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sonoma2

Id Subject Object Predicate Lexical cue
T0 0-4 GENE denotes OSMR
T1 5-16 VAR denotes gene effect
T2 24-36 CPA denotes pathogenesis
T3 40-68 DISEASE denotes chronic autoimmune Urticaria
T4 48-68 DISEASE denotes autoimmune Urticaria
T5 77-86 GENE denotes JAK/STAT3
T6 107-135 DISEASE denotes Chronic autoimmune urticari
T7 108-136 DISEASE denotes Chronic autoimmune urticaria
T8 138-141 DISEASE denotes CAU
T9 154-166 DISEASE denotes skin diseas
T10 275-282 CPA denotes therapy
T11 287-290 DISEASE denotes CAU
T12 352-363 MPA denotes functioning
T13 370-391 GENE denotes Oncostatin M recepto
T14 393-397 GENE denotes (OSM
T15 394-398 GENE denotes OSMR
T16 412-424 CPA denotes autoimmunity
T17 428-431 DISEASE denotes CAU
T18 436-446 REG denotes regulation
T19 453-462 GENE denotes JAK/STAT
T20 517-520 DISEASE denotes CAU
T21 729-733 GENE denotes f OS
T22 731-735 GENE denotes OSMR
T23 736-746 MPA denotes expression
T24 863-866 DISEASE denotes CAU
T25 925-935 MPA denotes expression
T26 964-973 REG denotes evaluated
T27 1021-1032 MPA denotes Expressions
T28 1050-1053 GENE denotes JAK
T29 1054-1104 GENE denotes , signal transducer and activator of transcription
T30 1106-1111 GENE denotes (STA
T31 1108-1113 GENE denotes STAT3
T32 1114-1143 GENE denotes , interferon-stimulated gene
T33 1116-1145 GENE denotes interferon-stimulated gene 15
T34 1145-1150 GENE denotes (ISG
T35 1147-1152 GENE denotes ISG15
T36 1153-1174 GENE denotes , CT10-regulated kina
T37 1176-1179 GENE denotes (C
T38 1178-1181 GENE denotes CRK
T39 1186-1216 GENE denotes d interferon regulatory factor
T40 1218-1222 GENE denotes (IR
T41 1220-1224 GENE denotes IRF9
T42 1343-1372 CPA denotes Epithelial cell proliferation
T43 1468-1491 CPA denotes cell cycle distribution
T44 1501-1510 CPA denotes apoptosis
T45 1579-1583 GENE denotes at O
T46 1582-1586 GENE denotes OSMR
T47 1595-1605 MPA denotes expression
T48 1610-1619 CPA denotes histamine
T49 1620-1627 MPA denotes release
T50 1644-1652 POSREG denotes elevated
T51 1662-1665 DISEASE denotes CAU
T52 1688-1698 MPA denotes expression
T53 1703-1712 GENE denotes he JAK/ST
T54 1746-1750 GENE denotes s (O
T55 1749-1753 GENE denotes OSMR
T56 1752-1756 GENE denotes R, J
T57 1755-1759 GENE denotes JAK2
T58 1758-1763 GENE denotes 2, ST
T59 1761-1766 GENE denotes STAT3
T60 1765-1770 GENE denotes 3, IS
T61 1768-1773 GENE denotes ISG15
T62 1772-1775 GENE denotes 5,
T63 1775-1778 GENE denotes CRK
T64 1780-1784 GENE denotes nd I
T65 1783-1787 GENE denotes IRF9
T66 1793-1805 POSREG denotes up-regulated
T67 1804-1808 GENE denotes d. O
T68 1807-1811 GENE denotes OSMR
T69 1817-1826 VAR denotes silencing
T70 1830-1833 DISEASE denotes CAU
T71 1853-1862 NEGREG denotes decreases
T72 1867-1874 MPA denotes content
T73 1897-1901 GENE denotes s (I
