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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 PR:Q5S006 denotes LRRK2
T2 0-5 PR:000003033 denotes LRRK2
T3 0-5 PR:Q5S007 denotes LRRK2
T7 97-103 Q9N297 denotes 5-HT1A
T8 97-103 Q0EAB6 denotes 5-HT1A
T9 97-103 PR:000001161 denotes 5-HT1A
T10 97-103 Q6XXX9 denotes 5-HT1A
T11 97-103 Q9N296 denotes 5-HT1A
T12 97-103 Q6XXY0 denotes 5-HT1A
T13 97-103 P19327 denotes 5-HT1A
T14 97-103 Q9N298 denotes 5-HT1A
T15 97-103 PR:P19327 denotes 5-HT1A
T16 97-103 Q64264 denotes 5-HT1A
T17 97-103 Q98998 denotes 5-HT1A
T18 97-103 PR:P28285 denotes 5-HT1A
T19 97-103 P08908 denotes 5-HT1A
T20 97-112 D044282 denotes 5-HT1A Receptor
T21 99-102 CVCL_4W51 denotes HT1
T24 129-133 D051379 denotes Mice
T26 129-133 10095 denotes Mice
T23 129-133 PR:000005054 denotes Mice
T25 129-133 O89094 denotes Mice
T28 152-159 6308 denotes leucine
T29 152-159 SO:0001437 denotes leucine
T27 152-159 CHEBI:15603 denotes leucine
T30 152-159 D007930 denotes leucine
T31 152-159 CHEBI:25017 denotes leucine
T32 152-159 D007930 denotes leucine
T33 165-171 SO:0001068 denotes repeat
T34 182-187 PR:Q5S006 denotes LRRK2
T35 182-187 PR:000003033 denotes LRRK2
T36 182-187 PR:Q5S007 denotes LRRK2
T37 189-193 SO:0000704 denotes gene
T42 231-250 D010300 denotes Parkinson's disease
T43 231-250 D010300 denotes Parkinson's disease
T46 279-284 PR:Q5S006 denotes LRRK2
T47 279-284 PR:000003033 denotes LRRK2
T48 279-284 PR:Q5S007 denotes LRRK2
T49 285-293 SO:0000109 denotes mutation
T50 457-462 PR:Q5S006 denotes LRRK2
T51 457-462 PR:000003033 denotes LRRK2
T52 457-462 PR:Q5S007 denotes LRRK2
T53 463-471 SO:0000109 denotes mutation
T54 556-566 UBERON:0004704 denotes depression
T55 641-651 SO:0000781 denotes transgenic
T56 657-661 PR:000005054 denotes mice
T58 657-661 O89094 denotes mice
T57 657-661 D051379 denotes mice
T59 657-661 10095 denotes mice
T60 673-678 D006801 denotes human
T61 686-691 PR:Q5S006 denotes LRRK2
T62 686-691 PR:000003033 denotes LRRK2
T63 686-691 PR:Q5S007 denotes LRRK2
T64 776-780 PR:000022285 denotes maze
T65 776-780 PR:P0AE72 denotes maze
T66 776-780 PR:P96621 denotes maze
T67 776-780 PR:Q2FWI7 denotes maze
T68 782-789 10159 denotes sucrose
T69 782-789 D013395 denotes sucrose
T70 782-789 CHEBI:17992 denotes sucrose
T71 782-789 D013395 denotes sucrose
T72 814-822 GO:0036268 denotes swimming
T73 833-837 UBERON:4000164 denotes tail
T74 833-837 UBERON:2001058 denotes tail
T75 833-837 UBERON:0002415 denotes tail
T76 877-887 UBERON:0004704 denotes depression
T77 943-947 PR:000005054 denotes mice
T79 943-947 O89094 denotes mice
T78 943-947 D051379 denotes mice
T80 943-947 10095 denotes mice
T81 1044-1048 UBERON:0003101 denotes male
T82 1044-1048 CHEBI:30780 denotes male
T83 1053-1059 UBERON:0003100 denotes female
T84 1060-1064 PR:000005054 denotes mice
T86 1060-1064 O89094 denotes mice
T85 1060-1064 D051379 denotes mice
T87 1060-1064 10095 denotes mice
T88 1152-1156 PR:000005054 denotes mice
T90 1152-1156 O89094 denotes mice
T89 1152-1156 D051379 denotes mice
T91 1152-1156 10095 denotes mice
T92 1189-1198 CHEBI:28790 denotes serotonin
T93 1189-1198 D012701 denotes serotonin
T94 1189-1198 CHEBI:350546 denotes serotonin
T95 1189-1198 D012701 denotes serotonin
T96 1241-1252 UBERON:0002421 denotes hippocampus
T97 1241-1252 UBERON:0001954 denotes hippocampus
T98 1241-1252 UBERON:0002961 denotes hippocampus
T99 1259-1263 PR:000005054 denotes mice
T101 1259-1263 O89094 denotes mice
T100 1259-1263 D051379 denotes mice
T102 1259-1263 10095 denotes mice
T106 1314-1320 Q9N297 denotes 5-HT1A
T107 1314-1320 Q0EAB6 denotes 5-HT1A
T108 1314-1320 PR:000001161 denotes 5-HT1A
T109 1314-1320 Q6XXX9 denotes 5-HT1A
T110 1314-1320 Q9N296 denotes 5-HT1A
T111 1314-1320 Q6XXY0 denotes 5-HT1A
T112 1314-1320 P19327 denotes 5-HT1A
T113 1314-1320 Q9N298 denotes 5-HT1A
T114 1314-1320 PR:P19327 denotes 5-HT1A
T115 1314-1320 Q64264 denotes 5-HT1A
T116 1314-1320 Q98998 denotes 5-HT1A
T117 1314-1320 PR:P28285 denotes 5-HT1A
T118 1314-1320 P08908 denotes 5-HT1A
T119 1314-1329 D044282 denotes 5-HT1A receptor
T120 1316-1319 CVCL_4W51 denotes HT1
T122 1321-1336 D044263 denotes receptor (5-HT1
T127 1333-1336 PR:Q2MHE4 denotes HT1
T126 1333-1336 CVCL_4W51 denotes HT1
T128 1367-1372 GO:0007568 denotes aging
T129 1398-1409 UBERON:0002421 denotes hippocampus
T130 1398-1409 UBERON:0001954 denotes hippocampus
T131 1398-1409 UBERON:0002961 denotes hippocampus
T132 1411-1419 UBERON:0001876 denotes amygdala
T134 1425-1445 UBERON:0002043 denotes dorsal raphe nucleus
T139 1438-1445 GO:0005634 denotes nucleus
T137 1438-1445 CHEBI:33252 denotes nucleus
T140 1485-1490 CVCL_D261 denotes RN46A
T141 1507-1511 CVCL_0321 denotes HT22
T142 1530-1534 CHEBI:28790 denotes 5-HT
T143 1530-1534 D012701 denotes 5-HT
T144 1530-1534 D012701 denotes 5-HT
T146 1532-1535 PR:Q2MHE4 denotes HT1
T145 1532-1535 CVCL_4W51 denotes HT1
T147 1589-1594 PR:Q5S006 denotes LRRK2
T148 1589-1594 PR:000003033 denotes LRRK2
T149 1589-1594 PR:Q5S007 denotes LRRK2
T150 1628-1633 PR:Q5S006 denotes LRRK2
T151 1628-1633 PR:000003033 denotes LRRK2
T152 1628-1633 PR:Q5S007 denotes LRRK2
T153 1634-1643 CHEBI:35222 denotes inhibitor
T154 1644-1649 PR:Q5S006 denotes LRRK2
T155 1644-1649 PR:000003033 denotes LRRK2
T156 1644-1649 PR:Q5S007 denotes LRRK2
T157 1644-1654 CHEBI:78413 denotes LRRK2-IN-1
T158 1644-1654 C582847 denotes LRRK2-IN-1
T159 1644-1654 C582847 denotes LRRK2-IN-1
T160 1650-1654 CVCL_W473 denotes IN-1
T161 1666-1671 PR:Q5S006 denotes LRRK2
T162 1666-1671 PR:000003033 denotes LRRK2
T163 1666-1671 PR:Q5S007 denotes LRRK2
T164 1701-1705 CHEBI:28790 denotes 5-HT
T165 1701-1705 D012701 denotes 5-HT
T166 1701-1705 D012701 denotes 5-HT
T168 1703-1706 PR:Q2MHE4 denotes HT1
T167 1703-1706 CVCL_4W51 denotes HT1
T169 1709-1722 GO:0006351 denotes transcription
T170 1814-1824 GO:0065007 denotes regulation
T171 1828-1832 CHEBI:28790 denotes 5-HT
T172 1828-1832 D012701 denotes 5-HT
T173 1828-1832 D012701 denotes 5-HT
T175 1830-1833 PR:Q2MHE4 denotes HT1
T174 1830-1833 CVCL_4W51 denotes HT1
T176 1876-1886 UBERON:0004704 denotes depression
T177 1927-1932 PR:Q5S006 denotes LRRK2
T178 1927-1932 PR:000003033 denotes LRRK2
T179 1927-1932 PR:Q5S007 denotes LRRK2
T184 1956-1975 D010300 denotes Parkinson's disease
T185 1956-1975 D010300 denotes Parkinson's disease
T190 2005-2031 D019636 denotes neurodegenerative disorder
T191 2005-2031 D019636 denotes neurodegenerative disorder
T193 2298-2305 6308 denotes leucine
T194 2298-2305 SO:0001437 denotes leucine
T192 2298-2305 CHEBI:15603 denotes leucine
T195 2298-2305 D007930 denotes leucine
T196 2298-2305 CHEBI:25017 denotes leucine
T197 2298-2305 D007930 denotes leucine
T198 2311-2317 SO:0001068 denotes repeat
T199 2328-2333 PR:Q5S006 denotes LRRK2
T200 2328-2333 PR:000003033 denotes LRRK2
T201 2328-2333 PR:Q5S007 denotes LRRK2
T202 2355-2363 SO:0000109 denotes mutation
T203 2395-2405 UBERON:0004704 denotes depression
T207 2450-2456 Q9N297 denotes 5-HT1A
T208 2450-2456 Q0EAB6 denotes 5-HT1A
T209 2450-2456 PR:000001161 denotes 5-HT1A
T210 2450-2456 Q6XXX9 denotes 5-HT1A
T211 2450-2456 Q9N296 denotes 5-HT1A
T212 2450-2456 Q6XXY0 denotes 5-HT1A
T213 2450-2456 P19327 denotes 5-HT1A
T214 2450-2456 Q9N298 denotes 5-HT1A
T215 2450-2456 PR:P19327 denotes 5-HT1A
T216 2450-2456 Q64264 denotes 5-HT1A
T217 2450-2456 Q98998 denotes 5-HT1A
T218 2450-2456 PR:P28285 denotes 5-HT1A
T219 2450-2456 P08908 denotes 5-HT1A
T220 2450-2465 D044282 denotes 5-HT1A receptor
T221 2452-2455 CVCL_4W51 denotes HT1
T223 2486-2497 UBERON:0002421 denotes hippocampus
T224 2486-2497 UBERON:0001954 denotes hippocampus
T225 2486-2497 UBERON:0002961 denotes hippocampus
T226 2499-2507 UBERON:0001876 denotes amygdala
T228 2513-2533 UBERON:0002043 denotes dorsal raphe nucleus
T233 2526-2533 GO:0005634 denotes nucleus
T231 2526-2533 CHEBI:33252 denotes nucleus
T234 2574-2579 PR:Q5S006 denotes LRRK2
T235 2574-2579 PR:000003033 denotes LRRK2
T236 2574-2579 PR:Q5S007 denotes LRRK2
T237 2693-2698 PR:Q5S006 denotes LRRK2
T238 2693-2698 PR:000003033 denotes LRRK2
T239 2693-2698 PR:Q5S007 denotes LRRK2
T240 2699-2707 SO:0000109 denotes mutation
T244 2744-2750 Q9N297 denotes 5-HT1A
T245 2744-2750 Q0EAB6 denotes 5-HT1A
T246 2744-2750 PR:000001161 denotes 5-HT1A
T247 2744-2750 Q6XXX9 denotes 5-HT1A
T248 2744-2750 Q9N296 denotes 5-HT1A
T249 2744-2750 Q6XXY0 denotes 5-HT1A
T250 2744-2750 P19327 denotes 5-HT1A
T251 2744-2750 Q9N298 denotes 5-HT1A
T252 2744-2750 PR:P19327 denotes 5-HT1A
T253 2744-2750 Q64264 denotes 5-HT1A
T254 2744-2750 Q98998 denotes 5-HT1A
T255 2744-2750 PR:P28285 denotes 5-HT1A
T256 2744-2750 P08908 denotes 5-HT1A
T257 2744-2759 D044282 denotes 5-HT1A receptor
T258 2746-2749 CVCL_4W51 denotes HT1
T260 2800-2805 CHEBI:23888 denotes drugs
T261 2824-2834 UBERON:0004704 denotes depression

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 145-256 DRI_Approach denotes in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD).
