PubMed:29946179 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/29946179","sourcedb":"PubMed","sourceid":"29946179","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/29946179","text":"Daily Norfloxacin vs. Weekly Ciprofloxacin to Prevent Spontaneous Bacterial Peritonitis: A Randomized Controlled Trial.\nOBJECTIVES: For the prevention of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites, norfloxacin 400 mg per day is recommended as a standard regimen. This study aims to investigate whether ciprofloxacin once weekly administration is not inferior to norfloxacin once daily administration for the prevention of SBP.\nMETHODS: This is an investigator-initiated open-label randomized controlled trial conducted at seven tertiary hospitals in South Korea. Liver cirrhosis patients with ascites were screened, and enrolled in this randomized controlled trial if ascitic protein ≤1.5 g/dL or the presence of history of SBP. Ascitic polymorphonucleated cell count needed to be \u003c250/mm3. Patients were randomly assigned into norfloxacin daily or ciprofloxacin weekly group, and followed-up for 12 months. Primary endpoint was the prevention of SBP.\nRESULTS: One hundred twenty-four patients met enrollment criteria and were assigned into each group by 1:1 ratio (62:62). Seven patients in the norfloxacin group and five patients in the ciprofloxacin group were lost to follow-up. SBP developed in four patients (4/55) and in three patients (3/57) in each group, respectively (7.3% vs. 5.3%, P = 0.712). The transplant-free survival rates at 1 year were comparable between the groups (72.7% vs. 73.7%, P = 0.970). Incidence of infectious complication, hepatorenal syndrome, hepatic encephalopathy, and variceal bleeding rates were not significantly different (all P = ns). The factors related to survival were models representing underlying liver function.\nCONCLUSION: Once weekly ciprofloxacin was as effective as daily norfloxacin for the prevention of SBP in cirrhotic patients with ascites.","tracks":[{"project":"yangbin123xm_800_3","denotations":[{"id":"T10","span":{"begin":230,"end":241},"obj":"CI"},{"id":"T11","span":{"begin":1128,"end":1139},"obj":"CI"},{"id":"T12","span":{"begin":1755,"end":1766},"obj":"CI"},{"id":"T13","span":{"begin":860,"end":871},"obj":"CI"},{"id":"T14","span":{"begin":394,"end":405},"obj":"CI"},{"id":"T15","span":{"begin":29,"end":42},"obj":"CI"},{"id":"T16","span":{"begin":334,"end":347},"obj":"CI"},{"id":"T17","span":{"begin":1171,"end":1184},"obj":"CI"},{"id":"T18","span":{"begin":881,"end":894},"obj":"CI"},{"id":"T19","span":{"begin":1715,"end":1728},"obj":"CI"},{"id":"T20","span":{"begin":197,"end":228},"obj":"DP"},{"id":"T21","span":{"begin":601,"end":632},"obj":"DP"},{"id":"T9","span":{"begin":6,"end":17},"obj":"CI"},{"id":"T22","span":{"begin":1796,"end":1827},"obj":"DP"}],"attributes":[{"subj":"T10","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T11","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T12","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T13","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T14","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T15","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T16","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T17","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T18","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T19","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T20","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T21","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T9","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T22","pred":"source","obj":"yangbin123xm_800_3"}]},{"project":"chenxin_473849_800_3","denotations":[{"id":"T10","span":{"begin":334,"end":347},"obj":"CI"},{"id":"T11","span":{"begin":881,"end":894},"obj":"CI"},{"id":"T12","span":{"begin":1171,"end":1184},"obj":"CI"},{"id":"T13","span":{"begin":1715,"end":1728},"obj":"CI"},{"id":"T14","span":{"begin":29,"end":42},"obj":"CI"},{"id":"T2","span":{"begin":197,"end":228},"obj":"DP"},{"id":"T3","span":{"begin":1796,"end":1827},"obj":"DP"},{"id":"T4","span":{"begin":230,"end":241},"obj":"CI"},{"id":"T5","span":{"begin":394,"end":405},"obj":"CI"},{"id":"T6","span":{"begin":860,"end":871},"obj":"CI"},{"id":"T7","span":{"begin":1128,"end":1139},"obj":"CI"},{"id":"T8","span":{"begin":1755,"end":1766},"obj":"CI"},{"id":"T9","span":{"begin":6,"end":17},"obj":"CI"},{"id":"T15","span":{"begin":601,"end":632},"obj":"DP"}],"attributes":[{"subj":"T10","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T11","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T12","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T13","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T14","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T2","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T3","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T4","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T5","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T6","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T7","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T8","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T9","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T15","pred":"source","obj":"chenxin_473849_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"yangbin123xm_800_3","color":"#93ecbe","default":true},{"id":"chenxin_473849_800_3","color":"#eca493"}]}]}}