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GoldHamster

Id Subject Object Predicate Lexical cue
T3 11-20 358263 denotes tadalafil
T1 11-20 D000068581 denotes tadalafil
T2 11-20 CHEBI:71940 denotes tadalafil
T4 11-20 D000068581 denotes tadalafil
T7 22-25 GO:0004114 denotes PDE
T6 22-25 C536254 denotes PDE
T11 22-26 PR:Q8MLZ3 denotes PDE5
T12 22-26 PR:Q28156 denotes PDE5
T13 22-26 PR:O76074 denotes PDE5
T14 22-26 PR:Q8CG03 denotes PDE5
T15 22-26 PR:O54735 denotes PDE5
T16 22-26 PR:000012477 denotes PDE5
T17 22-26 PR:P91119 denotes PDE5
T18 22-36 CHEBI:71942 denotes PDE5 inhibitor
T20 42-53 1091836 denotes roflumilast
T21 42-53 CHEBI:47657 denotes roflumilast
T22 42-53 C424423 denotes roflumilast
T23 42-53 C424423 denotes roflumilast
T26 55-58 GO:0004114 denotes PDE
T25 55-58 C536254 denotes PDE
T30 55-59 PR:Q86H13 denotes PDE4
T31 55-59 PR:Q22000 denotes PDE4
T32 55-69 CHEBI:68844 denotes PDE4 inhibitor
T34 74-80 UBERON:0000117 denotes airway
T35 74-80 UBERON:0001005 denotes airway
T36 107-119 GO:0006954 denotes inflammation
T37 107-119 D007249 denotes inflammation
T38 107-119 D007249 denotes inflammation
T39 123-132 PR:000025876 denotes ovalbumin
T40 123-132 E2RVI8 denotes ovalbumin
T41 123-132 P19104 denotes ovalbumin
T42 123-132 P01012 denotes ovalbumin
T45 123-132 O73860 denotes ovalbumin
T46 123-132 Q6V115 denotes ovalbumin
T43 123-132 D010047 denotes ovalbumin
T44 123-132 D010047 denotes ovalbumin
T47 141-147 UBERON:0000117 denotes airway
T48 141-147 UBERON:0001005 denotes airway
T49 171-182 D006168 denotes guinea pigs
T50 178-182 PR:Q9W3Y4 denotes pigs
T53 178-182 PR:Q6PD26 denotes pigs
T54 178-182 PR:Q5XI31 denotes pigs
T55 178-182 PR:Q96S52 denotes pigs
T56 178-182 PR:000012706 denotes pigs
T57 194-211 Q1M964 denotes phosphodiesterase
T58 194-211 Q45087 denotes phosphodiesterase
T59 194-211 GO:0008081 denotes phosphodiesterase
T62 213-216 GO:0004114 denotes PDE
T61 213-216 C536254 denotes PDE
T66 213-219 PR:Q86H13 denotes PDE) 4
T67 213-219 PR:Q22000 denotes PDE) 4
T68 213-230 CHEBI:68844 denotes PDE) 4 inhibitors
T69 213-230 D058988 denotes PDE) 4 inhibitors
T70 213-230 D058988 denotes PDE) 4 inhibitors
T74 281-318 D029424 denotes chronic obstructive pulmonary disease
T75 281-318 D029424 denotes chronic obstructive pulmonary disease
T84 344-350 UBERON:0000117 denotes airway
T85 344-350 UBERON:0001005 denotes airway
T86 379-391 GO:0006954 denotes inflammation
T87 379-391 D007249 denotes inflammation
T88 379-391 D007249 denotes inflammation
T89 405-418 GO:0005622 denotes intracellular
T90 419-423 CHEBI:17489 denotes cAMP
T91 447-463 D001249 denotes bronchial asthma
T92 447-463 D001249 denotes bronchial asthma
T97 473-476 GO:0004114 denotes PDE
T96 473-476 C536254 denotes PDE
T101 473-477 PR:Q8MLZ3 denotes PDE5
T102 473-477 PR:Q28156 denotes PDE5
T103 473-477 PR:O76074 denotes PDE5
T104 473-477 PR:Q8CG03 denotes PDE5
T105 473-477 PR:O54735 denotes PDE5
