PubMed:30969784
Annnotations
sonoma2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 0-10 | MPA | denotes | Biomarkers |
| T1 | 14-37 | CPA | denotes | Endothelial Dysfunction |
| T2 | 52-77 | DISEASE | denotes | Polycystic Ovary Syndrome |
| T3 | 79-104 | DISEASE | denotes | Polycystic ovary syndrome |
| T4 | 106-110 | DISEASE | denotes | PCOS |
| T5 | 124-130 | REG | denotes | common |
| T6 | 131-149 | DISEASE | denotes | endocrine disorder |
| T7 | 359-386 | GENE | denotes | adipocyte-secreted hormones |
| T8 | 424-447 | CPA | denotes | endothelial dysfunction |
| T9 | 424-447 | DISEASE | denotes | endothelial dysfunction |
| T10 | 451-455 | DISEASE | denotes | PCOS |
| T11 | 590-600 | MPA | denotes | biomarkers |
| T12 | 604-615 | CPA | denotes | endothelial |
| T13 | 604-627 | DISEASE | denotes | endothelial dysfunction |
| T14 | 629-637 | GENE | denotes | visfatin |
| T15 | 629-637 | GENE | denotes | visfatin |
| T16 | 639-647 | GENE | denotes | vascular |
| T17 | 639-673 | GENE | denotes | vascular endothelial growth factor |
| T18 | 648-659 | GENE | denotes | endothelial |
| T19 | 675-679 | GENE | denotes | VEGF |
| T20 | 682-708 | GENE | denotes | matrix metalloproteinase 9 |
| T21 | 710-715 | GENE | denotes | MMP-9 |
| T22 | 732-736 | DISEASE | denotes | PCOS |
| T23 | 749-753 | DISEASE | denotes | PCOS |
| T24 | 783-791 | GENE | denotes | visfatin |
| T25 | 783-791 | GENE | denotes | visfatin |
| T26 | 792-806 | MPA | denotes | concentrations |
| T27 | 866-875 | POSREG | denotes | increased |
| T28 | 876-880 | GENE | denotes | VEGF |
| T29 | 881-891 | MPA | denotes | production |
| T30 | 917-929 | CPA | denotes | inflammation |
| T31 | 917-929 | DISEASE | denotes | inflammation |
| T32 | 939-948 | POSREG | denotes | increased |
| T33 | 949-954 | GENE | denotes | MMP-9 |
| T34 | 955-969 | MPA | denotes | concentrations |
| T35 | 986-993 | REG | denotes | related |
| T36 | 1025-1038 | REG | denotes | abnormalities |
| T37 | 1025-1049 | DISEASE | denotes | abnormalities of ovarian |
| T38 | 1042-1070 | CPA | denotes | ovarian extracellular matrix |
| T39 | 1083-1106 | CPA | denotes | multiple cyst formation |
| T40 | 1108-1126 | CPA | denotes | follicular atresia |
| T41 | 1108-1126 | DISEASE | denotes | follicular atresia |
| T42 | 1140-1151 | CPA | denotes | anovulation |
| T43 | 1156-1160 | DISEASE | denotes | PCOS |
| T44 | 1170-1180 | REG | denotes | associated |
| T45 | 1219-1230 | CPA | denotes | endothelial |
| T46 | 1219-1242 | DISEASE | denotes | endothelial dysfunction |
| R41 | T39 | T35 | ThemeOf | multiple cyst formation,related |
| R42 | T39 | T36 | ThemeOf | multiple cyst formation,abnormalities |
| R43 | T40 | T35 | ThemeOf | follicular atresia,related |
| R44 | T43 | T44 | ThemeOf | PCOS,associated |
| R45 | T45 | T44 | ThemeOf | endothelial,associated |
| R0 | T1 | T0 | ThemeOf | Endothelial Dysfunction,Biomarkers |
| R1 | T2 | T0 | ThemeOf | Polycystic Ovary Syndrome,Biomarkers |
| R2 | T2 | T1 | ThemeOf | Polycystic Ovary Syndrome,Endothelial Dysfunction |
| R3 | T3 | T5 | ThemeOf | Polycystic ovary syndrome,common |
| R4 | T4 | T5 | ThemeOf | PCOS,common |
| R5 | T10 | T8 | ThemeOf | PCOS,endothelial dysfunction |
| R6 | T12 | T11 | ThemeOf | endothelial,biomarkers |
| R7 | T14 | T11 | ThemeOf | visfatin,biomarkers |
| R8 | T16 | T11 | ThemeOf | vascular,biomarkers |
| R9 | T18 | T11 | ThemeOf | endothelial,biomarkers |
| R10 | T19 | T11 | ThemeOf | VEGF,biomarkers |
| R11 | T20 | T11 | ThemeOf | matrix metalloproteinase 9,biomarkers |
| R12 | T21 | T11 | ThemeOf | MMP-9,biomarkers |
| R13 | T22 | T11 | ThemeOf | PCOS,biomarkers |
| R14 | T22 | T12 | ThemeOf | PCOS,endothelial |
| R15 | T24 | T26 | ThemeOf | visfatin,concentrations |
| R16 | T26 | T27 | ThemeOf | concentrations,increased |
| R17 | T29 | T27 | ThemeOf | production,increased |
| R18 | T30 | T27 | ThemeOf | inflammation,increased |
| R19 | T27 | T32 | CauseOf | increased,increased |
| R20 | T27 | T35 | CauseOf | increased,related |
| R21 | T27 | T36 | CauseOf | increased,abnormalities |
