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Id Subject Object Predicate Lexical cue
T50 980-992 MPA denotes NO-cysteinyl
T51 999-1012 DISEASE denotes schizophrenia
T52 1057-1062 MPA denotes ratio
T53 1066-1069 MPA denotes IgM
T54 1073-1080 GENE denotes zonulin
T55 1073-1080 GENE denotes zonulin
T56 1083-1097 GENE denotes occludin/talin
T57 1083-1097 GENE denotes occludin/talin
T58 1100-1105 GENE denotes actin
T59 1108-1115 GENE denotes viculin
T60 1117-1127 MPA denotes PARA/TRANS
T61 1147-1154 POSREG denotes greater
T62 1158-1165 DISEASE denotes deficit
T63 1180-1205 DISEASE denotes non-deficit schizophrenia
T64 1192-1205 DISEASE denotes schizophrenia
T65 1210-1216 POSREG denotes higher
T66 1220-1233 DISEASE denotes schizophrenia
T67 1279-1289 REG denotes associated
T68 1295-1304 POSREG denotes increased
T69 1305-1318 MPA denotes IgA responses
T70 1305-1308 GENE denotes IgA
T71 1350-1359 MPA denotes responses
T72 1363-1370 GENE denotes zonulin
T73 1363-1370 GENE denotes zonulin
T74 1376-1386 POSREG denotes positively
T75 1387-1397 REG denotes associated
T76 1403-1416 DISEASE denotes schizophrenia
T77 1442-1445 MPA denotes IgM
T78 1449-1457 GENE denotes occludin
T79 1449-1457 GENE denotes occludin
T80 1476-1486 REG denotes associated
T81 1492-1513 DISEASE denotes deficit schizophrenia
T82 1492-1547 DISEASE denotes deficit schizophrenia (versus non-deficit schizophrenia
T83 1534-1547 DISEASE denotes schizophrenia
T84 1616-1620 CPA denotes PHEM
T85 1622-1631 CPA denotes psychosis
T86 1622-1631 DISEASE denotes psychosis
T87 1633-1642 CPA denotes hostility
T88 1644-1669 CPA denotes excitation, and mannerism
T89 1697-1713 MPA denotes PARA/TRANS ratio
T90 1715-1718 MPA denotes IgA
T91 1715-1718 GENE denotes IgA
T92 1746-1749 MPA denotes IgM
T93 1753-1763 GENE denotes E-cadherin
T94 1753-1763 GENE denotes E-cadherin
T95 1768-1771 MPA denotes MDA
T96 1777-1796 MPA denotes memory dysfunctions
T97 1777-1796 DISEASE denotes memory dysfunctions
T98 1857-1873 MPA denotes PARA/TRANS ratio
T99 1875-1878 MPA denotes IgA
T100 1875-1878 GENE denotes IgA
T101 1906-1912 GENE denotes CCL-11
T102 1906-1912 GENE denotes CCL-11
T103 1914-1921 MPA denotes TRYCATs
T104 1927-1944 CPA denotes immune activation
T105 1966-1977 POSREG denotes upregulated
T106 1978-1998 PATHWAY denotes paracellular pathway
T107 2021-2049 MPA denotes tight and adherens junctions
T108 2054-2063 POSREG denotes increased
T109 2064-2087 CPA denotes bacterial translocation
T110 2091-2112 DISEASE denotes deficit schizophrenia
T111 2184-2191 NEGREG denotes lowered
T112 2200-2203 MPA denotes IgM
T113 2205-2222 CPA denotes immune activation
T114 2228-2238 MPA denotes production
T115 2242-2248 GENE denotes CCL-11
T116 2242-2248 GENE denotes CCL-11
T117 2253-2260 MPA denotes TRYCATs
T118 2261-2271 REG denotes contribute
T119 2296-2317 DISEASE denotes deficit schizophrenia
T0 0-12 POSREG denotes Upregulation
T1 20-51 PATHWAY denotes Intestinal Paracellular Pathway
T2 57-66 NEGREG denotes Breakdown
T3 70-98 MPA denotes Tight and Adherens Junctions
