PubMed:30745361
Annnotations
Inflammaging
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-161 | Sentence | denotes | α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma. |
T2 | 162-302 | Sentence | denotes | Asthma is a common inflammatory pulmonary disorder involving a diverse array of immune cells such as proinflammatory T helper 2 (Th2) cells. |
T3 | 303-505 | Sentence | denotes | We recently reported that intraperitoneal injection of α-galactosylceramide (α-GalCer) can stimulate the lung invariant natural killer T (iNKT) cells and does not lead to airway inflammation in WT mice. |
T4 | 506-637 | Sentence | denotes | Other studies indicate that iNKT cells play an important role in inducing regulatory T cells (Treg cells) and peripheral tolerance. |
T5 | 638-880 | Sentence | denotes | Using iNKT cell- knockout mice, functional inactivation of Treg cells, and co-culture experiments in murine asthma models, we investigated the immunoregulatory effects of α-GalCer treatment before allergen sensitization on Th2 cell responses. |
T6 | 881-980 | Sentence | denotes | We also studied whether α-GalCer's effects require lung Treg cells induced by activated iNKT cells. |
T7 | 981-1164 | Sentence | denotes | Our results disclosed that intraperitoneal administration of α-GalCer before allergen sensitization could promote the expansion and suppressive activity of lung CD4+FoxP3+ Treg cells. |
T8 | 1165-1305 | Sentence | denotes | These effects were accompanied by down-regulated Th2 cell responses and decreased immunogenic maturation of lung dendritic cells in WT mice. |
T9 | 1306-1498 | Sentence | denotes | However, these changes were absent in CD1d-/- mice immunized and challenged with ovalbumin or house dust mites, indicating that the effects of α-GalCer on Treg cells mainly require iNKT cells. |
T10 | 1499-1656 | Sentence | denotes | Moreover, functional inactivation of Treg cells could reverse the inhibitory ability of this α-GalCer therapy on Th2 cell responses in a murine asthma model. |
T11 | 1657-1902 | Sentence | denotes | Our findings indicate that intraperitoneal administration of α-GalCer before the development of asthma symptoms induces the generation of lung Treg cells via iNKT cells and may provide a potential therapeutic strategy to prevent allergic asthma. |
T1 | 0-161 | Sentence | denotes | α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma. |
T2 | 162-302 | Sentence | denotes | Asthma is a common inflammatory pulmonary disorder involving a diverse array of immune cells such as proinflammatory T helper 2 (Th2) cells. |
T3 | 303-505 | Sentence | denotes | We recently reported that intraperitoneal injection of α-galactosylceramide (α-GalCer) can stimulate the lung invariant natural killer T (iNKT) cells and does not lead to airway inflammation in WT mice. |
T4 | 506-637 | Sentence | denotes | Other studies indicate that iNKT cells play an important role in inducing regulatory T cells (Treg cells) and peripheral tolerance. |
T5 | 638-880 | Sentence | denotes | Using iNKT cell- knockout mice, functional inactivation of Treg cells, and co-culture experiments in murine asthma models, we investigated the immunoregulatory effects of α-GalCer treatment before allergen sensitization on Th2 cell responses. |
T6 | 881-980 | Sentence | denotes | We also studied whether α-GalCer's effects require lung Treg cells induced by activated iNKT cells. |
T7 | 981-1164 | Sentence | denotes | Our results disclosed that intraperitoneal administration of α-GalCer before allergen sensitization could promote the expansion and suppressive activity of lung CD4+FoxP3+ Treg cells. |
T8 | 1165-1305 | Sentence | denotes | These effects were accompanied by down-regulated Th2 cell responses and decreased immunogenic maturation of lung dendritic cells in WT mice. |
T9 | 1306-1498 | Sentence | denotes | However, these changes were absent in CD1d-/- mice immunized and challenged with ovalbumin or house dust mites, indicating that the effects of α-GalCer on Treg cells mainly require iNKT cells. |
T10 | 1499-1656 | Sentence | denotes | Moreover, functional inactivation of Treg cells could reverse the inhibitory ability of this α-GalCer therapy on Th2 cell responses in a murine asthma model. |
T11 | 1657-1902 | Sentence | denotes | Our findings indicate that intraperitoneal administration of α-GalCer before the development of asthma symptoms induces the generation of lung Treg cells via iNKT cells and may provide a potential therapeutic strategy to prevent allergic asthma. |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 2-20 | Glycan_Motif | denotes | Galactosylceramide | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
T2 | 360-378 | Glycan_Motif | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-161 | Sentence | denotes | α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma. |
T2 | 162-302 | Sentence | denotes | Asthma is a common inflammatory pulmonary disorder involving a diverse array of immune cells such as proinflammatory T helper 2 (Th2) cells. |