T74 1900-1904 GENE denotes IL-1
T75 1903-1907 GENE denotes 1, I
T76 1906-1910 GENE denotes IL-6
T77 1909-1918 GENE denotes 6, IFN-γ,
T78 1912-1917 GENE denotes IFN-γ
T79 1923-1926 GENE denotes IgE
T80 1933-1939 MPA denotes number
T81 1943-1954 CPA denotes eosinophils
T82 1960-1967 NEGREG denotes reduces
T83 1972-1982 MPA denotes expression
T84 1991-2000 GENE denotes AK/STAT3
T85 2045-2053 POSREG denotes enhances
T86 2054-2072 CPA denotes cell proliferation
T87 2074-2082 POSREG denotes promotes
T88 2083-2099 CPA denotes cell cycle entry
T89 2104-2112 NEGREG denotes inhibits
T90 2113-2122 CPA denotes apoptosis
T91 2126-2142 CPA denotes epithelial cells
T92 2197-2201 GENE denotes OSMR
T93 2207-2216 VAR denotes silencing
T94 2217-2225 NEGREG denotes inhibits
T95 2230-2240 POSREG denotes activation
T96 2248-2257 GENE denotes JAK/STAT3
T97 2285-2296 NEGREG denotes suppressing
T98 2301-2312 CPA denotes development
T99 2316-2319 DISEASE denotes CAU
R0 T0 T1 ThemeOf OSMR,gene effect
R1 T2 T1 ThemeOf pathogenesis,gene effect
R2 T3 T2 ThemeOf chronic autoimmune Urticaria,pathogenesis
R3 T3 T1 ThemeOf chronic autoimmune Urticaria,gene effect
R4 T11 T10 ThemeOf CAU,therapy
R5 T12 T18 ThemeOf functioning,regulation
R6 T15 T12 ThemeOf OSMR,functioning
R7 T15 T18 ThemeOf OSMR,regulation
R8 T16 T18 ThemeOf autoimmunity,regulation
R9 T17 T12 ThemeOf CAU,functioning
R10 T17 T16 ThemeOf CAU,autoimmunity
R11 T17 T18 ThemeOf CAU,regulation
R12 T22 T23 ThemeOf OSMR,expression
R13 T24 T26 ThemeOf CAU,evaluated
R14 T25 T26 ThemeOf expression,evaluated
R15 T28 T27 ThemeOf JAK,Expressions
R16 T31 T27 ThemeOf STAT3,Expressions
R17 T33 T27 ThemeOf interferon-stimulated gene 15,Expressions
R18 T35 T27 ThemeOf ISG15,Expressions
R19 T38 T27 ThemeOf CRK,Expressions
R20 T41 T27 ThemeOf IRF9,Expressions
R21 T46 T47 ThemeOf OSMR,expression
R22 T46 T49 ThemeOf OSMR,release
R23 T47 T49 ThemeOf expression,release
R24 T47 T50 ThemeOf expression,elevated
R25 T47 T66 ThemeOf expression,up-regulated
R26 T48 T49 ThemeOf histamine,release
R27 T48 T50 ThemeOf histamine,elevated
R28 T49 T50 ThemeOf release,elevated
R29 T49 T66 ThemeOf release,up-regulated
R30 T51 T49 ThemeOf CAU,release
R31 T51 T50 ThemeOf CAU,elevated
R32 T51 T52 ThemeOf CAU,expression
R33 T51 T66 ThemeOf CAU,up-regulated
R34 T52 T50 ThemeOf expression,elevated
R35 T52 T66 ThemeOf expression,up-regulated
R36 T55 T52 ThemeOf OSMR,expression
R37 T55 T66 ThemeOf OSMR,up-regulated
R38 T57 T52 ThemeOf JAK2,expression
R39 T57 T66 ThemeOf JAK2,up-regulated
R40 T59 T52 ThemeOf STAT3,expression
R41 T59 T66 ThemeOf STAT3,up-regulated
R42 T61 T52 ThemeOf ISG15,expression
R43 T61 T66 ThemeOf ISG15,up-regulated
R44 T63 T52 ThemeOf CRK,expression
R45 T63 T66 ThemeOf CRK,up-regulated
R46 T65 T52 ThemeOf IRF9,expression
R47 T65 T66 ThemeOf IRF9,up-regulated
