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kaiyin_test

Id Subject Object Predicate Lexical cue
T3 4-20 PosReg denotes gain-of-function
T2 30-34 Var denotes E76K
T1 38-42 Gene denotes SHP2
T4 43-51 PosReg denotes promotes
T36 52-55 Disease denotes CAC
T37 56-69 CPA denotes tumorigenesis
T10 74-81 PosReg denotes induces
T11 82-85 CPA denotes EMT
T42 94-125 Pathway denotes Wnt/β-catenin signaling pathway
T38 340-348 Var denotes mutation
T39 358-362 Gene denotes SHP2
T41 370-377 Reg denotes highest
T40 382-399 Disease denotes colorectal cancer
T23 977-983 Gene denotes Ptpn11
T24 983-987 Var denotes E76K
T25 1024-1034 PosReg denotes aggravated
T26 1035-1047 CPA denotes inflammation
T27 1052-1061 PosReg denotes increased
T28 1062-1065 Disease denotes CAC
T29 1066-1079 CPA denotes tumorigenesis
T30 1091-1095 Gene denotes SHP2
T31 1095-1099 Var denotes E76K
T32 1111-1119 PosReg denotes promoted
T33 1120-1163 CPA denotes malignant biological behaviors of CRC cells
T34 1168-1175 PosReg denotes induced
T35 1176-1215 CPA denotes epithelial-mesenchymal transition (EMT)
T21 1291-1295 Gene denotes SHP2
T22 1295-1299 Var denotes E76K
T17 1325-1333 PosReg denotes promotes
T18 1338-1351 CPA denotes tumorigenesis
T19 1356-1366 CPA denotes metastasis
T20 1370-1373 Disease denotes CRC
R1 T1 T2 ThemeOf SHP2,E76K
R10 T24 T25 CauseOf E76K,aggravated
R11 T26 T25 ThemeOf inflammation,aggravated
R12 T24 T27 CauseOf E76K,increased
R15 T30 T31 ThemeOf SHP2,E76K
R16 T31 T32 CauseOf E76K,promoted
R17 T31 T34 CauseOf E76K,induced
R18 T33 T32 ThemeOf malignant biological behaviors of CRC cells,promoted
R19 T35 T34 ThemeOf epithelial-mesenchymal transition (EMT),induced
R2 T2 T3 CauseOf E76K,gain-of-function
R20 T21 T22 ThemeOf SHP2,E76K
R21 T22 T17 CauseOf E76K,promotes
R22 T18 T17 ThemeOf tumorigenesis,promotes
R23 T19 T17 ThemeOf metastasis,promotes
R24 T20 T19 ThemeOf CRC,metastasis
R25 T20 T18 ThemeOf CRC,tumorigenesis
R26 T29 T27 ThemeOf tumorigenesis,increased
R27 T28 T29 ThemeOf CAC,tumorigenesis
R28 T36 T37 ThemeOf CAC,tumorigenesis
R29 T37 T4 ThemeOf tumorigenesis,promotes
R3 T3 T4 CauseOf gain-of-function,promotes
R30 T39 T38 ThemeOf SHP2,mutation
R31 T38 T41 CauseOf mutation,highest
R32 T40 T41 ThemeOf colorectal cancer,highest
R33 T42 T10 ThemeOf Wnt/β-catenin signaling pathway,induces
R7 T11 T10 ThemeOf EMT,induces
R8 T3 T10 CauseOf gain-of-function,induces
R9 T23 T24 ThemeOf Ptpn11,E76K