| R22 | T27 | T39 | CauseOf | increased,multiple cyst formation |
| R23 | T27 | T40 | CauseOf | increased,follicular atresia |
| R24 | T27 | T42 | CauseOf | increased,anovulation |
| R25 | T28 | T27 | ThemeOf | VEGF,increased |
| R26 | T28 | T29 | ThemeOf | VEGF,production |
| R27 | T32 | T30 | CauseOf | increased,inflammation |
| R28 | T34 | T32 | ThemeOf | concentrations,increased |
| R29 | T32 | T35 | CauseOf | increased,related |
| R30 | T32 | T36 | CauseOf | increased,abnormalities |
| R31 | T32 | T38 | CauseOf | increased,ovarian extracellular matrix |
| R32 | T32 | T39 | CauseOf | increased,multiple cyst formation |
| R33 | T32 | T40 | CauseOf | increased,follicular atresia |
| R34 | T32 | T42 | CauseOf | increased,anovulation |
| R35 | T33 | T32 | ThemeOf | MMP-9,increased |
| R36 | T33 | T34 | ThemeOf | MMP-9,concentrations |
| R37 | T34 | T35 | ThemeOf | concentrations,related |
| R38 | T38 | T36 | ThemeOf | ovarian extracellular matrix,abnormalities |
| R39 | T40 | T36 | ThemeOf | follicular atresia,abnormalities |
| R40 | T42 | T36 | ThemeOf | anovulation,abnormalities |
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-78 | Sentence | denotes | Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome. |
| T2 | 79-179 | Sentence | denotes | Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. |
| T3 | 180-334 | Sentence | denotes | The criteria required for the diagnosis identify various phenotypes, with different reproductive, metabolic, and cardiovascular (CV) risk characteristics. |
| T4 | 335-498 | Sentence | denotes | Emerging evidence links adipocyte-secreted hormones as candidates in the pathogenesis of endothelial dysfunction in PCOS, independently of additional risk factors. |
| T5 | 499-737 | Sentence | denotes | The aim of this review was to collect, analyze, and qualitatively resynthesize evidence on biomarkers of endothelial dysfunction (visfatin, vascular endothelial growth factor [VEGF], matrix metalloproteinase 9 [MMP-9]) in women with PCOS. |
| T6 | 738-1152 | Sentence | denotes | Women with PCOS exhibit (a) increased plasma visfatin concentrations compared with controls with a similar body mass index; (b) increased VEGF production along with chronic, mild inflammation; and (c) increased MMP-9 concentrations, which might be related to either excessive CV risk or abnormalities of ovarian extracellular matrix remodeling, multiple cyst formation, follicular atresia, and chronic anovulation. |
| T7 | 1153-1266 | Sentence | denotes | As PCOS has been associated with CV risk, early identification of endothelial dysfunction is clinically relevant. |
| T1 | 0-78 | Sentence | denotes | Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome. |
| T2 | 79-179 | Sentence | denotes | Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. |
| T3 | 180-334 | Sentence | denotes | The criteria required for the diagnosis identify various phenotypes, with different reproductive, metabolic, and cardiovascular (CV) risk characteristics. |
| T4 | 335-498 | Sentence | denotes | Emerging evidence links adipocyte-secreted hormones as candidates in the pathogenesis of endothelial dysfunction in PCOS, independently of additional risk factors. |
| T5 | 499-737 | Sentence | denotes | The aim of this review was to collect, analyze, and qualitatively resynthesize evidence on biomarkers of endothelial dysfunction (visfatin, vascular endothelial growth factor [VEGF], matrix metalloproteinase 9 [MMP-9]) in women with PCOS. |
| T6 | 738-1152 | Sentence | denotes | Women with PCOS exhibit (a) increased plasma visfatin concentrations compared with controls with a similar body mass index; (b) increased VEGF production along with chronic, mild inflammation; and (c) increased MMP-9 concentrations, which might be related to either excessive CV risk or abnormalities of ovarian extracellular matrix remodeling, multiple cyst formation, follicular atresia, and chronic anovulation. |
| T7 | 1153-1266 | Sentence | denotes | As PCOS has been associated with CV risk, early identification of endothelial dysfunction is clinically relevant. |