PubMed:30095381 JSONTXT

{"project":"wangzhuo19_800_2","denotations":[{"id":"T1","span":{"begin":71,"end":81},"obj":"CI"},{"id":"T2","span":{"begin":89,"end":99},"obj":"CI"},{"id":"T3","span":{"begin":243,"end":253},"obj":"CI"},{"id":"T4","span":{"begin":255,"end":258},"obj":"CI"},{"id":"T5","span":{"begin":451,"end":454},"obj":"CI"},{"id":"T6","span":{"begin":662,"end":665},"obj":"CI"},{"id":"T7","span":{"begin":1018,"end":1021},"obj":"CI"},{"id":"T8","span":{"begin":1385,"end":1388},"obj":"CI"},{"id":"T9","span":{"begin":1185,"end":1188},"obj":"CI"},{"id":"T10","span":{"begin":697,"end":707},"obj":"CI"},{"id":"T11","span":{"begin":1392,"end":1395},"obj":"CI"},{"id":"T12","span":{"begin":709,"end":712},"obj":"CI"}],"text":"A double-blind randomized controlled trial of the local application of vancomycin versus ampicillin powder into the operative field for thoracic and/or lumbar fusions.\nOBJECTIVERetrospective studies have reported that the local application of vancomycin (VCM) powder into the operative field decreases the incidence of surgical site infection (SSI) in thoracic and/or lumbar fusion. Authors of the present study prospectively evaluated the effects of VCM in patients undergoing thoracic and/or lumbar fusion.METHODSIn this randomized double-blind trial, 230 patients undergoing thoracic and/or lumbar fusion were randomly assigned to the local administration of VCM (interventional group, 1 g) or ampicillin (AMP; control group, 1 g) into the surgical field. The primary outcome was SSI results within 1 year of surgery.RESULTSThe trial was prematurely stopped according to predetermined rules. The results showed one superficial infection (0.9%, Staphylococcus aureus) and one deep infection (0.9%, S. aureus) in the VCM group and two superficial infections (1.8%, Staphylococcus epidermidis and culture negative) and one deep infection (0.9%, methicillin-resistant S. aureus) in the AMP group. No significant differences in infection rates were observed between the groups (p = 0.8).CONCLUSIONSThis double-blind randomized controlled trial demonstrated that the local application of VCM or AMP powder into the operative field in short thoracic and/or lumbar fusion procedures resulted in a similar incidence of SSI.■ CLASSIFICATION OF EVIDENCE Type of question: therapeutic; study design: randomized controlled trial; evidence: class III.Clinical trial registration no.: UMIN000009377 (umin.ac.jp/ctr)."}

{"project":"yaoziqian_800_2","denotations":[{"id":"T1","span":{"begin":71,"end":81},"obj":"CI"},{"id":"T2","span":{"begin":89,"end":99},"obj":"CI"},{"id":"T3","span":{"begin":243,"end":253},"obj":"CI"},{"id":"T4","span":{"begin":451,"end":454},"obj":"CI"},{"id":"T5","span":{"begin":662,"end":665},"obj":"CI"},{"id":"T6","span":{"begin":697,"end":707},"obj":"CI"},{"id":"T7","span":{"begin":1018,"end":1021},"obj":"CI"},{"id":"T8","span":{"begin":1185,"end":1188},"obj":"CI"},{"id":"T9","span":{"begin":1385,"end":1388},"obj":"CI"},{"id":"T10","span":{"begin":1392,"end":1395},"obj":"CI"}],"text":"A double-blind randomized controlled trial of the local application of vancomycin versus ampicillin powder into the operative field for thoracic and/or lumbar fusions.\nOBJECTIVERetrospective studies have reported that the local application of vancomycin (VCM) powder into the operative field decreases the incidence of surgical site infection (SSI) in thoracic and/or lumbar fusion. Authors of the present study prospectively evaluated the effects of VCM in patients undergoing thoracic and/or lumbar fusion.METHODSIn this randomized double-blind trial, 230 patients undergoing thoracic and/or lumbar fusion were randomly assigned to the local administration of VCM (interventional group, 1 g) or ampicillin (AMP; control group, 1 g) into the surgical field. The primary outcome was SSI results within 1 year of surgery.RESULTSThe trial was prematurely stopped according to predetermined rules. The results showed one superficial infection (0.9%, Staphylococcus aureus) and one deep infection (0.9%, S. aureus) in the VCM group and two superficial infections (1.8%, Staphylococcus epidermidis and culture negative) and one deep infection (0.9%, methicillin-resistant S. aureus) in the AMP group. No significant differences in infection rates were observed between the groups (p = 0.8).CONCLUSIONSThis double-blind randomized controlled trial demonstrated that the local application of VCM or AMP powder into the operative field in short thoracic and/or lumbar fusion procedures resulted in a similar incidence of SSI.■ CLASSIFICATION OF EVIDENCE Type of question: therapeutic; study design: randomized controlled trial; evidence: class III.Clinical trial registration no.: UMIN000009377 (umin.ac.jp/ctr)."}