T4 102-123 DISEASE denotes Deficit Schizophrenia
T5 179-192 DISEASE denotes schizophrenia
T6 196-206 REG denotes associated
T7 215-224 POSREG denotes increased
T8 225-234 MPA denotes frequency
T9 242-253 GENE denotes haptoglobin
T10 271-280 MPA denotes precursor
T11 284-288 GENE denotes Hp-2
T12 292-299 GENE denotes zonulin
T13 292-299 GENE denotes zonulin
T14 303-311 MPA denotes molecule
T15 317-324 REG denotes affects
T16 325-363 CPA denotes intercellular tight junction integrity
T17 387-396 POSREG denotes increased
T18 397-421 MPA denotes plasma IgA/IgM responses
T19 404-411 GENE denotes IgA/IgM
T20 451-472 DISEASE denotes deficit schizophrenia
T21 498-511 MPA denotes gut dysbiosis
T22 502-511 DISEASE denotes dysbiosis
T23 548-555 REG denotes examine
T24 675-682 DISEASE denotes deficit
T25 675-715 DISEASE denotes deficit versus non-deficit schizophrenia
T26 702-715 DISEASE denotes schizophrenia
T27 729-742 MPA denotes IgM responses
T28 746-753 GENE denotes zonulin
T29 746-753 GENE denotes zonulin
T30 755-763 GENE denotes occludin
T31 755-763 GENE denotes occludin
T32 765-775 GENE denotes E-cadherin
T33 777-782 GENE denotes talin
T34 784-789 GENE denotes actin
T35 795-803 GENE denotes vinculin
T36 795-803 GENE denotes vinculin
T37 807-818 REG denotes association
T38 824-837 MPA denotes IgA responses
T39 824-827 GENE denotes IgA
T40 865-871 GENE denotes CCL-11
T41 865-871 GENE denotes CCL-11
T42 873-886 MPA denotes IgA responses
T43 873-876 GENE denotes IgA
T44 890-912 MPA denotes tryptophan catabolites
T45 914-921 MPA denotes TRYCATs
T46 924-930 CPA denotes immune
T47 946-949 MPA denotes IgM
T48 953-968 MPA denotes malondialdehyde
T49 970-973 MPA denotes MDA
R22 T11 T8 ThemeOf Hp-2,frequency
R23 T11 T10 ThemeOf Hp-2,precursor
R24 T11 T14 ThemeOf Hp-2,molecule
R25 T12 T7 ThemeOf zonulin,increased
R99 T49 T38 ThemeOf MDA,IgA responses
R100 T49 T42 ThemeOf MDA,IgA responses
R101 T49 T45 ThemeOf MDA,TRYCATs
R102 T50 T37 ThemeOf NO-cysteinyl,association
R103 T50 T38 ThemeOf NO-cysteinyl,IgA responses
R104 T50 T42 ThemeOf NO-cysteinyl,IgA responses
R105 T50 T45 ThemeOf NO-cysteinyl,TRYCATs
R106 T50 T47 ThemeOf NO-cysteinyl,IgM
R107 T51 T27 ThemeOf schizophrenia,IgM responses
R157 T64 T61 ThemeOf schizophrenia,greater
R158 T64 T65 ThemeOf schizophrenia,higher
R159 T64 T67 ThemeOf schizophrenia,associated
R160 T64 T68 ThemeOf schizophrenia,increased
R161 T66 T52 ThemeOf schizophrenia,ratio
R162 T66 T53 ThemeOf schizophrenia,IgM
R163 T66 T60 ThemeOf schizophrenia,PARA/TRANS
R164 T66 T61 ThemeOf schizophrenia,greater
R238 T89 T96 ThemeOf PARA/TRANS ratio,memory dysfunctions
R239 T92 T90 ThemeOf IgM,IgA
R240 T95 T90 ThemeOf MDA,IgA
R241 T96 T90 ThemeOf memory dysfunctions,IgA
R242 T93 T92 ThemeOf E-cadherin,IgM
R243 T95 T92 ThemeOf MDA,IgM
R0 T1 T0 ThemeOf Intestinal Paracellular Pathway,Upregulation
R1 T2 T0 ThemeOf Breakdown,Upregulation
R2 T3 T2 ThemeOf Tight and Adherens Junctions,Breakdown
R3 T3 T0 ThemeOf Tight and Adherens Junctions,Upregulation
