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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-63 Sentence denotes Protective Role of Eosinophils and TNFa after Ozone Inhalation.
T2 64-77 Sentence denotes Introduction:
T3 78-125 Sentence denotes Exposure to ozone induces deleterious responses
T4 126-174 Sentence denotes in the airways that include shortness of breath,
T5 175-213 Sentence denotes inflammation, and bronchoconstriction.
T6 214-220 Sentence denotes People
T7 221-269 Sentence denotes with asthma have increased airway sensitivity to
T8 270-296 Sentence denotes ozone and other irritants.
T9 297-318 Sentence denotes Dr. Allison Fryer and
T10 319-369 Sentence denotes colleagues addressed how exposure to ozone affects
T11 370-411 Sentence denotes the immune and physiological responses in
T12 412-424 Sentence denotes guinea pigs.
T13 425-460 Sentence denotes Guinea pigs are considered a useful
T14 461-518 Sentence denotes animal model for studies of respiratory and physiological
T15 519-557 Sentence denotes responses in humans; their response to
T16 558-609 Sentence denotes airborne allergens is similar to that in humans and
T17 610-650 Sentence denotes shares some features of allergic asthma.
T18 651-695 Sentence denotes Fryer and colleagues had previously observed
T19 696-744 Sentence denotes that within 24 hours of exposure, ozone not only
T20 745-792 Sentence denotes induced bronchoconstriction but also stimulated
T21 793-840 Sentence denotes the production of new cells in the bone marrow,
T22 841-877 Sentence denotes where all white blood cells develop.
T23 878-889 Sentence denotes As a result
T24 890-935 Sentence denotes of ozone exposure, increased numbers of newly
T25 936-992 Sentence denotes synthesized white blood cells, particularly eosinophils,
T26 993-1024 Sentence denotes moved into the blood and lungs.
T27 1025-1072 Sentence denotes The central hypothesis of the current study was
T28 1073-1120 Sentence denotes that newly synthesized eosinophils recruited to
T29 1121-1174 Sentence denotes the lungs 3 days after ozone exposure were beneficial
T30 1175-1223 Sentence denotes to the animals because they reduced ozoneinduced
T31 1224-1244 Sentence denotes bronchoconstriction.
T32 1245-1262 Sentence denotes The investigators
T33 1263-1312 Sentence denotes also hypothesized that the beneficial effect seen
T34 1313-1366 Sentence denotes in normal (nonsensitized) animals was lost in animals
T35 1367-1417 Sentence denotes that had been injected with an allergen, ovalbumin
T36 1418-1431 Sentence denotes (sensitized).
T37 1432-1460 Sentence denotes They also planned to explore
T38 1461-1522 Sentence denotes the effects of inhibitors of certain cytokines (cellsignaling
T39 1523-1534 Sentence denotes molecules).
T40 1535-1577 Sentence denotes Immune responses in sensitized animals are
T41 1578-1628 Sentence denotes dominated by a Th2 pattern, which is characterized
T42 1629-1671 Sentence denotes by the synthesis of cytokines (interleukin
T43 1672-1723 Sentence denotes [IL]-4, IL-5, and IL-13) and the Th2 subset of CD4+
T44 1724-1780 Sentence denotes T lymphocytes and the cells they activate (predominantly
T45 1781-1816 Sentence denotes eosinophils, and B lymphocytes that
T46 1817-1858 Sentence denotes switch to making immunoglobulin E [IgE]).
T47 1859-1864 Sentence denotes Thus,
T48 1865-1916 Sentence denotes sensitized animals were used as a model of allergic
T49 1917-1958 Sentence denotes humans, whose immune responses tend to be
T50 1959-1976 Sentence denotes dominated by IgE.
T51 1977-1986 Sentence denotes Approach:
T52 1987-2037 Sentence denotes Fryer and colleagues exposed normal and sensitized
T53 2038-2087 Sentence denotes (allergic) guinea pigs to 2 ppm ozone or filtered
T54 2088-2132 Sentence denotes air for 4 hours and measured changes in cell
T55 2133-2180 Sentence denotes numbers and airway responses 1 or 3 days later.
T56 2181-2230 Sentence denotes They counted the numbers of eosinophils and other
T57 2231-2279 Sentence denotes white blood cells (macrophages, neutrophils, and
T58 2280-2335 Sentence denotes lymphocytes) in bone marrow, blood, and bronchoalveolar
T59 2336-2354 Sentence denotes lung lavage fluid.
