PubMed:30593372 / 864-1153 JSONTXT

{"project":"GoldHamster","denotations":[{"id":"T57","span":{"begin":41,"end":45},"obj":"SO:0000234"},{"id":"T55","span":{"begin":41,"end":45},"obj":"D012333"},{"id":"T56","span":{"begin":41,"end":45},"obj":"CHEBI:33699"},{"id":"T58","span":{"begin":60,"end":64},"obj":"PR:000001154"},{"id":"T59","span":{"begin":60,"end":64},"obj":"PR:Q99MB1"},{"id":"T61","span":{"begin":60,"end":64},"obj":"PR:O15455"},{"id":"T60","span":{"begin":60,"end":64},"obj":"CVCL_5601"},{"id":"T62","span":{"begin":66,"end":71},"obj":"D018664"},{"id":"T64","span":{"begin":66,"end":71},"obj":"D018664"},{"id":"T63","span":{"begin":66,"end":71},"obj":"GO:0005143"},{"id":"T65","span":{"begin":91,"end":94},"obj":"Q03963"},{"id":"T66","span":{"begin":91,"end":94},"obj":"PR:000006959"},{"id":"T67","span":{"begin":91,"end":94},"obj":"P19525"},{"id":"T68","span":{"begin":91,"end":94},"obj":"PR:Q03963"},{"id":"T69","span":{"begin":91,"end":94},"obj":"PR:P19525"},{"id":"T70","span":{"begin":91,"end":94},"obj":"Q63184"},{"id":"T71","span":{"begin":91,"end":94},"obj":"CVCL_2693"},{"id":"T72","span":{"begin":179,"end":186},"obj":"CVCL_E012"},{"id":"T86","span":{"begin":187,"end":193},"obj":"D020152"},{"id":"T87","span":{"begin":224,"end":231},"obj":"CVCL_E012"}],"text":"Importantly, PDCoV significantly induced mRNA expression of TLR3, IL-12, IFN-α, IFN-β, and PKR, the genes involved in modulation of the host immune responses, in infected Peyer's patches at 3 d.p.i., indicating that Peyer's patches play an important role in PDCoV immune responses in vivo."}

{"project":"PubMed_ArguminSci","denotations":[{"id":"T8","span":{"begin":0,"end":289},"obj":"DRI_Outcome"}],"text":"Importantly, PDCoV significantly induced mRNA expression of TLR3, IL-12, IFN-α, IFN-β, and PKR, the genes involved in modulation of the host immune responses, in infected Peyer's patches at 3 d.p.i., indicating that Peyer's patches play an important role in PDCoV immune responses in vivo."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T6","span":{"begin":60,"end":64},"obj":"CVCL_5601|Conditionally_immortalized_cell_line|Mus musculus"},{"id":"T7","span":{"begin":91,"end":94},"obj":"CVCL_2693|Spontaneously_immortalized_cell_line|Sus scrofa"},{"id":"T8","span":{"begin":179,"end":186},"obj":"CVCL_E012|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T9","span":{"begin":187,"end":191},"obj":"CVCL_0146|Cancer_cell_line|Rattus norvegicus"},{"id":"T10","span":{"begin":187,"end":191},"obj":"CVCL_VR89|Cancer_cell_line|Mus musculus"},{"id":"T11","span":{"begin":224,"end":231},"obj":"CVCL_E012|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T12","span":{"begin":237,"end":239},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T13","span":{"begin":237,"end":239},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"}],"text":"Importantly, PDCoV significantly induced mRNA expression of TLR3, IL-12, IFN-α, IFN-β, and PKR, the genes involved in modulation of the host immune responses, in infected Peyer's patches at 3 d.p.i., indicating that Peyer's patches play an important role in PDCoV immune responses in vivo."}