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sonoma2

Id Subject Object Predicate Lexical cue
T0 0-45 DISEASE denotes Neurodegenerative Charcot-Marie-Tooth disease
T1 149-154 DISEASE denotes aaRSs
T2 313-318 DISEASE denotes aaRSs
T3 342-352 REG denotes implicated
T4 418-424 REG denotes common
T5 425-440 GENE denotes aaRS-associated
T6 477-502 DISEASE denotes neurodegenerative disease
T7 503-533 DISEASE denotes Charcot-Marie-Tooth neuropathy
T8 535-538 DISEASE denotes CMT
T9 541-547 REG denotes caused
T10 573-582 VAR denotes mutations
T11 586-591 DISEASE denotes aaRSs
T12 627-632 GENE denotes GlyRS
T13 634-639 GENE denotes TyrRS
T14 641-646 GENE denotes AlaRS
T15 648-653 GENE denotes HisRS
T16 655-660 GENE denotes TrpRS
T17 666-671 GENE denotes MetRS
T18 674-679 DISEASE denotes aaRSs
T19 731-734 DISEASE denotes CMT
T20 781-786 DISEASE denotes aaRSs
T21 790-793 DISEASE denotes CMT
T22 847-855 NEGREG denotes impaired
T23 861-869 MPA denotes charging
T24 971-980 VAR denotes mutations
T25 984-989 DISEASE denotes aaRSs
T26 1005-1009 GENE denotes aaRS
T27 1014-1021 VAR denotes mutants
T28 1032-1036 NEGREG denotes loss
T29 1040-1068 MPA denotes tRNA aminoacylation function
T30 1121-1130 VAR denotes mutations
T31 1134-1139 GENE denotes GlyRS
T32 1140-1145 REG denotes cause
T33 1146-1149 DISEASE denotes CMT
T34 1164-1180 POSREG denotes gain-of-function
T35 1220-1235 DISEASE denotes aaRS-linked CMT
T36 1232-1235 DISEASE denotes CMT
T37 1465-1470 DISEASE denotes aaRSs
T38 1476-1486 DISEASE denotes neuropathy
T39 1530-1535 DISEASE denotes aaRSs
T40 1755-1770 DISEASE denotes aaRS-linked CMT
T41 1767-1770 DISEASE denotes CMT
T42 1856-1861 DISEASE denotes aaRSs
T43 1886-1901 DISEASE denotes aaRS-linked CMT
T44 1898-1901 DISEASE denotes CMT
R0 T7 T3 ThemeOf Charcot-Marie-Tooth neuropathy,implicated
R1 T7 T4 ThemeOf Charcot-Marie-Tooth neuropathy,common
R2 T7 T9 ThemeOf Charcot-Marie-Tooth neuropathy,caused
R3 T8 T3 ThemeOf CMT,implicated
R4 T8 T4 ThemeOf CMT,common
R5 T8 T9 ThemeOf CMT,caused
R6 T8 T10 ThemeOf CMT,mutations
R7 T10 T9 CauseOf mutations,caused
R8 T19 T10 ThemeOf CMT,mutations
R9 T19 T3 ThemeOf CMT,implicated
R10 T19 T4 ThemeOf CMT,common
R11 T23 T22 ThemeOf charging,impaired
R12 T27 T28 CauseOf mutants,loss
R13 T29 T28 ThemeOf tRNA aminoacylation function,loss
R14 T30 T32 CauseOf mutations,cause
R15 T30 T34 CauseOf mutations,gain-of-function
R16 T33 T30 ThemeOf CMT,mutations
R17 T33 T32 ThemeOf CMT,cause
R18 T33 T34 ThemeOf CMT,gain-of-function
R19 T36 T34 ThemeOf CMT,gain-of-function

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 121-312 DRI_Background denotes Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that catalyze the first reaction in protein biosynthesis, namely the charging of transfer RNAs (tRNAs) with their cognate amino acids.
T2 313-408 DRI_Background denotes aaRSs have been increasingly implicated in dominantly and recessively inherited human diseases.
T3 409-592 DRI_Background denotes The most common aaRS-associated monogenic disorder is the incurable neurodegenerative disease Charcot-Marie-Tooth neuropathy (CMT), caused by dominant mono-allelic mutations in aaRSs.
T4 593-744 DRI_Background denotes With six currently known members (GlyRS, TyrRS, AlaRS, HisRS, TrpRS, and MetRS), aaRSs represent the largest protein family implicated in CMT etiology.
T5 745-990 DRI_Outcome denotes After the initial discovery linking aaRSs to CMT, the field has progressed from understanding whether impaired tRNA charging is a critical component of this disease to elucidating the specific pathways affected by CMT-causing mutations in aaRSs.
T6 991-1245 DRI_Background denotes Although many aaRS CMT mutants result in loss of tRNA aminoacylation function, animal genetics studies demonstrated that dominant mutations in GlyRS cause CMT through toxic gain-of-function effects, which also may apply to other aaRS-linked CMT subtypes.
T7 1246-1439 DRI_Background denotes The CMT-causing mechanism is likely to be multifactorial and involves multiple cellular compartments, including the nucleus and the extracellular space, where the normal WT enzymes also appear.
T8 1440-1646 DRI_Background denotes Thus, the association of aaRSs with neuropathy is relevant to discoveries indicating that aaRSs also have nonenzymatic regulatory functions that coordinate protein synthesis with other biological processes.
T9 1647-1957 DRI_Outcome denotes Through genetic, functional, and structural analyses, commonalities among different mutations and different aaRS-linked CMT subtypes have begun to emerge, providing insights into the nonenzymatic functions of aaRSs and the pathogenesis of aaRS-linked CMT to guide therapeutic development to treat this disease.