R4 T4 T0 ThemeOf Deficit Schizophrenia,Upregulation
R5 T4 T1 ThemeOf Deficit Schizophrenia,Intestinal Paracellular Pathway
R6 T4 T2 ThemeOf Deficit Schizophrenia,Breakdown
R7 T4 T3 ThemeOf Deficit Schizophrenia,Tight and Adherens Junctions
R8 T4 T6 ThemeOf Deficit Schizophrenia,associated
R9 T4 T7 ThemeOf Deficit Schizophrenia,increased
R10 T5 T0 ThemeOf schizophrenia,Upregulation
R11 T5 T2 ThemeOf schizophrenia,Breakdown
R12 T5 T6 ThemeOf schizophrenia,associated
R13 T5 T7 ThemeOf schizophrenia,increased
R14 T8 T7 ThemeOf frequency,increased
R15 T9 T7 ThemeOf haptoglobin,increased
R16 T9 T8 ThemeOf haptoglobin,frequency
R17 T9 T10 ThemeOf haptoglobin,precursor
R18 T9 T14 ThemeOf haptoglobin,molecule
R19 T10 T7 ThemeOf precursor,increased
R20 T10 T14 ThemeOf precursor,molecule
R21 T11 T7 ThemeOf Hp-2,increased
R26 T12 T8 ThemeOf zonulin,frequency
R27 T12 T10 ThemeOf zonulin,precursor
R28 T12 T14 ThemeOf zonulin,molecule
R29 T14 T15 CauseOf molecule,affects
R30 T16 T15 ThemeOf intercellular tight junction integrity,affects
R31 T18 T17 ThemeOf plasma IgA/IgM responses,increased
R32 T20 T17 ThemeOf deficit schizophrenia,increased
R33 T20 T18 ThemeOf deficit schizophrenia,plasma IgA/IgM responses
R34 T20 T21 ThemeOf deficit schizophrenia,gut dysbiosis
R35 T20 T23 ThemeOf deficit schizophrenia,examine
R36 T24 T23 ThemeOf deficit,examine
R37 T26 T24 ThemeOf schizophrenia,deficit
R38 T26 T17 ThemeOf schizophrenia,increased
R39 T26 T23 ThemeOf schizophrenia,examine
R40 T26 T37 ThemeOf schizophrenia,association
R41 T26 T38 ThemeOf schizophrenia,IgA responses
R42 T26 T42 ThemeOf schizophrenia,IgA responses
R43 T27 T37 ThemeOf IgM responses,association
R44 T27 T38 ThemeOf IgM responses,IgA responses
R45 T27 T42 ThemeOf IgM responses,IgA responses
R46 T28 T27 ThemeOf zonulin,IgM responses
R47 T28 T37 ThemeOf zonulin,association
R48 T28 T38 ThemeOf zonulin,IgA responses
R49 T28 T42 ThemeOf zonulin,IgA responses
R50 T30 T27 ThemeOf occludin,IgM responses
R51 T30 T37 ThemeOf occludin,association
R52 T30 T38 ThemeOf occludin,IgA responses
R53 T30 T42 ThemeOf occludin,IgA responses
R54 T33 T27 ThemeOf talin,IgM responses
R55 T33 T37 ThemeOf talin,association
R56 T33 T38 ThemeOf talin,IgA responses
R57 T33 T42 ThemeOf talin,IgA responses
R58 T34 T27 ThemeOf actin,IgM responses
R59 T34 T37 ThemeOf actin,association
R60 T34 T38 ThemeOf actin,IgA responses
R61 T34 T42 ThemeOf actin,IgA responses
R62 T34 T47 ThemeOf actin,IgM
R63 T35 T27 ThemeOf vinculin,IgM responses
R64 T35 T37 ThemeOf vinculin,association
R65 T35 T38 ThemeOf vinculin,IgA responses
R66 T35 T42 ThemeOf vinculin,IgA responses
R67 T35 T47 ThemeOf vinculin,IgM
R68 T38 T37 ThemeOf IgA responses,association
R69 T42 T37 ThemeOf IgA responses,association
R70 T45 T37 ThemeOf TRYCATs,association
R71 T47 T37 ThemeOf IgM,association
R72 T42 T38 ThemeOf IgA responses,IgA responses
R73 T44 T38 ThemeOf tryptophan catabolites,IgA responses
R74 T45 T38 ThemeOf TRYCATs,IgA responses
R75 T47 T38 ThemeOf IgM,IgA responses
R76 T40 T27 ThemeOf CCL-11,IgM responses
