PubMed:30028624 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/30028624","sourcedb":"PubMed","sourceid":"30028624","text":"Synthesis and Biological Activity of Tetrameric Ribitol Phosphate Fragments of Staphylococcus aureus Wall Teichoic Acid.\nA systematically designed and synthesized ribitol phosphate (RboP) oligomer using a series of building blocks, which make up the wall teichoic acid (WTA) of S. aureus, is presented. Based on the use of a solution-phase phosphodiester synthesis, a library of ribitol phosphate tetramers, decorated with d-alanine and N-acetylglucosamine (GlcNAc), were generated. The synthesized RboP tetramers showed increased cytokine levels in mice in a subcutaneous air pouch model.","tracks":[{"project":"NGLY1-deficiency","denotations":[{"id":"PD-NGLY1-deficiency-B_T1","span":{"begin":437,"end":456},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T2","span":{"begin":458,"end":464},"obj":"chem:24139"},{"id":"T1","span":{"begin":437,"end":456},"obj":"chem:24139"},{"id":"T2","span":{"begin":458,"end":464},"obj":"chem:24139"}],"namespaces":[{"prefix":"hgnc","uri":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:"},{"prefix":"omim","uri":"https://www.omim.org/entry/"},{"prefix":"chem","uri":"https://pubchem.ncbi.nlm.nih.gov/compound/"}],"attributes":[{"subj":"PD-NGLY1-deficiency-B_T1","pred":"source","obj":"NGLY1-deficiency"},{"subj":"PD-NGLY1-deficiency-B_T2","pred":"source","obj":"NGLY1-deficiency"},{"subj":"T1","pred":"source","obj":"NGLY1-deficiency"},{"subj":"T2","pred":"source","obj":"NGLY1-deficiency"}]},{"project":"ngly1-sample5","denotations":[{"id":"T1","span":{"begin":437,"end":465},"obj":"chem:24139"}],"attributes":[{"subj":"T1","pred":"source","obj":"ngly1-sample5"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NGLY1-deficiency","color":"#93afec","default":true},{"id":"ngly1-sample5","color":"#c9ec93"}]}]}}