R48 T68 T69 ThemeOf OSMR,silencing
R49 T69 T71 CauseOf silencing,decreases
R50 T69 T82 CauseOf silencing,reduces
R51 T69 T85 CauseOf silencing,enhances
R52 T69 T87 CauseOf silencing,promotes
R53 T69 T89 CauseOf silencing,inhibits
R54 T70 T69 ThemeOf CAU,silencing
R55 T72 T71 ThemeOf content,decreases
R56 T72 T82 ThemeOf content,reduces
R57 T74 T72 ThemeOf IL-1,content
R58 T76 T72 ThemeOf IL-6,content
R59 T76 T80 ThemeOf IL-6,number
R60 T78 T72 ThemeOf IFN-γ,content
R61 T78 T80 ThemeOf IFN-γ,number
R62 T79 T72 ThemeOf IgE,content
R63 T79 T80 ThemeOf IgE,number
R64 T79 T83 ThemeOf IgE,expression
R65 T80 T71 ThemeOf number,decreases
R66 T81 T80 ThemeOf eosinophils,number
R67 T80 T82 ThemeOf number,reduces
R68 T81 T71 ThemeOf eosinophils,decreases
R69 T83 T82 ThemeOf expression,reduces
R70 T83 T85 ThemeOf expression,enhances
R71 T86 T85 ThemeOf cell proliferation,enhances
R72 T88 T87 ThemeOf cell cycle entry,promotes
R73 T90 T87 ThemeOf apoptosis,promotes
R74 T90 T89 ThemeOf apoptosis,inhibits
R75 T91 T90 ThemeOf epithelial cells,apoptosis
R76 T91 T87 ThemeOf epithelial cells,promotes
R77 T91 T89 ThemeOf epithelial cells,inhibits
R78 T92 T93 ThemeOf OSMR,silencing
R79 T93 T94 CauseOf silencing,inhibits
R80 T93 T95 CauseOf silencing,activation
R81 T93 T97 CauseOf silencing,suppressing
R82 T95 T94 ThemeOf activation,inhibits
R83 T98 T97 ThemeOf development,suppressing
R84 T99 T98 ThemeOf CAU,development
R85 T99 T94 ThemeOf CAU,inhibits
R86 T99 T95 ThemeOf CAU,activation
R87 T99 T97 ThemeOf CAU,suppressing

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes OSMR gene effect on the pathogenesis of chronic autoimmune Urticaria via the JAK/STAT3 pathway.
T2 96-107 Sentence denotes BACKGROUND:
T3 108-248 Sentence denotes Chronic autoimmune urticaria (CAU) is a common skin disease and remains unclear understanding of pathogenesis in the vast majority of cases.
T4 249-482 Sentence denotes In order to explore a new therapy for CAU, the current study was performed to investigate the possible functioning of the Oncostatin M receptor (OSMR) gene in the autoimmunity of CAU via regulation of the JAK/STAT3 signaling pathway.
T5 483-590 Sentence denotes METHODS: CAU skin tissues from 24 CAU patients and normal skin tissues from normal subjects were collected.
T6 591-776 Sentence denotes Hematoxylin-eosin (HE) staining was conducted to count eosinophils, and immunohistochemistry was carried out to detect the positive rate of OSMR expression in two kinds of skin tissues.
T7 777-920 Sentence denotes A total of 72 Kunming (KM) mice were selected, and 60 mice were used for establishing CAU models and later transfected with different plasmids.
T8 921-1020 Sentence denotes The expression of inflammatory factors was evaluated by enzyme-linked immunosorbent assays (ELISA).