T2 257-278 DRI_Challenge denotes The neuropathology of
T3 302-422 DRI_Challenge denotes PD, including increased dopaminergic neurodegeneration and Lewy bodies, is indistinguishable from that of idiopathic PD.
T4 423-456 DRI_Outcome denotes The subtle nonmotor phenotypes of
T5 480-513 DRI_Outcome denotes PD have not been fully evaluated.
T6 514-685 DRI_Outcome denotes In the present study, we examined anxiety/depression-like behaviors and accompanying neurochemical changes in differently aged transgenic (Tg) mice expressing human mutant
T7 698-699 DRI_Outcome denotes .
T8 700-994 DRI_Outcome denotes Through multiple behavioral tests, including light-dark test, elevated plus maze, sucrose preference test, forced swimming test, and tail-suspension test, we found that anxiety/depression-like behavior appeared in middle-aged (43-52 weeks) Tg mice before the onset of PD-like motor dysfunction.
T9 995-1157 DRI_Background denotes These behavioral tests were performed using both male and female mice, and there were no sex-related differences in behavioral changes in the middle-aged Tg mice.
T10 1158-1264 DRI_Background denotes Along with behavioral changes, serotonin levels also significantly declined in the hippocampus of Tg mice.
T11 1265-1446 DRI_Outcome denotes Additionally, increases in the expression of the 5-HT1A receptor (5-HT1AR) grew more significant with aging and were detected in the hippocampus, amygdala, and dorsal raphe nucleus.
T12 1447-1588 DRI_Background denotes In vitro study using the serotonergic RN46A and hippocampal HT22 cells showed that 5-HT1AR upregulation was related to enhanced expression of
T13 1602-1655 DRI_Background denotes and was attenuated by the LRRK2 inhibitor LRRK2-IN-1.
T14 1656-1723 DRI_Approach denotes Wild-type LRRK2 had no significant effect on 5-HT1AR transcription.
T15 1724-2083 DRI_Challenge denotes The present study provides the first in vivo and in vitro evidence demonstrating abnormal regulation of 5-HT1AR along with the manifestation of anxiety/depression-like, nonmotor symptom in PD related to LRRK2.SIGNIFICANCE STATEMENT Parkinson's disease (PD), the second most common neurodegenerative disorder, is clinically characterized by motor dysfunctions.
T16 2084-2254 DRI_Challenge denotes In most cases, various nonmotor symptoms present several years before the onset of the classical motor features of PD and severely affect the quality of life of patients.
T17 2255-2421 DRI_Approach denotes Here, we demonstrate the causative role of leucine-rich repeat kinase 2 (LRRK2), a common PD-linked mutation, in the development of anxiety/depression-like behaviors.
T18 2422-2597 DRI_Outcome denotes We found that age-dependent 5-HT1A receptor upregulation in the hippocampus, amygdala, and dorsal raphe nucleus is accompanied by the expression of the LRRK2 mutant phenotype.
T19 2598-2835 DRI_Outcome denotes Our findings demonstrating a potential mechanism for nonmotor psychiatric symptoms produced by LRRK2 mutation suggest that directly targeting the 5-HT1A receptor can improve the therapeutic efficacy of drugs for PD-associated depression.