PubMed:29388006
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 905-911 | Glycan_Motif | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
| T2 | 925-932 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
| T3 | 1018-1026 | Glycan_Motif | denotes | LacdiNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO |
| T5 | 1207-1216 | Glycan_Motif | denotes | galactose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
| T7 | 1327-1334 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
| T8 | 1547-1553 | Glycan_Motif | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-88 | Sentence | denotes | Glycan recognition by human blood mononuclear cells with an emphasis on dendritic cells. |
| TextSentencer_T2 | 89-284 | Sentence | denotes | Dendritic cells (DCs) play crucial roles in innate and adaptive immune response, for which reason targeting antigen to these cells is an important strategy for improvement of vaccine development. |
| TextSentencer_T3 | 285-348 | Sentence | denotes | To this end, we explored recognition of DCs lectins by glycans. |
| TextSentencer_T4 | 349-613 | Sentence | denotes | For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes. |
| TextSentencer_T5 | 614-632 | Sentence | denotes | It was found that: |
| TextSentencer_T6 | 633-1027 | Sentence | denotes | 1) the glycan-binding profiles of this CD14low/-CD16+CD83+ subpopulation were similar but not identical to DCs of monocyte origin (moDCs); 2) the highest percentage of probe-positive cells in this CD14 low/-CD16+CD83+ subpopulation was observed for GalNAcα1-2Galβ (Adi), (Neu5Acα)3 and three mannose-reach glycans; 3) subpopulation of CD14low/-CD16+ cells preferentially bound 4'-O-Su-LacdiNAc. |
| TextSentencer_T7 | 1028-1261 | Sentence | denotes | Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2. |
| TextSentencer_T8 | 1262-1348 | Sentence | denotes | In contrast, DC-SIGN is not apparently involved, even in case of mannose-rich glycans. |
| TextSentencer_T9 | 1349-1587 | Sentence | denotes | Taking into consideration potential in vivo competition between glycan "vectors" and glycans within glycocalyx, attempting to target vaccine to DCs glycan-binding receptors should focus on Adi and (Neu5Acα)3 as the most promising vectors. |
| T1 | 0-88 | Sentence | denotes | Glycan recognition by human blood mononuclear cells with an emphasis on dendritic cells. |
| T2 | 89-284 | Sentence | denotes | Dendritic cells (DCs) play crucial roles in innate and adaptive immune response, for which reason targeting antigen to these cells is an important strategy for improvement of vaccine development. |
| T3 | 285-348 | Sentence | denotes | To this end, we explored recognition of DCs lectins by glycans. |
| T4 | 349-613 | Sentence | denotes | For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes. |
| T5 | 614-632 | Sentence | denotes | It was found that: |
| T6 | 633-1027 | Sentence | denotes | 1) the glycan-binding profiles of this CD14low/-CD16+CD83+ subpopulation were similar but not identical to DCs of monocyte origin (moDCs); 2) the highest percentage of probe-positive cells in this CD14 low/-CD16+CD83+ subpopulation was observed for GalNAcα1-2Galβ (Adi), (Neu5Acα)3 and three mannose-reach glycans; 3) subpopulation of CD14low/-CD16+ cells preferentially bound 4'-O-Su-LacdiNAc. |
| T7 | 1028-1261 | Sentence | denotes | Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2. |
| T8 | 1262-1348 | Sentence | denotes | In contrast, DC-SIGN is not apparently involved, even in case of mannose-rich glycans. |
| T9 | 1349-1587 | Sentence | denotes | Taking into consideration potential in vivo competition between glycan "vectors" and glycans within glycocalyx, attempting to target vaccine to DCs glycan-binding receptors should focus on Adi and (Neu5Acα)3 as the most promising vectors. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 905-911 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T2 | 925-932 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
| T3 | 1018-1026 | https://glytoucan.org/Structures/Glycans/G00057MO | denotes | LacdiNAc |
| T4 | 1018-1026 | https://glytoucan.org/Structures/Glycans/G31736BK | denotes | LacdiNAc |
| T5 | 1207-1216 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactose |
| T6 | 1207-1216 | https://glytoucan.org/Structures/Glycans/G68158BT | denotes | galactose |
| T7 | 1327-1334 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
| T8 | 1547-1553 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 28-33 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
| T2 | 28-33 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
| T3 | 492-497 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
