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PubMed:29635275 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 204-223 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T2 464-472 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T4 493-501 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T6 874-882 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 464-472 http://www.glycoepitope.jp/epitopes/EP0004 denotes O-GlcNAc
T2 493-501 http://www.glycoepitope.jp/epitopes/EP0004 denotes O-GlcNAc
T3 874-882 http://www.glycoepitope.jp/epitopes/EP0004 denotes O-GlcNAc

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-60 Sentence denotes Demystifying O-GlcNAcylation: hints from peptide substrates.
TextSentencer_T2 61-231 Sentence denotes O-GlcNAcylation, analogous to phosphorylation, is an essential post-translational modification of proteins at Ser/Thr residues with a single β-N-acetylglucosamine moiety.
TextSentencer_T3 232-426 Sentence denotes This dynamic protein modification regulates many fundamental cellular processes and its deregulation has been linked to chronic diseases such as cancer, diabetes and neurodegenerative disorders.
TextSentencer_T4 427-544 Sentence denotes Reversible attachment and removal of O-GlcNAc is governed only by O-GlcNAc transferase and O-GlcNAcase, respectively.
TextSentencer_T5 545-805 Sentence denotes Peptide substrates, derived from natural O-GlcNAcylation targets, function in the catalytic cores of these two enzymes by maintaining interactions between enzyme and substrate, which makes them ideal models for the study of O-GlcNAcylation and deglycosylation.
TextSentencer_T6 806-902 Sentence denotes These peptides provide valuable tools for a deeper understanding of O-GlcNAc processing enzymes.
TextSentencer_T7 903-1149 Sentence denotes By taking advantage of peptide chemistry, recent progress in the study of activity and regulatory mechanisms of these two enzymes has advanced our understanding of their fundamental specificities as well as their potential as therapeutic targets.
TextSentencer_T8 1150-1388 Sentence denotes Hence, this review summarizes the recent achievements on this modification studied at the peptide level, focusing on enzyme activity, enzyme specificity, direct function, site-specific antibodies and peptide substrate-inspired inhibitors.
T1 0-60 Sentence denotes Demystifying O-GlcNAcylation: hints from peptide substrates.
T2 61-231 Sentence denotes O-GlcNAcylation, analogous to phosphorylation, is an essential post-translational modification of proteins at Ser/Thr residues with a single β-N-acetylglucosamine moiety.
T3 232-426 Sentence denotes This dynamic protein modification regulates many fundamental cellular processes and its deregulation has been linked to chronic diseases such as cancer, diabetes and neurodegenerative disorders.
T4 427-544 Sentence denotes Reversible attachment and removal of O-GlcNAc is governed only by O-GlcNAc transferase and O-GlcNAcase, respectively.
T5 545-805 Sentence denotes Peptide substrates, derived from natural O-GlcNAcylation targets, function in the catalytic cores of these two enzymes by maintaining interactions between enzyme and substrate, which makes them ideal models for the study of O-GlcNAcylation and deglycosylation.
T6 806-902 Sentence denotes These peptides provide valuable tools for a deeper understanding of O-GlcNAc processing enzymes.
T7 903-1149 Sentence denotes By taking advantage of peptide chemistry, recent progress in the study of activity and regulatory mechanisms of these two enzymes has advanced our understanding of their fundamental specificities as well as their potential as therapeutic targets.
T8 1150-1388 Sentence denotes Hence, this review summarizes the recent achievements on this modification studied at the peptide level, focusing on enzyme activity, enzyme specificity, direct function, site-specific antibodies and peptide substrate-inspired inhibitors.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 204-223 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T2 464-472 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T3 464-472 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T4 493-501 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T5 493-501 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T6 874-882 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T7 874-882 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
T1 204-223 chem:24139 denotes N-acetylglucosamine
T2 466-472 chem:24139 denotes GlcNAc
T3 495-501 chem:24139 denotes GlcNAc
T4 876-882 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T1 204-223 chem:24139 denotes N-acetylglucosamine
PD-NGLY1-deficiency-B_T2 466-472 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T3 495-501 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T4 876-882 chem:24139 denotes GlcNAc

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 377-383 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 385-393 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 377-383 Phenotype denotes cancer HP:0002664

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 464-472 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 493-501 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T3 874-882 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 377-383 Phenotype denotes cancer HP:0002664

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 377-383 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 385-393 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 293-311 Body_part denotes cellular processes http://purl.obolibrary.org/obo/GO_0042995