sentences

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes Neurodegenerative Charcot-Marie-Tooth disease as a case study to decipher novel functions of aminoacyl-tRNA synthetases.
T2 121-408 Sentence denotes Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that catalyze the first reaction in protein biosynthesis, namely the charging of transfer RNAs (tRNAs) with their cognate amino acids. aaRSs have been increasingly implicated in dominantly and recessively inherited human diseases.
T3 409-592 Sentence denotes The most common aaRS-associated monogenic disorder is the incurable neurodegenerative disease Charcot-Marie-Tooth neuropathy (CMT), caused by dominant mono-allelic mutations in aaRSs.
T4 593-744 Sentence denotes With six currently known members (GlyRS, TyrRS, AlaRS, HisRS, TrpRS, and MetRS), aaRSs represent the largest protein family implicated in CMT etiology.
T5 745-990 Sentence denotes After the initial discovery linking aaRSs to CMT, the field has progressed from understanding whether impaired tRNA charging is a critical component of this disease to elucidating the specific pathways affected by CMT-causing mutations in aaRSs.
T6 991-1245 Sentence denotes Although many aaRS CMT mutants result in loss of tRNA aminoacylation function, animal genetics studies demonstrated that dominant mutations in GlyRS cause CMT through toxic gain-of-function effects, which also may apply to other aaRS-linked CMT subtypes.
T7 1246-1439 Sentence denotes The CMT-causing mechanism is likely to be multifactorial and involves multiple cellular compartments, including the nucleus and the extracellular space, where the normal WT enzymes also appear.
T8 1440-1646 Sentence denotes Thus, the association of aaRSs with neuropathy is relevant to discoveries indicating that aaRSs also have nonenzymatic regulatory functions that coordinate protein synthesis with other biological processes.
T9 1647-1957 Sentence denotes Through genetic, functional, and structural analyses, commonalities among different mutations and different aaRS-linked CMT subtypes have begun to emerge, providing insights into the nonenzymatic functions of aaRSs and the pathogenesis of aaRS-linked CMT to guide therapeutic development to treat this disease.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 32-37 http://purl.obolibrary.org/obo/MAT_0000041 denotes Tooth
T2 517-522 http://purl.obolibrary.org/obo/MAT_0000041 denotes Tooth

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 18-45 Disease denotes Charcot-Marie-Tooth disease http://purl.obolibrary.org/obo/MONDO_0015626
T2 477-502 Disease denotes neurodegenerative disease http://purl.obolibrary.org/obo/MONDO_0005559
T3 523-533 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T4 535-538 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626
T5 731-734 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626
T6 790-793 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626
T7 959-962 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626
T8 1010-1013 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626
T9 1146-1149 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626
T10 1232-1235 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626
T11 1250-1253 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626
T12 1476-1486 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T13 1767-1770 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626
T14 1898-1901 Disease denotes CMT http://purl.obolibrary.org/obo/MONDO_0015626

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 393-398 OrganismTaxon denotes human 9606

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 32-37 Body_part denotes Tooth http://purl.obolibrary.org/obo/MAT_0000041
T2 517-522 Body_part denotes Tooth http://purl.obolibrary.org/obo/MAT_0000041

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 32-37 Body_part denotes Tooth http://purl.obolibrary.org/obo/UBERON_0001091
T2 517-522 Body_part denotes Tooth http://purl.obolibrary.org/obo/UBERON_0001091
T3 1362-1369 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T5 1378-1397 Body_part denotes extracellular space http://purl.obolibrary.org/obo/GO_0005615

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 477-502 Phenotype denotes neurodegenerative disease HP:0002180
T2 523-533 Phenotype denotes neuropathy HP:0009830
T3 1476-1486 Phenotype denotes neuropathy HP:0009830