| T4 | 492-497 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 882-888 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 905-911 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T3 | 1547-1553 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 22-27 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 34-51 | Cell | denotes | mononuclear cells | http://purl.obolibrary.org/obo/CL:0000842 |
| T2 | 72-87 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T4 | 89-104 | Cell | denotes | Dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T6 | 106-109 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T7 | 325-328 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T8 | 498-514 | Cell | denotes | mononuclear cell | http://purl.obolibrary.org/obo/CL:0000842 |
| T9 | 541-544 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T10 | 599-612 | Cell | denotes | T-lymphocytes | http://purl.obolibrary.org/obo/CL:0000084 |
| T11 | 740-743 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T12 | 747-755 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T14 | 1077-1080 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T15 | 1196-1206 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T17 | 1493-1496 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 28-33 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T2 | 34-51 | Body_part | denotes | mononuclear cells | http://purl.obolibrary.org/obo/CL_0000842 |
| T3 | 72-87 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T4 | 89-104 | Body_part | denotes | Dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T5 | 106-109 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T6 | 325-328 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T7 | 492-497 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T8 | 498-514 | Body_part | denotes | mononuclear cell | http://purl.obolibrary.org/obo/CL_0000842 |
| T9 | 541-544 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T10 | 599-612 | Body_part | denotes | T-lymphocytes | http://purl.obolibrary.org/obo/CL_0000084 |
| T11 | 740-743 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T12 | 747-755 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T14 | 1077-1080 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T15 | 1196-1206 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T16 | 1493-1496 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 28-33 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T3 | 492-497 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-88 | Sentence | denotes | Glycan recognition by human blood mononuclear cells with an emphasis on dendritic cells. |
| TextSentencer_T2 | 89-284 | Sentence | denotes | Dendritic cells (DCs) play crucial roles in innate and adaptive immune response, for which reason targeting antigen to these cells is an important strategy for improvement of vaccine development. |
| TextSentencer_T3 | 285-348 | Sentence | denotes | To this end, we explored recognition of DCs lectins by glycans. |
| TextSentencer_T4 | 349-613 | Sentence | denotes | For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes. |
| TextSentencer_T5 | 614-632 | Sentence | denotes | It was found that: |
| TextSentencer_T6 | 633-1027 | Sentence | denotes | 1) the glycan-binding profiles of this CD14low/-CD16+CD83+ subpopulation were similar but not identical to DCs of monocyte origin (moDCs); 2) the highest percentage of probe-positive cells in this CD14 low/-CD16+CD83+ subpopulation was observed for GalNAcα1-2Galβ (Adi), (Neu5Acα)3 and three mannose-reach glycans; 3) subpopulation of CD14low/-CD16+ cells preferentially bound 4'-O-Su-LacdiNAc. |
| TextSentencer_T7 | 1028-1261 | Sentence | denotes | Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2. |
| TextSentencer_T8 | 1262-1348 | Sentence | denotes | In contrast, DC-SIGN is not apparently involved, even in case of mannose-rich glycans. |
| TextSentencer_T9 | 1349-1587 | Sentence | denotes | Taking into consideration potential in vivo competition between glycan "vectors" and glycans within glycocalyx, attempting to target vaccine to DCs glycan-binding receptors should focus on Adi and (Neu5Acα)3 as the most promising vectors. |
| T1 | 0-88 | Sentence | denotes | Glycan recognition by human blood mononuclear cells with an emphasis on dendritic cells. |
| T2 | 89-284 | Sentence | denotes | Dendritic cells (DCs) play crucial roles in innate and adaptive immune response, for which reason targeting antigen to these cells is an important strategy for improvement of vaccine development. |
| T3 | 285-348 | Sentence | denotes | To this end, we explored recognition of DCs lectins by glycans. |
| T4 | 349-613 | Sentence | denotes | For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes. |
| T5 | 614-632 | Sentence | denotes | It was found that: |