T60 2355-2372 Sentence denotes The investigators
T61 2373-2421 Sentence denotes also measured important physiological responses,
T62 2422-2452 Sentence denotes including bronchoconstriction.
T63 2453-2470 Sentence denotes Some animals were
T64 2471-2523 Sentence denotes pretreated with etanercept and monoclonal anti-IL-5,
T65 2524-2576 Sentence denotes which block tumor necrosis factor-a (TNFa) and IL-5,
T66 2577-2590 Sentence denotes respectively.
T67 2591-2628 Sentence denotes TNFa and IL-5 blockers have been used
T68 2629-2659 Sentence denotes to treat patients with asthma.
T69 2660-2717 Sentence denotes A key feature of the study was a technique to distinguish
T70 2718-2764 Sentence denotes which white blood cells were synthesized after
T71 2765-2819 Sentence denotes exposure from those that already existed, by injecting
T72 2820-2858 Sentence denotes animals with bromodeoxyuridine (BrdU).
T73 2859-2863 Sentence denotes BrdU
T74 2864-2917 Sentence denotes is a thymidine analogue that is incorporated into the
T75 2918-2969 Sentence denotes DNA of dividing cells, serving as a marker of newly
T76 2970-2985 Sentence denotes produced cells.
T77 2986-3023 Sentence denotes Therefore, a snapshot can be obtained
T78 3024-3078 Sentence denotes of the proportion of newly synthesized (BrdU-positive)
T79 3079-3126 Sentence denotes versus pre-existing (BrdU-negative) cell types.
T80 3127-3139 Sentence denotes Key results:
T81 3140-3142 Sentence denotes 1.
T82 3143-3191 Sentence denotes Allergic and normal animals differed in the time
T83 3192-3241 Sentence denotes course of bronchoconstriction and changes in cell
T84 3242-3269 Sentence denotes types after ozone exposure.
T85 3270-3288 Sentence denotes In normal animals,
T86 3289-3335 Sentence denotes bronchoconstriction increased substantially at
T87 3336-3386 Sentence denotes day 1 but decreased by day 3 after ozone exposure.
T88 3387-3439 Sentence denotes In contrast, in allergic animals bronchoconstriction
T89 3440-3463 Sentence denotes remained high at day 3.
T90 3464-3484 Sentence denotes Ozone also increased
T91 3485-3522 Sentence denotes the percentage of newly formed, BrdU2
T92 3523-3566 Sentence denotes positive eosinophils in the bone marrow and
T93 3567-3608 Sentence denotes lungs of normal but not allergic animals.
T94 3609-3611 Sentence denotes 2.
T95 3612-3657 Sentence denotes Pretreatment with the TNFa blocker etanercept
T96 3658-3701 Sentence denotes had complex effects, which differed between
T97 3702-3730 Sentence denotes normal and allergic animals.
T98 3731-3749 Sentence denotes In normal animals,
T99 3750-3798 Sentence denotes etanercept decreased ozone-induced new synthesis
T100 3799-3836 Sentence denotes of eosinophils in the bone marrow and
T101 3837-3886 Sentence denotes blocked eosinophil migration to the lung; it also
T102 3887-3935 Sentence denotes increased bronchoconstriction at day 3 (relative
T103 3936-3965 Sentence denotes to day 1 without etanercept).
T104 3966-3986 Sentence denotes In allergic animals,
T105 3987-4035 Sentence denotes etanercept had no effect on any cell type in the
T106 4036-4083 Sentence denotes bone marrow or lung after exposure to ozone and
T107 4084-4127 Sentence denotes did not change bronchoconstriction compared
T108 4128-4178 Sentence denotes with allergic animals not treated with etanercept.
T109 4179-4223 Sentence denotes Etanercept tended to increase the numbers of
T110 4224-4267 Sentence denotes blood monocytes and lymphocytes in air- and
T111 4268-4312 Sentence denotes ozone-exposed normal and allergic animals at
T112 4313-4361 Sentence denotes day 3, but had no effect on eosinophils in blood
T113 4362-4381 Sentence denotes at this time point.
T114 4382-4419 Sentence denotes This was one of the few statistically
T115 4420-4464 Sentence denotes significant findings in the blood of exposed
T116 4465-4486 Sentence denotes animals in the study.