T3 | 303-505 | Sentence | denotes | We recently reported that intraperitoneal injection of α-galactosylceramide (α-GalCer) can stimulate the lung invariant natural killer T (iNKT) cells and does not lead to airway inflammation in WT mice. |
T4 | 506-637 | Sentence | denotes | Other studies indicate that iNKT cells play an important role in inducing regulatory T cells (Treg cells) and peripheral tolerance. |
T5 | 638-880 | Sentence | denotes | Using iNKT cell- knockout mice, functional inactivation of Treg cells, and co-culture experiments in murine asthma models, we investigated the immunoregulatory effects of α-GalCer treatment before allergen sensitization on Th2 cell responses. |
T6 | 881-980 | Sentence | denotes | We also studied whether α-GalCer's effects require lung Treg cells induced by activated iNKT cells. |
T7 | 981-1164 | Sentence | denotes | Our results disclosed that intraperitoneal administration of α-GalCer before allergen sensitization could promote the expansion and suppressive activity of lung CD4+FoxP3+ Treg cells. |
T8 | 1165-1305 | Sentence | denotes | These effects were accompanied by down-regulated Th2 cell responses and decreased immunogenic maturation of lung dendritic cells in WT mice. |
T9 | 1306-1498 | Sentence | denotes | However, these changes were absent in CD1d-/- mice immunized and challenged with ovalbumin or house dust mites, indicating that the effects of α-GalCer on Treg cells mainly require iNKT cells. |
T10 | 1499-1656 | Sentence | denotes | Moreover, functional inactivation of Treg cells could reverse the inhibitory ability of this α-GalCer therapy on Th2 cell responses in a murine asthma model. |
T11 | 1657-1902 | Sentence | denotes | Our findings indicate that intraperitoneal administration of α-GalCer before the development of asthma symptoms induces the generation of lung Treg cells via iNKT cells and may provide a potential therapeutic strategy to prevent allergic asthma. |
T1 | 0-161 | Sentence | denotes | α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma. |
T2 | 162-302 | Sentence | denotes | Asthma is a common inflammatory pulmonary disorder involving a diverse array of immune cells such as proinflammatory T helper 2 (Th2) cells. |
T3 | 303-505 | Sentence | denotes | We recently reported that intraperitoneal injection of α-galactosylceramide (α-GalCer) can stimulate the lung invariant natural killer T (iNKT) cells and does not lead to airway inflammation in WT mice. |
T4 | 506-637 | Sentence | denotes | Other studies indicate that iNKT cells play an important role in inducing regulatory T cells (Treg cells) and peripheral tolerance. |
T5 | 638-880 | Sentence | denotes | Using iNKT cell- knockout mice, functional inactivation of Treg cells, and co-culture experiments in murine asthma models, we investigated the immunoregulatory effects of α-GalCer treatment before allergen sensitization on Th2 cell responses. |
T6 | 881-980 | Sentence | denotes | We also studied whether α-GalCer's effects require lung Treg cells induced by activated iNKT cells. |
T7 | 981-1164 | Sentence | denotes | Our results disclosed that intraperitoneal administration of α-GalCer before allergen sensitization could promote the expansion and suppressive activity of lung CD4+FoxP3+ Treg cells. |
T8 | 1165-1305 | Sentence | denotes | These effects were accompanied by down-regulated Th2 cell responses and decreased immunogenic maturation of lung dendritic cells in WT mice. |
T9 | 1306-1498 | Sentence | denotes | However, these changes were absent in CD1d-/- mice immunized and challenged with ovalbumin or house dust mites, indicating that the effects of α-GalCer on Treg cells mainly require iNKT cells. |
T10 | 1499-1656 | Sentence | denotes | Moreover, functional inactivation of Treg cells could reverse the inhibitory ability of this α-GalCer therapy on Th2 cell responses in a murine asthma model. |
T11 | 1657-1902 | Sentence | denotes | Our findings indicate that intraperitoneal administration of α-GalCer before the development of asthma symptoms induces the generation of lung Treg cells via iNKT cells and may provide a potential therapeutic strategy to prevent allergic asthma. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 2-20 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | Galactosylceramide |
T2 | 360-378 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactosylceramide |
Glycosmos6-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 2-20 | http://www.glycoepitope.jp/epitopes/EP0074 | denotes | Galactosylceramide |
T2 | 360-378 | http://www.glycoepitope.jp/epitopes/EP0074 | denotes | galactosylceramide |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 408-412 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
T2 | 932-936 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
T3 | 1137-1141 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
T4 | 1273-1277 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
