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PubMed:30770840 JSONTXT

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mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 46-70 Disease denotes Streptococcus pneumoniae http://purl.obolibrary.org/obo/MONDO_0005972
T2 103-127 Disease denotes Streptococcus pneumoniae http://purl.obolibrary.org/obo/MONDO_0005972
T3 132-142 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T4 217-229 Disease denotes otitis media http://purl.obolibrary.org/obo/MONDO_0024330
T5 237-247 Disease denotes meningitis http://purl.obolibrary.org/obo/MONDO_0004796|http://purl.obolibrary.org/obo/MONDO_0021108
T7 971-981 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T8 1126-1136 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 237-247 Body_part denotes meningitis http://purl.obolibrary.org/obo/MAT_0000113

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 529-535 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 553-559 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 60-70 Phenotype denotes pneumoniae HP:0002090
T2 117-127 Phenotype denotes pneumoniae HP:0002090
T3 132-142 Phenotype denotes pneumoniae HP:0002090
T4 217-229 Phenotype denotes otitis media HP:0000388
T5 237-247 Phenotype denotes meningitis HP:0001287
T6 971-981 Phenotype denotes pneumoniae HP:0002090
T7 1126-1136 Phenotype denotes pneumoniae HP:0002090

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 46-70 Disease denotes Streptococcus pneumoniae MONDO:0005972
T2 103-127 Disease denotes Streptococcus pneumoniae MONDO:0005972
T3 132-142 Disease denotes pneumoniae MONDO:0005249
T4 217-229 Disease denotes otitis media MONDO:0005441|MONDO:0024330
T6 237-247 Disease denotes meningitis MONDO:0004796|MONDO:0021108
T8 971-981 Disease denotes pneumoniae MONDO:0005249
T9 1126-1136 Disease denotes pneumoniae MONDO:0005249

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 46-70 OrganismTaxon denotes Streptococcus pneumoniae 1313
T2 103-127 OrganismTaxon denotes Streptococcus pneumoniae 1313
T3 157-162 OrganismTaxon denotes human 9606

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 237-247 Body_part denotes meningitis http://purl.obolibrary.org/obo/MAT_0000113

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Comparative studies of catalytic pathways for Streptococcus pneumoniae sialidases NanA, NanB and NanC.
T2 103-264 Sentence denotes Streptococcus pneumoniae (S. pneumoniae) is a leading human pathogen, which takes large responsibility for severe otitis media, acute meningitis and septicaemia.
T3 265-308 Sentence denotes It encodes up to three distinct sialidases:
T4 309-363 Sentence denotes NanA, NanB and NanC, which are promising drug targets.
T5 364-732 Sentence denotes Recent experimental studies have shown that these three sialidases might work together up to the ultimate step, where NanA and NanB produce N-acetylneuraminic acid (Neu5Ac) and 2,7-anhydro-Neu5Ac following the functions of sialidase and intramolecular trans-sialidase, whilst NanC carries on a ping-pong mechanism that produces or removes 2-deoxy-2,3-didehydro-Neu5AC.
T6 733-847 Sentence denotes It is intriguing that these sialidases have similar active sites but operate via three distinct reaction pathways.
T7 848-1148 Sentence denotes To clarify this issue, herein we present the first systematic computational investigation on the catalytic pathways for S. pneumoniae NanA, NanB and NanC based on combined quantum mechanics/molecular mechanics simulations, and propose the most preferred routes for the three S. pneumoniae sialidases.
T8 1149-1350 Sentence denotes Our findings support the mechanisms of NanA and NanC that were proposed by previous experimental studies, whereas the role of water in NanB was found to differ slightly from our current understandings.
T9 1351-1515 Sentence denotes The mechanistic insights obtained from this work are expected to assist in the design of potent inhibitors targeting these key enzymes for therapeutic applications.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 529-535 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 553-559 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 46-70 OrganismTaxon denotes Streptococcus pneumoniae 1313
T2 103-127 OrganismTaxon denotes Streptococcus pneumoniae 1313
T3 157-162 OrganismTaxon denotes human 9606

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 60-70 Phenotype denotes pneumoniae HP:0002090
T2 117-127 Phenotype denotes pneumoniae HP:0002090
T3 132-142 Phenotype denotes pneumoniae HP:0002090
T4 217-229 Phenotype denotes otitis media HP:0000388
T5 237-247 Phenotype denotes meningitis HP:0001287
T6 971-981 Phenotype denotes pneumoniae HP:0002090
T7 1126-1136 Phenotype denotes pneumoniae HP:0002090