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PubMed:29387348 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
29387348_0 47-53 ProteinMutation denotes G2019S rs34637584
29387348_1 269-275 ProteinMutation denotes G2019S rs34637584
29387348_2 996-1002 ProteinMutation denotes 019S t rs34637584
29387348_3 1445-1451 ProteinMutation denotes 019S m rs34637584
29387348_4 1263-1269 ProteinMutation denotes 019S m rs34637584
29387348_5 1554-1560 ProteinMutation denotes 019S m rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T99 854-861 32644 denotes unknown
T100 913-918 PR:Q5S006 denotes LRRK2
T101 913-918 PR:000003033 denotes LRRK2
T102 913-918 PR:Q5S007 denotes LRRK2
T103 969-974 PR:Q5S006 denotes LRRK2
T104 969-974 PR:000003033 denotes LRRK2
T105 969-974 PR:Q5S007 denotes LRRK2
T106 975-984 SO:0000817 denotes wild-type
T107 1001-1011 SO:0000781 denotes transgenic
T108 1001-1016 10090 denotes transgenic mice
T109 1001-1016 D008822 denotes transgenic mice
T110 1012-1016 PR:000005054 denotes mice
T112 1012-1016 O89094 denotes mice
T114 1034-1040 PR:Q54JW9 denotes impact
T115 1034-1040 PR:Q642J4 denotes impact
T117 1044-1047 P17560 denotes AGE
T118 1044-1047 P51607 denotes AGE
T119 1044-1047 P82343 denotes AGE
T120 1044-1047 O18921 denotes AGE
T121 1044-1047 P51606 denotes AGE
T123 1044-1047 PR:000013884 denotes AGE
T124 1044-1047 Q2KIS1 denotes AGE
T116 1044-1047 CVCL_Z433 denotes AGE
T122 1044-1047 CHEBI:84123 denotes AGE
T125 1152-1156 PR:Q15109 denotes RAGE
T126 1152-1156 PR:000013691 denotes RAGE
T127 1152-1156 PR:000003828 denotes RAGE
T128 1152-1156 PR:Q9UQ07 denotes RAGE
T129 1157-1165 CHEBI:36080 denotes proteins
T130 1183-1193 SO:0000781 denotes transgenic
T131 1183-1198 10090 denotes transgenic mice
T132 1183-1198 D008822 denotes transgenic mice
T133 1194-1198 PR:000005054 denotes mice
T135 1194-1198 O89094 denotes mice
T137 1255-1260 PR:Q5S006 denotes LRRK2
T138 1255-1260 PR:000003033 denotes LRRK2
T139 1255-1260 PR:Q5S007 denotes LRRK2
T141 1317-1320 P17560 denotes AGE
T2 0-3 P17560 denotes AGE
T3 0-3 P51607 denotes AGE
T4 0-3 P82343 denotes AGE
T5 0-3 O18921 denotes AGE
T6 0-3 P51606 denotes AGE
T8 0-3 PR:000013884 denotes AGE
T9 0-3 Q2KIS1 denotes AGE
T1 0-3 CVCL_Z433 denotes AGE
T7 0-3 CHEBI:84123 denotes AGE
T10 12-31 GO:0070997 denotes neuronal cell death
T12 54-59 PR:Q5S006 denotes LRRK2
T13 54-59 PR:000003033 denotes LRRK2
T14 54-59 PR:Q5S007 denotes LRRK2
T15 60-68 SO:0000109 denotes mutation
T16 84-88 PR:Q15109 denotes RAGE
T17 84-88 PR:000013691 denotes RAGE
T18 84-88 PR:000003828 denotes RAGE
T19 84-88 PR:Q9UQ07 denotes RAGE
T21 113-120 6308 denotes Leucine
T22 113-120 SO:0001437 denotes Leucine
T20 113-120 CHEBI:15603 denotes Leucine
T23 113-120 D007930 denotes Leucine
T24 113-120 CHEBI:25017 denotes Leucine
T25 113-120 D007930 denotes Leucine
T26 126-132 SO:0001068 denotes repeat
T27 143-148 PR:Q5S006 denotes LRRK2
T28 143-148 PR:000003033 denotes LRRK2
T29 143-148 PR:Q5S007 denotes LRRK2
T34 225-244 D010300 denotes Parkinson's disease
T35 225-244 D010300 denotes Parkinson's disease
T38 263-268 PR:Q5S006 denotes LRRK2
T39 263-268 PR:000003033 denotes LRRK2
T40 263-268 PR:Q5S007 denotes LRRK2
T41 276-284 SO:0001583 denotes missense
T42 285-293 SO:0000109 denotes mutation
T43 357-367 D000067562 denotes late-onset
T44 357-367 D000067562 denotes late-onset
T45 372-403 D017127 denotes Advanced glycation end products