T5 | 1795-1799 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 408-412 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
T2 | 932-936 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
T3 | 1137-1141 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
T4 | 1273-1277 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
T5 | 1795-1799 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 154-160 | Phenotype | denotes | asthma | HP:0002099 |
T2 | 162-168 | Phenotype | denotes | Asthma | HP:0002099 |
T3 | 746-752 | Phenotype | denotes | asthma | HP:0002099 |
T4 | 1643-1649 | Phenotype | denotes | asthma | HP:0002099 |
T5 | 1753-1759 | Phenotype | denotes | asthma | HP:0002099 |
T6 | 1895-1901 | Phenotype | denotes | asthma | HP:0002099 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 154-160 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T2 | 162-168 | Disease | denotes | Asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T3 | 194-212 | Disease | denotes | pulmonary disorder | http://purl.obolibrary.org/obo/MONDO_0005275 |
T4 | 481-493 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T5 | 746-752 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T6 | 1643-1649 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T7 | 1753-1759 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T8 | 1886-1901 | Disease | denotes | allergic asthma | http://purl.obolibrary.org/obo/MONDO_0004784 |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 2-20 | Glycan | denotes | Galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
T2 | 360-378 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
GlyCosmos-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 2-20 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
T2 | 360-378 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
GlyCosmos15-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 154-160 | Phenotype | denotes | asthma | HP:0002099 |
T2 | 162-168 | Phenotype | denotes | Asthma | HP:0002099 |
T3 | 746-752 | Phenotype | denotes | asthma | HP:0002099 |
T4 | 1643-1649 | Phenotype | denotes | asthma | HP:0002099 |
T5 | 1753-1759 | Phenotype | denotes | asthma | HP:0002099 |
T6 | 1895-1901 | Phenotype | denotes | asthma | HP:0002099 |
GlyCosmos15-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 154-160 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T2 | 162-168 | Disease | denotes | Asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T3 | 194-212 | Disease | denotes | pulmonary disorder | http://purl.obolibrary.org/obo/MONDO_0005275 |
T4 | 481-493 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T5 | 746-752 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T6 | 1643-1649 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T7 | 1753-1759 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
T8 | 1886-1901 | Disease | denotes | allergic asthma | http://purl.obolibrary.org/obo/MONDO_0004784 |
GlyCosmos15-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 500-504 | OrganismTaxon | denotes | mice | 10088 |
T2 | 664-668 | OrganismTaxon | denotes | mice | 10088 |
T3 | 1300-1304 | OrganismTaxon | denotes | mice | 10088 |
T4 | 1352-1356 | OrganismTaxon | denotes | mice | 10088 |
GlyCosmos15-CL
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 102-106 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T3 | 125-133 | Cell | denotes | Th2 cell | http://purl.obolibrary.org/obo/CL:0000546 |
T4 | 242-254 | Cell | denotes | immune cells | http://purl.obolibrary.org/obo/CL:0000738 |
T5 | 571-598 | Cell | denotes | inducing regulatory T cells | http://purl.obolibrary.org/obo/CL:0000902 |
T6 | 580-598 | Cell | denotes | regulatory T cells | http://purl.obolibrary.org/obo/CL:0000815 |
T7 | 600-604 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T9 | 697-701 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T11 | 861-869 | Cell | denotes | Th2 cell | http://purl.obolibrary.org/obo/CL:0000546 |
T12 | 937-941 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T14 | 1153-1157 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T16 | 1214-1222 | Cell | denotes | Th2 cell | http://purl.obolibrary.org/obo/CL:0000546 |
T17 | 1278-1293 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
T19 | 1461-1465 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T21 | 1536-1540 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T23 | 1612-1620 | Cell | denotes | Th2 cell | http://purl.obolibrary.org/obo/CL:0000546 |
T24 | 1800-1804 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
GlyCosmos15-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 242-254 | Body_part | denotes | immune cells | http://purl.obolibrary.org/obo/CL_0000738 |
T2 | 408-412 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T3 | 474-480 | Body_part | denotes | airway | http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005 |