{"project":"chenxin_473849_800_3","denotations":[{"id":"T1","span":{"begin":71,"end":81},"obj":"CI"},{"id":"T10","span":{"begin":709,"end":712},"obj":"CI"},{"id":"T11","span":{"begin":1185,"end":1188},"obj":"CI"},{"id":"T12","span":{"begin":1392,"end":1395},"obj":"CI"},{"id":"T2","span":{"begin":89,"end":99},"obj":"CI"},{"id":"T3","span":{"begin":243,"end":253},"obj":"CI"},{"id":"T4","span":{"begin":255,"end":258},"obj":"CI"},{"id":"T5","span":{"begin":451,"end":454},"obj":"CI"},{"id":"T6","span":{"begin":662,"end":665},"obj":"CI"},{"id":"T7","span":{"begin":1018,"end":1021},"obj":"CI"},{"id":"T8","span":{"begin":1385,"end":1388},"obj":"CI"},{"id":"T9","span":{"begin":697,"end":707},"obj":"CI"}],"text":"A double-blind randomized controlled trial of the local application of vancomycin versus ampicillin powder into the operative field for thoracic and/or lumbar fusions.\nOBJECTIVERetrospective studies have reported that the local application of vancomycin (VCM) powder into the operative field decreases the incidence of surgical site infection (SSI) in thoracic and/or lumbar fusion. Authors of the present study prospectively evaluated the effects of VCM in patients undergoing thoracic and/or lumbar fusion.METHODSIn this randomized double-blind trial, 230 patients undergoing thoracic and/or lumbar fusion were randomly assigned to the local administration of VCM (interventional group, 1 g) or ampicillin (AMP; control group, 1 g) into the surgical field. The primary outcome was SSI results within 1 year of surgery.RESULTSThe trial was prematurely stopped according to predetermined rules. The results showed one superficial infection (0.9%, Staphylococcus aureus) and one deep infection (0.9%, S. aureus) in the VCM group and two superficial infections (1.8%, Staphylococcus epidermidis and culture negative) and one deep infection (0.9%, methicillin-resistant S. aureus) in the AMP group. No significant differences in infection rates were observed between the groups (p = 0.8).CONCLUSIONSThis double-blind randomized controlled trial demonstrated that the local application of VCM or AMP powder into the operative field in short thoracic and/or lumbar fusion procedures resulted in a similar incidence of SSI.■ CLASSIFICATION OF EVIDENCE Type of question: therapeutic; study design: randomized controlled trial; evidence: class III.Clinical trial registration no.: UMIN000009377 (umin.ac.jp/ctr)."}