T46 372-403 CHEBI:84123 denotes Advanced glycation end products
T47 405-409 CHEBI:84123 denotes AGEs
T48 464-469 GO:0007568 denotes aging
T49 497-519 D002318 denotes cardiovascular disease
T50 497-519 D002318 denotes cardiovascular disease
T53 527-534 D004194 denotes disease
T54 527-534 D004194 denotes disease
T55 553-560 D004194 denotes disease
T56 553-560 D004194 denotes disease
T57 562-566 CHEBI:84123 denotes AGEs
T58 575-588 GO:0005622 denotes intracellular
T59 575-606 GO:0035556 denotes intracellular signaling pathway
T62 599-606 CHEBI:34922 denotes pathway
T63 644-656 GO:0006954 denotes inflammation
T64 644-656 D007249 denotes inflammation
T65 644-656 D007249 denotes inflammation
T66 668-678 GO:0008219 denotes cell death
T67 680-684 PR:Q15109 denotes RAGE
T68 680-684 PR:000013691 denotes RAGE
T69 680-684 PR:000003828 denotes RAGE
T70 680-684 PR:Q9UQ07 denotes RAGE
T71 698-702 CHEBI:84123 denotes AGEs
T72 737-741 CHEBI:84123 denotes AGEs
T74 755-758 P17560 denotes AGE
T75 755-758 P51607 denotes AGE
T76 755-758 P82343 denotes AGE
T77 755-758 O18921 denotes AGE
T78 755-758 P51606 denotes AGE
T80 755-758 PR:000013884 denotes AGE
T81 755-758 Q2KIS1 denotes AGE
T73 755-758 CVCL_Z433 denotes AGE
T79 755-758 CHEBI:84123 denotes AGE
T83 789-792 P17560 denotes AGE
T84 789-792 P51607 denotes AGE
T85 789-792 P82343 denotes AGE
T86 789-792 O18921 denotes AGE
T87 789-792 P51606 denotes AGE
T89 789-792 PR:000013884 denotes AGE
T90 789-792 Q2KIS1 denotes AGE
T82 789-792 CVCL_Z433 denotes AGE
T88 789-792 CHEBI:84123 denotes AGE
T91 797-801 PR:Q15109 denotes RAGE
T92 797-801 PR:000013691 denotes RAGE
T93 797-801 PR:000003828 denotes RAGE
T94 797-801 PR:Q9UQ07 denotes RAGE
T95 822-834 GO:0009405 denotes pathogenesis
T96 845-850 PR:Q5S006 denotes LRRK2
T97 845-850 PR:000003033 denotes LRRK2
T98 845-850 PR:Q5S007 denotes LRRK2
T142 1317-1320 P51607 denotes AGE
T143 1317-1320 P82343 denotes AGE
T144 1317-1320 O18921 denotes AGE
T145 1317-1320 P51606 denotes AGE
T147 1317-1320 PR:000013884 denotes AGE
T148 1317-1320 Q2KIS1 denotes AGE
T140 1317-1320 CVCL_Z433 denotes AGE
T146 1317-1320 CHEBI:84123 denotes AGE
T149 1329-1339 GO:0008219 denotes cell death
T150 1403-1407 PR:Q15109 denotes RAGE
T151 1403-1407 PR:000013691 denotes RAGE
T152 1403-1407 PR:000003828 denotes RAGE
T153 1403-1407 PR:Q9UQ07 denotes RAGE
T154 1408-1416 CHEBI:36080 denotes proteins
T155 1437-1442 PR:Q5S006 denotes LRRK2
T156 1437-1442 PR:000003033 denotes LRRK2
T157 1437-1442 PR:Q5S007 denotes LRRK2
T159 1510-1513 P17560 denotes AGE
T160 1510-1513 P51607 denotes AGE
T161 1510-1513 P82343 denotes AGE
T162 1510-1513 O18921 denotes AGE
T163 1510-1513 P51606 denotes AGE
T165 1510-1513 PR:000013884 denotes AGE
T166 1510-1513 Q2KIS1 denotes AGE
T158 1510-1513 CVCL_Z433 denotes AGE
T164 1510-1513 CHEBI:84123 denotes AGE
T167 1514-1518 PR:Q15109 denotes RAGE
T168 1514-1518 PR:000013691 denotes RAGE
T169 1514-1518 PR:000003828 denotes RAGE
T170 1514-1518 PR:Q9UQ07 denotes RAGE
T171 1546-1551 PR:Q5S006 denotes LRRK2
T172 1546-1551 PR:000003033 denotes LRRK2
T173 1546-1551 PR:Q5S007 denotes LRRK2
T174 1559-1567 SO:0000109 denotes mutation

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression.
T2 101-112 Sentence denotes Background:
T3 113-250 Sentence denotes Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson's disease (PD).
T4 251-371 Sentence denotes Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the late-onset PD.