R77 T40 T37 ThemeOf CCL-11,association
R78 T40 T38 ThemeOf CCL-11,IgA responses
R79 T40 T45 ThemeOf CCL-11,TRYCATs
R80 T40 T47 ThemeOf CCL-11,IgM
R81 T44 T42 ThemeOf tryptophan catabolites,IgA responses
R82 T42 T45 ThemeOf IgA responses,TRYCATs
R83 T47 T42 ThemeOf IgM,IgA responses
R84 T44 T37 ThemeOf tryptophan catabolites,association
R85 T44 T45 ThemeOf tryptophan catabolites,TRYCATs
R86 T44 T47 ThemeOf tryptophan catabolites,IgM
R87 T47 T45 ThemeOf IgM,TRYCATs
R88 T46 T37 ThemeOf immune,association
R89 T46 T38 ThemeOf immune,IgA responses
R90 T46 T42 ThemeOf immune,IgA responses
R91 T46 T47 ThemeOf immune,IgM
R92 T48 T47 ThemeOf malondialdehyde,IgM
R93 T49 T47 ThemeOf MDA,IgM
R94 T48 T37 ThemeOf malondialdehyde,association
R95 T48 T38 ThemeOf malondialdehyde,IgA responses
R96 T48 T42 ThemeOf malondialdehyde,IgA responses
R97 T48 T45 ThemeOf malondialdehyde,TRYCATs
R98 T49 T37 ThemeOf MDA,association
R108 T51 T37 ThemeOf schizophrenia,association
R109 T51 T38 ThemeOf schizophrenia,IgA responses
R110 T51 T42 ThemeOf schizophrenia,IgA responses
R111 T51 T44 ThemeOf schizophrenia,tryptophan catabolites
R112 T51 T45 ThemeOf schizophrenia,TRYCATs
R113 T51 T46 ThemeOf schizophrenia,immune
R114 T51 T47 ThemeOf schizophrenia,IgM
R115 T51 T49 ThemeOf schizophrenia,MDA
R116 T51 T50 ThemeOf schizophrenia,NO-cysteinyl
R117 T53 T52 ThemeOf IgM,ratio
R118 T60 T52 ThemeOf PARA/TRANS,ratio
R119 T52 T61 ThemeOf ratio,greater
R120 T52 T65 ThemeOf ratio,higher
R121 T60 T53 ThemeOf PARA/TRANS,IgM
R122 T53 T61 ThemeOf IgM,greater
R123 T53 T65 ThemeOf IgM,higher
R124 T53 T67 ThemeOf IgM,associated
R125 T54 T52 ThemeOf zonulin,ratio
R126 T54 T53 ThemeOf zonulin,IgM
R127 T54 T60 ThemeOf zonulin,PARA/TRANS
R128 T54 T61 ThemeOf zonulin,greater
R129 T56 T52 ThemeOf occludin/talin,ratio
R130 T56 T53 ThemeOf occludin/talin,IgM
R131 T56 T60 ThemeOf occludin/talin,PARA/TRANS
R132 T56 T61 ThemeOf occludin/talin,greater
R133 T58 T52 ThemeOf actin,ratio
R134 T58 T53 ThemeOf actin,IgM
R135 T58 T60 ThemeOf actin,PARA/TRANS
R136 T58 T61 ThemeOf actin,greater
R137 T58 T65 ThemeOf actin,higher
R138 T59 T52 ThemeOf viculin,ratio
R139 T59 T53 ThemeOf viculin,IgM
R140 T59 T60 ThemeOf viculin,PARA/TRANS
R141 T59 T61 ThemeOf viculin,greater
R142 T59 T65 ThemeOf viculin,higher
R143 T59 T67 ThemeOf viculin,associated
R144 T60 T61 ThemeOf PARA/TRANS,greater
R145 T60 T65 ThemeOf PARA/TRANS,higher
R146 T60 T67 ThemeOf PARA/TRANS,associated
R147 T62 T52 ThemeOf deficit,ratio
R148 T62 T53 ThemeOf deficit,IgM
R149 T62 T60 ThemeOf deficit,PARA/TRANS
R150 T62 T61 ThemeOf deficit,greater
R151 T62 T65 ThemeOf deficit,higher
R152 T62 T67 ThemeOf deficit,associated
R153 T62 T68 ThemeOf deficit,increased
R154 T64 T52 ThemeOf schizophrenia,ratio
R155 T64 T53 ThemeOf schizophrenia,IgM
R156 T64 T60 ThemeOf schizophrenia,PARA/TRANS
R165 T66 T65 ThemeOf schizophrenia,higher
R166 T66 T67 ThemeOf schizophrenia,associated
R167 T66 T68 ThemeOf schizophrenia,increased
R168 T69 T67 ThemeOf IgA responses,associated
R169 T69 T68 ThemeOf IgA responses,increased
R170 T71 T74 ThemeOf responses,positively
R171 T71 T75 ThemeOf responses,associated
R172 T72 T71 ThemeOf zonulin,responses
R173 T72 T74 ThemeOf zonulin,positively
R174 T72 T75 ThemeOf zonulin,associated
R175 T75 T74 ThemeOf associated,positively
R176 T76 T67 ThemeOf schizophrenia,associated
R177 T76 T71 ThemeOf schizophrenia,responses
R178 T76 T74 ThemeOf schizophrenia,positively
R179 T76 T75 ThemeOf schizophrenia,associated
R180 T77 T80 ThemeOf IgM,associated
R181 T78 T77 ThemeOf occludin,IgM
R182 T78 T80 ThemeOf occludin,associated
R183 T81 T77 ThemeOf deficit schizophrenia,IgM
R184 T81 T80 ThemeOf deficit schizophrenia,associated
R185 T83 T81 ThemeOf schizophrenia,deficit schizophrenia
R186 T83 T77 ThemeOf schizophrenia,IgM
R187 T83 T80 ThemeOf schizophrenia,associated
R188 T85 T84 ThemeOf psychosis,PHEM
R189 T84 T87 ThemeOf PHEM,hostility
R190 T84 T88 ThemeOf PHEM,"excitation, and mannerism"
R191 T84 T89 ThemeOf PHEM,PARA/TRANS ratio
R192 T84 T90 ThemeOf PHEM,IgA
R193 T84 T92 ThemeOf PHEM,IgM
R194 T84 T95 ThemeOf PHEM,MDA
R195 T84 T96 ThemeOf PHEM,memory dysfunctions
R196 T84 T98 ThemeOf PHEM,PARA/TRANS ratio
R197 T84 T99 ThemeOf PHEM,IgA
R198 T84 T103 ThemeOf PHEM,TRYCATs
R199 T84 T104 ThemeOf PHEM,immune activation
R200 T84 T105 ThemeOf PHEM,upregulated
R201 T85 T87 ThemeOf psychosis,hostility
R202 T85 T88 ThemeOf psychosis,"excitation, and mannerism"
R203 T85 T89 ThemeOf psychosis,PARA/TRANS ratio
R204 T85 T90 ThemeOf psychosis,IgA
R205 T85 T92 ThemeOf psychosis,IgM
R206 T85 T95 ThemeOf psychosis,MDA
R207 T85 T96 ThemeOf psychosis,memory dysfunctions
R208 T85 T98 ThemeOf psychosis,PARA/TRANS ratio
R209 T85 T99 ThemeOf psychosis,IgA
R210 T85 T103 ThemeOf psychosis,TRYCATs
R211 T85 T104 ThemeOf psychosis,immune activation
R212 T85 T105 ThemeOf psychosis,upregulated
R213 T85 T106 ThemeOf psychosis,paracellular pathway
R214 T88 T87 ThemeOf "excitation, and mannerism",hostility
R215 T87 T89 ThemeOf hostility,PARA/TRANS ratio
R216 T87 T90 ThemeOf hostility,IgA
R217 T87 T92 ThemeOf hostility,IgM
R218 T87 T95 ThemeOf hostility,MDA
R219 T87 T96 ThemeOf hostility,memory dysfunctions
R220 T87 T98 ThemeOf hostility,PARA/TRANS ratio
R221 T87 T99 ThemeOf hostility,IgA
R222 T87 T103 ThemeOf hostility,TRYCATs
R223 T87 T104 ThemeOf hostility,immune activation
R224 T87 T105 ThemeOf hostility,upregulated
R225 T88 T89 ThemeOf "excitation, and mannerism",PARA/TRANS ratio
R226 T88 T90 ThemeOf "excitation, and mannerism",IgA
R227 T88 T92 ThemeOf "excitation, and mannerism",IgM
R228 T88 T95 ThemeOf "excitation, and mannerism",MDA
R229 T88 T96 ThemeOf "excitation, and mannerism",memory dysfunctions
R230 T88 T98 ThemeOf "excitation, and mannerism",PARA/TRANS ratio
R231 T88 T99 ThemeOf "excitation, and mannerism",IgA
R232 T88 T103 ThemeOf "excitation, and mannerism",TRYCATs
R233 T88 T104 ThemeOf "excitation, and mannerism",immune activation
R234 T88 T105 ThemeOf "excitation, and mannerism",upregulated
R235 T88 T108 ThemeOf "excitation, and mannerism",increased