T117 4487-4489 Sentence denotes 3.
T118 4490-4542 Sentence denotes Anti-IL-5 reduced bronchoconstriction at day 3 after
T119 4543-4581 Sentence denotes exposure of allergic animals to ozone.
T120 4582-4594 Sentence denotes In contrast,
T121 4595-4636 Sentence denotes bronchoconstriction was greatly increased
T122 4637-4678 Sentence denotes in normal animals treated with anti-IL-5.
T123 4679-4691 Sentence denotes Conclusions:
T124 4692-4745 Sentence denotes Fryer and colleagues explored the airway and cellular
T125 4746-4788 Sentence denotes responses in guinea pigs exposed to ozone.
T126 4789-4792 Sentence denotes The
T127 4793-4845 Sentence denotes HEI Review Committee, which conducted an independent
T128 4846-4891 Sentence denotes review of the study, agreed that the findings
T129 4892-4943 Sentence denotes supported the authors’ hypothesis (1) that exposure
T130 4944-4997 Sentence denotes to ozone stimulates production of eosinophils in bone
T131 4998-5053 Sentence denotes marrow, (2) that these newly formed eosinophils migrate
T132 5054-5103 Sentence denotes to the lungs, and (3) that those eosinophils play
T133 5104-5157 Sentence denotes a delayed but potentially beneficial role in reducing
T134 5158-5210 Sentence denotes ozone-induced inflammation in the airways of healthy
T135 5211-5266 Sentence denotes normal animals, but not in allergen-sensitized animals.
T136 5267-5309 Sentence denotes The Committee also agreed that guinea pigs
T137 5310-5366 Sentence denotes were a good model for studying responses to an allergen,
T138 5367-5410 Sentence denotes because a major subtype of asthma (the high
T139 5411-5466 Sentence denotes Th2 or allergic type) is associated with high levels of
T140 5467-5492 Sentence denotes eosinophils in the blood.
T141 5493-5545 Sentence denotes A novel finding was that the TNFa blocker etanercept
T142 5546-5594 Sentence denotes decreased ozone-induced formation of eosinophils
T143 5595-5636 Sentence denotes in the bone marrow and blocked eosinophil
T144 5637-5677 Sentence denotes migration to the lung in normal animals.
T145 5678-5686 Sentence denotes However,
T146 5687-5748 Sentence denotes because injecting etanercept had little effect on eosinophils
T147 5749-5792 Sentence denotes and did not decrease bronchoconstriction in
T148 5793-5850 Sentence denotes allergic guinea pigs, the potential for treating patients
T149 5851-5904 Sentence denotes with allergic asthma with TNFa blockers is uncertain.
T150 5905-5957 Sentence denotes This is consistent with the poor performance of TNFa
T151 5958-6007 Sentence denotes blockers in clinical studies of asthma treatment.
T152 6008-6061 Sentence denotes Blocking the cytokine IL-5 with an anti-IL-5 antibody
T153 6062-6108 Sentence denotes substantially decreased bronchoconstriction in
T154 6109-6128 Sentence denotes sensitized animals.
T155 6129-6167 Sentence denotes This suggests that therapies targeting
T156 6168-6213 Sentence denotes IL-5 and eosinophils would be promising in at
T157 6214-6241 Sentence denotes least some types of asthma.
T158 6242-6265 Sentence denotes The Committee expressed
T159 6266-6316 Sentence denotes caution toward experiments with cytokine blockers,
T160 6317-6363 Sentence denotes both in animal models and humans, because such
T161 6364-6421 Sentence denotes blockers are often not specific to a particular cell type
T162 6422-6468 Sentence denotes and may differ at different sites in the body.
T163 6469-6476 Sentence denotes Without
T164 6477-6528 Sentence denotes further detailed confirmation of the effects of the
T165 6529-6589 Sentence denotes blockers, interpreting these experiments can be challenging.
T166 6590-6637 Sentence denotes The Committee concluded that the study by Fryer
T167 6638-6693 Sentence denotes and colleagues raises several intriguing directions for
T168 6694-6744 Sentence denotes future research, including exploring ways in which
T169 6745-6794 Sentence denotes newly formed eosinophils differ from pre-existing
T170 6795-6843 Sentence denotes ones, and how such findings apply to humans with
T171 6844-6862 Sentence denotes allergy or asthma.