T106 473-477 PR:000012477 denotes PDE5
T107 473-477 PR:P91119 denotes PDE5
T108 473-488 D058986 denotes PDE5 inhibitors
T109 473-488 CHEBI:71942 denotes PDE5 inhibitors
T110 473-488 D058986 denotes PDE5 inhibitors
T112 517-537 D007172 denotes erectile dysfunction
T113 517-537 D007172 denotes erectile dysfunction
T114 539-561 D006976 denotes pulmonary hypertension
T115 539-561 D006976 denotes pulmonary hypertension
T118 573-596 D002318 denotes cardiovascular diseases
T119 573-596 D002318 denotes cardiovascular diseases
T122 619-622 GO:0004114 denotes PDE
T121 619-622 C536254 denotes PDE
T126 619-623 PR:Q8MLZ3 denotes PDE5
T127 619-623 PR:Q28156 denotes PDE5
T128 619-623 PR:O76074 denotes PDE5
T129 619-623 PR:Q8CG03 denotes PDE5
T130 619-623 PR:O54735 denotes PDE5
T131 619-623 PR:000012477 denotes PDE5
T132 619-623 PR:P91119 denotes PDE5
T133 677-689 GO:0006954 denotes inflammation
T134 677-689 D007249 denotes inflammation
T135 677-689 D007249 denotes inflammation
T138 772-775 GO:0004114 denotes PDE
T137 772-775 C536254 denotes PDE
T142 772-776 PR:Q86H13 denotes PDE4
T143 772-776 PR:Q22000 denotes PDE4
T146 781-784 GO:0004114 denotes PDE
T145 781-784 C536254 denotes PDE
T150 781-785 PR:Q8MLZ3 denotes PDE5
T151 781-785 PR:Q28156 denotes PDE5
T152 781-785 PR:O76074 denotes PDE5
T153 781-785 PR:Q8CG03 denotes PDE5
T154 781-785 PR:O54735 denotes PDE5
T155 781-785 PR:000012477 denotes PDE5
T156 781-785 PR:P91119 denotes PDE5
T157 781-796 D058986 denotes PDE5 inhibitors
T158 781-796 CHEBI:71942 denotes PDE5 inhibitors
T159 781-796 D058986 denotes PDE5 inhibitors
T161 809-821 GO:0006954 denotes inflammation
T162 809-821 D007249 denotes inflammation
T163 809-821 D007249 denotes inflammation
T166 884-887 GO:0004114 denotes PDE
T165 884-887 C536254 denotes PDE
T170 884-888 PR:Q8MLZ3 denotes PDE5
T171 884-888 PR:Q28156 denotes PDE5
T172 884-888 PR:O76074 denotes PDE5
T173 884-888 PR:Q8CG03 denotes PDE5
T174 884-888 PR:O54735 denotes PDE5
T175 884-888 PR:000012477 denotes PDE5
T176 884-888 PR:P91119 denotes PDE5
T177 884-898 CHEBI:71942 denotes PDE5 inhibitor
T181 899-908 358263 denotes tadalafil
T179 899-908 D000068581 denotes tadalafil
T180 899-908 CHEBI:71940 denotes tadalafil
T182 899-908 D000068581 denotes tadalafil
T185 913-916 GO:0004114 denotes PDE
T184 913-916 C536254 denotes PDE
T189 913-917 PR:Q86H13 denotes PDE4
T190 913-917 PR:Q22000 denotes PDE4
T191 913-927 CHEBI:68844 denotes PDE4 inhibitor
T193 928-939 1091836 denotes roflumilast
T194 928-939 CHEBI:47657 denotes roflumilast
T195 928-939 C424423 denotes roflumilast
T196 928-939 C424423 denotes roflumilast
T197 975-987 GO:0006954 denotes inflammation
T198 975-987 D007249 denotes inflammation
T199 975-987 D007249 denotes inflammation
T200 1032-1046 CHEBI:50858 denotes corticosteroid
T202 1047-1060 3264 denotes dexamethasone
T201 1047-1060 D003907 denotes dexamethasone
T203 1047-1060 CHEBI:41879 denotes dexamethasone