T9 1021-1342 Sentence denotes Expressions of janus kinase (JAK), signal transducer and activator of transcription 3 (STAT3), interferon-stimulated gene 15 (ISG15), CT10-regulated kinase (CRK), and interferon regulatory factor 9 (IRF9) were identified using Western blot assay and reverse transcription quantitative polymerase chain reaction (RT-qPCR).
T10 1343-1546 Sentence denotes Epithelial cell proliferation was assessed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay, and cell cycle distribution and cell apoptosis were assessed using flow cytometry.
T11 1547-1555 Sentence denotes RESULTS:
T12 1556-1806 Sentence denotes The findings confirm that OSMR protein expression and histamine release rate are highly elevated in human CAU skin tissues, and the expression of the JAK/STAT3 signaling pathway-related genes (OSMR, JAK2, STAT3, ISG15, CRK and IRF9) was up-regulated.
T13 1807-2143 Sentence denotes OSMR gene silencing in CAU mice significantly decreases the content of inflammatory factors (IL-1, IL-6, IFN-γ, and IgE), the number of eosinophils, and reduces the expression of the JAK/STAT3 signaling pathway related genes, and further enhances cell proliferation, promotes cell cycle entry and inhibits apoptosis of epithelial cells.
T14 2144-2155 Sentence denotes CONCLUSION:
T15 2156-2320 Sentence denotes All aforementioned results indicate that OSMR gene silencing inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of CAU.
T1 0-95 Sentence denotes OSMR gene effect on the pathogenesis of chronic autoimmune Urticaria via the JAK/STAT3 pathway.
T2 96-107 Sentence denotes BACKGROUND:
T3 108-248 Sentence denotes Chronic autoimmune urticaria (CAU) is a common skin disease and remains unclear understanding of pathogenesis in the vast majority of cases.
T4 249-482 Sentence denotes In order to explore a new therapy for CAU, the current study was performed to investigate the possible functioning of the Oncostatin M receptor (OSMR) gene in the autoimmunity of CAU via regulation of the JAK/STAT3 signaling pathway.
T5 483-590 Sentence denotes METHODS: CAU skin tissues from 24 CAU patients and normal skin tissues from normal subjects were collected.
T6 591-776 Sentence denotes Hematoxylin-eosin (HE) staining was conducted to count eosinophils, and immunohistochemistry was carried out to detect the positive rate of OSMR expression in two kinds of skin tissues.
T7 777-920 Sentence denotes A total of 72 Kunming (KM) mice were selected, and 60 mice were used for establishing CAU models and later transfected with different plasmids.
T8 921-1020 Sentence denotes The expression of inflammatory factors was evaluated by enzyme-linked immunosorbent assays (ELISA).
T9 1021-1342 Sentence denotes Expressions of janus kinase (JAK), signal transducer and activator of transcription 3 (STAT3), interferon-stimulated gene 15 (ISG15), CT10-regulated kinase (CRK), and interferon regulatory factor 9 (IRF9) were identified using Western blot assay and reverse transcription quantitative polymerase chain reaction (RT-qPCR).
T10 1343-1546 Sentence denotes Epithelial cell proliferation was assessed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay, and cell cycle distribution and cell apoptosis were assessed using flow cytometry.
T11 1547-1555 Sentence denotes RESULTS:
T12 1556-1806 Sentence denotes The findings confirm that OSMR protein expression and histamine release rate are highly elevated in human CAU skin tissues, and the expression of the JAK/STAT3 signaling pathway-related genes (OSMR, JAK2, STAT3, ISG15, CRK and IRF9) was up-regulated.
T13 1807-2143 Sentence denotes OSMR gene silencing in CAU mice significantly decreases the content of inflammatory factors (IL-1, IL-6, IFN-γ, and IgE), the number of eosinophils, and reduces the expression of the JAK/STAT3 signaling pathway related genes, and further enhances cell proliferation, promotes cell cycle entry and inhibits apoptosis of epithelial cells.
T14 2144-2155 Sentence denotes CONCLUSION:
T15 2156-2320 Sentence denotes All aforementioned results indicate that OSMR gene silencing inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of CAU.