name_no

Id Subject Object Predicate Lexical cue
T3 4-20 PosReg denotes gain-of-function
T2 30-34 Var denotes E76K
T1 38-42 Gene denotes SHP2
T4 43-51 PosReg denotes promotes
T36 52-55 Disease denotes CAC
T37 56-69 CPA denotes tumorigenesis
T10 74-81 PosReg denotes induces
T11 82-85 CPA denotes EMT
T42 94-125 Pathway denotes Wnt/β-catenin signaling pathway
T38 340-348 Var denotes mutation
T39 358-362 Gene denotes SHP2
T41 370-377 Reg denotes highest
T40 382-399 Disease denotes colorectal cancer
T23 977-983 Gene denotes Ptpn11
T24 983-987 Var denotes E76K
T25 1024-1034 PosReg denotes aggravated
T26 1035-1047 CPA denotes inflammation
T27 1052-1061 PosReg denotes increased
T28 1062-1065 Disease denotes CAC
T29 1066-1079 CPA denotes tumorigenesis
T30 1091-1095 Gene denotes SHP2
T31 1095-1099 Var denotes E76K
T32 1111-1119 PosReg denotes promoted
T33 1120-1163 CPA denotes malignant biological behaviors of CRC cells
T34 1168-1175 PosReg denotes induced
T35 1176-1215 CPA denotes epithelial-mesenchymal transition (EMT)
T21 1291-1295 Gene denotes SHP2
T22 1295-1299 Var denotes E76K
T17 1325-1333 PosReg denotes promotes
T18 1338-1351 CPA denotes tumorigenesis
T19 1356-1366 CPA denotes metastasis
T20 1370-1373 Disease denotes CRC
R1 T1 T2 ThemeOf SHP2,E76K
R10 T24 T25 CauseOf E76K,aggravated
R11 T26 T25 ThemeOf inflammation,aggravated
R12 T24 T27 CauseOf E76K,increased
R15 T30 T31 ThemeOf SHP2,E76K
R16 T31 T32 CauseOf E76K,promoted
R17 T31 T34 CauseOf E76K,induced
R18 T33 T32 ThemeOf malignant biological behaviors of CRC cells,promoted
R19 T35 T34 ThemeOf epithelial-mesenchymal transition (EMT),induced
R2 T2 T3 CauseOf E76K,gain-of-function
R20 T21 T22 ThemeOf SHP2,E76K
R21 T22 T17 CauseOf E76K,promotes
R22 T18 T17 ThemeOf tumorigenesis,promotes
R23 T19 T17 ThemeOf metastasis,promotes
R24 T20 T19 ThemeOf CRC,metastasis
R25 T20 T18 ThemeOf CRC,tumorigenesis
R26 T29 T27 ThemeOf tumorigenesis,increased
R27 T28 T29 ThemeOf CAC,tumorigenesis
R28 T36 T37 ThemeOf CAC,tumorigenesis
R29 T37 T4 ThemeOf tumorigenesis,promotes
R3 T3 T4 CauseOf gain-of-function,promotes
R30 T39 T38 ThemeOf SHP2,mutation
R31 T38 T41 CauseOf mutation,highest
R32 T40 T41 ThemeOf colorectal cancer,highest
R33 T42 T10 ThemeOf Wnt/β-catenin signaling pathway,induces
R7 T11 T10 ThemeOf EMT,induces
R8 T3 T10 CauseOf gain-of-function,induces
R9 T23 T24 ThemeOf Ptpn11,E76K

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes The gain-of-function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/β-catenin signaling pathway.
T2 127-196 Sentence denotes SHP2 is encoded by the protein tyrosine phosphatase 11 (Ptpn11) gene.
T3 197-322 Sentence denotes Several gain-of-function (GOF) mutations in Ptpn11 have been identified in human hematopoietic malignancies and solid tumors.
T4 323-425 Sentence denotes In addition, the mutation rate for SHP2 is the highest for colorectal cancer (CRC) among solid tumors.
T5 426-613 Sentence denotes The E76K GOF mutation is the most common and active SHP2 mutation; however, the pathogenic effects and function of this mutation in CRC tumor progression have not been well characterized.
T6 614-756 Sentence denotes The Wnt/β-catenin (CTNNB1) signaling pathway is crucial for CRC, and excessive activation of this pathway has been observed in several tumors.
T7 757-976 Sentence denotes We used Ptpn11E76K conditional knock-in mice to study this GOF mutation in colitis-associated CRC (CAC) and used the CRC cell lines HT29 and HCT116 to determine the relationship between SHP2 and Wnt/β-catenin signaling.
T8 977-1080 Sentence denotes Ptpn11E76K conditional knock-in mice exhibited aggravated inflammation and increased CAC tumorigenesis.
T9 1081-1256 Sentence denotes In vitro, SHP2E76K and SHP2WT promoted malignant biological behaviors of CRC cells and induced epithelial-mesenchymal transition (EMT) via the Wnt/β-catenin signaling pathway.
T10 1257-1374 Sentence denotes Together, our results showed that SHP2E76K acts as an oncogene that promotes the tumorigenesis and metastasis of CRC.
T1 0-126 Sentence denotes The gain-of-function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/β-catenin signaling pathway.
T2 127-196 Sentence denotes SHP2 is encoded by the protein tyrosine phosphatase 11 (Ptpn11) gene.
T3 197-322 Sentence denotes Several gain-of-function (GOF) mutations in Ptpn11 have been identified in human hematopoietic malignancies and solid tumors.
T4 323-425 Sentence denotes In addition, the mutation rate for SHP2 is the highest for colorectal cancer (CRC) among solid tumors.
T5 426-613 Sentence denotes The E76K GOF mutation is the most common and active SHP2 mutation; however, the pathogenic effects and function of this mutation in CRC tumor progression have not been well characterized.
T6 614-756 Sentence denotes The Wnt/β-catenin (CTNNB1) signaling pathway is crucial for CRC, and excessive activation of this pathway has been observed in several tumors.
T7 757-976 Sentence denotes We used Ptpn11E76K conditional knock-in mice to study this GOF mutation in colitis-associated CRC (CAC) and used the CRC cell lines HT29 and HCT116 to determine the relationship between SHP2 and Wnt/β-catenin signaling.
T8 977-1080 Sentence denotes Ptpn11E76K conditional knock-in mice exhibited aggravated inflammation and increased CAC tumorigenesis.
T9 1081-1256 Sentence denotes In vitro, SHP2E76K and SHP2WT promoted malignant biological behaviors of CRC cells and induced epithelial-mesenchymal transition (EMT) via the Wnt/β-catenin signaling pathway.
T10 1257-1374 Sentence denotes Together, our results showed that SHP2E76K acts as an oncogene that promotes the tumorigenesis and metastasis of CRC.