T5 | 932-936 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T6 | 1137-1141 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T7 | 1273-1277 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T8 | 1278-1293 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
T9 | 1795-1799 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
GlyCosmos15-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 408-412 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
T2 | 932-936 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
T3 | 1137-1141 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
T4 | 1273-1277 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
T5 | 1795-1799 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-161 | Sentence | denotes | α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma. |
T2 | 162-302 | Sentence | denotes | Asthma is a common inflammatory pulmonary disorder involving a diverse array of immune cells such as proinflammatory T helper 2 (Th2) cells. |
T3 | 303-505 | Sentence | denotes | We recently reported that intraperitoneal injection of α-galactosylceramide (α-GalCer) can stimulate the lung invariant natural killer T (iNKT) cells and does not lead to airway inflammation in WT mice. |
T4 | 506-637 | Sentence | denotes | Other studies indicate that iNKT cells play an important role in inducing regulatory T cells (Treg cells) and peripheral tolerance. |
T5 | 638-880 | Sentence | denotes | Using iNKT cell- knockout mice, functional inactivation of Treg cells, and co-culture experiments in murine asthma models, we investigated the immunoregulatory effects of α-GalCer treatment before allergen sensitization on Th2 cell responses. |
T6 | 881-980 | Sentence | denotes | We also studied whether α-GalCer's effects require lung Treg cells induced by activated iNKT cells. |
T7 | 981-1164 | Sentence | denotes | Our results disclosed that intraperitoneal administration of α-GalCer before allergen sensitization could promote the expansion and suppressive activity of lung CD4+FoxP3+ Treg cells. |
T8 | 1165-1305 | Sentence | denotes | These effects were accompanied by down-regulated Th2 cell responses and decreased immunogenic maturation of lung dendritic cells in WT mice. |
T9 | 1306-1498 | Sentence | denotes | However, these changes were absent in CD1d-/- mice immunized and challenged with ovalbumin or house dust mites, indicating that the effects of α-GalCer on Treg cells mainly require iNKT cells. |
T10 | 1499-1656 | Sentence | denotes | Moreover, functional inactivation of Treg cells could reverse the inhibitory ability of this α-GalCer therapy on Th2 cell responses in a murine asthma model. |
T11 | 1657-1902 | Sentence | denotes | Our findings indicate that intraperitoneal administration of α-GalCer before the development of asthma symptoms induces the generation of lung Treg cells via iNKT cells and may provide a potential therapeutic strategy to prevent allergic asthma. |
T1 | 0-161 | Sentence | denotes | α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma. |
T2 | 162-302 | Sentence | denotes | Asthma is a common inflammatory pulmonary disorder involving a diverse array of immune cells such as proinflammatory T helper 2 (Th2) cells. |
T3 | 303-505 | Sentence | denotes | We recently reported that intraperitoneal injection of α-galactosylceramide (α-GalCer) can stimulate the lung invariant natural killer T (iNKT) cells and does not lead to airway inflammation in WT mice. |
T4 | 506-637 | Sentence | denotes | Other studies indicate that iNKT cells play an important role in inducing regulatory T cells (Treg cells) and peripheral tolerance. |
T5 | 638-880 | Sentence | denotes | Using iNKT cell- knockout mice, functional inactivation of Treg cells, and co-culture experiments in murine asthma models, we investigated the immunoregulatory effects of α-GalCer treatment before allergen sensitization on Th2 cell responses. |
T6 | 881-980 | Sentence | denotes | We also studied whether α-GalCer's effects require lung Treg cells induced by activated iNKT cells. |
T7 | 981-1164 | Sentence | denotes | Our results disclosed that intraperitoneal administration of α-GalCer before allergen sensitization could promote the expansion and suppressive activity of lung CD4+FoxP3+ Treg cells. |
T8 | 1165-1305 | Sentence | denotes | These effects were accompanied by down-regulated Th2 cell responses and decreased immunogenic maturation of lung dendritic cells in WT mice. |
T9 | 1306-1498 | Sentence | denotes | However, these changes were absent in CD1d-/- mice immunized and challenged with ovalbumin or house dust mites, indicating that the effects of α-GalCer on Treg cells mainly require iNKT cells. |
T10 | 1499-1656 | Sentence | denotes | Moreover, functional inactivation of Treg cells could reverse the inhibitory ability of this α-GalCer therapy on Th2 cell responses in a murine asthma model. |
