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PubMed:29941455 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes Multiple regions in the extracellular domain of the glycine receptor determine receptor activity.
T2 98-219 Sentence denotes Glycine receptors (GlyRs) are Cys-loop receptors that mediate fast synaptic inhibition in the brain stem and spinal cord.
T3 220-394 Sentence denotes They are involved in the generation of motor rhythm, reflex circuit coordination, and sensory signal processing and therefore represent targets for therapeutic interventions.
T4 395-571 Sentence denotes The extracellular domains (ECDs) of Cys-loop receptors typically contain many aromatic amino acids, but only those in the receptor binding pocket have been extensively studied.
T5 572-698 Sentence denotes Here, we show that many Phe residues in the ECD that are not located in the binding pocket are also involved in GlyR function.
T6 699-1004 Sentence denotes We examined these Phe residues by creating several GlyR variants, characterizing these variants with the two-electrode voltage clamp technique in Xenopus oocytes, and interpreting changes in receptor parameters by using currently available structural information on the open and closed states of the GlyR.
T7 1005-1280 Sentence denotes Substitution of six of the eight Phe residues in the ECD with Ala resulted in loss of function or significantly increased the EC50 and also altered the maximal response to the partial GlyR agonist taurine compared with glycine in those receptor variants that were functional.
T8 1281-1603 Sentence denotes Substitutions with other amino acids, combined with examination of nearby residues that could potentially interact with these Phe residues, suggested interactions that could be important for GlyR function, and possibly similar interactions could contribute to the function of other members of the Cys-loop receptor family.
T9 1604-1780 Sentence denotes Overall, our results suggest that many ECD regions are important for GlyR function and that these regions could inform the design of therapeutic agents targeting GlyR activity.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 192-202 http://purl.obolibrary.org/obo/MAT_0000111 denotes brain stem
T2 192-197 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T3 198-202 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T4 207-218 http://purl.obolibrary.org/obo/MAT_0000183 denotes spinal cord

kaiyin_test

Id Subject Object Predicate Lexical cue
T5 1005-1070 Var denotes Substitution of six of the eight Phe residues in the ECD with Ala
T3 1083-1087 NegReg denotes loss
T4 1091-1099 MPA denotes function
T1 1117-1126 PosReg denotes increased
T2 1131-1135 MPA denotes EC50
T6 1145-1152 Reg denotes altered
T7 1157-1209 MPA denotes maximal response to the partial GlyR agonist taurine
R1 T5 T3 CauseOf Substitution of six of the eight Phe residues in the ECD with Ala,loss
R2 T4 T3 ThemeOf function,loss
R3 T5 T1 CauseOf Substitution of six of the eight Phe residues in the ECD with Ala,increased
R4 T2 T1 ThemeOf EC50,increased
R5 T5 T6 CauseOf Substitution of six of the eight Phe residues in the ECD with Ala,altered
R6 T7 T6 ThemeOf maximal response to the partial GlyR agonist taurine,altered

name_no

Id Subject Object Predicate Lexical cue
T5 1005-1070 Var denotes Substitution of six of the eight Phe residues in the ECD with Ala
T3 1083-1087 NegReg denotes loss
T4 1091-1099 MPA denotes function
T1 1117-1126 PosReg denotes increased
T2 1131-1135 MPA denotes EC50
T6 1145-1152 Reg denotes altered
T7 1157-1209 MPA denotes maximal response to the partial GlyR agonist taurine
R1 T5 T3 CauseOf Substitution of six of the eight Phe residues in the ECD with Ala,loss
R2 T4 T3 ThemeOf function,loss
R3 T5 T1 CauseOf Substitution of six of the eight Phe residues in the ECD with Ala,increased
R4 T2 T1 ThemeOf EC50,increased
R5 T5 T6 CauseOf Substitution of six of the eight Phe residues in the ECD with Ala,altered
R6 T7 T6 ThemeOf maximal response to the partial GlyR agonist taurine,altered

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 616-619 Disease denotes ECD http://purl.obolibrary.org/obo/MONDO_0018153|http://purl.obolibrary.org/obo/MONDO_0020290
T3 1058-1061 Disease denotes ECD http://purl.obolibrary.org/obo/MONDO_0018153|http://purl.obolibrary.org/obo/MONDO_0020290
T5 1643-1646 Disease denotes ECD http://purl.obolibrary.org/obo/MONDO_0018153|http://purl.obolibrary.org/obo/MONDO_0020290

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 192-202 Body_part denotes brain stem http://purl.obolibrary.org/obo/MAT_0000111
T2 207-218 Body_part denotes spinal cord http://purl.obolibrary.org/obo/MAT_0000183

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 52-59 OrganismTaxon denotes glycine 3846
T2 98-105 OrganismTaxon denotes Glycine 3846
T3 845-852 OrganismTaxon denotes Xenopus 262014|8353
T5 1224-1231 OrganismTaxon denotes glycine 3846

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 24-37 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T2 192-202 Body_part denotes brain stem http://purl.obolibrary.org/obo/UBERON_0002298
T3 207-218 Body_part denotes spinal cord http://purl.obolibrary.org/obo/UBERON_0002240
T4 399-412 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 853-860 Cell denotes oocytes http://purl.obolibrary.org/obo/CL:0000023