PubMed:30479041
Annnotations
silkwormbase
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 21-29 | Species:7091 | denotes | silkworm |
T10 | 387-404 | Chemical:MESH:D006851 | denotes | hydrochloric acid |
T11 | 407-414 | Chemical:MESH:D000431 | denotes | ethanol |
T12 | 423-436 | Disease:MESH:D013276 | denotes | gastric ulcer |
T13 | 447-455 | Species:7091 | denotes | Silkworm |
T14 | 476-499 | Chemical:MESH:D005231 | denotes | unsaturated fatty acids |
T15 | 511-527 | Chemical:MESH:C008757 | denotes | palmitoleic acid |
T16 | 542-552 | Chemical:MESH:D019301 | denotes | oleic acid |
T17 | 568-581 | Chemical:MESH:D019787 | denotes | linoleic acid |
T18 | 600-614 | Chemical:MESH:D017962 | denotes | linolenic acid |
T19 | 642-664 | Chemical:MESH:D005231 | denotes | unsaturated fatty acid |
T2 | 42-59 | Chemical:MESH:D006851 | denotes | hydrochloric acid |
T20 | 703-716 | Disease:MESH:D013276 | denotes | gastric ulcer |
T21 | 771-784 | Disease:MESH:D013276 | denotes | gastric ulcer |
T22 | 907-915 | Gene:692456 | denotes | catalase |
T23 | 917-920 | Gene:692456 | denotes | CAT |
T24 | 923-945 | Gene:692548 | denotes | glutathione peroxidase |
T25 | 1095-1109 | Disease:MESH:D009336 | denotes | tumor necrosis |
T26 | 1241-1249 | Species:7091 | denotes | silkworm |
T27 | 1283-1286 | Gene:692456 | denotes | CAT |
T28 | 1327-1359 | Gene:101741679 | denotes | Epidermal growth factor receptor |
T29 | 1361-1365 | Gene:101741679 | denotes | EGFR |
T3 | 60-67 | Chemical:MESH:D000431 | denotes | ethanol |
T30 | 1453-1462 | Gene:692639 | denotes | Cu/Zn-SOD |
T31 | 1569-1579 | Disease:MESH:D008223 | denotes | lymphoma-2 |
T32 | 1682-1690 | Species:7091 | denotes | Silkworm |
T33 | 1718-1734 | Disease:MESH:D004194 | denotes | oxidative damage |
T34 | 1739-1751 | Disease:MESH:D007249 | denotes | inflammation |
T35 | 1755-1759 | Species:10090 | denotes | mice |
T36 | 1775-1783 | Species:7091 | denotes | silkworm |
T37 | 1784-1792 | Chemical:- | denotes | pupa oil |
T38 | 1818-1826 | Species:7091 | denotes | silkworm |
T39 | 1832-1835 | Chemical:MESH:D009821 | denotes | oil |
T4 | 76-90 | Disease:MESH:D013276 | denotes | gastric ulcers |
T40 | 1847-1857 | Chemical:MESH:D011899 | denotes | ranitidine |
T5 | 104-112 | Species:7091 | denotes | Silkworm |
T6 | 167-204 | Chemical:- | denotes | saturated and unsaturated fatty acids |
T7 | 206-229 | Chemical:MESH:D005231 | denotes | Unsaturated fatty acids |
T8 | 271-287 | Disease:MESH:D004194 | denotes | oxidative damage |
T9 | 366-374 | Species:7091 | denotes | silkworm |
Inflammaging
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-91 | Sentence | denotes | Protective effect of silkworm pupa oil on hydrochloric acid/ethanol-induced gastric ulcers. |
T2 | 92-103 | Sentence | denotes | BACKGROUND: |
T3 | 104-205 | Sentence | denotes | Silkworm pupae are a traditional Chinese food, rich in various saturated and unsaturated fatty acids. |
T4 | 206-288 | Sentence | denotes | Unsaturated fatty acids have a certain protective effect against oxidative damage. |
T5 | 289-437 | Sentence | denotes | The present study used an animal model to determine the protective effect of silkworm pupa oil on hydrochloric acid / ethanol-induced gastric ulcer. |
