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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 119-313 DRI_Approach denotes Detection of cytosolic DNA by the enzyme cGAS triggers the production of cGAMP, a second messenger that binds and activates the adaptor protein STING, which leads to interferon (IFN) production.
T2 314-463 DRI_Approach denotes Here, we found that in vivo natural killer (NK) cell killing of tumor cells, but not of normal cells, depends on STING expression in non-tumor cells.
T3 464-634 DRI_Background denotes Experiments using transplantable tumor models in STING- and cGAS-deficient mice revealed that cGAS expression by tumor cells was critical for tumor rejection by NK cells.
T4 635-710 DRI_Background denotes In contrast, cGAS expression by host cells was dispensable, suggesting that
T5 731-791 DRI_Background denotes is transferred to non-tumor cells, where it activates STING.
T6 792-907 DRI_Approach denotes cGAMP administration triggered STING activation and IFN-β production in myeloid cells and B cells but not NK cells.
T7 908-1087 DRI_Outcome denotes Our results reveal that the anti-tumor response of NK cells critically depends on the cytosolic DNA sensing pathway, similar to its role in defense against pathogens, and identify
T8 1108-1198 DRI_Outcome denotes as a major determinant of tumor immunogenicity with implications for cancer immunotherapy.

test10

Id Subject Object Predicate Lexical cue
T1 0-5 D009369 denotes Tumor
T10 31-36 A8E5V9 denotes STING
T100 524-528 I3LM39 denotes cGAS
T101 524-528 E1BGN7 denotes cGAS
T102 524-528 PR:Q8C6L5 denotes cGAS
T103 524-528 PR:Q8N884 denotes cGAS
T104 524-528 A7SFB5 denotes cGAS
T105 524-528 PR:000030833 denotes cGAS
T106 524-528 Q8C6L5 denotes cGAS
T107 524-528 Q8N884 denotes cGAS
T108 539-543 PR:000005054 denotes mice
T109 539-543 D051379 denotes mice
T11 31-36 E1C7U0 denotes STING
T110 539-543 O89094 denotes mice
T111 539-543 10095 denotes mice
T112 558-562 I3LM39 denotes cGAS
T113 558-562 E1BGN7 denotes cGAS
T114 558-562 PR:Q8C6L5 denotes cGAS
T115 558-562 PR:Q8N884 denotes cGAS
T116 558-562 A7SFB5 denotes cGAS
T117 558-562 PR:000030833 denotes cGAS
T118 558-562 Q8C6L5 denotes cGAS
T119 558-562 Q8N884 denotes cGAS
T12 31-36 D001733 denotes STING
T120 577-582 D009369 denotes tumor
T121 577-582 D009369 denotes tumor
T122 606-611 D009369 denotes tumor
T123 606-611 D009369 denotes tumor
T124 648-652 I3LM39 denotes cGAS
T125 648-652 E1BGN7 denotes cGAS
T126 648-652 PR:Q8C6L5 denotes cGAS
T127 648-652 PR:Q8N884 denotes cGAS
T128 648-652 A7SFB5 denotes cGAS
T129 648-652 PR:000030833 denotes cGAS
T13 31-36 Q2KI99 denotes STING
T130 648-652 Q8C6L5 denotes cGAS
T131 648-652 Q8N884 denotes cGAS
T132 711-716 D009369 denotes tumor
T133 711-716 D009369 denotes tumor
T134 725-730 C584311 denotes cGAMP
T135 725-730 C584311 denotes cGAMP
T136 753-758 D009369 denotes tumor
T137 753-758 D009369 denotes tumor
T138 785-790 A7SLZ2 denotes STING
T139 785-790 PR:F1M391 denotes STING
T14 31-36 D001733 denotes STING
T140 785-790 PR:000016417 denotes STING
T141 785-790 PR:Q86WV6 denotes STING
T142 785-790 PR:E7F4N7 denotes STING
T143 785-790 A8E5V9 denotes STING
T144 785-790 E1C7U0 denotes STING
T145 785-790 D001733 denotes STING
T146 785-790 Q2KI99 denotes STING
T147 785-790 D001733 denotes STING
T148 785-790 PR:Q3TBT3 denotes STING
T149 785-790 E7F4N7 denotes STING
T15 31-36 PR:Q3TBT3 denotes STING
T150 785-790 PR:E1C7U0 denotes STING
T151 792-797 C584311 denotes cGAMP
T152 792-797 C584311 denotes cGAMP
T153 823-828 A7SLZ2 denotes STING
T154 823-828 PR:F1M391 denotes STING
T155 823-828 PR:000016417 denotes STING
T156 823-828 PR:Q86WV6 denotes STING
T157 823-828 PR:E7F4N7 denotes STING
T158 823-828 A8E5V9 denotes STING
T159 823-828 E1C7U0 denotes STING
T16 31-36 E7F4N7 denotes STING
T160 823-828 D001733 denotes STING
T161 823-828 Q2KI99 denotes STING
T162 823-828 D001733 denotes STING
T163 823-828 PR:Q3TBT3 denotes STING
T164 823-828 E7F4N7 denotes STING
T165 823-828 PR:E1C7U0 denotes STING
T166 844-849 P05012 denotes IFN-β
T167 844-849 P01574 denotes IFN-β
T168 844-849 PR:000008924 denotes IFN-β
T169 844-849 P70499 denotes IFN-β
T17 31-36 PR:E1C7U0 denotes STING
T170 844-849 P01575 denotes IFN-β
T171 844-849 Q90873 denotes IFN-β
T172 844-849 Q6XZW6 denotes IFN-β
T173 844-849 Q9N2J0 denotes IFN-β
T174 844-849 O77812 denotes IFN-β
T175 844-860 GO:0032608 denotes IFN-β production
T176 941-946 D009369 denotes tumor
T177 941-946 D009369 denotes tumor
T178 1004-1007 GO:0005574 denotes DNA
T179 1004-1007 CHEBI:16991 denotes DNA
T18 46-56 P51526 denotes Interferon
T180 1004-1007 SO:0000352 denotes DNA
T181 1004-1007 D004247 denotes DNA
T182 1016-1023 CHEBI:34922 denotes pathway
T183 1088-1093 D009369 denotes tumor
T184 1088-1093 D009369 denotes tumor
T185 1102-1107 C584311 denotes cGAMP
T186 1102-1107 C584311 denotes cGAMP
T187 1134-1139 D009369 denotes tumor
T188 1134-1139 D009369 denotes tumor
T19 46-56 P51527 denotes Interferon
T2 0-5 D009369 denotes Tumor
T20 46-56 D007372 denotes Interferon
T21 46-56 D007372 denotes Interferon
T22 46-56 CHEBI:52999 denotes Interferon
T23 73-78 D009369 denotes tumor
T24 73-78 D009369 denotes tumor
T25 101-108 CL:0000623 denotes NK Cell
T26 101-108 UBERON:3010310 denotes NK Cell
T27 142-145 GO:0005574 denotes DNA
T28 142-145 CHEBI:16991 denotes DNA
T29 142-145 SO:0000352 denotes DNA
T3 14-19 C584311 denotes cGAMP
T30 142-145 D004247 denotes DNA
T31 160-164 I3LM39 denotes cGAS
T32 160-164 E1BGN7 denotes cGAS
T33 160-164 PR:Q8C6L5 denotes cGAS
T34 160-164 PR:Q8N884 denotes cGAS
T35 160-164 A7SFB5 denotes cGAS
T36 160-164 PR:000030833 denotes cGAS
T37 160-164 Q8C6L5 denotes cGAS
T38 160-164 Q8N884 denotes cGAS
T39 192-197 C584311 denotes cGAMP
T4 14-19 C584311 denotes cGAMP
T40 192-197 C584311 denotes cGAMP
T41 255-262 GO:0003675 denotes protein
T42 255-262 CHEBI:36080 denotes protein
T43 255-262 CHEBI:11122 denotes protein
T45 255-262 SO:0000104 denotes protein
T46 255-268 O76922 denotes protein STING
T5 31-36 A7SLZ2 denotes STING
T54 263-268 D001733 denotes STING
T56 263-268 D001733 denotes STING
T6 31-36 PR:F1M391 denotes STING
T60 285-295 P51526 denotes interferon
T61 285-295 P51527 denotes interferon
T62 285-295 D007372 denotes interferon
T63 285-295 D007372 denotes interferon
T64 285-295 CHEBI:52999 denotes interferon
T68 378-383 D009369 denotes tumor
T69 378-383 D009369 denotes tumor
T7 31-36 PR:000016417 denotes STING
T70 427-432 A7SLZ2 denotes STING
T71 427-432 PR:F1M391 denotes STING
T72 427-432 PR:000016417 denotes STING
T73 427-432 PR:Q86WV6 denotes STING
T74 427-432 PR:E7F4N7 denotes STING
T75 427-432 A8E5V9 denotes STING
T76 427-432 E1C7U0 denotes STING
T77 427-432 D001733 denotes STING
T78 427-432 Q2KI99 denotes STING
T79 427-432 D001733 denotes STING
T8 31-36 PR:Q86WV6 denotes STING
T80 427-432 PR:Q3TBT3 denotes STING
T81 427-432 E7F4N7 denotes STING
T82 427-432 PR:E1C7U0 denotes STING
T83 451-456 D009369 denotes tumor
T84 451-456 D009369 denotes tumor
T85 497-502 D009369 denotes tumor
T86 497-502 D009369 denotes tumor
T87 513-518 A7SLZ2 denotes STING
T88 513-518 PR:F1M391 denotes STING
T89 513-518 PR:000016417 denotes STING
T9 31-36 PR:E7F4N7 denotes STING
T90 513-518 PR:Q86WV6 denotes STING
T91 513-518 PR:E7F4N7 denotes STING
T92 513-518 A8E5V9 denotes STING
T93 513-518 E1C7U0 denotes STING
T94 513-518 D001733 denotes STING
T95 513-518 Q2KI99 denotes STING
T96 513-518 D001733 denotes STING
T97 513-518 PR:Q3TBT3 denotes STING
T98 513-518 E7F4N7 denotes STING
T99 513-518 PR:E1C7U0 denotes STING