T5 372-561 Sentence denotes Advanced glycation end products (AGEs) are produced in high amounts in diabetes and diverse aging-related disorders, such as cardiovascular disease, renal disease, and neurological disease.
T6 562-679 Sentence denotes AGEs trigger intracellular signaling pathway associated with oxidative stress and inflammation as well as cell death.
T7 680-780 Sentence denotes RAGE, receptor of AGEs, is activated by interaction with AGEs and mediates AGE-induced cytotoxicity.
T8 781-862 Sentence denotes Whether AGE and RAGE are involved in the pathogenesis of mutant LRRK2 is unknown.
T9 863-871 Sentence denotes Methods:
T10 872-1120 Sentence denotes Using cell lines transfected with mutant LRRK2 as well as primary neuronal cultures derived from LRRK2 wild-type (WT) and G2019S transgenic mice, we compared the impact of AGE treatment on the survival of control and mutant cells by immunostaining.
T11 1121-1232 Sentence denotes We also examined the levels of RAGE proteins in the brains of transgenic mice and PD patients by western blots.
T12 1233-1241 Sentence denotes Results:
T13 1242-1361 Sentence denotes We show that LRRK2 G2019S mutant-expressing neurons were more sensitive to AGE-induced cell death compared to controls.
T14 1362-1463 Sentence denotes Furthermore, we found that the levels of RAGE proteins were upregulated in LRRK2 G2019S mutant cells.
T15 1464-1476 Sentence denotes Conclusions:
T16 1477-1609 Sentence denotes These data suggest that enhanced AGE-RAGE interaction contributes to LRRK2 G2019S mutation-mediated progressive neuronal loss in PD.
T1 0-100 Sentence denotes AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression.
T2 101-112 Sentence denotes Background:
T3 113-250 Sentence denotes Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson's disease (PD).
T4 251-371 Sentence denotes Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the late-onset PD.
T5 372-561 Sentence denotes Advanced glycation end products (AGEs) are produced in high amounts in diabetes and diverse aging-related disorders, such as cardiovascular disease, renal disease, and neurological disease.
T6 562-679 Sentence denotes AGEs trigger intracellular signaling pathway associated with oxidative stress and inflammation as well as cell death.
T7 680-780 Sentence denotes RAGE, receptor of AGEs, is activated by interaction with AGEs and mediates AGE-induced cytotoxicity.
T8 781-862 Sentence denotes Whether AGE and RAGE are involved in the pathogenesis of mutant LRRK2 is unknown.
T9 863-871 Sentence denotes Methods:
T10 872-1120 Sentence denotes Using cell lines transfected with mutant LRRK2 as well as primary neuronal cultures derived from LRRK2 wild-type (WT) and G2019S transgenic mice, we compared the impact of AGE treatment on the survival of control and mutant cells by immunostaining.
T11 1121-1232 Sentence denotes We also examined the levels of RAGE proteins in the brains of transgenic mice and PD patients by western blots.
T12 1233-1241 Sentence denotes Results:
T13 1242-1361 Sentence denotes We show that LRRK2 G2019S mutant-expressing neurons were more sensitive to AGE-induced cell death compared to controls.
T14 1362-1463 Sentence denotes Furthermore, we found that the levels of RAGE proteins were upregulated in LRRK2 G2019S mutant cells.
T15 1464-1476 Sentence denotes Conclusions:
T16 1477-1609 Sentence denotes These data suggest that enhanced AGE-RAGE interaction contributes to LRRK2 G2019S mutation-mediated progressive neuronal loss in PD.

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 113-862 UNASSIGNED denotes Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson's disease (PD). Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the late-onset PD. Advanced glycation end products (AGEs) are produced in high amounts in diabetes and diverse aging-related disorders, such as cardiovascular disease, renal disease, and neurological disease. AGEs trigger intracellular signaling pathway associated with oxidative stress and inflammation as well as cell death. RAGE, receptor of AGEs, is activated by interaction with AGEs and mediates AGE-induced cytotoxicity. Whether AGE and RAGE are involved in the pathogenesis of mutant LRRK2 is unknown.
T2 872-1232 UNASSIGNED denotes Using cell lines transfected with mutant LRRK2 as well as primary neuronal cultures derived from LRRK2 wild-type (WT) and G2019S transgenic mice, we compared the impact of AGE treatment on the survival of control and mutant cells by immunostaining. We also examined the levels of RAGE proteins in the brains of transgenic mice and PD patients by western blots.
T3 1242-1463 UNASSIGNED denotes We show that LRRK2 G2019S mutant-expressing neurons were more sensitive to AGE-induced cell death compared to controls. Furthermore, we found that the levels of RAGE proteins were upregulated in LRRK2 G2019S mutant cells.
T4 1477-1609 UNASSIGNED denotes These data suggest that enhanced AGE-RAGE interaction contributes to LRRK2 G2019S mutation-mediated progressive neuronal loss in PD.