R236 T89 T92 ThemeOf PARA/TRANS ratio,IgM
R237 T95 T89 ThemeOf MDA,PARA/TRANS ratio
R244 T92 T96 ThemeOf IgM,memory dysfunctions
R245 T93 T89 ThemeOf E-cadherin,PARA/TRANS ratio
R246 T93 T90 ThemeOf E-cadherin,IgA
R247 T93 T96 ThemeOf E-cadherin,memory dysfunctions
R248 T93 T99 ThemeOf E-cadherin,IgA
R249 T103 T96 ThemeOf TRYCATs,memory dysfunctions
R250 T103 T98 ThemeOf TRYCATs,PARA/TRANS ratio
R251 T104 T98 ThemeOf immune activation,PARA/TRANS ratio
R252 T103 T99 ThemeOf TRYCATs,IgA
R253 T104 T99 ThemeOf immune activation,IgA
R254 T101 T90 ThemeOf CCL-11,IgA
R255 T101 T96 ThemeOf CCL-11,memory dysfunctions
R256 T101 T98 ThemeOf CCL-11,PARA/TRANS ratio
R257 T101 T99 ThemeOf CCL-11,IgA
R258 T101 T104 ThemeOf CCL-11,immune activation
R259 T106 T105 ThemeOf paracellular pathway,upregulated
R260 T105 T108 CauseOf upregulated,increased
R261 T107 T105 ThemeOf tight and adherens junctions,upregulated
R262 T109 T108 ThemeOf bacterial translocation,increased
R263 T110 T96 ThemeOf deficit schizophrenia,memory dysfunctions
R264 T110 T98 ThemeOf deficit schizophrenia,PARA/TRANS ratio
R265 T110 T99 ThemeOf deficit schizophrenia,IgA
R266 T110 T104 ThemeOf deficit schizophrenia,immune activation
R267 T110 T105 ThemeOf deficit schizophrenia,upregulated
R268 T110 T106 ThemeOf deficit schizophrenia,paracellular pathway
R269 T110 T108 ThemeOf deficit schizophrenia,increased
R270 T110 T109 ThemeOf deficit schizophrenia,bacterial translocation
R271 T110 T111 ThemeOf deficit schizophrenia,lowered
R272 T110 T118 ThemeOf deficit schizophrenia,contribute
R273 T112 T111 ThemeOf IgM,lowered
R274 T112 T114 ThemeOf IgM,production
R275 T112 T118 ThemeOf IgM,contribute
R276 T113 T111 ThemeOf immune activation,lowered
R277 T117 T113 ThemeOf TRYCATs,immune activation
R278 T113 T118 ThemeOf immune activation,contribute
R279 T114 T111 ThemeOf production,lowered
R280 T115 T114 ThemeOf CCL-11,production
R281 T117 T114 ThemeOf TRYCATs,production
R282 T114 T118 ThemeOf production,contribute
R283 T115 T112 ThemeOf CCL-11,IgM
R284 T115 T118 ThemeOf CCL-11,contribute
R285 T117 T111 ThemeOf TRYCATs,lowered
R286 T117 T118 ThemeOf TRYCATs,contribute
R287 T119 T111 ThemeOf deficit schizophrenia,lowered
R288 T119 T114 ThemeOf deficit schizophrenia,production
R289 T119 T117 ThemeOf deficit schizophrenia,TRYCATs
R290 T119 T118 ThemeOf deficit schizophrenia,contribute

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Upregulation of the Intestinal Paracellular Pathway with Breakdown of Tight and Adherens Junctions in Deficit Schizophrenia.
T2 125-266 Sentence denotes In 2001, the first author of this paper reported that schizophrenia is associated with an increased frequency of the haptoglobin (Hp)-2 gene.
T3 267-364 Sentence denotes The precursor of Hp-2 is zonulin, a molecule that affects intercellular tight junction integrity.
T4 365-512 Sentence denotes Recently, we reported increased plasma IgA/IgM responses to Gram-negative bacteria in deficit schizophrenia indicating leaky gut and gut dysbiosis.
