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PubMed:31028175 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells.
T2 129-274 Sentence denotes Dysfunctional p53 formation and activity can result from aberrant expression and subcellular localization of distinct p53 isoforms or aggregates.
T3 275-424 Sentence denotes Endometrial carcinoma (EC) is a cancer type in which p53 status is correlated with prognosis, and TP53 mutations are a frequent genetic modification.
T4 425-644 Sentence denotes Here we aimed to evaluate the expression patterns of different p53 isoforms and their contributions to the formation and subcellular localization of p53 amyloid aggregates in both EC and endometrial nontumor cell lines.
T5 645-872 Sentence denotes We found that full-length (fl) p53 and a truncated p53 isoform, Δ40p53, resulting from alternative splicing of exon 2 or alternative initiation of translation at ATG-40, are the predominantly expressed p53 variants in EC cells.
T6 873-945 Sentence denotes However, Δ40p53 was the major p53 isoform in endometrial nontumor cells.
T7 946-1151 Sentence denotes Immunofluorescence assays revealed that Δ40p53 is mainly localized to cytoplasmic punctate structures of EC cells, resembling solid-phase structures similar to those found in neurodegenerative pathologies.
T8 1152-1412 Sentence denotes Using light-scattering kinetics, CD, and transmission EM, we noted that the p53 N-terminal transactivation domain significantly reduces aggregation of the WT p53 DNA-binding domain, confirming the higher aggregation tendency of Δ40p53, which lacks this domain.
T9 1413-1518 Sentence denotes This is the first report of cytoplasmic Δ40p53 in EC cells being a major component of amyloid aggregates.
T10 1519-1748 Sentence denotes The differential aggregation properties of p53 isoforms in EC cells may open up new avenues in the development of therapeutic strategies that preferentially target specific p53 isoforms to prevent p53 amyloid aggregate formation.

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 100-121 Phenotype denotes endometrial carcinoma HP:0012114
T2 275-296 Phenotype denotes Endometrial carcinoma HP:0012114
T3 298-300 Phenotype denotes EC HP:0012114
T4 307-313 Phenotype denotes cancer HP:0002664
T5 605-607 Phenotype denotes EC HP:0012114
T6 863-865 Phenotype denotes EC HP:0012114
T7 1051-1053 Phenotype denotes EC HP:0012114
T8 1463-1465 Phenotype denotes EC HP:0012114
T9 1578-1580 Phenotype denotes EC HP:0012114

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 55-62 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 100-121 Disease denotes endometrial carcinoma http://purl.obolibrary.org/obo/MONDO_0002447
T3 275-296 Disease denotes Endometrial carcinoma http://purl.obolibrary.org/obo/MONDO_0002447
T4 298-300 Disease denotes EC http://purl.obolibrary.org/obo/MONDO_0002447
T5 307-313 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T6 578-585 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T7 605-607 Disease denotes EC http://purl.obolibrary.org/obo/MONDO_0002447
T8 863-865 Disease denotes EC http://purl.obolibrary.org/obo/MONDO_0002447
T9 1051-1053 Disease denotes EC http://purl.obolibrary.org/obo/MONDO_0002447
T10 1463-1465 Disease denotes EC http://purl.obolibrary.org/obo/MONDO_0002447
T11 1499-1506 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T12 1578-1580 Disease denotes EC http://purl.obolibrary.org/obo/MONDO_0002447
T13 1720-1727 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1016-1027 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T2 1441-1452 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737