T6 | 438-446 | Sentence | denotes | RESULTS: |
T7 | 447-688 | Sentence | denotes | Silkworm pupa oil is rich in unsaturated fatty acids, including palmitoleic acid 63.4 g kg-1 , oleic acid 249.1 g kg-1 , linoleic acid 47.0 g kg-1 , and linolenic acid 337.8 g kg-1 , whereas its unsaturated fatty acid content is 700 g kg-1 . |
T8 | 689-842 | Sentence | denotes | Compared to a gastric ulcer control group, high and low doses of pupa oil reduced gastric ulcer area and gastric secretion, whereas gastric pH increased. |
T9 | 843-1191 | Sentence | denotes | It also increased serum antioxidant superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) levels, somatostatin (SST), and vasoactive intestinal peptide (VIP) levels, and reduced serum interleukin-6 (IL-6), interleukin-12 (IL-12), tumor necrosis factor (TNF-α), and interferon-γ (IFN-γ), motilin (MTL), and gastrin (GT) levels. |
T10 | 1192-1669 | Sentence | denotes | RT-qPCR and western blot analyses indicated that silkworm pupa oil significantly increased CAT, GSH-Px, epidermal growth factor (EGF), Epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), Cu/Zn-SOD, Mn-SOD, and NF-kappa-B inhibitor-α (IκB-α) expression and lowered nuclear factor-kappa B (NF-κB), B-cell lymphoma-2 (Bcl-2), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) expression. |
T11 | 1670-1681 | Sentence | denotes | CONCLUSION: |
T12 | 1682-1895 | Sentence | denotes | Silkworm pupa oil treatment reduced oxidative damage and inflammation in mice, and high-dose silkworm pupa oil was superior to low-dose silkworm pupa oil, following ranitidine. © 2018 Society of Chemical Industry. |
T1 | 0-91 | Sentence | denotes | Protective effect of silkworm pupa oil on hydrochloric acid/ethanol-induced gastric ulcers. |
T2 | 92-103 | Sentence | denotes | BACKGROUND: |
T3 | 104-205 | Sentence | denotes | Silkworm pupae are a traditional Chinese food, rich in various saturated and unsaturated fatty acids. |
T4 | 206-288 | Sentence | denotes | Unsaturated fatty acids have a certain protective effect against oxidative damage. |
T5 | 289-437 | Sentence | denotes | The present study used an animal model to determine the protective effect of silkworm pupa oil on hydrochloric acid / ethanol-induced gastric ulcer. |
T6 | 438-446 | Sentence | denotes | RESULTS: |
T7 | 447-688 | Sentence | denotes | Silkworm pupa oil is rich in unsaturated fatty acids, including palmitoleic acid 63.4 g kg-1 , oleic acid 249.1 g kg-1 , linoleic acid 47.0 g kg-1 , and linolenic acid 337.8 g kg-1 , whereas its unsaturated fatty acid content is 700 g kg-1 . |
T8 | 689-842 | Sentence | denotes | Compared to a gastric ulcer control group, high and low doses of pupa oil reduced gastric ulcer area and gastric secretion, whereas gastric pH increased. |
T9 | 843-1191 | Sentence | denotes | It also increased serum antioxidant superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) levels, somatostatin (SST), and vasoactive intestinal peptide (VIP) levels, and reduced serum interleukin-6 (IL-6), interleukin-12 (IL-12), tumor necrosis factor (TNF-α), and interferon-γ (IFN-γ), motilin (MTL), and gastrin (GT) levels. |
