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PubMed:29752874 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-80 Sentence denotes Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation.
T2 81-141 Sentence denotes In human skin, melanogenesis is a tightly regulated process.
T3 142-414 Sentence denotes Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis.
T4 415-608 Sentence denotes The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes.
T5 609-683 Sentence denotes The melanosomes loaded with melanin are then transferred to keratinocytes.
T6 684-806 Sentence denotes A more elaborate level of melanogenesis regulation comes into play via the action of non-coding RNAs (microRNAs, lncRNAs).
T7 807-1058 Sentence denotes Besides this canonical regulation, melanogenesis can also be modulated by other non-specific intrinsic pathways (hormonal environment, inflammation) and by extrinsic factors (solar irradiation such as ultraviolet irradiation, environmental pollution).
T8 1059-1249 Sentence denotes We developed a bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin pigmentation as a resource to better understand and study skin pigmentation biology.
T1 0-80 Sentence denotes Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation.
T2 81-141 Sentence denotes In human skin, melanogenesis is a tightly regulated process.
T3 142-414 Sentence denotes Indeed, several extracellular signals are transduced via dedicated signalling pathways and mostly converge to MITF, a transcription factor integrating upstream signalling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis.
T4 415-608 Sentence denotes The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes.
T5 609-683 Sentence denotes The melanosomes loaded with melanin are then transferred to keratinocytes.
T6 684-806 Sentence denotes A more elaborate level of melanogenesis regulation comes into play via the action of non-coding RNAs (microRNAs, lncRNAs).
T7 807-1058 Sentence denotes Besides this canonical regulation, melanogenesis can also be modulated by other non-specific intrinsic pathways (hormonal environment, inflammation) and by extrinsic factors (solar irradiation such as ultraviolet irradiation, environmental pollution).
T8 1059-1249 Sentence denotes We developed a bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin pigmentation as a resource to better understand and study skin pigmentation biology.