T5 513-716 Sentence denotes The current study was performed to examine the integrity of the paracellular (tight and adherens junctions) and transcellular (cytoskeletal proteins) pathways in deficit versus non-deficit schizophrenia.
T6 717-1038 Sentence denotes We measured IgM responses to zonulin, occludin, E-cadherin, talin, actin, and vinculin in association with IgA responses to Gram-negative bacteria, CCL-11, IgA responses to tryptophan catabolites (TRYCATs), immune activation and IgM to malondialdehyde (MDA), and NO-cysteinyl in 78 schizophrenia patients and 40 controls.
T7 1039-1345 Sentence denotes We found that the ratio of IgM to zonulin + occludin/talin + actin + viculin (PARA/TRANS) was significantly greater in deficit than those in non-deficit schizophrenia and higher in schizophrenia than those in controls and was significantly associated with increased IgA responses to Gram-negative bacteria.
T8 1346-1562 Sentence denotes IgM responses to zonulin were positively associated with schizophrenia (versus controls), while IgM to occludin was significantly associated with deficit schizophrenia (versus non-deficit schizophrenia and controls).
T9 1563-1945 Sentence denotes A large part of the variance (90.8%) in negative and PHEM (psychosis, hostility, excitation, and mannerism) symptoms was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, IgM to E-cadherin and MDA, and memory dysfunctions, while 53.3% of the variance in the latter was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, CCL-11, TRYCATs, and immune activation.
T10 1946-2113 Sentence denotes The results show an upregulated paracellular pathway with breakdown of the tight and adherens junctions and increased bacterial translocation in deficit schizophrenia.
T11 2114-2318 Sentence denotes These dysfunctions in the intestinal paracellular route together with lowered natural IgM, immune activation, and production of CCL-11 and TRYCATs contribute to the phenomenology of deficit schizophrenia.
T1 0-124 Sentence denotes Upregulation of the Intestinal Paracellular Pathway with Breakdown of Tight and Adherens Junctions in Deficit Schizophrenia.
T2 125-266 Sentence denotes In 2001, the first author of this paper reported that schizophrenia is associated with an increased frequency of the haptoglobin (Hp)-2 gene.
T3 267-364 Sentence denotes The precursor of Hp-2 is zonulin, a molecule that affects intercellular tight junction integrity.
T4 365-512 Sentence denotes Recently, we reported increased plasma IgA/IgM responses to Gram-negative bacteria in deficit schizophrenia indicating leaky gut and gut dysbiosis.
T5 513-716 Sentence denotes The current study was performed to examine the integrity of the paracellular (tight and adherens junctions) and transcellular (cytoskeletal proteins) pathways in deficit versus non-deficit schizophrenia.
T6 717-1038 Sentence denotes We measured IgM responses to zonulin, occludin, E-cadherin, talin, actin, and vinculin in association with IgA responses to Gram-negative bacteria, CCL-11, IgA responses to tryptophan catabolites (TRYCATs), immune activation and IgM to malondialdehyde (MDA), and NO-cysteinyl in 78 schizophrenia patients and 40 controls.
T7 1039-1345 Sentence denotes We found that the ratio of IgM to zonulin + occludin/talin + actin + viculin (PARA/TRANS) was significantly greater in deficit than those in non-deficit schizophrenia and higher in schizophrenia than those in controls and was significantly associated with increased IgA responses to Gram-negative bacteria.
T8 1346-1562 Sentence denotes IgM responses to zonulin were positively associated with schizophrenia (versus controls), while IgM to occludin was significantly associated with deficit schizophrenia (versus non-deficit schizophrenia and controls).
T9 1563-1945 Sentence denotes A large part of the variance (90.8%) in negative and PHEM (psychosis, hostility, excitation, and mannerism) symptoms was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, IgM to E-cadherin and MDA, and memory dysfunctions, while 53.3% of the variance in the latter was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, CCL-11, TRYCATs, and immune activation.
T10 1946-2113 Sentence denotes The results show an upregulated paracellular pathway with breakdown of the tight and adherens junctions and increased bacterial translocation in deficit schizophrenia.
T11 2114-2318 Sentence denotes These dysfunctions in the intestinal paracellular route together with lowered natural IgM, immune activation, and production of CCL-11 and TRYCATs contribute to the phenomenology of deficit schizophrenia.