T1 0-63 Sentence denotes Protective Role of Eosinophils and TNFa after Ozone Inhalation.
T2 64-77 Sentence denotes Introduction:
T3 78-125 Sentence denotes Exposure to ozone induces deleterious responses
T4 126-174 Sentence denotes in the airways that include shortness of breath,
T5 175-213 Sentence denotes inflammation, and bronchoconstriction.
T6 214-220 Sentence denotes People
T7 221-269 Sentence denotes with asthma have increased airway sensitivity to
T8 270-296 Sentence denotes ozone and other irritants.
T9 297-318 Sentence denotes Dr. Allison Fryer and
T10 319-369 Sentence denotes colleagues addressed how exposure to ozone affects
T11 370-411 Sentence denotes the immune and physiological responses in
T12 412-424 Sentence denotes guinea pigs.
T13 425-460 Sentence denotes Guinea pigs are considered a useful
T14 461-518 Sentence denotes animal model for studies of respiratory and physiological
T15 519-557 Sentence denotes responses in humans; their response to
T16 558-609 Sentence denotes airborne allergens is similar to that in humans and
T17 610-650 Sentence denotes shares some features of allergic asthma.
T18 651-695 Sentence denotes Fryer and colleagues had previously observed
T19 696-744 Sentence denotes that within 24 hours of exposure, ozone not only
T20 745-792 Sentence denotes induced bronchoconstriction but also stimulated
T21 793-840 Sentence denotes the production of new cells in the bone marrow,
T22 841-877 Sentence denotes where all white blood cells develop.
T23 878-889 Sentence denotes As a result
T24 890-935 Sentence denotes of ozone exposure, increased numbers of newly
T25 936-992 Sentence denotes synthesized white blood cells, particularly eosinophils,
T26 993-1024 Sentence denotes moved into the blood and lungs.
T27 1025-1072 Sentence denotes The central hypothesis of the current study was
T28 1073-1120 Sentence denotes that newly synthesized eosinophils recruited to
T29 1121-1174 Sentence denotes the lungs 3 days after ozone exposure were beneficial
T30 1175-1223 Sentence denotes to the animals because they reduced ozoneinduced
T31 1224-1244 Sentence denotes bronchoconstriction.
T32 1245-1262 Sentence denotes The investigators
T33 1263-1312 Sentence denotes also hypothesized that the beneficial effect seen
T34 1313-1366 Sentence denotes in normal (nonsensitized) animals was lost in animals
T35 1367-1417 Sentence denotes that had been injected with an allergen, ovalbumin
T36 1418-1431 Sentence denotes (sensitized).
T37 1432-1460 Sentence denotes They also planned to explore
T38 1461-1522 Sentence denotes the effects of inhibitors of certain cytokines (cellsignaling
T39 1523-1534 Sentence denotes molecules).
T40 1535-1577 Sentence denotes Immune responses in sensitized animals are
T41 1578-1628 Sentence denotes dominated by a Th2 pattern, which is characterized
T42 1629-1671 Sentence denotes by the synthesis of cytokines (interleukin
T43 1672-1723 Sentence denotes [IL]-4, IL-5, and IL-13) and the Th2 subset of CD4+
T44 1724-1780 Sentence denotes T lymphocytes and the cells they activate (predominantly
T45 1781-1816 Sentence denotes eosinophils, and B lymphocytes that
T46 1817-1858 Sentence denotes switch to making immunoglobulin E [IgE]).
T47 1859-1864 Sentence denotes Thus,
T48 1865-1916 Sentence denotes sensitized animals were used as a model of allergic
T49 1917-1958 Sentence denotes humans, whose immune responses tend to be
T50 1959-1976 Sentence denotes dominated by IgE.
T51 1977-1986 Sentence denotes Approach:
T52 1987-2037 Sentence denotes Fryer and colleagues exposed normal and sensitized
T53 2038-2087 Sentence denotes (allergic) guinea pigs to 2 ppm ozone or filtered
T54 2088-2132 Sentence denotes air for 4 hours and measured changes in cell
T55 2133-2180 Sentence denotes numbers and airway responses 1 or 3 days later.
T56 2181-2230 Sentence denotes They counted the numbers of eosinophils and other
T57 2231-2279 Sentence denotes white blood cells (macrophages, neutrophils, and
T58 2280-2335 Sentence denotes lymphocytes) in bone marrow, blood, and bronchoalveolar
T59 2336-2354 Sentence denotes lung lavage fluid.
T60 2355-2372 Sentence denotes The investigators
T61 2373-2421 Sentence denotes also measured important physiological responses,
T62 2422-2452 Sentence denotes including bronchoconstriction.
T63 2453-2470 Sentence denotes Some animals were
T64 2471-2523 Sentence denotes pretreated with etanercept and monoclonal anti-IL-5,
T65 2524-2576 Sentence denotes which block tumor necrosis factor-a (TNFa) and IL-5,
T66 2577-2590 Sentence denotes respectively.
T67 2591-2628 Sentence denotes TNFa and IL-5 blockers have been used
T68 2629-2659 Sentence denotes to treat patients with asthma.
T69 2660-2717 Sentence denotes A key feature of the study was a technique to distinguish
T70 2718-2764 Sentence denotes which white blood cells were synthesized after
T71 2765-2819 Sentence denotes exposure from those that already existed, by injecting
T72 2820-2858 Sentence denotes animals with bromodeoxyuridine (BrdU).
T73 2859-2863 Sentence denotes BrdU
T74 2864-2917 Sentence denotes is a thymidine analogue that is incorporated into the
T75 2918-2969 Sentence denotes DNA of dividing cells, serving as a marker of newly
T76 2970-2985 Sentence denotes produced cells.
T77 2986-3023 Sentence denotes Therefore, a snapshot can be obtained
T78 3024-3078 Sentence denotes of the proportion of newly synthesized (BrdU-positive)
T79 3079-3126 Sentence denotes versus pre-existing (BrdU-negative) cell types.
T80 3127-3139 Sentence denotes Key results:
T81 3140-3142 Sentence denotes 1.
T82 3143-3191 Sentence denotes Allergic and normal animals differed in the time
T83 3192-3241 Sentence denotes course of bronchoconstriction and changes in cell
T84 3242-3269 Sentence denotes types after ozone exposure.
T85 3270-3288 Sentence denotes In normal animals,
T86 3289-3335 Sentence denotes bronchoconstriction increased substantially at
T87 3336-3386 Sentence denotes day 1 but decreased by day 3 after ozone exposure.
T88 3387-3439 Sentence denotes In contrast, in allergic animals bronchoconstriction
T89 3440-3463 Sentence denotes remained high at day 3.
T90 3464-3484 Sentence denotes Ozone also increased
T91 3485-3522 Sentence denotes the percentage of newly formed, BrdU2
T92 3523-3566 Sentence denotes positive eosinophils in the bone marrow and
T93 3567-3608 Sentence denotes lungs of normal but not allergic animals.
T94 3609-3611 Sentence denotes 2.
T95 3612-3657 Sentence denotes Pretreatment with the TNFa blocker etanercept
T96 3658-3701 Sentence denotes had complex effects, which differed between
T97 3702-3730 Sentence denotes normal and allergic animals.
T98 3731-3749 Sentence denotes In normal animals,
T99 3750-3798 Sentence denotes etanercept decreased ozone-induced new synthesis
T100 3799-3836 Sentence denotes of eosinophils in the bone marrow and
T101 3837-3886 Sentence denotes blocked eosinophil migration to the lung; it also
T102 3887-3935 Sentence denotes increased bronchoconstriction at day 3 (relative
T103 3936-3965 Sentence denotes to day 1 without etanercept).
T104 3966-3986 Sentence denotes In allergic animals,
T105 3987-4035 Sentence denotes etanercept had no effect on any cell type in the
T106 4036-4083 Sentence denotes bone marrow or lung after exposure to ozone and
T107 4084-4127 Sentence denotes did not change bronchoconstriction compared
T108 4128-4178 Sentence denotes with allergic animals not treated with etanercept.
T109 4179-4223 Sentence denotes Etanercept tended to increase the numbers of
T110 4224-4267 Sentence denotes blood monocytes and lymphocytes in air- and
T111 4268-4312 Sentence denotes ozone-exposed normal and allergic animals at
T112 4313-4361 Sentence denotes day 3, but had no effect on eosinophils in blood
T113 4362-4381 Sentence denotes at this time point.
T114 4382-4419 Sentence denotes This was one of the few statistically
T115 4420-4464 Sentence denotes significant findings in the blood of exposed
T116 4465-4486 Sentence denotes animals in the study.
