PubMed:3084782
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/3084782","sourcedb":"PubMed","sourceid":"3084782","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/3084782","text":"Toxicity due to remission inducing drugs in rheumatoid arthritis. Association with HLA-B35 and Cw4 antigens.\nTwenty-five patients with rheumatoid arthritis (RA) who developed toxicity while taking remission inducing drugs and 30 without toxicity were studied for possible associations with class I and II HLA antigens. A strong association has been found between nephritis and dermatitis due to Tiopronin (a D-Penicillamine like compound) and class I antigens B35-Cw4, and between dermatitis due to gold thiosulphate and B35. Compared to healthy controls a lower DR5 frequency was observed in patients with RA except for the Tiopronin related nephritis 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