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PubMed:29435315 JSONTXT

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Inflammaging

Id	Subject	Object	Predicate	Lexical cue
T1	0-91	Sentence	denotes	Fluid resuscitation with lactated Ringer's solution vs normal saline in acute pancreatitis:
T2	92-137	Sentence	denotes	A triple-blind, randomized, controlled trial.
T3	138-149	Sentence	denotes	BACKGROUND:
T4	150-243	Sentence	denotes	Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP).
T5	244-254	Sentence	denotes	OBJECTIVE:
T6	255-403	Sentence	denotes	The objective of this article was to compare the effect of lactated Ringer's solution (LR) vs normal saline (NS) in the inflammatory response in AP.
T7	404-412	Sentence	denotes	METHODS:
T8	413-471	Sentence	denotes	We conducted a triple-blind, randomized, controlled trial.
T9	472-517	Sentence	denotes	Patients ≥ 18 admitted with AP were eligible.
T10	518-563	Sentence	denotes	Patients were randomized to receive LR or NS.
T11	564-763	Sentence	denotes	Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours.
T12	764-886	Sentence	denotes	In vitro complementary experiments were performed to further explore the interaction between pH, lactate and inflammation.
T13	887-895	Sentence	denotes	RESULTS:
T14	896-961	Sentence	denotes	Nineteen patients receiving LR and 21 receiving NS were analyzed.
T15	962-1068	Sentence	denotes	The median (p25-p75) number of SIRS criteria at 48 hours were 1 (1-2) for NS vs 1 (0-1) for LR, p = 0.060.
T16	1069-1217	Sentence	denotes	CRP levels (mg/l) were as follows: at 48 hours NS 166 (78-281) vs LR 28 (3-124), p = 0.037; at 72 hours NS 217 (59-323) vs LR 25 (3-169), p = 0.043.
T17	1218-1317	Sentence	denotes	In vitro, LR inhibited the induction of inflammatory phenotype of macrophages and NF-κB activation.
T18	1318-1449	Sentence	denotes	This effect was not observed when using Ringer's solution without lactate, suggesting a direct anti-inflammatory effect of lactate.
T19	1450-1462	Sentence	denotes	CONCLUSIONS:
T20	1463-1564	Sentence	denotes	Lactated Ringer's is associated with an anti-inflammatory effect in patients with acute pancreatitis.
T1	0-91	Sentence	denotes	Fluid resuscitation with lactated Ringer's solution vs normal saline in acute pancreatitis:
T2	92-137	Sentence	denotes	A triple-blind, randomized, controlled trial.
T3	138-149	Sentence	denotes	BACKGROUND:
T4	150-243	Sentence	denotes	Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP).
T5	244-254	Sentence	denotes	OBJECTIVE:
T6	255-403	Sentence	denotes	The objective of this article was to compare the effect of lactated Ringer's solution (LR) vs normal saline (NS) in the inflammatory response in AP.
T7	404-412	Sentence	denotes	METHODS:
T8	413-471	Sentence	denotes	We conducted a triple-blind, randomized, controlled trial.
T9	472-517	Sentence	denotes	Patients ≥ 18 admitted with AP were eligible.
T10	518-563	Sentence	denotes	Patients were randomized to receive LR or NS.
T11	564-763	Sentence	denotes	Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours.
T12	764-886	Sentence	denotes	In vitro complementary experiments were performed to further explore the interaction between pH, lactate and inflammation.
T13	887-895	Sentence	denotes	RESULTS:
T14	896-961	Sentence	denotes	Nineteen patients receiving LR and 21 receiving NS were analyzed.
T15	962-1068	Sentence	denotes	The median (p25-p75) number of SIRS criteria at 48 hours were 1 (1-2) for NS vs 1 (0-1) for LR, p = 0.060.
T16	1069-1217	Sentence	denotes	CRP levels (mg/l) were as follows: at 48 hours NS 166 (78-281) vs LR 28 (3-124), p = 0.037; at 72 hours NS 217 (59-323) vs LR 25 (3-169), p = 0.043.
T17	1218-1317	Sentence	denotes	In vitro, LR inhibited the induction of inflammatory phenotype of macrophages and NF-κB activation.
T18	1318-1449	Sentence	denotes	This effect was not observed when using Ringer's solution without lactate, suggesting a direct anti-inflammatory effect of lactate.
T19	1450-1462	Sentence	denotes	CONCLUSIONS:
T20	1463-1564	Sentence	denotes	Lactated Ringer's is associated with an anti-inflammatory effect in patients with acute pancreatitis.

luoyt2021_800_3

Id	Subject	Object	Predicate	Lexical cue
T1	219-237	DP	denotes	acute pancreatitis
T2	72-90	DP	denotes	acute pancreatitis
T3	239-241	DP	denotes	AP
T4	500-502	DP	denotes	AP
T5	400-402	DP	denotes	AP
T6	25-51	CI	denotes	lactated Ringer's solution
T7	55-68	CI	denotes	normal saline
T8	314-340	CI	denotes	lactated Ringer's solution
T9	342-344	CI	denotes	LR
T10	1228-1230	CI	denotes	LR
T11	1192-1194	CI	denotes	LR
T12	1135-1137	CI	denotes	LR
T13	1054-1056	CI	denotes	LR
T14	924-926	CI	denotes	LR
T15	554-556	CI	denotes	LR
T16	349-362	CI	denotes	normal saline
T17	364-366	CI	denotes	NS
T18	1173-1175	CI	denotes	NS
T19	1116-1118	CI	denotes	NS
T20	1036-1038	CI	denotes	NS
T21	944-946	CI	denotes	NS
T22	560-562	CI	denotes	NS

Linmchun_800_3

Id	Subject	Object	Predicate	Lexical cue
T1	239-241	DP	denotes	AP
T2	219-237	DP	denotes	acute pancreatitis
T3	72-90	DP	denotes	acute pancreatitis
T4	500-502	DP	denotes	AP
T5	400-402	DP	denotes	AP
T6	342-344	CI	denotes	LR
T7	364-366	CI	denotes	NS
T8	349-362	CI	denotes	normal saline
T9	314-340	CI	denotes	lactated Ringer's solution
T10	25-51	CI	denotes	lactated Ringer's solution
T11	55-68	CI	denotes	normal saline
T12	554-556	CI	denotes	LR
T13	560-562	CI	denotes	NS
T14	924-926	CI	denotes	LR
T15	944-946	CI	denotes	NS
T16	1054-1056	CI	denotes	LR
T17	1036-1038	CI	denotes	NS
T18	1116-1118	CI	denotes	NS
T19	1135-1137	CI	denotes	LR
T20	1173-1175	CI	denotes	NS
T21	1228-1230	CI	denotes	LR
T22	1192-1194	CI	denotes	LR