T11 | 1657-1902 | Sentence | denotes | Our findings indicate that intraperitoneal administration of α-GalCer before the development of asthma symptoms induces the generation of lung Treg cells via iNKT cells and may provide a potential therapeutic strategy to prevent allergic asthma. |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-161 | Sentence | denotes | α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma. |
T2 | 162-302 | Sentence | denotes | Asthma is a common inflammatory pulmonary disorder involving a diverse array of immune cells such as proinflammatory T helper 2 (Th2) cells. |
T3 | 303-505 | Sentence | denotes | We recently reported that intraperitoneal injection of α-galactosylceramide (α-GalCer) can stimulate the lung invariant natural killer T (iNKT) cells and does not lead to airway inflammation in WT mice. |
T4 | 506-637 | Sentence | denotes | Other studies indicate that iNKT cells play an important role in inducing regulatory T cells (Treg cells) and peripheral tolerance. |
T5 | 638-880 | Sentence | denotes | Using iNKT cell- knockout mice, functional inactivation of Treg cells, and co-culture experiments in murine asthma models, we investigated the immunoregulatory effects of α-GalCer treatment before allergen sensitization on Th2 cell responses. |
T6 | 881-980 | Sentence | denotes | We also studied whether α-GalCer's effects require lung Treg cells induced by activated iNKT cells. |
T7 | 981-1164 | Sentence | denotes | Our results disclosed that intraperitoneal administration of α-GalCer before allergen sensitization could promote the expansion and suppressive activity of lung CD4+FoxP3+ Treg cells. |
T8 | 1165-1305 | Sentence | denotes | These effects were accompanied by down-regulated Th2 cell responses and decreased immunogenic maturation of lung dendritic cells in WT mice. |
T9 | 1306-1498 | Sentence | denotes | However, these changes were absent in CD1d-/- mice immunized and challenged with ovalbumin or house dust mites, indicating that the effects of α-GalCer on Treg cells mainly require iNKT cells. |
T10 | 1499-1656 | Sentence | denotes | Moreover, functional inactivation of Treg cells could reverse the inhibitory ability of this α-GalCer therapy on Th2 cell responses in a murine asthma model. |
T11 | 1657-1902 | Sentence | denotes | Our findings indicate that intraperitoneal administration of α-GalCer before the development of asthma symptoms induces the generation of lung Treg cells via iNKT cells and may provide a potential therapeutic strategy to prevent allergic asthma. |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 2-20 | Glycan | denotes | Galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
T2 | 360-378 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
GlyCosmos15-GlycoEpitope
Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
---|---|---|---|---|---|
T1 | 2-20 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
T2 | 360-378 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 500-504 | OrganismTaxon | denotes | mice | 10088 |
T2 | 664-668 | OrganismTaxon | denotes | mice | 10088 |
T3 | 1300-1304 | OrganismTaxon | denotes | mice | 10088 |
T4 | 1352-1356 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 242-254 | Body_part | denotes | immune cells | http://purl.obolibrary.org/obo/CL_0000738 |
T2 | 408-412 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T3 | 474-480 | Body_part | denotes | airway | http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005 |
T5 | 932-936 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T6 | 1137-1141 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T7 | 1273-1277 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T8 | 1278-1293 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
T9 | 1795-1799 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 102-106 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T3 | 125-133 | Cell | denotes | Th2 cell | http://purl.obolibrary.org/obo/CL:0000546 |
T4 | 242-254 | Cell | denotes | immune cells | http://purl.obolibrary.org/obo/CL:0000738 |
T5 | 571-598 | Cell | denotes | inducing regulatory T cells | http://purl.obolibrary.org/obo/CL:0000902 |
T6 | 580-598 | Cell | denotes | regulatory T cells | http://purl.obolibrary.org/obo/CL:0000815 |
T7 | 600-604 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T9 | 697-701 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T11 | 861-869 | Cell | denotes | Th2 cell | http://purl.obolibrary.org/obo/CL:0000546 |
T12 | 937-941 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T14 | 1153-1157 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T16 | 1214-1222 | Cell | denotes | Th2 cell | http://purl.obolibrary.org/obo/CL:0000546 |
T17 | 1278-1293 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
T19 | 1461-1465 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T21 | 1536-1540 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |
T23 | 1612-1620 | Cell | denotes | Th2 cell | http://purl.obolibrary.org/obo/CL:0000546 |
T24 | 1800-1804 | Cell | denotes | Treg | http://purl.obolibrary.org/obo/CL:0000792|http://purl.obolibrary.org/obo/CL:0000815 |