{"project":"Zierdiyeerkenaili_800_2","denotations":[{"id":"T1","span":{"begin":71,"end":81},"obj":"CI"},{"id":"T2","span":{"begin":243,"end":253},"obj":"CI"},{"id":"T3","span":{"begin":255,"end":258},"obj":"CI"},{"id":"T4","span":{"begin":451,"end":454},"obj":"CI"},{"id":"T5","span":{"begin":662,"end":665},"obj":"CI"},{"id":"T6","span":{"begin":1018,"end":1021},"obj":"CI"},{"id":"T7","span":{"begin":1385,"end":1388},"obj":"CI"},{"id":"T8","span":{"begin":89,"end":99},"obj":"CI"},{"id":"T9","span":{"begin":697,"end":707},"obj":"CI"},{"id":"T10","span":{"begin":319,"end":342},"obj":"DP"},{"id":"T11","span":{"begin":344,"end":347},"obj":"DP"},{"id":"T12","span":{"begin":783,"end":786},"obj":"DP"},{"id":"T13","span":{"begin":1513,"end":1516},"obj":"DP"}],"text":"A double-blind randomized controlled trial of the local application of vancomycin versus ampicillin powder into the operative field for thoracic and/or lumbar fusions.\nOBJECTIVERetrospective studies have reported that the local application of vancomycin (VCM) powder into the operative field decreases the incidence of surgical site infection (SSI) in thoracic and/or lumbar fusion. Authors of the present study prospectively evaluated the effects of VCM in patients undergoing thoracic and/or lumbar fusion.METHODSIn this randomized double-blind trial, 230 patients undergoing thoracic and/or lumbar fusion were randomly assigned to the local administration of VCM (interventional group, 1 g) or ampicillin (AMP; control group, 1 g) into the surgical field. The primary outcome was SSI results within 1 year of surgery.RESULTSThe trial was prematurely stopped according to predetermined rules. The results showed one superficial infection (0.9%, Staphylococcus aureus) and one deep infection (0.9%, S. aureus) in the VCM group and two superficial infections (1.8%, Staphylococcus epidermidis and culture negative) and one deep infection (0.9%, methicillin-resistant S. aureus) in the AMP group. No significant differences in infection rates were observed between the groups (p = 0.8).CONCLUSIONSThis double-blind randomized controlled trial demonstrated that the local application of VCM or AMP powder into the operative field in short thoracic and/or lumbar fusion procedures resulted in a similar incidence of SSI.■ CLASSIFICATION OF EVIDENCE Type of question: therapeutic; study design: randomized controlled trial; evidence: class III.Clinical trial registration no.: UMIN000009377 (umin.ac.jp/ctr)."}

{"project":"yangbin123xm_800_3","denotations":[{"id":"T1","span":{"begin":71,"end":81},"obj":"CI"},{"id":"T2","span":{"begin":89,"end":99},"obj":"CI"},{"id":"T3","span":{"begin":243,"end":253},"obj":"CI"},{"id":"T4","span":{"begin":255,"end":258},"obj":"CI"},{"id":"T5","span":{"begin":451,"end":454},"obj":"CI"},{"id":"T6","span":{"begin":662,"end":665},"obj":"CI"},{"id":"T7","span":{"begin":697,"end":707},"obj":"CI"},{"id":"T8","span":{"begin":709,"end":712},"obj":"CI"},{"id":"T9","span":{"begin":1018,"end":1021},"obj":"CI"},{"id":"T10","span":{"begin":1185,"end":1188},"obj":"CI"},{"id":"T11","span":{"begin":1385,"end":1388},"obj":"CI"},{"id":"T12","span":{"begin":1392,"end":1395},"obj":"CI"}],"text":"A double-blind randomized controlled trial of the local application of vancomycin versus ampicillin powder into the operative field for thoracic and/or lumbar fusions.\nOBJECTIVERetrospective studies have reported that the local application of vancomycin (VCM) powder into the operative field decreases the incidence of surgical site infection (SSI) in thoracic and/or lumbar fusion. Authors of the present study prospectively evaluated the effects of VCM in patients undergoing thoracic and/or lumbar fusion.METHODSIn this randomized double-blind trial, 230 patients undergoing thoracic and/or lumbar fusion were randomly assigned to the local administration of VCM (interventional group, 1 g) or ampicillin (AMP; control group, 1 g) into the surgical field. The primary outcome was SSI results within 1 year of surgery.RESULTSThe trial was prematurely stopped according to predetermined rules. The results showed one superficial infection (0.9%, Staphylococcus aureus) and one deep infection (0.9%, S. aureus) in the VCM group and two superficial infections (1.8%, Staphylococcus epidermidis and culture negative) and one deep infection (0.9%, methicillin-resistant S. aureus) in the AMP group. No significant differences in infection rates were observed between the groups (p = 0.8).CONCLUSIONSThis double-blind randomized controlled trial demonstrated that the local application of VCM or AMP powder into the operative field in short thoracic and/or lumbar fusion procedures resulted in a similar incidence of SSI.■ CLASSIFICATION OF EVIDENCE Type of question: therapeutic; study design: randomized controlled trial; evidence: class III.Clinical trial registration no.: UMIN000009377 (umin.ac.jp/ctr)."}