PubMed:29389900 JSONTXT

{"project":"sonoma2","denotations":[{"id":"T10","span":{"begin":385,"end":392},"obj":"CPA"},{"id":"T23","span":{"begin":746,"end":749},"obj":"REG"},{"id":"T0","span":{"begin":27,"end":36},"obj":"GENE"},{"id":"T1","span":{"begin":99,"end":103},"obj":"REG"},{"id":"T2","span":{"begin":142,"end":151},"obj":"GENE"},{"id":"T3","span":{"begin":245,"end":254},"obj":"MPA"},{"id":"T4","span":{"begin":245,"end":254},"obj":"GENE"},{"id":"T5","span":{"begin":264,"end":267},"obj":"REG"},{"id":"T6","span":{"begin":278,"end":289},"obj":"DISEASE"},{"id":"T7","span":{"begin":281,"end":296},"obj":"DISEASE"},{"id":"T8","span":{"begin":346,"end":351},"obj":"MPA"},{"id":"T9","span":{"begin":357,"end":359},"obj":"REG"},{"id":"T11","span":{"begin":425,"end":434},"obj":"MPA"},{"id":"T12","span":{"begin":425,"end":434},"obj":"GENE"},{"id":"T13","span":{"begin":448,"end":452},"obj":"REG"},{"id":"T14","span":{"begin":479,"end":482},"obj":"REG"},{"id":"T15","span":{"begin":496,"end":513},"obj":"MPA"},{"id":"T16","span":{"begin":534,"end":536},"obj":"GENE"},{"id":"T17","span":{"begin":537,"end":546},"obj":"REG"},{"id":"T18","span":{"begin":537,"end":546},"obj":"GENE"},{"id":"T19","span":{"begin":547,"end":569},"obj":"MPA"},{"id":"T20","span":{"begin":556,"end":573},"obj":"GENE"},{"id":"T21","span":{"begin":672,"end":681},"obj":"GENE"},{"id":"T22","span":{"begin":688,"end":690},"obj":"REG"},{"id":"T24","span":{"begin":835,"end":844},"obj":"GENE"}],"relations":[{"id":"R0","pred":"ThemeOf","subj":"T3","obj":"T5"},{"id":"R1","pred":"ThemeOf","subj":"T6","obj":"T5"},{"id":"R2","pred":"ThemeOf","subj":"T8","obj":"T9"},{"id":"R3","pred":"ThemeOf","subj":"T11","obj":"T13"},{"id":"R4","pred":"ThemeOf","subj":"T14","obj":"T13"},{"id":"R5","pred":"ThemeOf","subj":"T15","obj":"T13"},{"id":"R6","pred":"ThemeOf","subj":"T15","obj":"T14"},{"id":"R7","pred":"ThemeOf","subj":"T19","obj":"T17"}],"text":"The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease.\nA distinct G-protein coupled receptor that senses changes in extracellular Zn2+, ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most prominently, ZnR/GPR39 activity was described in prostate cancer, skin keratinocytes, and colon epithelial cells, where zinc is essential for cell growth, wound closure, and barrier formation. ZnR/GPR39 activity was also described in neurons that are postsynaptic to vesicular Zn2+ release. Activation of ZnR/GPR39 triggers Gαq-dependent signaling and subsequent cellular pathways associated with cell growth and survival. Furthermore, ZnR/GPR39 was shown to regulate the activity of ion transport mechanisms that are essential for the physiological function of epithelial and neuronal cells. Thus, ZnR/GPR39 provides a unique target for therapeutically modifying the actions of zinc in a specific and selective manner."}