T117 4487-4489 Sentence denotes 3.
T118 4490-4542 Sentence denotes Anti-IL-5 reduced bronchoconstriction at day 3 after
T119 4543-4581 Sentence denotes exposure of allergic animals to ozone.
T120 4582-4594 Sentence denotes In contrast,
T121 4595-4636 Sentence denotes bronchoconstriction was greatly increased
T122 4637-4678 Sentence denotes in normal animals treated with anti-IL-5.
T123 4679-4691 Sentence denotes Conclusions:
T124 4692-4745 Sentence denotes Fryer and colleagues explored the airway and cellular
T125 4746-4788 Sentence denotes responses in guinea pigs exposed to ozone.
T126 4789-4792 Sentence denotes The
T127 4793-4845 Sentence denotes HEI Review Committee, which conducted an independent
T128 4846-4891 Sentence denotes review of the study, agreed that the findings
T129 4892-4943 Sentence denotes supported the authors’ hypothesis (1) that exposure
T130 4944-4997 Sentence denotes to ozone stimulates production of eosinophils in bone
T131 4998-5053 Sentence denotes marrow, (2) that these newly formed eosinophils migrate
T132 5054-5103 Sentence denotes to the lungs, and (3) that those eosinophils play
T133 5104-5157 Sentence denotes a delayed but potentially beneficial role in reducing
T134 5158-5210 Sentence denotes ozone-induced inflammation in the airways of healthy
T135 5211-5266 Sentence denotes normal animals, but not in allergen-sensitized animals.
T136 5267-5309 Sentence denotes The Committee also agreed that guinea pigs
T137 5310-5366 Sentence denotes were a good model for studying responses to an allergen,
T138 5367-5410 Sentence denotes because a major subtype of asthma (the high
T139 5411-5466 Sentence denotes Th2 or allergic type) is associated with high levels of
T140 5467-5492 Sentence denotes eosinophils in the blood.
T141 5493-5545 Sentence denotes A novel finding was that the TNFa blocker etanercept
T142 5546-5594 Sentence denotes decreased ozone-induced formation of eosinophils
T143 5595-5636 Sentence denotes in the bone marrow and blocked eosinophil
T144 5637-5677 Sentence denotes migration to the lung in normal animals.
T145 5678-5686 Sentence denotes However,
T146 5687-5748 Sentence denotes because injecting etanercept had little effect on eosinophils
T147 5749-5792 Sentence denotes and did not decrease bronchoconstriction in
T148 5793-5850 Sentence denotes allergic guinea pigs, the potential for treating patients
T149 5851-5904 Sentence denotes with allergic asthma with TNFa blockers is uncertain.
T150 5905-5957 Sentence denotes This is consistent with the poor performance of TNFa
T151 5958-6007 Sentence denotes blockers in clinical studies of asthma treatment.
T152 6008-6061 Sentence denotes Blocking the cytokine IL-5 with an anti-IL-5 antibody
T153 6062-6108 Sentence denotes substantially decreased bronchoconstriction in
T154 6109-6128 Sentence denotes sensitized animals.
T155 6129-6167 Sentence denotes This suggests that therapies targeting
T156 6168-6213 Sentence denotes IL-5 and eosinophils would be promising in at
T157 6214-6241 Sentence denotes least some types of asthma.
T158 6242-6265 Sentence denotes The Committee expressed
T159 6266-6316 Sentence denotes caution toward experiments with cytokine blockers,
T160 6317-6363 Sentence denotes both in animal models and humans, because such
T161 6364-6421 Sentence denotes blockers are often not specific to a particular cell type
T162 6422-6468 Sentence denotes and may differ at different sites in the body.
T163 6469-6476 Sentence denotes Without
T164 6477-6528 Sentence denotes further detailed confirmation of the effects of the
T165 6529-6589 Sentence denotes blockers, interpreting these experiments can be challenging.
T166 6590-6637 Sentence denotes The Committee concluded that the study by Fryer
T167 6638-6693 Sentence denotes and colleagues raises several intriguing directions for
T168 6694-6744 Sentence denotes future research, including exploring ways in which
T169 6745-6794 Sentence denotes newly formed eosinophils differ from pre-existing
T170 6795-6843 Sentence denotes ones, and how such findings apply to humans with
T171 6844-6862 Sentence denotes allergy or asthma.