
T16 1406-1496 Sentence denotes HF MyoFb express high levels of profibrotic cytokines and the TGF-β1 pathway is activated.
T17 1497-1742 Sentence denotes Inhibition of TGF-β1 receptor kinase in HF MyoFb promotes dedifferentiation of MyoFb with loss of α-smooth muscle actin and depolymerization of stress fibers, and reduces the expression of profibrotic genes and cytokines levels to non-HF levels.
T18 1743-1754 Sentence denotes CONCLUSION:
T19 1755-1957 Sentence denotes MyoFb in end-stage HF have a variable degree of differentiation and retain the capacity to return to a less activated state, validating the potential for developing antifibrotic therapy targeting MyoFb.
T1 0-95 Sentence denotes Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure.
T2 96-107 Sentence denotes BACKGROUND:
T3 108-307 Sentence denotes Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts into myofibroblasts (MyoFb).
T4 308-392 Sentence denotes Recent clinical evidence suggests that in late-stage HF, fibrosis is not reversible.
T5 393-404 Sentence denotes OBJECTIVES:
T6 405-547 Sentence denotes The study aims to examine the degree of differentiation of cardiac MyoFb in end-stage HF and the potential for their phenotypic reversibility.
T7 548-556 Sentence denotes METHODS:
T8 557-725 Sentence denotes Fibroblasts were isolated from the left ventricle of the explanted hearts of transplant recipients (ischemic and dilated cardiomyopathy), and from nonused donor hearts.
T9 726-819 Sentence denotes Fibroblasts were maintained in culture without passaging for 4 or 8 days (treatment studies).
T10 820-931 Sentence denotes Phenotyping included functional testing, immunostaining, and expression studies for markers of differentiation.
T11 932-1023 Sentence denotes These data were complemented with immunohistology and expression studies in tissue samples.
T12 1024-1032 Sentence denotes RESULTS:
T13 1033-1143 Sentence denotes Interstitial fibrosis with cross-linked collagen is prominent in HF hearts, with presence of activated MyoFbs.
T14 1144-1253 Sentence denotes Tissue levels of transforming growth factor (TGF)-β1, lysyl oxidase, periostin, and osteopontin are elevated.
T15 1254-1405 Sentence denotes Fibroblastic cells isolated from HF hearts are predominantly MyoFb, proliferative or nonproliferative, with mature α-smooth muscle actin stress fibers.
T16 1406-1496 Sentence denotes HF MyoFb express high levels of profibrotic cytokines and the TGF-β1 pathway is activated.
T17 1497-1742 Sentence denotes Inhibition of TGF-β1 receptor kinase in HF MyoFb promotes dedifferentiation of MyoFb with loss of α-smooth muscle actin and depolymerization of stress fibers, and reduces the expression of profibrotic genes and cytokines levels to non-HF levels.
T18 1743-1754 Sentence denotes CONCLUSION:
T19 1755-1957 Sentence denotes MyoFb in end-stage HF have a variable degree of differentiation and retain the capacity to return to a less activated state, validating the potential for developing antifibrotic therapy targeting MyoFb.