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-60 Sentence denotes Demystifying O-GlcNAcylation: hints from peptide substrates.
TextSentencer_T2 61-231 Sentence denotes O-GlcNAcylation, analogous to phosphorylation, is an essential post-translational modification of proteins at Ser/Thr residues with a single β-N-acetylglucosamine moiety.
TextSentencer_T3 232-426 Sentence denotes This dynamic protein modification regulates many fundamental cellular processes and its deregulation has been linked to chronic diseases such as cancer, diabetes and neurodegenerative disorders.
TextSentencer_T4 427-544 Sentence denotes Reversible attachment and removal of O-GlcNAc is governed only by O-GlcNAc transferase and O-GlcNAcase, respectively.
TextSentencer_T5 545-805 Sentence denotes Peptide substrates, derived from natural O-GlcNAcylation targets, function in the catalytic cores of these two enzymes by maintaining interactions between enzyme and substrate, which makes them ideal models for the study of O-GlcNAcylation and deglycosylation.
TextSentencer_T6 806-902 Sentence denotes These peptides provide valuable tools for a deeper understanding of O-GlcNAc processing enzymes.
TextSentencer_T7 903-1149 Sentence denotes By taking advantage of peptide chemistry, recent progress in the study of activity and regulatory mechanisms of these two enzymes has advanced our understanding of their fundamental specificities as well as their potential as therapeutic targets.
TextSentencer_T8 1150-1388 Sentence denotes Hence, this review summarizes the recent achievements on this modification studied at the peptide level, focusing on enzyme activity, enzyme specificity, direct function, site-specific antibodies and peptide substrate-inspired inhibitors.
T1 0-60 Sentence denotes Demystifying O-GlcNAcylation: hints from peptide substrates.
T2 61-231 Sentence denotes O-GlcNAcylation, analogous to phosphorylation, is an essential post-translational modification of proteins at Ser/Thr residues with a single β-N-acetylglucosamine moiety.
T3 232-426 Sentence denotes This dynamic protein modification regulates many fundamental cellular processes and its deregulation has been linked to chronic diseases such as cancer, diabetes and neurodegenerative disorders.
T4 427-544 Sentence denotes Reversible attachment and removal of O-GlcNAc is governed only by O-GlcNAc transferase and O-GlcNAcase, respectively.
T5 545-805 Sentence denotes Peptide substrates, derived from natural O-GlcNAcylation targets, function in the catalytic cores of these two enzymes by maintaining interactions between enzyme and substrate, which makes them ideal models for the study of O-GlcNAcylation and deglycosylation.
T6 806-902 Sentence denotes These peptides provide valuable tools for a deeper understanding of O-GlcNAc processing enzymes.
T7 903-1149 Sentence denotes By taking advantage of peptide chemistry, recent progress in the study of activity and regulatory mechanisms of these two enzymes has advanced our understanding of their fundamental specificities as well as their potential as therapeutic targets.
T8 1150-1388 Sentence denotes Hence, this review summarizes the recent achievements on this modification studied at the peptide level, focusing on enzyme activity, enzyme specificity, direct function, site-specific antibodies and peptide substrate-inspired inhibitors.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes Demystifying O-GlcNAcylation: hints from peptide substrates.
T2 61-231 Sentence denotes O-GlcNAcylation, analogous to phosphorylation, is an essential post-translational modification of proteins at Ser/Thr residues with a single β-N-acetylglucosamine moiety.
T3 232-426 Sentence denotes This dynamic protein modification regulates many fundamental cellular processes and its deregulation has been linked to chronic diseases such as cancer, diabetes and neurodegenerative disorders.
T4 427-544 Sentence denotes Reversible attachment and removal of O-GlcNAc is governed only by O-GlcNAc transferase and O-GlcNAcase, respectively.
T5 545-805 Sentence denotes Peptide substrates, derived from natural O-GlcNAcylation targets, function in the catalytic cores of these two enzymes by maintaining interactions between enzyme and substrate, which makes them ideal models for the study of O-GlcNAcylation and deglycosylation.
T6 806-902 Sentence denotes These peptides provide valuable tools for a deeper understanding of O-GlcNAc processing enzymes.
T7 903-1149 Sentence denotes By taking advantage of peptide chemistry, recent progress in the study of activity and regulatory mechanisms of these two enzymes has advanced our understanding of their fundamental specificities as well as their potential as therapeutic targets.
T8 1150-1388 Sentence denotes Hence, this review summarizes the recent achievements on this modification studied at the peptide level, focusing on enzyme activity, enzyme specificity, direct function, site-specific antibodies and peptide substrate-inspired inhibitors.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 464-472 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 493-501 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T3 874-882 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 464-472 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 493-501 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 874-882 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 464-472 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 493-501 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 874-882 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 293-311 Body_part denotes cellular processes http://purl.obolibrary.org/obo/GO_0042995