| T6 | 633-1027 | Sentence | denotes | 1) the glycan-binding profiles of this CD14low/-CD16+CD83+ subpopulation were similar but not identical to DCs of monocyte origin (moDCs); 2) the highest percentage of probe-positive cells in this CD14 low/-CD16+CD83+ subpopulation was observed for GalNAcα1-2Galβ (Adi), (Neu5Acα)3 and three mannose-reach glycans; 3) subpopulation of CD14low/-CD16+ cells preferentially bound 4'-O-Su-LacdiNAc. |
| T7 | 1028-1261 | Sentence | denotes | Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2. |
| T8 | 1262-1348 | Sentence | denotes | In contrast, DC-SIGN is not apparently involved, even in case of mannose-rich glycans. |
| T9 | 1349-1587 | Sentence | denotes | Taking into consideration potential in vivo competition between glycan "vectors" and glycans within glycocalyx, attempting to target vaccine to DCs glycan-binding receptors should focus on Adi and (Neu5Acα)3 as the most promising vectors. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-88 | Sentence | denotes | Glycan recognition by human blood mononuclear cells with an emphasis on dendritic cells. |
| T2 | 89-284 | Sentence | denotes | Dendritic cells (DCs) play crucial roles in innate and adaptive immune response, for which reason targeting antigen to these cells is an important strategy for improvement of vaccine development. |
| T3 | 285-348 | Sentence | denotes | To this end, we explored recognition of DCs lectins by glycans. |
| T4 | 349-613 | Sentence | denotes | For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes. |
| T5 | 614-632 | Sentence | denotes | It was found that: |
| T6 | 633-1027 | Sentence | denotes | 1) the glycan-binding profiles of this CD14low/-CD16+CD83+ subpopulation were similar but not identical to DCs of monocyte origin (moDCs); 2) the highest percentage of probe-positive cells in this CD14 low/-CD16+CD83+ subpopulation was observed for GalNAcα1-2Galβ (Adi), (Neu5Acα)3 and three mannose-reach glycans; 3) subpopulation of CD14low/-CD16+ cells preferentially bound 4'-O-Su-LacdiNAc. |
| T7 | 1028-1261 | Sentence | denotes | Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2. |
| T8 | 1262-1348 | Sentence | denotes | In contrast, DC-SIGN is not apparently involved, even in case of mannose-rich glycans. |
| T9 | 1349-1587 | Sentence | denotes | Taking into consideration potential in vivo competition between glycan "vectors" and glycans within glycocalyx, attempting to target vaccine to DCs glycan-binding receptors should focus on Adi and (Neu5Acα)3 as the most promising vectors. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 882-888 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 905-911 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T3 | 1547-1553 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 22-27 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 28-33 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T2 | 34-51 | Body_part | denotes | mononuclear cells | http://purl.obolibrary.org/obo/CL_0000842 |
| T3 | 72-87 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T4 | 89-104 | Body_part | denotes | Dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T5 | 106-109 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T6 | 325-328 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T7 | 492-497 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T8 | 498-514 | Body_part | denotes | mononuclear cell | http://purl.obolibrary.org/obo/CL_0000842 |
| T9 | 541-544 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T10 | 599-612 | Body_part | denotes | T-lymphocytes | http://purl.obolibrary.org/obo/CL_0000084 |
| T11 | 740-743 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T12 | 747-755 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T14 | 1077-1080 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T15 | 1196-1206 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T16 | 1493-1496 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 28-33 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T3 | 492-497 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 34-51 | Cell | denotes | mononuclear cells | http://purl.obolibrary.org/obo/CL:0000842 |
| T2 | 72-87 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T4 | 89-104 | Cell | denotes | Dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T6 | 106-109 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T7 | 325-328 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T8 | 498-514 | Cell | denotes | mononuclear cell | http://purl.obolibrary.org/obo/CL:0000842 |
| T9 | 541-544 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T10 | 599-612 | Cell | denotes | T-lymphocytes | http://purl.obolibrary.org/obo/CL:0000084 |
| T11 | 740-743 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T12 | 747-755 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T14 | 1077-1080 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T15 | 1196-1206 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T17 | 1493-1496 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |