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sonoma2

Id Subject Object Predicate Lexical cue
T0 0-6 GENE denotes TIMP-1
T1 7-15 REG denotes Mediates
T2 16-28 CPA denotes Inflammatory
T3 33-48 CPA denotes Immune Response
T4 52-56 GENE denotes IL-6
T5 66-101 DISEASE denotes Orbital Xanthogranulomatous Disease
T6 127-139 MPA denotes pathogenesis
T7 145-151 GENE denotes TIMP-1
T8 152-160 REG denotes mediated
T9 164-205 DISEASE denotes adult orbital xanthogranulomatous disease
T10 170-205 DISEASE denotes orbital xanthogranulomatous disease
T11 207-212 DISEASE denotes AOXGD
T12 230-258 DISEASE denotes non-Langerhans histiocytosis
T13 264-271 NEGREG denotes damages
T14 276-286 CPA denotes appearance
T15 302-306 CPA denotes life
T16 366-371 DISEASE denotes AOXGD
T17 458-468 MPA denotes expression
T18 472-478 GENE denotes TIMP-1
T19 473-479 GENE denotes IMP-1
T20 483-487 GENE denotes IL-6
T21 484-488 GENE denotes L-6
T22 510-515 DISEASE denotes AOXGD
T23 551-559 REG denotes involved
T24 567-576 POSREG denotes induction
T25 580-586 GENE denotes TIMP-1
T26 581-587 GENE denotes IMP-1
T27 591-595 GENE denotes L-6.
T28 604-608 GENE denotes IL-6
T29 606-610 GENE denotes -6 a
T30 613-619 GENE denotes TIMP-1
T31 615-621 GENE denotes MP-1 w
T32 639-648 POSREG denotes increased
T33 652-657 DISEASE denotes AOXGD
T34 669-673 GENE denotes -6 p
T35 672-680 POSREG denotes promoted
T36 683-689 GENE denotes MP-1 p
T37 688-698 MPA denotes production
T38 720-731 POSREG denotes stimulating
T39 736-751 MPA denotes phosphorylation
T40 755-759 GENE denotes JAK2
T41 757-761 GENE denotes K2 a
T42 766-771 GENE denotes AT3.
T43 781-786 GENE denotes IL-17
T44 783-788 GENE denotes -17 a
T45 793-802 GENE denotes N-γ, the
T46 812-819 MPA denotes markers
T47 823-826 CPA denotes Th1
T48 829-832 GENE denotes d T
T49 831-841 CPA denotes Th17 cells
T50 848-857 POSREG denotes increased
T51 890-897 REG denotes implied
T52 907-947 PATHWAY denotes IL6~JAK2/STAT3-TIMP-1 signalling pathway
T53 914-935 GENE denotes 2/STAT3-TIMP-1 signal
T54 951-960 POSREG denotes activated
T55 964-969 DISEASE denotes AOXGD
T56 995-998 GENE denotes Th
T57 996-1010 CPA denotes Th17 responses
T58 1015-1023 REG denotes involved
T59 1046-1051 DISEASE denotes AOXGD
R18 T14 T13 ThemeOf appearance,damages
R19 T15 T13 ThemeOf life,damages
R20 T16 T23 ThemeOf AOXGD,involved
R21 T17 T23 ThemeOf expression,involved
R22 T17 T24 ThemeOf expression,induction
R23 T18 T17 ThemeOf TIMP-1,expression
R24 T18 T23 ThemeOf TIMP-1,involved
R0 T0 T1 ThemeOf TIMP-1,Mediates
R1 T2 T1 ThemeOf Inflammatory,Mediates
R2 T3 T1 ThemeOf Immune Response,Mediates
R3 T5 T1 ThemeOf Orbital Xanthogranulomatous Disease,Mediates
R4 T5 T3 ThemeOf Orbital Xanthogranulomatous Disease,Immune Response
R5 T6 T8 ThemeOf pathogenesis,mediated
R6 T7 T6 ThemeOf TIMP-1,pathogenesis
R7 T7 T8 ThemeOf TIMP-1,mediated
R8 T7 T17 ThemeOf TIMP-1,expression
R9 T9 T6 ThemeOf adult orbital xanthogranulomatous disease,pathogenesis
R10 T9 T8 ThemeOf adult orbital xanthogranulomatous disease,mediated
R11 T9 T13 ThemeOf adult orbital xanthogranulomatous disease,damages
R12 T11 T6 ThemeOf AOXGD,pathogenesis
R13 T11 T8 ThemeOf AOXGD,mediated
R14 T11 T13 ThemeOf AOXGD,damages
R15 T12 T6 ThemeOf non-Langerhans histiocytosis,pathogenesis
R16 T12 T8 ThemeOf non-Langerhans histiocytosis,mediated
R17 T12 T13 CauseOf non-Langerhans histiocytosis,damages
R25 T20 T17 ThemeOf IL-6,expression
R26 T20 T23 ThemeOf IL-6,involved
R27 T22 T17 ThemeOf AOXGD,expression
R28 T22 T23 ThemeOf AOXGD,involved
R29 T22 T24 ThemeOf AOXGD,induction
R30 T24 T13 CauseOf induction,damages
R31 T24 T23 CauseOf induction,involved
R32 T25 T17 ThemeOf TIMP-1,expression
R33 T25 T23 ThemeOf TIMP-1,involved
R34 T25 T24 ThemeOf TIMP-1,induction
R35 T28 T32 ThemeOf IL-6,increased
R36 T30 T32 ThemeOf TIMP-1,increased
R37 T33 T32 ThemeOf AOXGD,increased
R38 T37 T35 ThemeOf production,promoted
R39 T38 T35 CauseOf stimulating,promoted
R40 T37 T38 ThemeOf production,stimulating
R41 T39 T38 ThemeOf phosphorylation,stimulating
R42 T40 T39 ThemeOf JAK2,phosphorylation
R43 T40 T38 ThemeOf JAK2,stimulating
R44 T43 T46 ThemeOf IL-17,markers
R45 T43 T50 ThemeOf IL-17,increased
R46 T47 T46 ThemeOf Th1,markers
R47 T49 T46 ThemeOf Th17 cells,markers
R48 T46 T50 ThemeOf markers,increased
R49 T47 T50 ThemeOf Th1,increased
R50 T49 T50 ThemeOf Th17 cells,increased
R51 T51 T54 ThemeOf implied,activated
R52 T52 T51 ThemeOf IL6~JAK2/STAT3-TIMP-1 signalling pathway,implied
R53 T52 T54 ThemeOf IL6~JAK2/STAT3-TIMP-1 signalling pathway,activated
R54 T55 T51 ThemeOf AOXGD,implied
R55 T55 T54 ThemeOf AOXGD,activated
R56 T55 T58 ThemeOf AOXGD,involved
R57 T57 T51 ThemeOf Th17 responses,implied
R58 T57 T54 ThemeOf Th17 responses,activated
R59 T57 T58 ThemeOf Th17 responses,involved
R60 T59 T51 ThemeOf AOXGD,implied
R61 T59 T54 ThemeOf AOXGD,activated
R62 T59 T58 ThemeOf AOXGD,involved

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes TIMP-1 Mediates Inflammatory and Immune Response to IL-6 in Adult Orbital Xanthogranulomatous Disease.
T2 103-111 Sentence denotes Purpose:
T3 112-326 Sentence denotes To explore the pathogenesis that TIMP-1 mediated in adult orbital xanthogranulomatous disease (AOXGD), a rare type of non-Langerhans histiocytosis that damages the appearance and quality of life of patientsMethods:
T4 327-666 Sentence denotes We reviewed 22 patients diagnosed with AOXGD based on clinical manifestations and histological analysis, and then investigated the expression of TIMP-1 and IL-6 with q-PCR and IHC in AOXGD tissues and the possible mechanism involved in the induction of TIMP-1 by IL-6.Results: IL-6 and TIMP-1 were significantly increased in AOXGD tissues.
T5 667-770 Sentence denotes IL-6 promoted TIMP-1 production by M1 macrophages by stimulating the phosphorylation of JAK2 and STAT3.
T6 771-878 Sentence denotes Moreover, IL-17 and IFN-γ, the classical markers of Th1 and Th17 cells, were increased in AOXGD.Conclusion:
T7 879-1052 Sentence denotes These data implied that the IL6~JAK2/STAT3-TIMP-1 signalling pathway is activated in AOXGD and that adaptive Th1 and Th17 responses are involved in the development of AOXGD.
T1 0-102 Sentence denotes TIMP-1 Mediates Inflammatory and Immune Response to IL-6 in Adult Orbital Xanthogranulomatous Disease.
T2 103-111 Sentence denotes Purpose:
T3 112-326 Sentence denotes To explore the pathogenesis that TIMP-1 mediated in adult orbital xanthogranulomatous disease (AOXGD), a rare type of non-Langerhans histiocytosis that damages the appearance and quality of life of patientsMethods:
T4 327-666 Sentence denotes We reviewed 22 patients diagnosed with AOXGD based on clinical manifestations and histological analysis, and then investigated the expression of TIMP-1 and IL-6 with q-PCR and IHC in AOXGD tissues and the possible mechanism involved in the induction of TIMP-1 by IL-6.Results: IL-6 and TIMP-1 were significantly increased in AOXGD tissues.
T5 667-770 Sentence denotes IL-6 promoted TIMP-1 production by M1 macrophages by stimulating the phosphorylation of JAK2 and STAT3.
T6 771-878 Sentence denotes Moreover, IL-17 and IFN-γ, the classical markers of Th1 and Th17 cells, were increased in AOXGD.Conclusion:
T7 879-1052 Sentence denotes These data implied that the IL6~JAK2/STAT3-TIMP-1 signalling pathway is activated in AOXGD and that adaptive Th1 and Th17 responses are involved in the development of AOXGD.