T10 | 1192-1669 | Sentence | denotes | RT-qPCR and western blot analyses indicated that silkworm pupa oil significantly increased CAT, GSH-Px, epidermal growth factor (EGF), Epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), Cu/Zn-SOD, Mn-SOD, and NF-kappa-B inhibitor-α (IκB-α) expression and lowered nuclear factor-kappa B (NF-κB), B-cell lymphoma-2 (Bcl-2), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) expression. |
T11 | 1670-1681 | Sentence | denotes | CONCLUSION: |
T12 | 1682-1895 | Sentence | denotes | Silkworm pupa oil treatment reduced oxidative damage and inflammation in mice, and high-dose silkworm pupa oil was superior to low-dose silkworm pupa oil, following ranitidine. © 2018 Society of Chemical Industry. |
silkworm
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 21-29 | Species:7091 | denotes | silkworm |
T2 | 42-59 | Chemical:MESH:D006851 | denotes | hydrochloric acid |
T3 | 60-67 | Chemical:MESH:D000431 | denotes | ethanol |
T4 | 76-90 | Disease:MESH:D013276 | denotes | gastric ulcers |
T5 | 104-112 | Species:7091 | denotes | Silkworm |
T6 | 167-204 | Chemical:- | denotes | saturated and unsaturated fatty acids |
T7 | 206-229 | Chemical:MESH:D005231 | denotes | Unsaturated fatty acids |
T8 | 271-287 | Disease:MESH:D004194 | denotes | oxidative damage |
T9 | 366-374 | Species:7091 | denotes | silkworm |
T10 | 387-404 | Chemical:MESH:D006851 | denotes | hydrochloric acid |
T11 | 407-414 | Chemical:MESH:D000431 | denotes | ethanol |
T12 | 423-436 | Disease:MESH:D013276 | denotes | gastric ulcer |
T13 | 447-455 | Species:7091 | denotes | Silkworm |
T14 | 476-499 | Chemical:MESH:D005231 | denotes | unsaturated fatty acids |
T15 | 511-527 | Chemical:MESH:C008757 | denotes | palmitoleic acid |
T16 | 542-552 | Chemical:MESH:D019301 | denotes | oleic acid |
T17 | 568-581 | Chemical:MESH:D019787 | denotes | linoleic acid |
T18 | 600-614 | Chemical:MESH:D017962 | denotes | linolenic acid |
T19 | 642-664 | Chemical:MESH:D005231 | denotes | unsaturated fatty acid |
T20 | 703-716 | Disease:MESH:D013276 | denotes | gastric ulcer |
T21 | 771-784 | Disease:MESH:D013276 | denotes | gastric ulcer |
T22 | 907-915 | Gene:692456 | denotes | catalase |
T23 | 917-920 | Gene:692456 | denotes | CAT |
T24 | 923-945 | Gene:692548 | denotes | glutathione peroxidase |
T25 | 1095-1109 | Disease:MESH:D009336 | denotes | tumor necrosis |
T26 | 1241-1249 | Species:7091 | denotes | silkworm |
T27 | 1283-1286 | Gene:692456 | denotes | CAT |
T28 | 1327-1359 | Gene:101741679 | denotes | Epidermal growth factor receptor |
T29 | 1361-1365 | Gene:101741679 | denotes | EGFR |
T30 | 1453-1462 | Gene:692639 | denotes | Cu/Zn-SOD |
T31 | 1569-1579 | Disease:MESH:D008223 | denotes | lymphoma-2 |
T32 | 1682-1690 | Species:7091 | denotes | Silkworm |
T33 | 1718-1734 | Disease:MESH:D004194 | denotes | oxidative damage |
T34 | 1739-1751 | Disease:MESH:D007249 | denotes | inflammation |
T35 | 1755-1759 | Species:10090 | denotes | mice |
T36 | 1775-1783 | Species:7091 | denotes | silkworm |
T37 | 1784-1792 | Chemical:- | denotes | pupa oil |
T38 | 1818-1826 | Species:7091 | denotes | silkworm |
T39 | 1832-1835 | Chemical:MESH:D009821 | denotes | oil |
T40 | 1847-1857 | Chemical:MESH:D011899 | denotes | ranitidine |