PubMed:30262663
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 932-943 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 932-943 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-151 | Sentence | denotes | The human gut microbe Bacteroides thetaiotaomicron encodes the founding member of a novel glycosaminoglycan-degrading polysaccharide lyase family PL29. |
| T2 | 152-282 | Sentence | denotes | Glycosaminoglycans (GAGs) and GAG-degrading enzymes have wide-ranging applications in the medical and biotechnological industries. |
| T3 | 283-430 | Sentence | denotes | The former are also an important nutrient source for select species of the human gut microbiota (HGM), a key player in host-microbial interactions. |
| T4 | 431-590 | Sentence | denotes | How GAGs are metabolized by the HGM is therefore of interest and has been extensively investigated in the model human gut microbe Bacteroides thetaiotaomicron. |
| T5 | 591-758 | Sentence | denotes | The presence of as-yet uncharacterized GAG-inducible genes in its genome and of related species, however, is testament to our incomplete understanding of this process. |
| T6 | 759-863 | Sentence | denotes | Nevertheless, it presents a potential opportunity for the discovery of additional GAG-degrading enzymes. |
| T7 | 864-1259 | Sentence | denotes | Here, we investigated a gene of unknown function (BT_3328) from the chondroitin sulfate (CS) utilization locus of B. thetaiotaomicron NMR and UV spectroscopic assays revealed that it encodes a novel polysaccharide lyase (PL), hereafter referred to as BtCDH, reflecting its source (B. thetaiotaomicron (Bt)) and its ability to degrade the GAGs CS, dermatan sulfate (DS), and hyaluronic acid (HA). |
| T8 | 1260-1504 | Sentence | denotes | When incubated with HA, BtCDH generated a series of unsaturated HA sugars, including Δ4,5UA-GlcNAc, Δ4,5UA-GlcNAc-GlcA-GlcNac, Δ4,5UA-[GlcNAc-GlcA]2-GlcNac, and Δ4,5UA-[GlcNAc-GlcA]3-GlcNac, as end products and hence was classed as endo-acting. |
| T9 | 1505-1673 | Sentence | denotes | A combination of genetic and biochemical assays revealed that BtCDH localizes to the cell surface of B. thetaiotaomicron where it enables extracellular GAG degradation. |
| T10 | 1674-1846 | Sentence | denotes | BtCDH homologs were also detected in several other HGM species, and we therefore propose that it represents the founding member of a new polysaccharide lyase family (PL29). |
| T11 | 1847-1929 | Sentence | denotes | The current discovery also contributes new insights into CS metabolism by the HGM. |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 932-943 | GlycoEpitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 10-13 | http://purl.obolibrary.org/obo/MAT_0000043 | denotes | gut |
| T2 | 364-367 | http://purl.obolibrary.org/obo/MAT_0000043 | denotes | gut |
| T3 | 549-552 | http://purl.obolibrary.org/obo/MAT_0000043 | denotes | gut |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 1352-1358 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 1367-1373 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 1379-1385 | chem:24139 | denotes | GlcNac |
| PD-NGLY1-deficiency-B_T4 | 1395-1401 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T5 | 1409-1415 | chem:24139 | denotes | GlcNac |
| PD-NGLY1-deficiency-B_T6 | 1429-1435 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T7 | 1443-1449 | chem:24139 | denotes | GlcNac |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 10-13 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/MAT_0000043 |
| T2 | 364-367 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/MAT_0000043 |
| T3 | 549-552 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/MAT_0000043 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 4-9 | OrganismTaxon | denotes | human | 9606 |
| T2 | 22-50 | OrganismTaxon | denotes | Bacteroides thetaiotaomicron | 818 |
| T3 | 358-363 | OrganismTaxon | denotes | human | 9606 |
| T4 | 368-378 | OrganismTaxon | denotes | microbiota | 13613 |
| T5 | 543-548 | OrganismTaxon | denotes | human | 9606 |
| T6 | 561-589 | OrganismTaxon | denotes | Bacteroides thetaiotaomicron | 818 |
Glycosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 932-943 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 10-13 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907 |
| T4 | 364-367 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907 |
| T7 | 549-552 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907 |
| T10 | 1643-1656 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |