PubMed:30975214
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 124-258 | DRI_Challenge | denotes | Staphylococcus aureus is the most commonly isolated pathogen from clinical bovine mastitis samples and a difficult pathogen to combat. |
| T2 | 259-386 | DRI_Background | denotes | Mesenchymal stem cells (MSC) are multipotent progenitor cells equipped with a variety of factors that inhibit bacterial growth. |
| T3 | 387-598 | DRI_Background | denotes | The aim of the present study was to evaluate the in vitro antibacterial potential against S. aureus of conditioned medium (CM) from MSC derived from fetal bovine bone marrow (BM-MSC) and adipose tissue (AT-MSC). |
| T4 | 599-693 | DRI_Background | denotes | BM-MSC, AT-MSC and fetal fibroblasts (FB) cultures were activated by infection with S. aureus. |
| T5 | 694-841 | DRI_Background | denotes | Bacterial growth was evaluated in presence of CM, concentrated CM (CCM), activated CM (ACM) and concentrated ACM (CACM) from BM-MSC, AT-MSC and FB. |
| T6 | 842-1068 | DRI_Approach | denotes | Gene expression of β-defensin 4A (bBD-4A), NK-lysine 1 (NK1), cathelicidin 2 (CATHL2), hepcidin (HEP) and indoleamine 2,3 dioxygenase (IDO) and protein expression of bBD-4A were determined in activated and non-activated cells. |
| T7 | 1069-1162 | DRI_Background | denotes | The majority of BM-MSC and AT-MSC expressed CD73, Oct4 and Nanog, and were negative for CD34. |
| T8 | 1163-1246 | DRI_Background | denotes | Growth of S. aureus decreased when it was exposed to CM from BM-MSC, AT-MSC and FB. |
| T9 | 1247-1358 | DRI_Background | denotes | Moreover, growth of S. aureus in CCM, ACM and CACM was lower compared to controls of CM from BM-MSC and AT-MSC. |
| T10 | 1359-1450 | DRI_Background | denotes | Activated AT-MSC increased mRNA levels of bBD4A and NK1, and protein levels of bBD4A in CM. |
| T11 | 1451-1594 | DRI_Approach | denotes | Thus, CM from fetal bovine BM-MSC and AT-MSC has the capacity to reduce in average ~30% of S. aureus relative growth under in vitro conditions. |
| T12 | 1595-1691 | DRI_Outcome | denotes | The in vitro antibacterial effect of fetal bovine MSC may be mediated by bBD4A and NK1 activity. |
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-6 | 9913 | denotes | Bovine |
| T2 | 75-83 | D008413 | denotes | mastitis |
| T3 | 75-83 | D008413 | denotes | mastitis |
| T5 | 101-122 | D013211 | denotes | Staphylococcus aureus |
| T6 | 101-122 | 1280 | denotes | Staphylococcus aureus |
| T7 | 199-205 | 9913 | denotes | bovine |
| T8 | 199-214 | D008414 | denotes | bovine mastitis |
| T9 | 199-214 | D008414 | denotes | bovine mastitis |
| T12 | 283-286 | PR:000010664 | denotes | MSC |
| T13 | 283-286 | PR:O60682 | denotes | MSC |
| T14 | 283-286 | PR:O88940 | denotes | MSC |
| T15 | 283-286 | CL:0000134 | denotes | MSC |
| T16 | 490-508 | D017077 | denotes | conditioned medium |
| T17 | 519-522 | PR:000010664 | denotes | MSC |
| T18 | 519-522 | PR:O60682 | denotes | MSC |
| T19 | 519-522 | PR:O88940 | denotes | MSC |
| T20 | 519-522 | CL:0000134 | denotes | MSC |
| T21 | 542-548 | 9913 | denotes | bovine |
| T22 | 542-560 | CVCL_4399 | denotes | bovine bone marrow |
| T26 | 549-560 | UBERON:0002371 | denotes | bone marrow |
| T25 | 549-560 | D001855 | denotes | bone marrow |
| T27 | 549-560 | D001855 | denotes | bone marrow |
| T28 | 565-568 | PR:000010664 | denotes | MSC |
| T29 | 565-568 | PR:O60682 | denotes | MSC |
| T30 | 565-568 | PR:O88940 | denotes | MSC |
| T31 | 565-568 | CL:0000134 | denotes | MSC |
| T33 | 574-588 | UBERON:0001013 | denotes | adipose tissue |
| T35 | 593-596 | PR:000010664 | denotes | MSC |
| T36 | 593-596 | PR:O60682 | denotes | MSC |
| T37 | 593-596 | PR:O88940 | denotes | MSC |
| T38 | 593-596 | CL:0000134 | denotes | MSC |
| T39 | 602-605 | PR:000010664 | denotes | MSC |
| T40 | 602-605 | PR:O60682 | denotes | MSC |
| T41 | 602-605 | PR:O88940 | denotes | MSC |
| T42 | 602-605 | CL:0000134 | denotes | MSC |
| T43 | 610-613 | PR:000010664 | denotes | MSC |
| T44 | 610-613 | PR:O60682 | denotes | MSC |
| T45 | 610-613 | PR:O88940 | denotes | MSC |
| T46 | 610-613 | CL:0000134 | denotes | MSC |
| T47 | 668-677 | D007239 | denotes | infection |
| T48 | 668-677 | D007239 | denotes | infection |
| T49 | 761-764 | CVCL_2613 | denotes | CCM |
| T50 | 761-764 | CVCL_R825 | denotes | CCM |
| T51 | 761-764 | D020786 | denotes | CCM |
| T52 | 781-784 | UBERON:0012649 | denotes | ACM |
| T53 | 803-806 | UBERON:0012649 | denotes | ACM |
| T54 | 822-825 | PR:000010664 | denotes | MSC |
| T55 | 822-825 | PR:O60682 | denotes | MSC |
| T56 | 822-825 | PR:O88940 | denotes | MSC |
| T57 | 822-825 | CL:0000134 | denotes | MSC |
| T58 | 830-833 | PR:000010664 | denotes | MSC |
| T59 | 830-833 | PR:O60682 | denotes | MSC |
| T60 | 830-833 | PR:O88940 | denotes | MSC |
| T61 | 830-833 | CL:0000134 | denotes | MSC |
| T62 | 842-857 | GO:0010467 | denotes | Gene expression |
| T63 | 863-871 | Q86QN6 | denotes | defensin |
| T64 | 863-871 | Q5BU36 | denotes | defensin |
| T65 | 863-871 | P83404 | denotes | defensin |
| T66 | 863-871 | C0HJX7 | denotes | defensin |
| T67 | 863-871 | P80407 | denotes | defensin |
| T68 | 863-871 | P37364 | denotes | defensin |
| T69 | 863-871 | Q10745 | denotes | defensin |
| T70 | 863-871 | Q17027 | denotes | defensin |
| T71 | 863-871 | Q8WQZ3 | denotes | defensin |
| T72 | 863-871 | P85213 | denotes | defensin |
| T73 | 863-871 | Q86LE4 | denotes | defensin |
| T74 | 863-871 | P81462 | denotes | defensin |
| T76 | 863-871 | Q86QI5 | denotes | defensin |
| T77 | 863-871 | B2D2C0 | denotes | defensin |
| T78 | 863-871 | O96049 | denotes | defensin |
| T79 | 863-871 | P80154 | denotes | defensin |
| T80 | 863-871 | P36192 | denotes | defensin |
| T75 | 863-871 | CHEBI:82761 | denotes | defensin |
| T84 | 888-894 | 6536 | denotes | lysine |
| T81 | 888-894 | SO:0001450 | denotes | lysine |
| T82 | 888-894 | CHEBI:25094 | denotes | lysine |
| T83 | 888-894 | D008239 | denotes | lysine |
| T85 | 888-894 | D008239 | denotes | lysine |
| T86 | 888-894 | CHEBI:18019 | denotes | lysine |
| T87 | 898-901 | PR:P22807 | denotes | NK1 |
| T88 | 904-916 | C070646 | denotes | cathelicidin |
| T89 | 904-916 | CHEBI:81578 | denotes | cathelicidin |
| T90 | 904-916 | C070646 | denotes | cathelicidin |
| T91 | 904-918 | P19660 | denotes | cathelicidin 2 |
| T92 | 904-918 | P82018 | denotes | cathelicidin 2 |
| T93 | 904-918 | Q2IAL7 | denotes | cathelicidin 2 |
| T94 | 904-918 | P79362 | denotes | cathelicidin 2 |
| T95 | 920-926 | PR:Q2IAL7 | denotes | CATHL2 |
| T96 | 929-937 | PR:000008438 | denotes | hepcidin |
| T97 | 929-937 | Q99MH3 | denotes | hepcidin |
| T98 | 929-937 | P82951 | denotes | hepcidin |
| T99 | 929-937 | Q5U9D2 | denotes | hepcidin |
| T100 | 929-937 | Q9DFD6 | denotes | hepcidin |
| T101 | 929-937 | Q9EQ21 | denotes | hepcidin |
| T102 | 929-937 | P81172 | denotes | hepcidin |
| T103 | 929-937 | Q5NVR8 | denotes | hepcidin |
| T104 | 929-937 | Q8MJ80 | denotes | hepcidin |
| T106 | 929-937 | A1Z0M0 | denotes | hepcidin |
| T105 | 929-937 | D064451 | denotes | hepcidin |
| T108 | 939-942 | PR:000008741 | denotes | HEP |
| T109 | 939-942 | PR:Q23977 | denotes | HEP |
| T110 | 939-942 | PR:Q9Y251 | denotes | HEP |
| T112 | 939-942 | PR:Q71RP1 | denotes | HEP |
| T113 | 939-942 | O15197 | denotes | HEP |
| T114 | 939-942 | PR:000007133 | denotes | HEP |
| T107 | 939-942 | CHEBI:48293 | denotes | HEP |
| T111 | 939-942 | CHEBI:60991 | denotes | HEP |
| T116 | 948-975 | P47125 | denotes | indoleamine 2,3 dioxygenase |
| T117 | 948-975 | PR:000009030 | denotes | indoleamine 2,3 dioxygenase |
| T118 | 948-975 | D050503 | denotes | indoleamine 2,3 dioxygenase |
| T119 | 964-980 | D050503 | denotes | dioxygenase (IDO |
| T120 | 977-980 | PR:P28776 | denotes | IDO |
| T121 | 977-980 | PR:P14902 | denotes | IDO |
| T122 | 977-980 | P47125 | denotes | IDO |
| T124 | 977-980 | PR:000009030 | denotes | IDO |
| T125 | 977-980 | E2GIN1 | denotes | IDO |
| T128 | 977-980 | PR:Q9ERD9 | denotes | IDO |
| T126 | 977-980 | GO:0033754 | denotes | IDO |
| T127 | 977-980 | GO:0047719 | denotes | IDO |
| T133 | 986-993 | SO:0000104 | denotes | protein |
| T132 | 986-993 | PR:000000001 | denotes | protein |
| T129 | 986-993 | GO:0003675 | denotes | protein |
| T130 | 986-993 | CHEBI:36080 | denotes | protein |
| T131 | 986-993 | CHEBI:11122 | denotes | protein |
| T134 | 1088-1091 | PR:000010664 | denotes | MSC |
| T135 | 1088-1091 | PR:O60682 | denotes | MSC |
| T136 | 1088-1091 | PR:O88940 | denotes | MSC |
| T137 | 1088-1091 | CL:0000134 | denotes | MSC |
| T138 | 1099-1102 | PR:000010664 | denotes | MSC |
| T139 | 1099-1102 | PR:O60682 | denotes | MSC |
| T140 | 1099-1102 | PR:O88940 | denotes | MSC |
| T141 | 1099-1102 | CL:0000134 | denotes | MSC |
| T142 | 1113-1117 | PR:000001800 | denotes | CD73 |
| T143 | 1119-1123 | P20263 | denotes | Oct4 |
| T144 | 1119-1123 | Q5TM49 | denotes | Oct4 |
| T145 | 1119-1123 | Q9TSV5 | denotes | Oct4 |
| T146 | 1119-1123 | PR:P20263 | denotes | Oct4 |
| T147 | 1119-1123 | PR:Q01860 | denotes | Oct4 |
| T148 | 1119-1123 | PR:Q9LHQ6 | denotes | Oct4 |
| T149 | 1119-1123 | Q01860 | denotes | Oct4 |
| T150 | 1119-1123 | PR:000013044 | denotes | Oct4 |
| T151 | 1128-1133 | PR:A7Y7W3 | denotes | Nanog |
| T152 | 1128-1133 | PR:Q80Z64 | denotes | Nanog |
| T153 | 1128-1133 | PR:000010968 | denotes | Nanog |
| T154 | 1128-1133 | PR:Q9H9S0 | denotes | Nanog |
| T155 | 1157-1161 | PR:P28906 | denotes | CD34 |
| T156 | 1157-1161 | PR:000001003 | denotes | CD34 |
| T157 | 1157-1161 | PR:Q64314 | denotes | CD34 |
| T158 | 1227-1230 | PR:000010664 | denotes | MSC |
| T159 | 1227-1230 | PR:O60682 | denotes | MSC |
| T160 | 1227-1230 | PR:O88940 | denotes | MSC |
| T161 | 1227-1230 | CL:0000134 | denotes | MSC |
| T162 | 1235-1238 | PR:000010664 | denotes | MSC |
| T163 | 1235-1238 | PR:O60682 | denotes | MSC |
| T164 | 1235-1238 | PR:O88940 | denotes | MSC |
| T165 | 1235-1238 | CL:0000134 | denotes | MSC |
| T166 | 1280-1283 | CVCL_2613 | denotes | CCM |
| T167 | 1280-1283 | CVCL_R825 | denotes | CCM |
| T168 | 1280-1283 | D020786 | denotes | CCM |
| T169 | 1285-1288 | UBERON:0012649 | denotes | ACM |
| T170 | 1343-1346 | PR:000010664 | denotes | MSC |
| T171 | 1343-1346 | PR:O60682 | denotes | MSC |
| T172 | 1343-1346 | PR:O88940 | denotes | MSC |
| T173 | 1343-1346 | CL:0000134 | denotes | MSC |
| T174 | 1354-1357 | PR:000010664 | denotes | MSC |
| T175 | 1354-1357 | PR:O60682 | denotes | MSC |
| T176 | 1354-1357 | PR:O88940 | denotes | MSC |
| T177 | 1354-1357 | CL:0000134 | denotes | MSC |
| T178 | 1372-1375 | PR:000010664 | denotes | MSC |
| T179 | 1372-1375 | PR:O60682 | denotes | MSC |
| T180 | 1372-1375 | PR:O88940 | denotes | MSC |
| T181 | 1372-1375 | CL:0000134 | denotes | MSC |
| T184 | 1386-1390 | SO:0000234 | denotes | mRNA |
| T182 | 1386-1390 | D012333 | denotes | mRNA |
| T183 | 1386-1390 | CHEBI:33699 | denotes | mRNA |
| T185 | 1411-1414 | PR:P22807 | denotes | NK1 |
| T189 | 1420-1427 | PR:000000001 | denotes | protein |
| T190 | 1420-1427 | SO:0000104 | denotes | protein |
| T186 | 1420-1427 | GO:0003675 | denotes | protein |
| T187 | 1420-1427 | CHEBI:36080 | denotes | protein |
| T188 | 1420-1427 | CHEBI:11122 | denotes | protein |
| T191 | 1471-1477 | 9913 | denotes | bovine |
| T192 | 1481-1484 | PR:000010664 | denotes | MSC |
| T193 | 1481-1484 | PR:O60682 | denotes | MSC |
| T194 | 1481-1484 | PR:O88940 | denotes | MSC |
| T195 | 1481-1484 | CL:0000134 | denotes | MSC |
| T196 | 1492-1495 | PR:000010664 | denotes | MSC |
| T197 | 1492-1495 | PR:O60682 | denotes | MSC |
| T198 | 1492-1495 | PR:O88940 | denotes | MSC |
| T199 | 1492-1495 | CL:0000134 | denotes | MSC |
| T200 | 1638-1644 | 9913 | denotes | bovine |
| T201 | 1645-1648 | PR:000010664 | denotes | MSC |
| T202 | 1645-1648 | PR:O60682 | denotes | MSC |
| T203 | 1645-1648 | PR:O88940 | denotes | MSC |
| T204 | 1645-1648 | CL:0000134 | denotes | MSC |
| T205 | 1678-1681 | PR:P22807 | denotes | NK1 |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 227-228 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T2 | 335-336 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T3 | 510-512 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CM |
| T4 | 542-560 | CVCL_4399|Finite_cell_line|Bos taurus | denotes | bovine bone marrow |
| T5 | 562-564 | CVCL_E481|Transformed_cell_line|Homo sapiens | denotes | BM |
| T6 | 562-564 | CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer | denotes | BM |
| T7 | 599-601 | CVCL_E481|Transformed_cell_line|Homo sapiens | denotes | BM |
| T8 | 599-601 | CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer | denotes | BM |
| T9 | 655-664 | CVCL_C410|Hybridoma|Mus musculus | denotes | activated |
| T10 | 740-742 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CM |
| T11 | 757-759 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CM |
| T12 | 761-764 | CVCL_2613|Cancer_cell_line|Homo sapiens | denotes | CCM |
| T13 | 761-764 | CVCL_R825|Spontaneously_immortalized_cell_line|Labeo catla | denotes | CCM |
| T14 | 761-764 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CCM |
| T15 | 767-776 | CVCL_C410|Hybridoma|Mus musculus | denotes | activated |
| T16 | 777-779 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CM |
| T17 | 819-821 | CVCL_E481|Transformed_cell_line|Homo sapiens | denotes | BM |
| T18 | 819-821 | CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer | denotes | BM |
| T19 | 885-887 | CVCL_1D01|Cancer_cell_line|Rattus norvegicus | denotes | NK |
| T20 | 1034-1043 | CVCL_C410|Hybridoma|Mus musculus | denotes | activated |
| T21 | 1052-1061 | CVCL_C410|Hybridoma|Mus musculus | denotes | activated |
| T22 | 1085-1087 | CVCL_E481|Transformed_cell_line|Homo sapiens | denotes | BM |
| T23 | 1085-1087 | CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer | denotes | BM |
| T24 | 1216-1218 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CM |
| T25 | 1224-1226 | CVCL_E481|Transformed_cell_line|Homo sapiens | denotes | BM |
| T26 | 1224-1226 | CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer | denotes | BM |
| T27 | 1280-1283 | CVCL_2613|Cancer_cell_line|Homo sapiens | denotes | CCM |
| T28 | 1280-1283 | CVCL_R825|Spontaneously_immortalized_cell_line|Labeo catla | denotes | CCM |
| T29 | 1280-1283 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CCM |
| T30 | 1332-1334 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CM |
| T31 | 1340-1342 | CVCL_E481|Transformed_cell_line|Homo sapiens | denotes | BM |
| T32 | 1340-1342 | CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer | denotes | BM |
| T33 | 1359-1368 | CVCL_C410|Hybridoma|Mus musculus | denotes | Activated |
| T34 | 1447-1449 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CM |
| T35 | 1457-1459 | CVCL_H246|Cancer_cell_line|Homo sapiens | denotes | CM |
| T36 | 1478-1480 | CVCL_E481|Transformed_cell_line|Homo sapiens | denotes | BM |
| T37 | 1478-1480 | CVCL_S926|Spontaneously_immortalized_cell_line|Lates calcarifer | denotes | BM |
| T38 | 1496-1499 | CVCL_6758|Undefined_cell_line_type|Cricetulus griseus | denotes | has |
| T39 | 1496-1499 | CVCL_E689|Transformed_cell_line|Homo sapiens | denotes | has |
| T40 | 1535-1537 | CVCL_J925|Hybridoma|Mus musculus | denotes | 30 |
| T41 | 1649-1652 | CVCL_E773|Transformed_cell_line|Homo sapiens | denotes | may |
| T42 | 1682-1690 | CVCL_C410|Hybridoma|Mus musculus | denotes | activity |