T204 1047-1060 D003907 denotes dexamethasone
T205 1076-1080 UBERON:0003101 denotes male
T206 1076-1080 CHEBI:30780 denotes male
T207 1081-1086 UBERON:0007023 denotes adult
T208 1087-1098 D006168 denotes guinea pigs
T209 1094-1098 PR:Q9W3Y4 denotes pigs
T212 1094-1098 PR:Q6PD26 denotes pigs
T213 1094-1098 PR:Q5XI31 denotes pigs
T214 1094-1098 PR:Q96S52 denotes pigs
T215 1094-1098 PR:000012706 denotes pigs
T216 1169-1178 PR:000025876 denotes ovalbumin
T217 1169-1178 E2RVI8 denotes ovalbumin
T218 1169-1178 P19104 denotes ovalbumin
T219 1169-1178 P01012 denotes ovalbumin
T222 1169-1178 O73860 denotes ovalbumin
T223 1169-1178 Q6V115 denotes ovalbumin
T220 1169-1178 D010047 denotes ovalbumin
T221 1169-1178 D010047 denotes ovalbumin
T226 1262-1271 358263 denotes tadalafil
T224 1262-1271 D000068581 denotes tadalafil
T225 1262-1271 CHEBI:71940 denotes tadalafil
T227 1262-1271 D000068581 denotes tadalafil
T228 1275-1286 1091836 denotes roflumilast
T229 1275-1286 CHEBI:47657 denotes roflumilast
T230 1275-1286 C424423 denotes roflumilast
T231 1275-1286 C424423 denotes roflumilast
T233 1372-1385 3264 denotes dexamethasone
T232 1372-1385 D003907 denotes dexamethasone
T234 1372-1385 CHEBI:41879 denotes dexamethasone
T235 1372-1385 D003907 denotes dexamethasone
T238 1426-1435 358263 denotes tadalafil
T236 1426-1435 D000068581 denotes tadalafil
T237 1426-1435 CHEBI:71940 denotes tadalafil
T239 1426-1435 D000068581 denotes tadalafil
T240 1440-1451 1091836 denotes roflumilast
T241 1440-1451 CHEBI:47657 denotes roflumilast
T242 1440-1451 C424423 denotes roflumilast
T243 1440-1451 C424423 denotes roflumilast
T244 1473-1479 UBERON:0000117 denotes airway
T245 1473-1479 UBERON:0001005 denotes airway
T247 1513-1522 5333 denotes histamine
T246 1513-1522 CHEBI:58432 denotes histamine
T248 1513-1522 CHEBI:18295 denotes histamine
T249 1513-1522 D006632 denotes histamine
T250 1513-1522 D006632 denotes histamine
T251 1544-1550 UBERON:0000117 denotes airway
T252 1544-1550 UBERON:0001005 denotes airway
T253 1591-1597 UBERON:0000117 denotes airway
T254 1591-1597 UBERON:0001005 denotes airway
T256 1632-1641 5333 denotes histamine
T255 1632-1641 CHEBI:58432 denotes histamine
T257 1632-1641 CHEBI:18295 denotes histamine
T258 1632-1641 D006632 denotes histamine
T259 1632-1641 D006632 denotes histamine
T261 1646-1659 194 denotes acetylcholine
T260 1646-1659 D000109 denotes acetylcholine
T262 1646-1659 CHEBI:15355 denotes acetylcholine
T263 1646-1659 D000109 denotes acetylcholine
T264 1696-1707 1091836 denotes roflumilast
T265 1696-1707 CHEBI:47657 denotes roflumilast
T266 1696-1707 C424423 denotes roflumilast
T267 1696-1707 C424423 denotes roflumilast
T268 1716-1720 UBERON:0002048 denotes lung
T269 1721-1727 UBERON:0000479 denotes tissue
T270 1778-1783 UBERON:0000062 denotes organ
T271 1778-1783 UBERON:0003103 denotes organ
T272 1916-1928 D007378 denotes interleukins
T273 1916-1928 CHEBI:52998 denotes interleukins
T274 1916-1928 D007378 denotes interleukins
T275 1938-1960 D016328 denotes nuclear factor kappa B
T276 1965-1970 D009369 denotes tumor
T277 1965-1970 D009369 denotes tumor
T309 1965-1986 GO:0005164 denotes tumor necrosis factor
T319 1965-1992 PR:000000134 denotes tumor necrosis factor alpha
T318 1965-1992 D014409 denotes tumor necrosis factor alpha
T320 1965-1992 D014409 denotes tumor necrosis factor alpha
T321 1971-1979 GO:0019835 denotes necrosis
T322 1971-1979 GO:0008219 denotes necrosis
T325 1971-1979 GO:0008220 denotes necrosis
T326 1971-1979 GO:0001906 denotes necrosis
T327 1971-1979 GO:0070265 denotes necrosis
T323 1971-1979 D009336 denotes necrosis
T324 1971-1979 D009336 denotes necrosis
T329 2000-2004 UBERON:0002048 denotes lung
T331 2045-2058 3264 denotes dexamethasone
T330 2045-2058 D003907 denotes dexamethasone
T332 2045-2058 CHEBI:41879 denotes dexamethasone
T333 2045-2058 D003907 denotes dexamethasone
T334 2060-2071 1091836 denotes Roflumilast
T335 2060-2071 CHEBI:47657 denotes Roflumilast
T336 2060-2071 C424423 denotes Roflumilast
T337 2060-2071 C424423 denotes Roflumilast
T340 2076-2085 358263 denotes tadalafil
T338 2076-2085 D000068581 denotes tadalafil
T339 2076-2085 CHEBI:71940 denotes tadalafil
T341 2076-2085 D000068581 denotes tadalafil
T342 2141-2145 UBERON:0002048 denotes lung
T343 2146-2151 D017392 denotes TBARS
T344 2146-2151 D017392 denotes TBARS
T345 2165-2170 CHEBI:18059 denotes lipid
T346 2165-2180 GO:0034440 denotes lipid oxidation
T347 2171-2180 MOP:0000568 denotes oxidation
T350 2192-2195 GO:0004114 denotes PDE
T349 2192-2195 C536254 denotes PDE
T354 2192-2196 PR:Q8MLZ3 denotes PDE5
T355 2192-2196 PR:Q28156 denotes PDE5
T356 2192-2196 PR:O76074 denotes PDE5
T357 2192-2196 PR:Q8CG03 denotes PDE5
T358 2192-2196 PR:O54735 denotes PDE5
T359 2192-2196 PR:000012477 denotes PDE5
T360 2192-2196 PR:P91119 denotes PDE5
T361 2228-2234 UBERON:0000117 denotes airway
T362 2228-2234 UBERON:0001005 denotes airway
T363 2235-2247 GO:0006954 denotes inflammation
T364 2235-2247 D007249 denotes inflammation
T365 2235-2247 D007249 denotes inflammation
T368 2277-2280 GO:0004114 denotes PDE
T367 2277-2280 C536254 denotes PDE
T372 2277-2281 PR:Q86H13 denotes PDE4
T373 2277-2281 PR:Q22000 denotes PDE4
T374 2334-2337 W8E7D1 denotes PDE
T377 2334-2337 A0A2D0TC04 denotes PDE
T378 2334-2337 J3SBP3 denotes PDE
T379 2334-2337 J3SEZ3 denotes PDE
T376 2334-2337 GO:0004114 denotes PDE
T375 2334-2337 C536254 denotes PDE
T380 2334-2348 CHEBI:50568 denotes PDE inhibitors
T383 2382-2395 3264 denotes dexamethasone
T382 2382-2395 D003907 denotes dexamethasone
T384 2382-2395 CHEBI:41879 denotes dexamethasone
T385 2382-2395 D003907 denotes dexamethasone

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 184-319 DRI_Background denotes Selective phosphodiesterase (PDE) 4 inhibitors have recently been introduced into the therapy of chronic obstructive pulmonary disease.
T2 320-472 DRI_Challenge denotes However, suppression of airway reactivity and eosinophilic inflammation by increased intracellular cAMP could be beneficial in bronchial asthma as well.
T3 473-699 DRI_Background denotes PDE5 inhibitors are used for the therapy of erectile dysfunction, pulmonary hypertension, and other cardiovascular diseases, but an expression of PDE5 in several immune cells suggests its perspectives in inflammation, as well.
T4 700-1061 DRI_Outcome denotes To bring a new information on the therapeutically relevant potential of PDE4 and PDE5 inhibitors in allergic inflammation, this study evaluated the effects of 7-days administration of PDE5 inhibitor tadalafil and PDE4 inhibitor roflumilast in experimentally-induced allergic inflammation and compared their action with effects of a corticosteroid dexamethasone.
T5 1062-1109 DRI_Background denotes In the study, male adult guinea pigs were used.
T6 1110-1313 DRI_Background denotes Control group was non-sensitized, while other animals were ovalbumin-sensitized over two weeks and thereafter treated intraperitoneally for 7 days with tadalafil or roflumilast (daily dose 1.0 mg/kg b.w.
T7 1421-1796 DRI_Background denotes Both tadalafil and roflumilast reduced the specific airway resistance after nebulization of histamine (a marker of in vivo airway reactivity), and decreased the in vitro airway reactivity to cumulative doses of histamine and acetylcholine in tracheal strips (significant for roflumilast) and in lung tissue strips (significant for both agents), analyzed by organ bath method.
T8 1797-2005 DRI_Approach denotes These changes were associated with decreased numbers of circulating leukocytes and eosinophils and lower production of interleukins 4 and 5, nuclear factor kappa B and tumor necrosis factor alpha in the lung.
T9 2006-2059 DRI_Background denotes Similar effects were observed also for dexamethasone.
T10 2060-2181 DRI_Background denotes Roflumilast and tadalafil, but not their combination with reduced doses, lowered lung TBARS, a marker of lipid oxidation.
T11 2182-2396 DRI_Outcome denotes Selective PDE5 inhibition alleviated allergic airway inflammation, but it was less potent than PDE4 inhibition, whereas anti-inflammatory action of the PDE inhibitors was comparable to the effects of dexamethasone.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 602-604 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T2 602-604 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T3 709-710 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 1030-1031 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T5 1524-1525 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 1803-1810 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T7 1959-1960 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T8 2153-2154 CVCL_6479|Finite_cell_line|Mus musculus denotes a

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-183 Sentence denotes Effects of tadalafil (PDE5 inhibitor) and roflumilast (PDE4 inhibitor) on airway reactivity and markers of inflammation in ovalbumin-induced airway hyperresponsiveness in guinea pigs.
T2 184-319 Sentence denotes Selective phosphodiesterase (PDE) 4 inhibitors have recently been introduced into the therapy of chronic obstructive pulmonary disease.
T3 320-472 Sentence denotes However, suppression of airway reactivity and eosinophilic inflammation by increased intracellular cAMP could be beneficial in bronchial asthma as well.
T4 473-699 Sentence denotes PDE5 inhibitors are used for the therapy of erectile dysfunction, pulmonary hypertension, and other cardiovascular diseases, but an expression of PDE5 in several immune cells suggests its perspectives in inflammation, as well.
T5 700-1061 Sentence denotes To bring a new information on the therapeutically relevant potential of PDE4 and PDE5 inhibitors in allergic inflammation, this study evaluated the effects of 7-days administration of PDE5 inhibitor tadalafil and PDE4 inhibitor roflumilast in experimentally-induced allergic inflammation and compared their action with effects of a corticosteroid dexamethasone.
T6 1062-1109 Sentence denotes In the study, male adult guinea pigs were used.
T7 1110-1420 Sentence denotes Control group was non-sensitized, while other animals were ovalbumin-sensitized over two weeks and thereafter treated intraperitoneally for 7 days with tadalafil or roflumilast (daily dose 1.0 mg/kg b.w. each), with their combination (0.5 mg/kg b.w. each), with dexamethasone (1.0 mg/kg b.w.), or with vehicle.
T8 1421-1796 Sentence denotes Both tadalafil and roflumilast reduced the specific airway resistance after nebulization of histamine (a marker of in vivo airway reactivity), and decreased the in vitro airway reactivity to cumulative doses of histamine and acetylcholine in tracheal strips (significant for roflumilast) and in lung tissue strips (significant for both agents), analyzed by organ bath method.
T9 1797-2005 Sentence denotes These changes were associated with decreased numbers of circulating leukocytes and eosinophils and lower production of interleukins 4 and 5, nuclear factor kappa B and tumor necrosis factor alpha in the lung.
T10 2006-2059 Sentence denotes Similar effects were observed also for dexamethasone.
T11 2060-2181 Sentence denotes Roflumilast and tadalafil, but not their combination with reduced doses, lowered lung TBARS, a marker of lipid oxidation.
T12 2182-2396 Sentence denotes Selective PDE5 inhibition alleviated allergic airway inflammation, but it was less potent than PDE4 inhibition, whereas anti-inflammatory action of the PDE inhibitors was comparable to the effects of dexamethasone.
T1 0-183 Sentence denotes Effects of tadalafil (PDE5 inhibitor) and roflumilast (PDE4 inhibitor) on airway reactivity and markers of inflammation in ovalbumin-induced airway hyperresponsiveness in guinea pigs.
T2 184-319 Sentence denotes Selective phosphodiesterase (PDE) 4 inhibitors have recently been introduced into the therapy of chronic obstructive pulmonary disease.
T3 320-472 Sentence denotes However, suppression of airway reactivity and eosinophilic inflammation by increased intracellular cAMP could be beneficial in bronchial asthma as well.
T4 473-699 Sentence denotes PDE5 inhibitors are used for the therapy of erectile dysfunction, pulmonary hypertension, and other cardiovascular diseases, but an expression of PDE5 in several immune cells suggests its perspectives in inflammation, as well.
T5 700-1061 Sentence denotes To bring a new information on the therapeutically relevant potential of PDE4 and PDE5 inhibitors in allergic inflammation, this study evaluated the effects of 7-days administration of PDE5 inhibitor tadalafil and PDE4 inhibitor roflumilast in experimentally-induced allergic inflammation and compared their action with effects of a corticosteroid dexamethasone.
T6 1062-1109 Sentence denotes In the study, male adult guinea pigs were used.
T7 1110-1420 Sentence denotes Control group was non-sensitized, while other animals were ovalbumin-sensitized over two weeks and thereafter treated intraperitoneally for 7 days with tadalafil or roflumilast (daily dose 1.0 mg/kg b.w. each), with their combination (0.5 mg/kg b.w. each), with dexamethasone (1.0 mg/kg b.w.), or with vehicle.
T8 1421-1796 Sentence denotes Both tadalafil and roflumilast reduced the specific airway resistance after nebulization of histamine (a marker of in vivo airway reactivity), and decreased the in vitro airway reactivity to cumulative doses of histamine and acetylcholine in tracheal strips (significant for roflumilast) and in lung tissue strips (significant for both agents), analyzed by organ bath method.
T9 1797-2005 Sentence denotes These changes were associated with decreased numbers of circulating leukocytes and eosinophils and lower production of interleukins 4 and 5, nuclear factor kappa B and tumor necrosis factor alpha in the lung.
T10 2006-2059 Sentence denotes Similar effects were observed also for dexamethasone.
T11 2060-2181 Sentence denotes Roflumilast and tadalafil, but not their combination with reduced doses, lowered lung TBARS, a marker of lipid oxidation.
T12 2182-2396 Sentence denotes Selective PDE5 inhibition alleviated allergic airway inflammation, but it was less potent than PDE4 inhibition, whereas anti-inflammatory action of the PDE inhibitors was comparable to the effects of dexamethasone.